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Volume 48, Issue 12
Displaying 1-17 of 17 articles from this issue
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Article type: Cover
1999 Volume 48 Issue 12 Pages Cover10-
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (527K) -
Article type: Cover
1999 Volume 48 Issue 12 Pages Cover11-
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (527K) -
Toshiyuki TakaiArticle type: Article
1999 Volume 48 Issue 12 Pages 1291-1295
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
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Takeru IshikawaArticle type: Article
1999 Volume 48 Issue 12 Pages 1296-1305
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
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Toshiyuki AokiArticle type: Article
1999 Volume 48 Issue 12 Pages 1306-1308
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
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Kaoru Endo, Takayuki Hizawa, Takayuki Fukuzumi, Yoko KataokaArticle type: Article
1999 Volume 48 Issue 12 Pages 1309-1315
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe had a two-month-old girl with severe dermatitis since birth. Her serum RAST to HD, Df and Dp were 1.06, 0.03 and 0.01 Ua/ml respectively. A Yorkshire terrier were kept at her mother's parents' home where the patient had lived for a month since birth. Her eczema, which became markedly aggravated whenever she visited there, improved after the elimination of the dog. We investigated the relationship between keeping dogs and infantile atopic dermatitis. We studied 368 patients under the age of two years (211 boys and 157 girls). Skin symptoms were graded globally mild, moderate or severe. Total serum IgE and specific antibody titer to dog dander were measured. We asked them whether they kept dogs and specifically, where they kept dogs, outdoor, indoor, in their own house, or in their grandparents' house. 197 patients had no contact with dogs, 90 patients kept dogs outdoor and 81 patients did indoor. The positive rate of RAST (≧0.7 Ua/ml) to dog dander was 6.1%, 17.8% and 46.9% respectively in these three groups. There were strong statistical differences between three groups. On the other hand, among the 81 patients who kept indoor, the RAST positive rates were almost same regarding where the dogs were kept, in their own house or their grandparents' house. Interestingly this difference happens only with patients under the age of 3 months. Patients older than 4 months showed no significant differences in the positive RAST rates, whether they kept dogs indoor or outdoor. This suggests the sensitization occurs before the age of 3 months. Speaking of symptoms, patients who kept dogs indoor showed significantly more severe symptoms than patients who had no contact with dogs and patients who kept dogs outdoor. There was no significant difference between the symptoms of patients who had no contact with dogs and those of patients who kept dogs outdoor. This implies the patient's symptom will improve only by moving the dog out of the house.View full abstractDownload PDF (776K) -
Makoto Nagata, Kazuaki Tabe, Hideaki Yamamoto, Yoshio Sakamoto, Hirosh ...Article type: Article
1999 Volume 48 Issue 12 Pages 1316-1321
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe objective of this study was to evaluate the clinical significance of allergen-specific immunotherapy in house-dust-mite-sensitive adult bronchial asthma. Fifty patients treated with rush immunotherapy using house dust antigen were examined. The disease severity was compared between before and a year after the maintenance immunotherapy : reduction in the severity was observed in 27 patients (54.O%) following the treatment. The response rate was greater in the patients with step 3 (moderate, persistent) or step 4 (severe, persistent), disease period less than 10 years, or reversible airway obstruction. Patients who showed favorable clinical response also demonstrated the reduction in medical costs. These results suggest that allergen immunotherapy reduces the disease severity and medical cost in a certain population of adult atopic asthma.View full abstractDownload PDF (733K) -
Takenori Okada, Hironori Sagara, Yasuhiro Nakano, Takako Hiyama, Takes ...Article type: Article
1999 Volume 48 Issue 12 Pages 1322-1330
