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Volume 36, Issue 7
Displaying 1-12 of 12 articles from this issue
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Article type: Cover
1987 Volume 36 Issue 7 Pages Cover28-
Published: July 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (113K) -
Article type: Cover
1987 Volume 36 Issue 7 Pages Cover29-
Published: July 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (113K) -
Tokuko Mukoyama, Minoru Baba, Takeshi Noma, Junichi YataArticle type: Article
1987 Volume 36 Issue 7 Pages 351-357
Published: July 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to detect the presence of lymphocytes specifically sensitized to Dermatophagoides farinae (Df) antigen in asthmatic children, induction of interleukin 2 (IL-2) production and IL-2 responsiveness of the lymphocytes by stimulation with Df antigen and a mitogen was studied. IL-2 responsiveness and IL-2 production of the peripheral blood lymphocytes stimulated with PHA were almost the same in asthmatic children and normal healthy adults. IL-2 responsiveness and IL-2 production of the peripheral blood lymphocytes stimulated with Df were elicited in asthmatic children but not in healthy adults. The induction of IL-2 responsiveness by Df stimulation was observed only the children who showed RAST and skin test positive for Df. Therefore, it seemed to be an antigen specific phenomenon. These data showed that the lymphocytes of asthmatic children are sensitized by Df antigen and sensitization can be abrogated by immunotherapy.View full abstractDownload PDF (653K) -
Masano Ueda, Hideko IguchiArticle type: Article
1987 Volume 36 Issue 7 Pages 358-366
Published: July 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe investigated intradermal test, levels of IgE antibodies, history of exposure and allergic symptoms to cats vs.dogs in asthmatic children (7-17 years old) who have been treated in National Chubu Hospital for a long time. The results were as follows. 1) The rates of positive intradermal tests for cat or dog hair and cat dander were 17%, 13% and 7% respectively. Those for cat hair and dander were reversed after 1980. 2) About twice as many dogs as cats were kept, but the rate of positive RAST to dogs was lower (15/92:16%) than that to cats (57/101:57%). 3) 83% (5/6) of the asthmatic children who kept cats had positive RAST as opposed to 26% (5/19) of those who kept dogs. 4) 53% of the patients who did not keep cats had positive RAST. So we suggested they were sensitized with another exposure. 5) 62% (31/50) of the patients who showed positive RAST to cats had allergic symptoms, and 26% (13/50) had stridor or asthma attacks after exposure to cats as opposed to 14% (2/14) of those who showed positive RAST to dogs. 6) In future, case of cat or dog allergy may increase in Japan. We should research their antigenicity and use the major allergen of them.View full abstractDownload PDF (902K) -
Yoshihisa AbeArticle type: Article
1987 Volume 36 Issue 7 Pages 367-376
Published: July 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe degree of seriousness and improvement of bronchial asthma have been determined after a long term of clinical observation. In this study, 12 items concerning patients' symptoms, signs in the 1st medical examination and laboratory findings (sex, onset age, atopic dermatitis, family history of allergy, positive counts in skin tests, skin reaction to house dust, molds and pollens, IgE (RIST), eosinophile counts, IgG, start of therapy) were analysed by the Quantification Theory (Type II). Then, the possibility of prognosis presumption with bronchial asthma was studied. Concerning the degree of seriousness, the descrimination ratio between the mild group and the moderate + severe groups was 82.31%. Concerning the degree of improvement, the descrimination ratio between the markedly improved + improved groups and the no change + deteriorated groups was 78.65%. These results reveal that it's possible to expect the degree of seriousness and improvement by using 12 items. To examination the influence of each item on the prognosis, I calculated the correlation ratio and selected 6 items (onset age, atopic dermatitis, family history of allergy, positive counts in skin tests, IgE (RIST) and eosinophile counts) which were recognized as being dependent of the other items. The range ratio of these 6 items was investigated and the greatest factor of influence on the prognosis was eosinophile counts and followed by onset age. It is concluded that the Quantification Theory (Type II) applied to patients' symptoms, signs in the 1st medical examination and laboratory findings was usefull in the prognosis presumption with bronchial asthma.View full abstractDownload PDF (1171K) -
