Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 9, Issue 6
Displaying 1-16 of 16 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1960 Volume 9 Issue 6 Pages Cover9-
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.Cover9
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1960 Volume 9 Issue 6 Pages Cover10-
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.Cover10
    JOURNAL FREE ACCESS
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  • The Shwartzman Phenomenon in the Rabbit Brain Produced by the Purified Endotoxin of Pseudomonas Aeruginosa
    Yasushi Wakabayashi, J. Yuzuru Homma
    Article type: Article
    1960 Volume 9 Issue 6 Pages 469-475
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.469
    JOURNAL FREE ACCESS
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    The article is to report a successful production of the Shwartzman phenomenon in the rabbit brain in high percentage by means of an improved method of the treatment. By using the sesame oil containing 1 per cent of endotoxin and 1.5 per cent of span 60 (surface active agent), brain was prepared to be effective sufficiently by two successive injections (each containing 2mg of toxin in 0.1ml of sesame oil) into cisterna cerebello-medularis of the material, followed by a single intravenous (1mg of toxin per capita) or intracisterna eliciting injection of the endotoxin (3mg of toxin per capita) dissolved in physiological saline after 18-20 hours. Histological Histological findings such as meningitis with leucocytes infiltration and thrombus, hemorrhages, oedema, fibrinoid necrosis of small vessels in parenchym were observed.
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  • Experimental Studies on Anaphylactic Shock from the View Point of Hemodynamics
    Tatsuo Nakai
    Article type: Article
    1960 Volume 9 Issue 6 Pages 476-489
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.476
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    The anaphylactic shock was produced in the guinea pig weighing of 300 grams sensitized actively with the horse serum. They were divided into two groups, one is acute type of death within 20 minutes and the other is delayed type of death more than 20 minutes after the shock. The hemodynamics showed that the cause of the former might be asphyxia and the latter might be metabolic acidosis. All cases injected 10 mgms. of chlorpromazine survived. But the effects of buscopan, theabron or parasympathectomy were not necessarily demonstrated. The preoperative tracheotomy with an artificial respiration prolonged the of survival time. The hemodynamics also showed that O_2 in the arterial blood slightly decreased at first and came back to the normal lebel, but the concentration of CO_2 decreased continously and pH changed to acid and amino-N increased. PaCO_2, (HCO_3^-)_s and (B_B^+)_B decreased significantly and non-compensatory alkaline deficit were observed. The forced respiration right after the shocking injection and the treatment of chlorpromazine, administered 2 minutes after the provocative injection, reduced the death rate and prolonged the survival time. The result of the gas analysis (Scholander) showed that chlorpromazine have the facility of making pulmonary gas exchange easily to the guinea pig.
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  • Problems on the Food Proteins in the Clinical Allergy (1) : Studies by Precipitation Test
    Fumi Takase
    Article type: Article
    1960 Volume 9 Issue 6 Pages 490-499
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.490
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    It can be assumed that, in the clinical allergy, food proteins or their antibodies might be found in the blood of allergic patients. For this purpose, the author performed on more than 140 cases the precipitation reactions by using several kinds of food protein antigens and their anti-rabbit-sera, The results showed that antigen could not be found in the sera of either the normal or allergic patients. Moreover, in the latter cases any antigen was not found, even in the sera obtaind during the time of the severe asthmatic attack clinically. However, in a few cases with nephrose and purpura, the reaction was positive. On the other hand, antibodiy titers, in the sera were low positive, in about half of normal persons, but not a difference was observed between the sera before and after meal. In the cases of allergic patients, especially having definite food allergy, the antibody titer was high. During and after treatment of Meticorten and during disturbance of liver function or nephritis, the antibody titer was low. In other diseases the antibody titer was varied or did not show any marked change.
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  • Problems on the Food Proteins in the Clinical Allergy (2) : Studies by Agglutination Test with Sensitized Red Blood Cells by Egg Proteins
    Fumi Takase
    Article type: Article
    1960 Volume 9 Issue 6 Pages 500-514
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.500
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    In our previous experiments by precipitation test (see Report 1) antibodies was demonstrated in the blood of patients, but antigens could not be found. Now, using agglutination test of tannic acid-treated red blood cells, the author attempted to find antigens in the blood of patients, which can not be approached by other methods (precipitation, hemoagglutination, hemolyse-reaction, etc.). After confirming by the intracutaneous test that the egg protein administered orally entered the blood circulation, agglutination test was performed. The results showed that the red blood cells of normal persons without tannic acid-treatments did not combine egg preteins. However, red blood cells of allergic patients without tannic acid-treatments could combine egg proteins. When antisere were added to tannic acid-treated red blood cells sensitized with the sere after meal, hemoagglutination reaction was positive. The results also suggested that proteins entered in the blood circulation of patients having allergic diathesis would combine easily red blood cells in vivo. Moreover, even in normal persons when a large amount of proteins were taken some of them seemed to combine easily red blood cells in vivo. When the proteino of cow milk and beef were used instead of egg proteins, they combined the non-treatedd red blood cells with tannic acid of allergic patients, but did not combine the non-treated red blood cells with tannic acid of normal persons.
