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Volume 26, Issue 5
Displaying 1-14 of 14 articles from this issue
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Article type: Cover
1977 Volume 26 Issue 5 Pages Cover29-
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (33K) -
Article type: Cover
1977 Volume 26 Issue 5 Pages Cover30-
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (33K) -
Article type: Bibliography
1977 Volume 26 Issue 5 Pages Misc7-
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
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Satoru Oka, Setsuo Takeda, Toshihiko JyoArticle type: Article
1977 Volume 26 Issue 5 Pages 421-430,463
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAntigenically active acidic glycopeptides, Gp and Ep, were prepared from the purified sea-squirt antigens, Gi-2 and Ei-2, respectively, by elimination of a large amount of amino-acid residues by proteolytic treatment with Pronase E. Gp and Ep were further treated with NaOH-NaBH_4 and more than 75% of threonine residues were eliminated, Leaving the antigenically still active acidic glycopeptides, Gp-A and Ep-A, respectively. Analytical data showed that Gp-A and Ep-A contained, in common, 3-4 moles of glucosamine, 2-3 moles of galactosamine, 1-3 moles of uronic acid and 3-6 moles of sulfuric acid per mole of aspartic acid. The alkali-stability of Gp-A and Ep-A suggested that these sugar components constructed some sulfated oligosaccharide moieties in each glycopeptide and the moieties were attached N-glycosidically to the asparaginyl residues (determined as aspartic acid) of the peptide chain. Thus, it was considered that the N-glycosidic side chain carried the antigenic activity. Accordingly, it was expected that the above indicated common constituents, if not all but many of them, constructed the antigenic determinant in the side chain which was distributed in common in the sea-squirt allergen, the purified antigens, Gi-2 and Ei-2, and their antigeniclly active acidic glycopeptide products.View full abstractDownload PDF (922K) -
Makoto Ushiyama, Msanori Horie, Teruo Honda, Yukio KitajimaArticle type: Article
1977 Volume 26 Issue 5 Pages 431-437,463
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAs the allergic tension-fatigue syndrome, there are tension such as restlessness, hyperactivity, excitability, irritability etc., fatigue such as tiredness, dullness etc., mental and nervous symptoms such as tics, epilepsy, bizarre and irradional behavior, paranoid ideas, feeling of unreality, mental depression etc., and associated systemic manifestation such as bronchial asthma, eczema, pallor, dark circle of th eyes, increased sweating, headache, polyuria, bed-wetting, abdominal pain, constipation, diarrhea etc. The case cited here is a boy 12 years old who was hysteric, defiant, tiredness-prome, hard to rise in the morning, paranoid ideas, school phobia, abdominal pain, headache, dark circle of the eyes and bronchial asthma. As a result of complete elimination of milk and diary products, these symptoms have been diminished removed in three weeks. In this syndrome symptoms such as eczema, allergic coughing, allergic rhinitis, bronchial asthma begin to appear in infant ages and become conspicous in the ages of five to six years. The allergic tension-fatigue syndrome is liable to develop mental inpediment.View full abstractDownload PDF (956K) -
Yasuyuki Sano, Koji ItoArticle type: Article
1977 Volume 26 Issue 5 Pages 438-445,464
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe radioallergosorbent test (RAST) described by Wide et al. is now widely used for detection of IgE antibodies. The relative concentration of IgE antibodies can be calculated from dose response curves obtained from a reference serum and patient sera. However, the relation of this relative concentration of IgE antibodies to the absolute concentration of IgE antibodies is unknown. Our work was attempted to estimate antigen binding activity of IgE antibodies to mite antigen by a radioimmunoassay designated as triple antibody assay which was developed in our laboratory and to examine its correlation with relative concentration of IgE antibodies determined by RAST. The procedures of triple antibody assay are as follows. One twentieth ml of patient serum diluted 10 times was mixed with 0.05 ml solution of mite antigen, incubated overnight at 4℃, added with 0.05 ml of sheep anti human IgE diluted 10 