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Volume 33, Issue 3
Displaying 1-14 of 14 articles from this issue
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Article type: Cover
1984 Volume 33 Issue 3 Pages Cover15-
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
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Article type: Cover
1984 Volume 33 Issue 3 Pages Cover16-
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (337K) -
Article type: Bibliography
1984 Volume 33 Issue 3 Pages Misc6-
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1984 Volume 33 Issue 3 Pages App2-
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
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Haruki Komagoe, Michiyasu Sudo, Yoshiro Tanizaki, Hikaru Kitani, Yoshi ...Article type: Article
1984 Volume 33 Issue 3 Pages 131-134
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSPercentage of basophils reactive to house dust and anti-IgE, histamine release from basophils, and total IgE together with specific IgE in serum were examined in sixteen asthmatic patients during immunotherapy with house dust. 1) Morphological changes in basophils (to reactive basophils) induced by house dust were significantly decreased after one year of immunotherapy. Release of histamine from basophils induced by house dust decreased compared to the value of pre-immunotherapy, but it was not statistically significant. 2) Percentage of basophils reactive to anti-IgE was significantly reduced after one year of immunotherapy. 3) Immunotherapy resulted in no significant decrease in the level of total serum IgE. On the other hand, the levels of specific IgE antibody were slightly reduced during immunotherapy. There was no correlation between the reduction in basophil reactivity and the reduction in the level of specific IgE antibody.View full abstractDownload PDF (468K) -
Yasuhiro Mizoguchi, Hiroko Tsutsui, Sukeo Yamamoto, Seiji MorisawaArticle type: Article
1984 Volume 33 Issue 3 Pages 135-141
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDNA synthesis in ascites hepatoma cells was significantly reduced when specific antibody-coated cells were cocultured with the peritoneal exudate cells from syngeneic donors. This antibody-dependent hepatoma cell damage was augmented by a pretreatment of the peritoneal exudate cells with OK432. This hepatoma cell injury was presumed to be induced, through the antibody-dependent macrophage-mediated cytotoxicity and its augmentation by OK432 was attributable to the activation of macrophages.View full abstractDownload PDF (726K) -
Masato MaedaArticle type: Article
1984 Volume 33 Issue 3 Pages 142-147
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo clarify the levels of secretory IgA (s-IgA) in sera from anaphylactoid purpura (AP), the author measured serum IgA and s-IgA levels in sera from 12 AP patients and 8 healthy children and evaluated the correlation between these levels with AP and GI symptoms (for example, abdominal pain, nausea, vomiting and melena). IgA levels were measured by single radial immunodiffusion and s-IgA levels were measured by radio-immunoassay. The results were as follows: 1. The serum IgA and s-IgA levels in healthy children were 125±40mg/dl and 0.85±0.28mg/dl. 2. The serum IgA levels in AP patients were high in 8 of 12 cases and decreased in the recovery stage. 3. There was no difference between the s-IgA levels of 8 healthy children and those of the cases without GI symptoms in acute and recovery stages. 4. The cases with GI symptoms a) There was no difference in serum s-IgA levels between the cases without melena and the cases without GI symptoms in the acute and the recovery stage. b) The serum s-IgA levels in the cases with melena in the acute stage were significantly higher than those in the cases in the recovery stage (p<0.001). 5. There was no correlation between IgA levels and s-IgA levels from sera in the acute and the recovery stage. The results suggest that the increase of s-IgA levels in the sera may indicate the disturbance of intestinal mucosa.View full abstractDownload PDF (802K) -
Kazuro YagiArticle type: Article
1984 Volume 33 Issue 3 Pages 148-157
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIt has been thought that benzylpenicilloyl (BPO) protein might be a major antigenic determinant in penicillin allergy. On the other hand, it has been pointed out that materials of high molecular weight (polymers) might have an important role in elicitation of penicillin allergy. These materials have immunogenicity to experimental animals and produce specific antibodies to penicillin. It has been also demonstrated that polymers of benzylpenicillin and aminobenzylpenicillin (ABPC) are formed in the aqueous solution of these drugs. And it has reported that polymers in antibiotic preparations might be related to elicitation of PCA mediated by IgE antibody. However, there are a few direct verifications in regard to whether the preparations contain a small amount of polymers. Furthermore, PCA reaction was elicited by side chain analogous compound or 6-aminopenicillanic acid, having not essential participation of polymers. Experiments were carried out in order to re-examine the capacity to elicit PCA reaction by ABPC preparation, and the following results were obtained. 1) By gel chromatography of ABPC preparation, only one main peak showing Kav at 0.8 (Sephadex) or at 0.7 (Biogel) was revealed in the elution pattern of the sample. 2) This preparation showed a high capacity to elicit 8-day PCA mediated by anti-ABPC IgE antibody, and the antigenic specificity was demonstrated by quantitative PCA inhibition test. 3) ABPC preparation at optimal concentrations did not induce degranulation of mast cells or histamine release from basophils of the intact guinea pig. However, ABPC at this concentration induced degranulation of mast cells and histamine release of basophils isolated from the cells sensitized with anti ABPC-Ase antiserum. These results suggest that ABPC preparation may have the capacity to induce allergic reaction and that the reaction may not depend on ABPC polymers in the preparation.View full abstractDownload PDF (1267K) -