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe accumulation of eosinophils in the airway is one of the characteristics seen in patients with bronchial asthma. One of the newly develorped anti-asthma drugs (controller), nedocromil sodium (nedocromil) is known to suppress the influx of eosinophils into allergic lesions. However, little is known about this mechanism. Therefore, in this report we investigated the effects of nedocromil on Mac-1 expression on PAF-stimulated eosinophils, and adhesion molecule expression on endothelial cells stimulated by either IL-1β or IL-4. We also investigated the eosinophil chemotaxis. A significant suppression of the Mac-1 expression on PAF-induced eosinophils was observed at both concentrations of 10^<-5> and 10^<-7>M of nedocromil. The expression of adhesion molecules, particularly ICAM-l and E-selectin, on IL-lβ-stimulated human umbilical vascular endothelial cells (HUVEC) was significantly suppressed at these concentrations, whereas the VCAM-l expression was not changed. No significant suppression of VCAM-1 expression on IL-4-stimulated HUVEC was observed, although there was a tendency of suppression at these concentrations. On the other hand, the expression of the E-selectin molecule was significantly suppressed by nedocromil even under resting (non-stimulated) condition. PAF-induced eosinophil chemotactic activities were also suppressed at these concentrations in a dosedependent manner. These results suggested that nedocromil suppressed the influx of eosinophils to inflammatory lesions by inhibiting not only the expression of the Mac-1 on eosinophils and of E-selectin and ICAM-1 molecules on HUVEC, but also the eosinophil chemotactic activities.View full abstractDownload PDF (997K) -
Hirokuni Hirata, Tatsuo Yukawa, Masafumi Arima, Goro Yamada, Sohei Mak ...Article type: Article
1999 Volume 48 Issue 12 Pages 1331-1336
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn our country approximately forty peopel die every year from anaphylaxis caused by hymenopterastings. Between 1988 and 1996, 48 patients, who had experienced a systemic reaction to hymenoptera sting and were proved to have specific IgE antibodies to wasp, yellow or both (RAST score≧2), received rush immunotherapy (RIT) using vonom extracts in our hospital. Fifteen patients had re-sting after RIT. Fourteen out of the 15 patients showed only local reaction to the hymenoptera re-sting and one patient had mild generalized symptoms. Although one patient showed mild generalized uriticaria during RIT, no adverse reaction occurred during and after RIT in the other subjects. Follow-up studies on the titers of serum total IgE antibodies and hymenoptera specific IgE and IgG4 antibodies revealed that total and specific IgE antibodies transiently increased one month after RIT and returned to their baseline values by 6 months after RIT, while specific IgG4 antibodies continued to gradually increase up to al least 3 years after RIT. These results demonstrates that RIT is effective in prevention of a systemic reaction to hymenoptera re-sting and an increase in the titer of hymenoptera specifdc IgG4 anti<bodies may at least par>___-tly explain the efficacy of RIT.View full abstractDownload PDF (621K) -
Hiroyuki Namba, Katuyoshi Saitou, Norio SahashiArticle type: Article
1999 Volume 48 Issue 12 Pages 1337-1347
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIt is very important to predict and disseminate information about the total pollen counts of both Cryptomeria japonica and Cupressaceae for patients with pollinosis. In Okayama Prefecture, we have reported that the pollen counts of both Cryptomeria japonica and Cupressaceae are influenced by the meteorological conditions in the previous July. We predicted the area supplying Okayama Prefecture with Cryptomeria japonica and Cupressaceae pollen, and also the route of airborne pollen from the meteorological conditions and a topographical map of Okayama and four neighboring prefectures. It was found that Cryptomeria japonica and Cupressaceae pollen counts at the four observation sites correlated very well with the meteorological conditions at Tsuyama weather station in Okayama prefecture. Therefore, we considered that the areas supplying Okayama prefecture with Cryptomeria japonica and Cupressaceae pollen were the central northern areas including Tsuyama, 85.7% of whose plantation areas contained Cryptomeria japonica and Chamaecyparis obtusa, and that their pollen was carried along the routes of three major rivers, R. Takahashi, R. Asahi and R. Yoshii.View full abstractDownload PDF (1319K) -
Article type: Appendix
1999 Volume 48 Issue 12 Pages 1348-1354
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1999 Volume 48 Issue 12 Pages 1355-
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
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Article type: Index
1999 Volume 48 Issue 12 Pages 1356-1362
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
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Article type: Index
1999 Volume 48 Issue 12 Pages 1363-1366
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
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Article type: Index
1999 Volume 48 Issue 12 Pages 1367-1370
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (198K) -
Article type: Appendix
1999 Volume 48 Issue 12 Pages 1371-1377
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
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Article type: Cover
1999 Volume 48 Issue 12 Pages Cover12-
Published: December 30, 1999
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (311K)
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