RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
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Volume 29, Issue 1
Displaying 1-13 of 13 articles from this issue
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  • Exchange Diffusion of D-Leucine in Mouse Ehrlich Ascites Tumor Cells
    Rensuke GOTO, Osamu TAMEMASA
    1980 Volume 29 Issue 1 Pages 1-6
    Published: 1980
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.1
    JOURNAL FREE ACCESS
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    The present investigation was undertaken to examine an evidence for the exchange diffusion of D-leucine as well as L-leucine and further to study the effect of temperature reduction on the exchange diffusion, in Ehrlich ascites tumor cells in vitro. The homoexchange diffusion for D-leucine was observed at 37°C, the extent being nearly equal to that for L-leucine. The heteroexchange diffusion between D-and L-leucines also occurred at 37°C. These findings were compatible with an assumption that there is a common pathway for D- and L-leucine transport in the tumor cells. It was demonstrated that the exchangeability of D-leucine was depressed remarkably at 0 °C, while L-leucine still had a considerable exchangeability. This difference in exchangeability of D- and L-leucines in temperature reduction seems to reflect that the bulky hydrocarbon side chains of both the isomers are bound to the different site of carrier as described in the preceding paper.
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  • Enhancement of 67Ga Tumor-to-Blood Ratios by Chelating Agent
    Hideo SAJI, Akira YOKOYAMA, Naotaka HATA, Atsushi MISAKI, Hisashi TANA ...
    1980 Volume 29 Issue 1 Pages 7-12
    Published: 1980
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.7
    JOURNAL FREE ACCESS
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    Chelating agent, such as, CaEDTA, CaDTPA, D-penicillamine, DMSA, desferoxamine, NTA, cysteine ethyl ester, BAL, α-MPG, phthalein complexone, were tested as a possible contrast enhancing agent for tumor imaging with67Ga-citrate.
    The intravenous administration of a chelating agent to Ehrlich's tumor bearing mice, one hour after the injection of67Ga-citrate, accelerated the blood clearance with only a very slight change of activity in the target, increasing the tumor-to-blood ratio, and consequently achieving a better visualization. Among the tested chelating agents, D-penicillamine showed the highest target-to-nontarget ratio at a shorter time: a good tumor-to-blood ratio, performed after 24 hr with non-treated animals, was achieved in only 1-3 hr with post-treated animals, Thus, D-penicillamine hold a considerable promise as a contrast enhancing agent for future clinical use.
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  • Studies on the Abnormal Accumulations in Vertebrae Found on the Bone Scintigram in Cancer Patients
    Hiyoshimaru OYAMADA, Shoji TERUI, Toshitaka UEHARA, Hisatoshi FUKUMA
    1980 Volume 29 Issue 1 Pages 13-19
    Published: 1980
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.13
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    From Jan. 1975 to Dec. 1977, 700 patients with various types of cancer were examined by bone scanning with99mTc-phosphate compounds for metastatic bone lesions at the National Cancer Center Hospital. Of these patients, 335 were found to have abnormal accumulations in their vertebrae. They were carefully surveyed through their clinical records, and finally 156 patients were selected for this study (70 from autopsy findings and 86 from more than one and a half year-follow-up studies) .
    Abnormal accumulations were classified into two categories; significantly positive and equivocal.
    Among these 156 patients, significant accumulations were found in 120, and equivocal in 21. The remaining 15 showed both significant and equivocal accumulations.
    In 116 out of 135 (120+15) patients, the significant accumulations were due to metastases; and in 19 out of 36 (21+15) patients, the equivocal accumulations were due to metastases. However, if the cases with equivocal accumulation only are taken into consideration, the true positive cases are only 5 of the 21. The major factor for false positive was degenerative changes of the vertebrae in either group of significant or equivocal accumulation and collapse of the vertebral body followed thereafter.
    Our careful investigation disclosed that some of the benign conditions could present somewhat different scintigraphic patterns from the metastases. These are as follows; (1) a cushionlike accumulation in the intervertebral space in the cases with disc degeneration, which is occasionally noted also in the cases with collapse of the vertebral body, (2) an irregular marginal accumulation of the vertebral body with an occasional cushion-like accumulation in the intervertebral space in the cases spondylosis deformans, (3) a vague and equivocal accumulation covering an entire vertebral body with an occasional extension to the next vertebral body in the cases with spondylosis deformans, (4) symmetrical accumulations in the intervertebral joints due to sclerotic changes. The 4th pattern mentioned above may be noted in the cases with metastases also.