Yuichi Takahashi, Susumu Katagiri, Fumio IwaoArticle type: Article
1987 Volume 36 Issue 7 Pages 377-385
Published: July 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe have investigated immunological corss-reactivity among aqueous pollen extracts from six species of fruit trees: cherry (Prunus avium), Yoshino cherry (Prunus yedoensis), peach (Prunus persica), Japanese apricot (Prunus mume), pear (Pyrus serotina), and apple (Malus pumila), by means of RAST test, RAST inhibition test, agar double immunodiffusion test, crossed immunoelectrophoresis (CIE) and tandem CIE. Sera obtained from patients allergic to cherry pollen strongly reacted with the allergens of the pollen extracts within the cherry genus, and weakly with the pear subfamily. On the other hand, sera from patients with apple pollinosis strongly reacted with the extracts of the pear subfamily, and weakly with the cherry genus. The results obtained from the analysis of sera from immunized rabbits were similar to those of sera from patients allergic to cherry or apple pollen. In the agar immunodiffusion test, little precipitate was formed the extracts of fruit tree pollens and antisera against Japanese cedar and cocksfoot pollens. In the CIE analysis, 12 precipitates were observed from the aqueous extract of cherry pollen and the rabbit antiserum to cherry pollen. Two of the precipitates moved to the cathode and the others to the anode. In the extract of apple pollen and the antiserum to apple pollen, 13 precipitates moved to the anode. With tandem-CIE analysis, it was proved that there are two cross-reactive antigens between cherry and peach, and three antigens between apple and pear. No cross-reactive antigens between cherry and apple were dertectable.View full abstractDownload PDF (1309K) -
Kotaro Ukai, Ryo Amesara, Yasuo SakakuraArticle type: Article
1987 Volume 36 Issue 7 Pages 386-393
Published: July 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThis study was undertaken to investigate nasal hypersensitivity and reactivity to histamine in normal guinea pigs. Nasal mucosal hypersensitivity was measured by dropping 10μl of histamine into both nares. A series of histamine dilutions was used to determine the threshold of sensitivity, which in the individual animal was required to cause a secretory response in the nose. One or two days after measurement of nasal hypersensitivity, the animals were anesthetized intraperitoneally with sodium pentobarbital. After tracheostomy, a polyethylene tube was placed in the post cavity through the stoma. Nasal resistance and, protein and albumin in the nasal washing fluids were measured before and 10 minutes after provocation of 10 μl of histamine 10^5 μg/ml in each nostril. The results obtained are as follows; 1. The threshold of nasal hypersensitivity to histamine was the range of 10^4 μg/ml to 10^5 μg/ml in the 90.8% of the 65 animals. 2. Nasal resistance and the amount of protein in nasal washing fluid was significantly increased after provocation with histamine. 3. The protein and albumin levels in nasal washing fluids, and nasal resistance showed significant dosedependent response to histamine. As these results show, intensities of nasal mucosal hypersensitivity and reactivity in normal guinea pigs were evaluated in this study.View full abstractDownload PDF (759K) -
Masaru Terai, Yoichi Kohno, Koichiro Niwa, Hironori Nakajima, Toshifum ...Article type: Article
1987 Volume 36 Issue 7 Pages 394-403
