Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 44, Issue 6
Displaying 1-26 of 26 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1995 Volume 44 Issue 6 Pages Cover27-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.Cover27
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1995 Volume 44 Issue 6 Pages Cover28-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.Cover28
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages App6-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.App6
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1995 Volume 44 Issue 6 Pages 581-585
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.581
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  • COMPARISON BY TWIN IMPINGER OF THE DISTRIBUTION PATTERNS OF TWO BECLOMETHASONE DIPROPIONATE METERED DOSE INHALERS AND OF TWO SPACER DEVICES
    Fumiyoshi Ojima, Teiko Toyoguchi, Tohru Shoji, Yoshito Nakagawa
    Article type: Article
    1995 Volume 44 Issue 6 Pages 586-592
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.586
    JOURNAL FREE ACCESS
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    A Twin Impinger was used to assess the influence of the number of puffs on the distribution paterns of two commercially available beclomethasone dipropionate (BDP) metered dose inhalers, and the effects of two kinds of spacer devices were also compared. No difference was observed in the distribution pattern up to the 10th puff between the two metered dose inhalers. Clinically, the amount of BDP inhaled into the lungs is said to depend on the number of puffs taken, but in this study, there was a significant difference in the distribution pattern between these 2 inhalers. In the stage assumed to represent the oropharynx site, the distribution ratio of BDP was greater after administration with an Aldecin than with a Becotide inhaler. In contrast, in the stage assumed to represent the lung, the distribution ratio of BDP was greater with the Becotide inhaler. This result suggests that the amount of BDP inhaled in the lungs may vary between these two preparations. The effects of spacer devices were also investigated in 4 puffs. These spacer devices caused the distribution ratio in the stage assumed to represent the oropharynx to decrease by at least 90%, irrespective of the type of metered dose inhaler. This result suggests that spacer devices are useful in reducing local side effects in the oropharynx. In the stage assumed to represent the lung, the distribution ratio achieved with the Becotide inhaler with Volumatic was greater than that with the Aldecin with InspirEase. This study suggests that the best therapeutic effects can be expected from a combination of Becotide inhaler and Volumatic.
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  • THE EFFECT OF DISODIUM CROMOGLYCATE (DSCG) ON INFILTRATION OF INFLAMMATORY CELLS INTO BRONCHIAL MUCOSA AND ON EXPRESSION OF ADHESION MOLECULES IN ASTHMATICS
    Makoto Hoshino, Yutaka Nakamura
    Article type: Article
    1995 Volume 44 Issue 6 Pages 593-601
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.593
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    We studied the effect of disodium cromoglycate (DSCG) used as a therapeutic drug for the treatment of bronchial asthma on infiltration of inflammatory cells into the bronchial mucosa and on the expression of adhesion molecules in asthmatic patients. Biopsies of the bronchial mucosa of 9 patients with atopic asthma were performed before and after the administration of an aerosol containing DSCG (8 mg/day). Staining with anti-EG2 antibody was made on the tissues obtained to determine the number of eosinophils, with anti-NP57 antibody to determine the number of neutrophils, with anti-AA1 antibody for mast cells, with anti-CD4, -CD8, -CD3 for T lymphocytes, and with anti-CD68 antibody for macrophages. Another staining was made to examine the expression of adhesion molecules including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1) on the vascular endothelium and to determine the presence of P-selection. Moreover, the intensity of the expression of ICAM-1 on the bronchial epithelium was investigated. The numbers of eosinophils, mast cells, T lymphocytes and macrophages were significantly decreased, and the expressions of ICAM-1, VCAM-1 and ELAM-1 were significantly inhibited by the administration of DSCG. There were significant correlations between ICAM-1 and the number of T lymphocytes, and between VCAM-1 and the number of eosinophils. These results suggest that DSCG inhibits the expression of adhesion molecules as an anti-inflammatory action, and decreases the number of inflammatory cells in the airways of asthmatic patients.
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  • EPIDEMIOLOGIC STUDY OF ALNUS SIEBOLDIANA MATSUMURA (ALDER) POLLINOSIS IN ASHIYA CITY
    Shiro Yoshimura, Hiroshi Ogasawara, Toshi Nakahara, Tetsuzo Fujitani
    Article type: Article
    1995 Volume 44 Issue 6 Pages 602-608
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.602
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    Alnus sieboldiana has been planted widely on denuded sites in the Rokko mountains. Its pollination season is in the latter half of that of Japanese cedar. This epidemiologic study was carried out in Ashiya in the 1991 spring hay fever season. The subjects were 532 female residents chosen at random, who had been living there more than ten years. There was an evident relation between the airbone alder pollen count and the prevalence of alder pollinosis. In the mountain town most severely inundated with alder pollen (977/sq. cm/year), the prevalence rate of alder pollinosis alone or both alder and cedar pollinosis was 26.1%. In the flat area 5 km far from south of the mountain town, where aribome pollen count was 386/sq.cm/year, the prevalence rate of alder pollinosis was 4.3%. The heavy traffic main road pass through the flat area, thus the air pollution was significantly strong in the flat area more than in the mountain town. However, we couldn't find adjuvant effect of air pollution on the alder pollinosis, which was often reported about Japanese cedar pollinosis.
