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Tamaru ABURAI, Makoto TAKIUE, Hiroaki ISHIKAWA
1981Volume 30Issue 11 Pages
579-583
Published: 1981
Released on J-STAGE: September 07, 2010
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A new a-ray quantitative measurement method has been proposed, where the measurement system is designed to connect a liquid scintillation counter with a multichannel pulse-height analyzer. This technique provides the remarkable advantages such as a simplicity of sample preparation, a 100% counting efficiency measurement and the elimination of interfering radiations.
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Yukio MORI, Masayoshi SHIBATA, Kazumi TOYOSHI, Shigeo BABA, Masanobu H ...
1981Volume 30Issue 11 Pages
584-589
Published: 1981
Released on J-STAGE: September 07, 2010
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2- (4- (2-Thienylcarbonyl) phenyl) propionic acid (suprofen), an anti-inflammatory agent, was labeled with tritium or carbon-14 for the purpose of investigating its metabolic fate in animals. The selectively tritiated suprofen (26.3-32.1 GBq (710-867mCi) lmmol) was obtained by catalytic dehalogenation of the brominated precursor with 185-370 GBq (5-10 Ci) of tritium gas. The labeled position of the suprofen was confirmed by spectral data of the deuterated suprofen similarly synthesized. On the other hand, suprofen-14C (48.8 MBq (1.4 mCi) /mmol) was obtained by five-step synthesis from toluene [methyl-14C] in a 19% yield.
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Yukio MORI, Masayoshi SHIBATA, Kazumi TOYOSHI, Shigeo BABA, Masanobu H ...
1981Volume 30Issue 11 Pages
590-595
Published: 1981
Released on J-STAGE: September 07, 2010
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2- (4- (2-Thienylcarbonyl) phenyl) propionic acid (suprofen), an anti-inflammatory agent, was labeled with multiple-deuterium for the purpose of investigating the metabolism in man and animals by the ion cluster technique. Racemic suprofen-d4 was prepared by ten-step synthesis from bromobenzene-d5 in a 32% yield, and its deuterium content was 99 atom%. This racemic suprofen-d4was resolved by use of an optically active a-methylbenzylamine, resulting that optically active suprofen-d4 was obtained in a 11% yield and was 96.5 atom% D. On the other hand, suprofen-d7 (99 atom% D) was obtained by five-step synthesis from toluene-d8 and methyl-d3iodide in a 24% yield.
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Tomoo SAITO, Kunio OOHASHI, Naotake MORIKAWA
1981Volume 30Issue 11 Pages
596-598
Published: 1981
Released on J-STAGE: July 21, 2010
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Akibumi DANNO, Masaakira KAMADA, Yasuo NISHIYAMA, Hayao SAKAMOTO
1981Volume 30Issue 11 Pages
599-601
Published: 1981
Released on J-STAGE: July 21, 2010
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—With special reference to radioactive iodine—
Tsutomu SAGO
1981Volume 30Issue 11 Pages
602-605
Published: 1981
Released on J-STAGE: July 21, 2010
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Yasushi ISOBE, Seishu KO, Yoichiro UMEGAKI, Seiji TAKAHASHI, Noriyoshi ...
1981Volume 30Issue 11 Pages
606-608
Published: 1981
Released on J-STAGE: July 21, 2010
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Masato YAMASHITA, Tadashi AOKI, Takeshi KAKIUCHI, Hisao MABUCHI, Yoshi ...
1981Volume 30Issue 11 Pages
609-611
Published: 1981
Released on J-STAGE: July 21, 2010
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Kouichi TOYOSHIMA, Masaaki YONEMORI, Yasuji FUKUDA, Kimiyoshi TAKADA, ...
1981Volume 30Issue 11 Pages
612-615
Published: 1981
Released on J-STAGE: July 21, 2010
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Kazuo WATARI, Kiyoko IMAI, Jun-ichi OHISHI, Masami IZAWA
1981Volume 30Issue 11 Pages
616-617
Published: 1981
Released on J-STAGE: July 21, 2010
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Hideo HIGUCHI
1981Volume 30Issue 11 Pages
618-627
Published: 1981
Released on J-STAGE: July 21, 2010
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Nagao IKEDA, Masaharu KAWANISHI, Norio KURIHARA, Otomaru SATO, Susumu ...
1981Volume 30Issue 11 Pages
628-637
Published: 1981
Released on J-STAGE: July 21, 2010
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Shinichiro KURIHARA, Tadashi SAITO, Takashi KIKEGAWA, Shinichi KANAYA, ...
1981Volume 30Issue 11 Pages
638-645
Published: 1981
Released on J-STAGE: July 21, 2010
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1981Volume 30Issue 11 Pages
A2171-A252
Published: 1981
Released on J-STAGE: July 21, 2010
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