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Volume 36, Issue 12
Displaying 1-19 of 19 articles from this issue
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Article type: Cover
1987 Volume 36 Issue 12 Pages Cover10-
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (90K) -
Article type: Cover
1987 Volume 36 Issue 12 Pages Cover11-
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1987 Volume 36 Issue 12 Pages App2-
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
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Yuji Maeda, Hiroshi Yasueda, Yasuo Yui, Takao ShidaArticle type: Article
1987 Volume 36 Issue 12 Pages 1037-1046
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe studied the effects of aging on IgE concentration, histamine releasability from peripheral blood leukocytes and the responses of tissues to chemical mediators in the house-dust-mite asthmatics. Out results were as follows: The concentrations of non-specific and specific IgE to house-dust-mite allergens were lower in the old age group than in the young age group. The grades of histamine releasability from leukocytes stimulated by crude mite, house-dust allergens and anti-IgE antibody were lower in the old age group and significantly lower in the case of house-dust-mite allergens. In contrast to this, we did not find any effects of aging on responses to chemical mediators, namely, skin response to histamine or bronchial response to acethylcholine. Moreover, these parameters were not affected by the onset age of asthma. The low concentration of specific IgE to mite was due to the low concentration of specific IgE itself and not to the high concentration of specific IgG4. From these results, we have come to the conclusion that the fact that there are fewer extrinsic asthmatics in the old age group than in the young age group is because the concentration of specific IgE decreases and not because the concentration of specific IgG4 increases.View full abstractDownload PDF (1230K) -
Kazuharu Tsukioka, Masami Nakamata, Shigeru HironoArticle type: Article
1987 Volume 36 Issue 12 Pages 1047-1053
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to elucidate the mechanism producing bronchial asthma induced by Candida albicans(Candida), role of IgE antibody was studied and compared with bronchial asthma induced by Aspergillus fumigatus(Aspergillus), Penicillium luteum(Penicillium), Alternaria kikuchiana(Alternaria), Cladosporium cladosporioides(Cladosporium) and house dust(HD). IgE antibody was detected by Prausnitz-Kustner(PK)response, and the following results were obtained: 1. Bronchial provocation test(BPT)was positive in a high rate without significant difference in a patients with positive PK response as to the antigen with Candida, HD, Aspergillus and Penicillium. 2. BPT was positive in a low rate without significant difference in patients with negative PK response as to the antigen with HD, Aspergillus, Penisillium, Alternaria and Cladosporium, but in a significant high rate in patients with negative PK response as to Candida antigen. 3. In BPT with Candida, 53.5% of the patients showed late asthmatic response(LAR)("isolated LAR"), and only 26.1% of the patients who showed LAR("isolated LAR") was positive PK response with Candida.View full abstractDownload PDF (831K) -
Yohko Saeki, Takao Igarashi, Gyohkei Murakami, Yuichi Adachi, Masatomo ...Article type: Article
1987 Volume 36 Issue 12 Pages 1054-1060
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSPhadezyme radioallergosorbent tests and bronchial provocation tests to extracts to Chironomus plumosus(C.p.)were performed on 459 asthmatic children, 19 atopic children without asthma and 37 non-atopic children. The number of cases who showed positive RAST to C.p was 202(44.0%), 5(26.3%)and 3(8.1%), respectively. The positive rates in the asthmatics increased in proportion to their age, and significantly differed according to where they liver(54.9% of 82 asthmatics living near paddy fields out orchards were positive to C.p extracts by RAST, compared with 40.2% of 117 asthmatics living in residential areas). In the asthmatic children with positive RAST, the average number of asthmatic attacks per month during the chironomid season was significantly greater that that of the negative. Inhalation tests to exracts of C.p were carried out on 5 asthmatic children who were positive to skin prick tests. 2 children showed immediate asthmatic reactions and 2 otheres showed late asthmatic reactions. Chironomidea are widespread in nearly all types of inland waters worldwide and chironomid antigens also exist in house dust, so it seems to be one of the most common inhalant antigens.View full abstractDownload PDF (1019K) -
Kazumasa Tanaka, Namika Tanaka, Hajime Suzuki, Eisei NoguchiArticle type: Article
1987 Volume 36 Issue 12 Pages 1061-1067
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe studied the measurement of saliva and serum theophylline concentrations(175 pair samples in adult asthmatic patients)which were analysed by the i-PiT system in the nephelometory method. There was a significant relationship in 92 pair samples (r=0.973, y=1.12x + 2.79). The application of a conversion equation (y=1.12x + 2.79) produced a good relationship between the observed and predicted serum theophylline concentrations in 83 pair samples. This result shows that saliva concentrations are valuable in monitoring serum theophylline concentrations. The therapeutic range for saliva corresponding to the generally accepted serum concentration range(10-20μg/ml)was approximately 6.5-15.5 μg/ml in our study. The half life(3.8hr)calculated from saliva concentrations, however was shorter than that(6.3hr)calculated from observed serum theophylline concentrations. Therefore the calculation of Pharmacokinetics from saliva theophylline concentrations is not useful and may be dangerous.View full abstractDownload PDF (769K) -
Yutoku Kinjo, Katsuyoshi Shimoji, Mutsuko Miyagi, HIroshi Fukuhara, Hi ...Article type: Article
1987 Volume 36 Issue 12 Pages 1068-1074