    These findings are helpful in evaluating the bone scintigram of cancer patients to avoid unnecessary irradiation.
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  • Studies on the Tumor and Organ Affinity of 201Tl
    Hirofumi MORI, Itsuko ANDO, Tetsuo TAKEUCHI, Atsushi ANDO, Tatsunosuke ...
    1980 Volume 29 Issue 1 Pages 20-25
    Published: 1980
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.20
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    In order to evaluate the tumor and organ affinity of201Tl, using the Yoshida sarcoma bearing rats, the distribution of201Tl+in tissues and tumor was examined and compared to22Na+, 42K+, 86Rb+, 134Cs+, and67Ga-citrate.
    201Tl+showed almost same organ accumulation and kinetics as42K+, 86Rb+, 134Cs, whereas201Tl+and22Na+had completely different organ distribution. These results suggest that organ affinity of201Tl+might be related to active transport, namelyNa+-K+-ATPase pump mechanism as well as blood flow. However, it appeared to be take into account the other factors such as different accumulation and clearance rate due to different substrates of organs. Kidney accumulation rate of201Tl+was much higher than42K+, 86Rb+, 134Cs+and about 10 times as42K+.Maeroautoradiograms of rat kidneys showed that201Tl+exhibited an initial high accumulation in the cortex and appeared in the outer cortex, as the cortex cleared of radioactivity.201Tlmight be interchangeable withK+in the tubular system, reabsorbed with more affinity and cleared more slowly thanK+.
    The tumor accumulation201Tl+might be related toNa+-K+-ATPase pump mechanism as well as other organs. However, in terms of tumor accumulation and concentration ratio to other organs, 201Tl+was inferior to67Ga-citrate, although the tumor to blood ratio was identical to that of67Ga-citrate. Since201Tl+++showed almost same distribution as201Tl+, 201Tl+++might change into201Tl+in vivo.
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  • Study on Renal Affinity with 99mTc-labeled Nsubstitution of Imino Di Carbonate.
    Yoshihiro OHKUBO, Mitsuyuki KITAZAWA, Ginichiro SEKI, Masaomi TAKIZAWA ...
    1980 Volume 29 Issue 1 Pages 26-28
    Published: 1980
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.26
    JOURNAL FREE ACCESS
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  • Compensative Value of the 99mTc-DTPA and 99mTC-MDP Scintigraphy on Bain Lesion
    Toshio MAEDA, Norihisa TONAMI, Kenichi NAKAJIMA, Hiroshi MATSUDA, Mana ...
    1980 Volume 29 Issue 1 Pages 29-31
    Published: 1980
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.29
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  • Clinical Evaluation of Hepatobiliary Imaging with 99mTc- (p-butyl) imincdiacetic acid
    Hiromichi SAKATA, Masayuki NAKAJO, Kazuo SHIRONO, Kunisada SHIMABUKURO ...
    1980 Volume 29 Issue 1 Pages 32-34
    Published: 1980
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.32
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  • Fundamental Studies of TSH RIA Kit
    Atsuo NAGATA, Yoshikatsu SAKAGISHI, Tatsuya MIYAMAE
    1980 Volume 29 Issue 1 Pages 35-38
    Published: 1980
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.35
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  • Radioimmunoassay for Serum Thyroxine by the Antibody-Coated Test Tube Method (SPAC-T4 Kit)
    Akira ISHIHARA, Satoshi HAMADA, Rikiyo IMAMURA, Yasunao YOSHIMASA, Shu ...
    1980 Volume 29 Issue 1 Pages 39-41
    Published: 1980
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.39
    JOURNAL FREE ACCESS
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  • Application of Synchrotron Radiation
    Taizo SASAKI
    1980 Volume 29 Issue 1 Pages 42-51
    Published: 1980
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.42
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  • Shielding for I-125
    Shigeo FUKANO, Norio NOGAWA
    1980 Volume 29 Issue 1 Pages 52-57
    Published: 1980
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.52
    JOURNAL FREE ACCESS
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  • Radioactive and Radiation Standards (XI)
    9. Energy Standards of Radiation
    Akira HASHIZUME
    1980 Volume 29 Issue 1 Pages 58-66
    Published: 1980
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.58
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  • [title in Japanese]
    1980 Volume 29 Issue 1 Pages A1993-A48
    Published: 1980
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.29.A1993
    JOURNAL FREE ACCESS
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