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2006 Volume 55 Issue 6 Pages
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2006 Volume 55 Issue 6 Pages
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2006 Volume 55 Issue 6 Pages
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2006 Volume 55 Issue 6 Pages
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Kyosuke Ishihara
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2006 Volume 55 Issue 6 Pages
613-620
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Itsuo Iwamoto
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2006 Volume 55 Issue 6 Pages
621-625
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Atsuo Urisu
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2006 Volume 55 Issue 6 Pages
626-631
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Masako Ikushima, Masatoshi Takaoka, Sachie Kawahashi, Sakiko Tanno
Article type: Article
2006 Volume 55 Issue 6 Pages
632-640
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Background: In order to estimate the sensitization to inhalant allergen in childhood, prevalence of allergen-specific IgE antibodies was retrospectively surveyed on sera from school children aged from 9 to 15 living in rural area of Saitama prefecture, Japan, in 2001 and five years ago from 2001 (1996). Methods: Allergen-specific IgE antibodies against Japanese cedar pollen (JCP), ragweed, sweet vernal grass, Dermatophagoides pteronyssinus (Dp), house dust (HD) and cat dander were examined on sera from 79 school children aged from 9 to 11 (group A) and 119 school children aged from 12 to 15 (group B) collected in 2001, and sera from 117 school children aged from 9 to 11 and 56 school children aged from 12 to 15 collected in 1996. Furthermore, a questionnaire survey about diagnosis of any allergic diseases and symptoms associated with the diseases was conducted on the same subjects in 2001. Results: On the survey from school children, group A and B, collected in 2001, percentage of positive cases for allergen-specific IgE antibodies against any of 6 allergens were 49 in both of the groups for JCP, 10 and 12 for ragweed, 18 and 19 for sweet vernal grass, 39 in both of the groups for Dp, 42 in both of the groups for HD, 23 and 14 for cat dander, respectively. On the survey from school children collected in 1996, there is no significant difference from the percentage of positive cases for allergen-specific IgE antibodies against each allergen in 2001. Among the subjects followed-up on the survey in both of the years, the percentage of positive cases for allergen-specific IgE antibodies against each of six allergens on the survey in 2001 increased as compared with those in 1996. As a result of questionnaire survey in 2001, percentage (70: group A, 89: group B) of positive cases for allergen-specific IgE antibodies against any 6 allergens in the subjects with any symptoms associated with allergic diseases, but not diagnosed, was significantly higher than the percentage (34: group A, 48: group B) of that in the subjects without any symptoms associated with the diseases. Conclusion: Further prospective study is required to clarify a cause of allergic diseases in childhood, and it should be taken precautionary measures during childhood against sensitization with inhalant allergen to prevent allergic diseases in surveyed area.
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Atsuko Sato, Yukio Tanifuji, Hitoshi Kobayashi, Hiroshi Inoue
Article type: Article
2006 Volume 55 Issue 6 Pages
641-646
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Background: Previous data suggest the high incidence of gastroesophageal reflux (GER) in asthmatics, although the relationship between GER and the respiratory condition in asthmatics remain unclear. We investigated the incidence of GER in asthmatics and the association between the effects of proton-pump inhibitor (PPI) on respiratory functions and esophageal pH in asthmatics with GER. Methods: Two hundreds ninety outpatients who attended our unit with asthma received GER symptoms questionnaire used at Mayo Clinic. Twenty three of them who answered to have any GER symptom were treated with PPI (lansoprazole 30mg/day) for eight weeks, and investigated changes in the GER symptoms and peak expiratory flow rates (PEFR) before and after treatment. Furthermore, in six of twenty three, airway hyperresponsiveness to methacholine and esophageal pH monitor for 24 hours were measured in order to evaluate the association between esophageal pH and the effect of PPI on GER during the test. Furthermore, the serum level of theophylline was analyzed for assessment of the PPI effect on theophylline metabolism. Results: 150 of 290 asthmatics had answered to have any GER symptom including cough. Most of GER symptoms had improved except for cough after treatment with PPI. The airway hyperresponsiveness significantly improved after treatment with PPI (n=6,p<0.03), although PEF and FEV_1 were not significantly changed. Conclusion: These results suggest that PPI may be an effective drug for asthmatics with GER through suppression of airway hyperresponsiveness.
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Takeshi Hattori, Nobuyuki Hizawa, Daisuke Takahashi, Akira Isada, Ayum ...