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  • INVESTIGATION OF CRYPTOMERIA JAPONICA POLLINOSIS IN IZU-OSHIMA
    Norio Kihara, Tetsuya Adachi, Hideko Fujinaga, Ryuichi Ogawa, Takashi ...
    Article type: Article
    1995 Volume 44 Issue 6 Pages 609-617
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.609
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    We surveyed by questionnaire 4,673 residents of Izu-Oshima who were 15 or more years of age with regard to Crytomeria japonica pollinosis. The response rate was 22.3%. In the early spring, nasal symptoms were reported by 8.9% of the respondents, ocular symptoms by 5.7%, and dermal symptoms by 8.1%. On scratch tests of symptomatic subjects, 13.8% were positive for Cryptomeria japonica antigen, and 33.3% had an IgE RAST score of 2 or more. The peak Cryptomeria japonica pollen concentrations between February and April 1990 were 118/cm^2 on March 7 at the Northern Clinic and 271/cm^2 at the Southern Clinic. A second questionnaire survey (response rate: 53.1%), designed to estimate the number of persons with Cryptomeria japonica pollinosis among all residents, revealed that 4.7% concurrently had three or more nasal symptoms and two ocular symptoms. By combining these results with those of a telephone survey of 100 randomly selected nonrespondents, 5.64% of all inhabitants were estimated to have suspected Cryptomeria japonica pollinosis.
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  • ADHESION TO FIBRONECTIN REGULATES EXPRESSION OF ADHESION MOLECULES ON EOSINOPHILS
    Ikkou Higashimoto, Junichi Chihara, Mitsuhiro Osame, Shigenori Nakajim ...
    Article type: Article
    1995 Volume 44 Issue 6 Pages 618-623
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.618
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    To elucidate the mechanism for the accumulation of eosinophils through adherence in allergic inflammation, we investigate whether adhesion of eosinophils to extracellular matrix (ECM) regulates the expression of adhesion molecules on eosinophils. Highly purified eosinophils obtained from asthmatic patients were cultured on BSA or fibronectin (FN) coated plates for 4 or 48 hours. After then, removed cells were examined about the expression of each adhesion molecule. Cultured on FN resulted in the increment of the expressive CR 3 (CD11b) (BSA vs FN; MFI ratio 10.50 vs 12.09 P<0.05), and decrement of the expressive VLA-4 (CD49d) on the eosinophills (3.93 vs 2.91 (4h) p<0.05, 2.86 vs 2.0g (48 h) p<0.05). Thus, we could conclude that eosinophils adhesion to ECM via adhesion molecules might play an important role in the pathogenesis of allergic inflammation through the involvement in the regulation of the expression of adhesion molecules on eosinophils.
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  • EFFECTS OF ANTIALLERGIC DRUG, PEMIROLAST POTASSIUM ON PHOSPHOLIPASE D ACTIVATION IN ANTIGEN-STIMULATED RAT BASOPHILIC LEUKEMIA (RBL-2H3) CELLS
    Yoshikatsu Nakamura, Hiroshi Fujimiya, Takahiko Kumada, Katsuhiro Ojio ...
    Article type: Article
    1995 Volume 44 Issue 6 Pages 624-629
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.624
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    An anti-allergic drug, pemirolast potassium (TBX), inhibited antigen (Ag)-induced phospholipase D (PLD) activation in rat basophilic leukemia (RBL-2H3) cells. The concentration-dependent inhibitory profile for Ag-induced PLD activation was parallel to those for secretory response and inositol phosphate formation. In contrast, TBX had no effect on PLD activation caused by calcium ionophore A23187 or phorbol myristate acetate. These results suggest that TBX inhibits Ag-induced PLD activation by interfering with the signal transduction pathway upstream of Ca^<2+> mobilization and protein kinase C activation.
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  • DELAYED ALLERGIC REACTION TO SILK SUTURES : A Case Report
    Toshio Katsunuma, Yoji Iikura
    Article type: Article
    1995 Volume 44 Issue 6 Pages 630-632
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.630
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 633-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.633_1
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 633-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.633_2
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 634-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.634
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 635-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.635
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 636-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.636
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 637-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.637
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 638-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.638
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 639-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.639
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 640-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.640
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 641-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.641
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 642-653
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.642
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 654-655
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.654
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 656-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.656
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 6 Pages 657-660
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.657
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  • [title in Japanese]
    Article type: Cover
    1995 Volume 44 Issue 6 Pages Cover29-
    Published: June 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.Cover29
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