Published: July 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo investigate the mechanisms of vasculitis in Kawasaki disease, we studied the populations of circulating T cells in 46 patients with Kawasaki disease and characterized the immunophenotype of the perivascular inflammatory cells on cryostat-cut myocardial tissues obtained from a patient who died of acute Kawasaki disease. Patients who developed coronary aneurysms, compared with age-matched controls, had an imbalance between OKT4 and OKT8 during the second week of the illness, characterized by a decrease in the number of OKT8^+ cells and an increase in the number of OKT4^+ cells, resulting in a high OKT4/OKT8 ratio (p<0.01). The perivascular inflammatory cells consisted of LeuM3^+ macrophages and OKT3^+/Leul^+ T cells as determined by immunoperoxidase staining. In contrast, B cells were not detected and granulocytes were rarely seen in the perivascular lesions. In addition, the majority of coronary endothelial cells in the arteries, veins and capillaries expressed HLA-DR antigen at the inflammatory sites where macrophages and T cells coexsited. These immunological findings suggest that cell-mediated immune reactions contribute to the pathogenesis of vasculitis in Kawasaki disease. HLA-DR^+ endothelium may play an important role in the process of vasculitis.View full abstractDownload PDF (2198K) -
Takashi Tomoda, Noriko Zushi, Yoichi Tone, Takanobu Kurashige, Isamu K ...Article type: Article
1987 Volume 36 Issue 7 Pages 404-412
Published: July 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo determine whether abnormalities among subpopulations of human T-lymphocytes exist in patients with insulin dependent diabetes mellitus (IDDM), 29 IDDM patients and 22 normal controls were studied by direct immunofluorescence by means of monoclonal antibodies. Ia antigen positive (Ia^+) T cells were also investigated by two color analysis. The results were as follows: 1. There was no significant difference in the percentage of OKT4^+ and OKT8^+ positive T cells between IDDM patients and normal controls. 2. In IDDM patients the percentage of OKT10^+ T cells was significantly high (p<0.001) and the percentage of Leu7^+ cells was significantly lower (p<0.001) compated with normal controls, but there was no close correlation with their age. 3. Expression of Ia antigen of T cells is thought to be the sign of activation of T cells. Ia^+ T cells, especially those of OKT4 subset were significantly increased in IDDM patients as compared with normal controls (p<0.001). 4. Ia^+ OKT4^+/Ia^+ OKT8^+ ratio was significantly high in IDDM, though OKT4^+/OKT8^+ ratio itself was normal.View full abstractDownload PDF (699K) -
Yasumasa Yoshie, Kunihiko Iizuka, Yosio Umegae, Setsuo Kobayashi, Tugi ...Article type: Article
1987 Volume 36 Issue 7 Pages 413-416
Published: July 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe have investigated the inhibitory effect of selective alpha-2 adrenoceptor blocker, 2-[2-(4, 5-dihydro-1H-imidazol-2-yl)-1-phenylethyl] pyridine dihydrochloride sesquihydrate (DG-5128) on intractable asthma. Ten steroid dependent asthmatics were studied. The forced expiratory volume in 1 second (FEV_1), the forced vital capacity (FVC) and the respiratory resistance (R_<rs>) were measured at 1, 2 and 3 hours after DG-5128 200 mg oral administration and compared with those of premedication. At 2 hours after DG-5128 administration, the FEV_1 and FVC significantly (p<0.01) rose and R_<rs> significantly (p<0.05) decreased. Asthmatic symptoms (cough, stridor, dyspnea) also improved in 80% of the patients. DG-5128 is a selective alpha-2 adrenoceptor antagonist which acts on the adenylate cyclase of the cell membrane through the alpha-2 receptor and the inhibitory subunit of theguanine nucleotide regulatory protein (N_i). Our findings suggested that the over-function of the alpha-2 receptor or/excess of N_i possibly cause a dysfunction of the β adrenergic system in the case of intractable asthma and that this selective alpha-2 adrenoceptor antagonist may be a useful new drug for asthma.View full abstractDownload PDF (470K) -
Article type: Appendix
1987 Volume 36 Issue 7 Pages 417-420
Published: July 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (285K) -
Article type: Cover
1987 Volume 36 Issue 7 Pages Cover30-
Published: July 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (622K)
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