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  • Studies on Tuberculous Allergy Using Developing Chick Embryo, with Special Reference to the Relationship between Allergy and Immunity in Tuberculosis
    Shiro Ishiyama
    Article type: Article
    1960 Volume 9 Issue 6 Pages 515-521
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.515
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    Varying doses of avian type of tubercle bacilli (strain Takeo) were injected into yolk sacs of developing chick embryos simultaneously with varying doses of anti-tuberculous sera derived from chicken, in order to examine the effects of antigen-antibody reaction between the bacilli and antituberculous sera upon survival time of the chick embryos. Thus, the relationship between allergy and immunity in tuberculosis was analysed from a simplified viewpoint of quantitative relation between antigen and antibody, inasmuch as secondary production of humoral or sessile antibodies may be ignored in chick embryo. The results indicated that the survival time of chick embryos was proportional to the quantity of tubercle bacilli injected, when normal chicken sera were injected into yolk sacs simultaneously with the infection, namely, the larger the quantity of bacilli, the shorter the survival time. The survival time of infected chick embryos was lengthened, when larger doses of anti-tuberculous sera were injected into yolk sacs. Anti-tuberculous sere in this case are considered to show a "favourable" effect upon embryo (immunity). The survival time of infected chick embryos was markedly shortened, when smaller or moderate doses of anti-tuberculous sera were injected into yolk sacs. Anti-tuberculous sera in this case are considered to show an "unfavourable" effect upon embryo (allergy). From the results mentioned above, the relationship between allergy and immunity in tuberculosis were discussed.
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  • Pharmacological Studies on Anaphylaxis (Ist Report) : Electrocardiographical Studies on Anaphylactic Shock
    Akira Shimura
    Article type: Article
    1960 Volume 9 Issue 6 Pages 522-536
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.522
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    In anaphylactic shock of the guinea pig sensitized with diphtherial toxoid bradycardia, arrhythmia, elevation of ST, inversion of T and complete block in elactrocardiograph (ECG) were observed and most of them were shocked to death. The pretreatment of Tropin, Tropin+Dibenamine, Procain amide, Hydergine, Ipsiron, adrenaline, Vitacampher, Neophylline, cutting vagus, artificial respiration or oxygen inhalation could not prevent guinea pigs from the death. Only chlorpromazine and prometazine showed the protective effect. Similar findings in ECG were observed both in the cases those bronchus closed and repleted with water. These findings could not be prevented by the pretreatment of any drug, even by chlorpromazine. These results suggest that the electrocardiographical finding in anaphylaxis may depends upon the result of antigen-antibody reaction in the heart muscle and the ECG changes in the latter may be due to the lack of oxygen in the heart muscle. Anyway the symptoms in both cases may not be the reflexive phenomenon.
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  • Pharmacological Studies on Anaphylaxis (2nd Report) : Experimental Studies on the Relationship between the Various Conditions of the Sensitized Guinea Pig During the Survival Period and Schultz-Dale Reaction
    Eiko Watanabe
    Article type: Article
    1960 Volume 9 Issue 6 Pages 537-542
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.537
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    The contracting or relaxing actions of the extracted intestine of the guinea pig were investigated comparing with the actions to the blood pressure. The blocking agents of sympathetic and parasympathetic nerves relaxed the isolated intestine. Atonin O, having the rising action of blood pressure, also relaxed the intestine, however, Veratrine which falls the blood pressure contracted the intestine. Thus the contracting or relaxing actions of the extracted intestine in vitro were not always parallel to the rising or falling effect of the blood pressure. The inhibiting action of the drug in anaphylacttc reaction in vitro was almost parallel to the inhibiting action of the drug in acetylcholinic contraction, and it was also parallel to the changes of ECG observed by Shimura. In other words, the anaphylactic reaction of the small intestine sensitized with diphtherial toxoid was not influenced by the blocking agents of sympathetic and parasympathetic nerves, but inhibited by chlorpromazine or antihistamines. However, the shock symptoms in vivo and Schultz-Dale reaction in the guinea pigs, extracted one side of suprarenal bodies, pretreated with chlorpromazine or anaesthetized with aether were not necessarily parallel.
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  • Pharmacological Studies on Anaphylaxis (3rd Report) : Role of Central Nervous System to the Findings of ECG and Schultz-Dale's Reaction in Anaphylactic Shock
    Kikuji Tokita, Akira Shimura, Eiko Watanbe, Yasuko Inoh, Akio Kadowaki ...
    Article type: Article
    1960 Volume 9 Issue 6 Pages 543-548
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.543
    JOURNAL FREE ACCESS
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    Guinea pigs were sensitized with diphtherial toxoid and shocked. Not a difference in the symptoms and the findings of ECG was observed between the control and the guinea pig cut the upper quadigeminal bodies, but Schultz-Dale reaction was observed to be weakened. However, the shock symptoms, ECG findings and Schultz-Dale reaction were remarkbly weakened when the bottom of the quadrigeminal bodies were cut down. These findings were also observed under the ether anaesthesia, phenobalbital, or urethane anaesthesia. When the thoracic spinal were cut down, the convulsion in anaphylaxis was only observed at upper limbs, but the findings of ECG and Schultz-Dale reaction was as same as the control. These results suggest that the main cause of death in anaphylaxis may depends upon the antigen-antibody reaction at the convulsious and vascular center. So the main cause of the death in anaphylaxis may be the fall of blood-pressure, next is the myocardial obstruction and thirdly edema in lung.
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  • [title in Japanese]
    Article type: Bibliography
    1960 Volume 9 Issue 6 Pages 549-552
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.549
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  • [title in Japanese]
    Article type: Appendix
    1960 Volume 9 Issue 6 Pages 553-
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.553
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  • [title in Japanese]
    Article type: Appendix
    1960 Volume 9 Issue 6 Pages 554-
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.554
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1960 Volume 9 Issue 6 Pages App4-
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.App4
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  • [title in Japanese]
    Article type: Cover
    1960 Volume 9 Issue 6 Pages Cover11-
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.Cover11
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1960 Volume 9 Issue 6 Pages Cover12-
    Published: June 01, 1960
    Released on J-STAGE: October 20, 2016
    DOIhttps://doi.org/10.15036/arerugi.9.Cover12
    JOURNAL FREE ACCESS
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