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Article type: Cover
2014 Volume 63 Issue 8 Pages
Cover15-
Published: September 01, 2014
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Article type: Index
2014 Volume 63 Issue 8 Pages
Toc7-
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
App19-
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Atsuko Araki, Yu Ait Bamai, Reiko Kishi
Article type: Article
2014 Volume 63 Issue 8 Pages
1075-1084
Published: September 01, 2014
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Takamichi Ichinose
Article type: Article
2014 Volume 63 Issue 8 Pages
1085-1094
Published: September 01, 2014
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Hiroshi Takenaka
Article type: Article
2014 Volume 63 Issue 8 Pages
1095-1101
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
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Etsuko Takamura
Article type: Article
2014 Volume 63 Issue 8 Pages
1103-1109
Published: September 01, 2014
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Ichiro Taniuch
Article type: Article
2014 Volume 63 Issue 8 Pages
1110-1114
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Hiroto Matsuse
Article type: Article
2014 Volume 63 Issue 8 Pages
1115-1118
Published: September 01, 2014
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Yoko Muto
Article type: Article
2014 Volume 63 Issue 8 Pages
1119-1125
Published: September 01, 2014
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Tetsuri Kondo, Takanori Shimizu, Toshimori Tanigaki, Makoto Hibino, Mo ...
Article type: Article
2014 Volume 63 Issue 8 Pages
1126-1131
Published: September 01, 2014
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Background: Trainer devices are widely employed for flow instruction in the use of dry powder inhalers (DPI). However, their aerodynamic characteristics in actual use have yet to be investigated. Methods: We recorded inhalation flow signals and sounds produced from trainers for Diskus^[○!R], Symbicort^[○!R], Pulmicort^[○!R] and Twisthaler^[○!R] while five volunteers inhaled from the trainers with various inhalation patterns. Results: Inhalation flow was classified into four patterns; the best, trapezoid, delayed peak and others. All the trainers exhibited flow-thresholds with appropriate precision for instruction. Sound intensity from the Diskus^[○!R] trainer was almost proportional to inhaled flow rate, and it may be useful for flow pattern estimation. In other trainers, when flow exceeded some thresholds, sounds abruptly developed and continued with high intensity. Thus, they may be convenient for recognizing appropriate flow rates. In all trainers, when the subjects inhaled rapidly and forcefully, sound developed at 0.19-0.24s after the onset of inhalation. Thus, with this flow pattern, trainers may indicate a flow rate approaching the peak of drug dispersion from the DPI. When the subject inhaled less rapidly, the threshold for sound development decreased by 10%. Conclusion: The instructor in DPI use should be aware of the aerodynamic characteristics of each individual trainer. Rapid inhalation should also be encouraged.
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Aya Yoshimura, Manabu Musashi, Takeaki Kaneko, Shunsuke Ohnishi, Chiek ...
Article type: Article
2014 Volume 63 Issue 8 Pages
1132-1139
Published: September 01, 2014
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Background: Based on a case who developed anaphylaxis after mouse bite which occurred at Hokkaido University, we studied on allergic sensitization prevalence for laboratory animals among students and researchers who are exposed to laboratory rodents and rabbit, for the purpose of allergy prevention, particularly anaphylaxis. Methods: We carried out the health check-up on laboratory animal allergy (LAA) by questionnaires and specific-IgE antibody test for 555 rodents and/or rabbit handlers from whom informed consent was obtained. Result: Prevalence of positive IgE antibody higher than class 1 to mice, rats, hamsters, guinea pigs, and/or rabbits in the examinees was 14.1% (62/441), 17.9% (50/279), 18.8% (6/32), 17.4% (4/23), and 11.3% (12/106), respectively. Moreover, among users of mouse, those who had allergic symptoms during contact with animals resulted in significantly higher positive rate for anti-mouse IgE antibody test than the other (38.1% vs 8.8%, p<0.01). Conclusion: Health check-up including measurement of specific-IgE antibody against laboratory animals is useful for understanding allergic sensitization.
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[in Japanese]
Article type: Article
2014 Volume 63 Issue 8 Pages
1140-1141
Published: September 01, 2014
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[in Japanese], [in Japanese]
Article type: Article
2014 Volume 63 Issue 8 Pages
1142-1143
Published: September 01, 2014
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[in Japanese]
Article type: Article
2014 Volume 63 Issue 8 Pages
1144-1145
Published: September 01, 2014
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
1147-
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
1148-1193
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
1194-1195
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
1197-1198
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
1199-1201
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
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Article type: Appendix
2014 Volume 63 Issue 8 Pages
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Article type: Cover
2014 Volume 63 Issue 8 Pages
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Published: September 01, 2014
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