Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 27, Issue 12
Displaying 1-16 of 16 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1978 Volume 27 Issue 12 Pages Cover10-
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.Cover10
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1978 Volume 27 Issue 12 Pages Cover11-
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.Cover11
    JOURNAL FREE ACCESS
    Download PDF (72K)
  • [title in Japanese]
    Article type: Bibliography
    1978 Volume 27 Issue 12 Pages Misc4-
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.Misc4
    JOURNAL FREE ACCESS
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  • Effect of N-(3', 4'-Dimethoxycinnamoyl) Anthranilic Acid (N-5') on Antibody Formation
    Hiroshi Mori, Kennichi Sakamoto, Akihide Koda
    Article type: Article
    1978 Volume 27 Issue 12 Pages 905-909,943
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.905
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    A study was carried out to determine the effect of N-5', a new anti-allergic drug, on antibody formation, and the following results were obtained. 1) Rats were immunized with dinirophenylated ascaris extract (DNP-As) plus killed Bordetella pertussis, and boosted with DNP-As alone after 5 days. Eight days after the first immunization, IgE and hemagglutinin titers were assayed by the 48 hr homologous PCA and passive hemagglutination test, respectively. Neither IgE or hemagglutinin titers were affected by N-5', in doses of 2, 5, 10 and 20 mg/kg/day given p.o. for 5 days after the first immunization. 2) Formation of hemolytic plaque foming cells in the spleens of mice immunized with sheep red blood cells (SRBC) was not significantly affected by N-5' in doses of 5, 10 and 20 mg/kg/day given i.p.for 5 days following SRBC-immunization. After 5 days, spleen weight and number of spleen cells increased in animals treated with 10 and 20mg/kg/day of N-5'. A slight increase was also found in hemolysin and hemagglutinin titers of animals given 5 and 20 mg/kg/day of the agent on day 7 following the immunization. These results suggest that N-5' would be harmless on antibody forming tissue. The anti-allergic action is apparently not due to suppression of pathogenic antibody, i.e. IgE, formation.
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  • Suppressive Effect of Guinea Pig Thymic Factor on the Proliferation of Immunocompetent T Lymphocytes
    Sachio Kanamori
    Article type: Article
    1978 Volume 27 Issue 12 Pages 910-913,944
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.910
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    The effect of T cell rosette decreasing factor extracted from guinea pig thymus on T cell function was examined. Normal guinea pig lymph node cells were cultured in the presence of this thymic factor for 8 hr. ^3H-TdR incorporation into DNA was measured after pulsing with T cell mitogen (Con A, PHA) for 2 hr. No change was observed in cell viability in comparison with controls. DNA synthesis, however, was inhibited to 60.2% during the pulse of Con A and 56.4% during the PHA pulse. The effect of the thymic factor on antigen primed T lymphocytes was also examined. The lymph node cells of a guinea pig immunized with pABS_<20>-GPA were stimulated-with pABS_<20>-GPA in vitro and ^3H-TdR incorporation into DNA measured. 73.2% inhibiton in by thymic factor was noted. Thus guinea pig thymic factor inhibits not only E rosette formation between rabbit red blood cells and T lymphocytes of the guinea pig, but also in vitro DNA synthesis of lymphocytes stimulated with T cell mitogens (Con A, PHA) or antigen.
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  • Studies on Histamine in Bronchial Asthma : II.Changes in Whole Blood and Plasma Histamine Levels During Asthmatic Attacks
    Michitoshi Komatsu
    Article type: Article
    1978 Volume 27 Issue 12 Pages 914-918,944
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.914
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    To elucidate the mechanism of asthmatic attack, the histamine level in both whole blood and plasma was measured in 119 asthmatics by the modified method of Shore's fluorometric assay. The histamine level in the asthmatics was significantly higher, even in the symptom-free period, than that in normal subjects. The histamine level in whole blood decreased during a severe attack, especially in status asthamtics, while that during a mild or moderately severe attack was not significantly different from the symptom-free period. The plasma histamine level, however, increased during the attack, being most remarkable severe attacks were not significantly clifferent. From the change in peripheral basophil and eosinophil counts an asthmatic attack, it is considered probable that histamine mainly released from mast cells in the lung at the begining at an attack, while in the severe prolonged attack blood cells may also take part in histamine release.