times and incubated overnight at 4℃. Then the mixture was added with excess of rabbit anti sheep IgG (approximately 0.5 ml), incubated overnight and centrifuged. The precipitate was washed 3 times with phosphate buffered saline of pH 7.2. Radioactivity of the precipitate was counted by an automatic gammacounter. The relative concentration of IgE antibodies to mite was determined by RAST. The antigen binding activity of IgE antibodies to mite correlated well with the relative concentration of the antibodies (r=0.907) This result suggests that the absolute concentration of IgE antibodies may be determined by RAST by using a reference serum of known absolute concentration of IgE antibodies.View full abstractDownload PDF (974K) -
Yukinobu Ichikawa, Mitsumoto Komatsuda, Yozo Shimizu, Kenji Koriyama, ...Article type: Article
1977 Volume 26 Issue 5 Pages 446-451,464
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSGuinea-pigs were immunized with the isolated rat sarcolemmal membrane and Freund's complete adjuvant to produce experimental myositis. Delayed-type skin reactions with several rat bio-membranes as an antigen including sarcolemmal membrane, sarcoplasmic reticulum and red cell ghosts, and also dissolved sarcolemmal membranes treated with alkaline water, sodium deoxycholate, sodium dodecyl sulfate or urea, respectively, was examined in these myositic guinea-pigs. Myositic animals showed positive skin reaction with both sarcolemmal membrane and its dissolved fractions in regardless of a kind of solvents. No skin hypersensitivity against sarcoplasmic reticulum and red cell ghost was demonstrated in the same animals. Migration of the macrophages obtained from the myositic guinea-pig was inhibited completely in the medium containing a sarcolemmal membrane fraction dissolved with alkaline water. From these data, it was highly suspected that the antigen responsible for hypersensitivity reactions might be an extractable extrinsic protein of the sarcolemmal membrane.View full abstractDownload PDF (1518K) -
Toshiyuki Nishimuta, Tsuyoshi Toba, shinji Kiuchi, Kazuo Sugimoto, Sei ...Article type: Article
1977 Volume 26 Issue 5 Pages 452-456,465
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe prolongation of the expiratory phase is one of characteristics of patients with asthmatic attack. To our knowleged, there are found few literature dealing with the expiratory/inspiratory time ratio in infants under two years of age, because of technical difficulties in this age group. In this study, respiration curves were obtained using thermistor and electrocardiograph as recording system in 195 healthy infants and children and 13 adults; and also 17 patients with asthma (22 attacks). The results are as follows: 1) The values of the exp./insp. Time ratio increased lineally through infancy and mean values were 1.11 in newborns, 1.30 in infants of 7-24 months of age and 1.46 in children of 2-3 years. Reaching its peak at the age 2-3, the values decreased slowly among the children older than 3, and then increased again to 1.41 in adults. 2) When the normal ratio would be regarded as within m+2S.D. range, upper critical values were 1.4 or the more in newborns, 1.5-1.6 in infants and 1.7 children and adults. 3) The values of the exp./insp. Time ratio in asthmatic infants and children at attack were generally correlated with the severity of attack. This method to measure exp./insp. Time ratio is rather simple and avairable for infants.View full abstractDownload PDF (714K) -
[in Japanese], [in Japanese]Article type: Article
1977 Volume 26 Issue 5 Pages 457-459
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
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[in Japanese], [in Japanese]Article type: Article
1977 Volume 26 Issue 5 Pages 459-462
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
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Article type: Bibliography
1977 Volume 26 Issue 5 Pages 463-465
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1977 Volume 26 Issue 5 Pages 466-468
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
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Article type: Cover
1977 Volume 26 Issue 5 Pages Cover31-
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (34K) -
Article type: Cover
1977 Volume 26 Issue 5 Pages Cover32-
Published: May 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (34K)
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