Article type: Article
2006 Volume 55 Issue 6 Pages
647-654
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Background: We previously reported elevated levels of total serum IgE in patients with asthma, regardless of their atopic status. We hypothesized that certain factors inherent to asthma may contribute to this nonspecific elevation of total serum IgE. In the current study, to evaluate the role of eosinophils in the regulation of total serum IgE, we examined whether peripheral blood eosinophil count is associated with total serum IgE level in patients with eosinophilic lung diseases. Methods: Ninety-nine healthy controls, 277 patients with asthma, 15 patients with acute eosinophilic pneumonia, 21 patients with chronic eosinophilic pneumonia were studied for total serum IgE levels and peripheral blood eosinophil counts. Results: Patients with acute or chronic eosibophilic pneumonia had significantly increased total serum IgE levels compared with healthy controls regardless as atopic status (p<0.001). In non-atopic subjects with eosinophilic lung diseases, total serum IgE level was significantly correlated with peripheral blood eosinophil count (r=0.42, p<0.001, n=57). Conclusion: Our findings suggest that, in addition to antigen-specific IgE production, non-specific IgE production may contribute to elevated levels of total serum IgE in patients with asthma or eosinophilic pneumonia. An increased number of activated eosinophils may underlie an increased total serum IgE level in these conditions.
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Minoru Okuda
Article type: Article
2006 Volume 55 Issue 6 Pages
655-661
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Background: To elucidate how long the effect of immunotherapy (IT) persist after discontinuation in patients with Japanese cedar pollinosis (JCP). Methods: After discontinuation of IT 485 patients with JCP who completed one course of IT for 3.6 years in average were followed repeatedly up by means of author's original evaluation system of symptom-mediacation system from 1996 to 2005 using the method of questionnaire. Since the variations of terms after discontinuation and times of examination existed, the outcomes were averaged in every one year and follow-up seasons after discontinuation. Comparison of score and type in the year of discontinuation (base-line level) with those of follow-up was made for evaluation of outcomes. In addition, of these, 100 JCP patients, who had both intervals of 3 years or more from the discontinuation and examination times of 3 or more during the follow-up period, were examined as the evidence of reliability. Results: Although the scores and types in each year were affected slightly by yearly changes in air borne pollen count, the effect persisted for 10 years with a slight change, keeping score 3 to 4. Forty two% of patients had no symptom and medication even in 2005, a year of large pollen count. Conclusively effect of the JCP IT persists satisfactorily for at least 10 years. This is the first study of long term follow-up in JCP against cross sectional study.
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Akiko Kokunai, Hiroaki Azusawa, Hiroyuki Murota, Chika Ohhata, Ichiro ...
Article type: Article
2006 Volume 55 Issue 6 Pages
662-666
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A 38-year-man developed diffuse erythema 3 days after the administration of 2-chlorodeoxyadenosine (cladribine or 2-CdA) and many other drugs for hairy cell leukemia (HCL).Patch-testing and scratch patch-testing showed positive reactions for clindamycin (10%, 30%) at 24 hours and 48 hours. Furthermore, provocation-testing showed positive reactions for sulfamethoxazole・trimethoprim, allopurinol, fluconazole, so our diagnosis was erythroderma-type drug eruption due to clindamycin, sulfamethoxazole-trimethoprim, allopurinol, fluconazole. Cutaneous side-effects associated with cladribine have seldom been described in cases of HCL. Our case suggests that there is a relationship between the drug hypersensitivity and the prolonged suppressed CD4 cell levels caused by cladribine.
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Article type: Appendix
2006 Volume 55 Issue 6 Pages
667-
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Article type: Appendix
2006 Volume 55 Issue 6 Pages
668-669
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2006 Volume 55 Issue 6 Pages
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672-673
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2006 Volume 55 Issue 6 Pages
674-675
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2006 Volume 55 Issue 6 Pages
679-682
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683-685
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686-689
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2006 Volume 55 Issue 6 Pages
690-696
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697-705
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2006 Volume 55 Issue 6 Pages
706-728
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2006 Volume 55 Issue 6 Pages
729-739
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2006 Volume 55 Issue 6 Pages
740-748
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2006 Volume 55 Issue 6 Pages
749-756
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2006 Volume 55 Issue 6 Pages
758-759
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2006 Volume 55 Issue 6 Pages
760-761
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2006 Volume 55 Issue 6 Pages
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