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe studied air-borne pollens from May 1985 to May 1987 in Okinawa. The gravity slide method with Durham's standard device was applied for sampling air-borne pollens. The distribution of plants was also investigated in this period. The results obtained were as follows; 1. The total number of pollens was smaller than that in the mainland of Japan throughout the period. 2. The primary air-borne pollen counted on an average weekly basis was Graminae with 41.2/cm^2/day in 1985 and 43.4/cm^2/day in 1986, followed by Pinus luchuensis, fagaceae, Morus australis and Casuarinaceae. 3. The followering of both Casuarinaceae and Leucaena leucocephala was observed throughout the years and this is a characteristic of subtropical plants. The peak flowering periods were in May and November. 4. The tree season begin two or three months earlier in Okinawa than in Kyushu and the duration of the season is much longer. The period of pollination of Artemisia is longer in Okinawa. 5. Wind-pollinated plants such as Cryptomeria, Ulmus, Zelkova, Carpinus and Humulus japoincus, which are clinically important as allergens in the mainland of Japan, are not native to Okinawa. Ambrosia artemisiaefolia and Solidago altissima are rarely observed.View full abstractDownload PDF (710K) -
Takeshi Noma, Izumi Yoshizawa, Yutaka Kawano, Masahiko Itoh, Minoru Ba ...Article type: Article
1987 Volume 36 Issue 12 Pages 1075-1085
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSInterleukin 2(IL2) responsiveness was induced in lymphocytes from patients with atopic dermatitis and/or bronchial asthma, specifically on stimulation with the antigen causing clinical symptoms. There was no correlation between the intensity of induced responsiveness and IgE RAST scores of the sera. Although healthy infants and early pre-school children showed some responsiveness, it was usually weaker than that of atopic children. The responsiveness of the patients decreased in accordance with the improvement of clinical symptoms. The disappearance of the responsiveness in healthy elder children or in the patients who showed clinical improvement might be due to the development of specific suppressor T cells. The lymphocytes which acquired IL2 responsiveness on stimulation with allergens may work as an effector of delayed type hypersensitivity reaction or a helper of antibody formation. This in vitro lymphocyte phenomenon can be used to identify the etiological allergens and to monitor clinical activity of atopic diseases.View full abstractDownload PDF (1222K) -
Keiko SasaiArticle type: Article
1987 Volume 36 Issue 12 Pages 1086-1093
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe measured plasma immunoreactive leukotriene C_4(i-LTC_4)levels in 33 patients with Kawasaki disease both during the acute and convalescent stages and one year after the onset of the illness. The results were as follows: 1) Plasma i-LTC_4 levels during the acute stage(0.10±0.09 pmol/ml) were significantly higher than those of age-matched healthy children(0.02±0.03 pmol/ml, p<0.015). 2) Plasma i-LTC_4 levels during the convalescent stage(0.11±0.08 pmol/ml), when aspirin was administered, were significantly higher than those of healthy children(p<0.005). 3) Plasma i-LTC_4 levels one year after the onset of the disease(0.016±0.02 pmol-ml) returned to the normal level. 4) Leukotriene C_4, leukotriene D_4 and leukotriene E_4 analysed by high performance liquid chromatography method, were detected in the plasma of patients with Kawasaki disease. In conclusion, we demonstrated activation of the arachidonic acid metabolism via the lipoxygenase pathway as well as via the cyclooxygenase pathway. Peptide-leukotrienes may play an important role in the pathogenesis of Kawasaki disease.View full abstractDownload PDF (916K) -
Akira Yagi, Takao Shida, Hiroshi NishimuraArticle type: Article
1987 Volume 36 Issue 12 Pages 1094-1101
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe dialyzable material from fresh leaves of Aloe arborescens var. natalensis was examined in phagocytosis and a phagocytic killing test of Candida albicans. Separation of the active component was carried out by chromatography on ion exchange resins, and the activity was detected in the neutral amino acid fraction. The results from the bioassay and comparative study on amino acid compositions in the fractions isolated showed a positive participation by cysteine and proline in phagocytosis. A mixture of cysteine and proline(1:1)significantly enhanced the depressed phagocytosis of neutrophils in adult bronchial asthma.View full abstractDownload PDF (869K) -
Sumihiko Higashitani, Yasushi Yamazoe, Masahide Minoda, Atsushi Horiuc ...Article type: Article
1987 Volume 36 Issue 12 Pages 1102-1105
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIt is well known that anti DNA antibody is very important in the pathogenesis of systemic lupus erythematosus(SLE). There are many reports demonstrating anti DNA antibodies as an autoantibody but few for DNA as an autoantigen. We have reported on antigenic specificity for DNA extracted from lymphocytes in SLE patients by ELISA. As a control, lymphocytic DNA of RA, MCTD, PM and healthy donors, and calf thymus DNA were used. We obtained the following: when the DNA from SLE patients was used as an antigen, the titer of IgG anti DNA antibody in the sera of the SLE patients was higher than that from the control group. The titer of IgG anti DNA antibody in clinically active sera of the SLE patients was higher than in inactive sera. The titer of IgM anti DNA antibody in the sera of SLE patients, however, did not vary between active and inactive sera. Renal dysfunction did not correlate with the titer of IgG and IgM anti DNA antibodies. These results seem to indicate that DNA from peripheral blood lymphocytes in SLE patients reacts to IgG antibody specifically.View full abstractDownload PDF (461K) -
[in Japanese]Article type: Article
1987 Volume 36 Issue 12 Pages 1106-1107
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1987 Volume 36 Issue 12 Pages 1108-
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
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Article type: Index
1987 Volume 36 Issue 12 Pages 1109-1114
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
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Article type: Index
1987 Volume 36 Issue 12 Pages 1115-1117
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
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Article type: Index
1987 Volume 36 Issue 12 Pages 1118-1136
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1987 Volume 36 Issue 12 Pages 1137-1142
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
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Article type: Cover
1987 Volume 36 Issue 12 Pages Cover12-
Published: December 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (433K)
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