Koji Ito, Seiichi Kitani, Yoshio Sakamoto, Terumasa MiyamotoArticle type: Article
1984 Volume 33 Issue 3 Pages 158-166
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSFor the simple estimation of IgG-, IgA- and IgM antibodies to mite, enzyme-liked immunosorbent assay (ELISA) was carried out using microplates. Our findings are as follows. 1) IgG and IgA antibodies were positive in 70% and 53% respectively of asthmatic patients with positive IgE antibodies to mite. IgM antibodies were positive in only 10% of the same group of patients. 2) A significant correlation was found between the IgG antibody levels and the IgA antibody levels in asthmatic patients treated with house dust- or mite extracts. However, no correlation was found when the treated group was mixed with a group of untreated patients. 3) Measurement of IgG-, IgA- and IgM antibodies by ELISA using microplates seems to be simple and useful for clinical studies because such measurement does not require radioactive isotopes.View full abstractDownload PDF (963K) -
Sohei Makino, Ryosuke Ikemori, Takeshi Fukuda, Shinji Motojima, Seiich ...Article type: Article
1984 Volume 33 Issue 3 Pages 167-175
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAcetylcholine (Ach) inhalation test was carried out by standard method on 45 normal subjects and 132 asthmatic subjects. Subjects inhaled aerosols of Ach solution of serially doubling concentration for 2 minutes. Respiratory threshold to Ach (RT-Ach) was defined as the minimal concentration of Ach solution needed to induce a more than 20% decrease in FEV_<1.0>. The geometric means of RT-Ach among normal and asthmatic subjects were 32384 and 1538μg/ml, respectively. The boundary value of RT-Ach separating normal and asthmatic subjects was considered to be 10000μg/ml. Patients with more severe asthmatic symptoms had lower RT-Ach than patients with milder symptoms. This relationship was still observed, even when patients with FEV_<1.0>% lover than 70% were excluded. RT-Ach showed a low but stantistically significant correlation with FEV_<1.0>% and FEV_<1.0> expressed as the percentage of the predicted value. There was no significant correlation between RT-Ach and age of the subjects. On dose-response curve of the concentration of Ach solutions and percent decrease of FEV_<1.0> after inhalations, the slope of the curve in the area of RT-Ach was measured. No apparent relationship were observed between the slope value and clincal features of asthma in this study.View full abstractDownload PDF (850K) -
Tohru TakeuchiArticle type: Article
1984 Volume 33 Issue 3 Pages 176-181
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe serum IgE levels in 51 families consisting of children and their both parents were measured by PRIST. The majority of these families had one or more children with atopic diseases, and some had healthy children. The values obtained for these children were compared with the mean levels of serum IgE in healthy controls reported in my previous paper, and the correlation between serum IgE levels of children and their parents was examined. The results were as follows. 1. In the families in which IgE levels of both parents were over M+2SD, 88 percent of their children had IgE levels over M+SD, and 63 percent were found to have levels over M+2SD. In the families in which IgE levels of either or both of the parents were over M+SD, 52 percent of their children had levels over M+SD. In the families in which IgE levels of both parents were below M+SD, only 35 percent of their children had levels over M+SD. 2. In the families in which the father's IgE levels were over M+SD and the mother's levels below M+SD, 59 percent of the children had levels over M+SD, and in the families in which the mother's IgE levels were over M+SD and the father's levels below M+SD, 52 percent of the children had levels over M+SD. No significant difference was found in the incidence of high IgE levels in children in the two types of families. These results suggest that serum IgE levels of children may be controlled by genetic factors, and that there appears to be no sex difference involved as to the parents' genetic influence on serum IgE levels of their children.View full abstractDownload PDF (700K) -
Hiroshi Hayakawa, Noboru Kobayashi, Junichi YataArticle type: Article
1984 Volume 33 Issue 3 Pages 182-193
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAmong the 629 patients with various primary immunodeficiency diseases reported to the All Japan Immunodeficiency Registry (during the period from January 1, 1975 to May 5, 1983), there were forty six cases of ataxia-telangiectasia registered. Twenty-five of them were patients with ataxia-telangiectasia in their family histories. Fifteen of the 46 patients had already expired by the time of the registration and the most frequent cause of death was pneumonia. The incidence of the major symptoms observed in these reported cases was as follows; ataxia 97.8%, telangiectasia 71.7%, and susceptibility to infection, 69.7%. Six patients had developed malignant diseases such as leukemia, malignant lymphoma, hepatoma and gastric cancer. Either very low levels or absence of serum IgA was reported in 47.2% of 36 cases who were reported the detailed laboratory data and in vitro PHA responses were diminished in 75.6% of those patients.View full abstractDownload PDF (1279K) -
Article type: Appendix
1984 Volume 33 Issue 3 Pages 194-197
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
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Article type: Cover
1984 Volume 33 Issue 3 Pages Cover17-
Published: March 30, 1984
Released on J-STAGE: February 10, 2017
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