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  • Effect of N-(3', 4'-Dimethoxycinnamolyl) Anthranilic Acid (N-5') on Antigen-Induced Histamine Release from Human Leukocytes and Level of Cyclic Nucleotide
    Yusuke Tomita, [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    Article type: Article
    1978 Volume 27 Issue 12 Pages 919-925,945
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.919
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    A study was made to investigate the effect of N-5' on both the antigen-induced histamine release and the level of cyclic nuclotide in human leukocytes. The results were as follows. 1. Inhibition of histamine release was observed with N-5' in a concentration of 10^<-3>M. Inhibition was 28.7% on the whole stage, 28.6% on the first stage and 23.7% on the second stage. 2. N-5' at a concentration of 10^<-3>M hardly affecte cyclic nucleotide levels in human leukocytes during a 10 minutes incuabtion. These results suggest that the inhibition mechanism of N-5' is not correlated with the β-receptor-cyclic nucleotide system.
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  • Circulating Immune Complexes Detected by Polyethylene Glycol Technique in Immunological Diseases of Infans and Children : Part 1:Circulating Immune Complexes in Anaphylactoid Purpura
    Kazuhiro Asako
    Article type: Article
    1978 Volume 27 Issue 12 Pages 926-932,945
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.926
    JOURNAL FREE ACCESS
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    In 16 children with anaphylactoid purpura (AP) from 2 to 8 years of age, dirculating immune complexes were measured by Abe's method using the 4% polyethylene glycol (PEG) technique. Circulating soluble immune complexes were precipitated with 4% PEG and the precipitated immunoglobulins were measured by radial immunodiffusion. PEG precipitated index (PP index) was calculated as follows. PP index=<PEG precipitated immunoglobulin levels>/<serum immunoglobulin levels>×100 The following results were obtained: 1) In 16 healthy children from 3 to 16 years of age, PP indices of IgG, IgA and IgM were 11.11±2.65, 3.22±0.73 and 39.64±7.47 respectively. 2) PP indices of IgG, IgA and IgM were elevated in 10, 7 and 3 cases out of 16 patients with AP respectively. 3) PP indices of IgG, IgA and IgM in AP patients with preceding streptococcosis were higher than in those without it. 4) PP indices of IgG, IgA and IgM in AP patients with bloodly stools were higher than in those without it. The index of IgA showed a remarkably high level.
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  • The Biologic Significance of The HLA-Bw52-DHO Haplotype
    Yoichi Kohno
    Article type: Article
    1978 Volume 27 Issue 12 Pages 933-942,946
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.933
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    HLA-Bw52-DHO haplotype, formed due to a strong linkage disequilibrium between Bw52 and DHO, is characteristically seen in the Japanese population. The biologic significance of this haplotype in the genetic control of the immune response and in the control of disease susceptibility was investigated. The immune response to tetanus toxoid showed a clear bimodal distribution among the healthy Japanese population, indicating that there exist high and low responders to this antigen. Since low responders to tetanus toxoid had a significant association with HLA-Bw52-DHO haplotype and were all heterozygous at the HLA-D locus, the low responsiveness to tetanus toxoid is perhaps controlled by an immune suppression gene which is in linkage disequilibrium with HLA-Bw52-DHO. Graves' disease, known to be one of the organ specific autoimmune diseases, was shown to be associated with HLA-Bw52-DHO in the Japanese population. In Caucasians, however, Graves' disease has been reported to be associated with HLA-B8-Dw3, a haplotype completely absent from the Japanese population. These data suggest that the HLA-Bw52-DHO haplotype is a counterpart of the Caucasian HLA-B8-Dw3 haplotype with respect to its biologic significance. As the susceptibility to the organ specific autoimmune diseases has been shown to be controlled by immune response genes in mice, it is suggested that one of the most important genetic factors controlling the susceptibility to Graves' disease is an immune response gene shared by the HLA-B8-Dw3 and HLA-Bw52-DHO haplotypes.
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  • [title in Japanese]
    Article type: Bibliography
    1978 Volume 27 Issue 12 Pages 943-946
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.943
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  • [title in Japanese]
    Article type: Appendix
    1978 Volume 27 Issue 12 Pages 947-
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.947_1
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  • [title in Japanese]
    Article type: Appendix
    1978 Volume 27 Issue 12 Pages 947-
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.947_2
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  • [title in Japanese]
    Article type: Appendix
    1978 Volume 27 Issue 12 Pages 948-
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.948
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  • [title in Japanese]
    Article type: Index
    1978 Volume 27 Issue 12 Pages 949-954
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.949
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1978 Volume 27 Issue 12 Pages 955-959
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.955
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1978 Volume 27 Issue 12 Pages 960-
    Published: December 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.960
    JOURNAL FREE ACCESS
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