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Volume 30, Issue 12
Displaying 1-13 of 13 articles from this issue
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Article type: Cover
1981 Volume 30 Issue 12 Pages Cover10-
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (50K) -
Article type: Cover
1981 Volume 30 Issue 12 Pages Cover11-
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (50K) -
Article type: Bibliography
1981 Volume 30 Issue 12 Pages Misc4-
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (299K) -
Hikaru Nagatomi, tadaatsu Ogita, Hirokazu Okudaira, Terumasa Miyamoto, ...Article type: Article
1981 Volume 30 Issue 12 Pages 1099-1105
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe studied the effect of intravenous administration of protein- or hapten-containing liposomes (OA-LP, DNP-LP) with or without Mitomycin-C(MMC) on IgE antibody formation in BDF_1 mice. Pre-treatment with OA-LP suppressed not only anti-OA IgE antibody formation but also anti-DNP antibody formation irrespective of the co-existence of MMC. On the other hand, only slight suppression of anti-DNP IgE antibody formation was observed with DNP-LP in the absence of MMC. But an enhanced suppressive effect was observed with the addition of MMC in liposomes containing hapten antigen. None of the liposomes tested had any significant suppressive effect on ongoing anti-hapten or anti-protein IgG antibody responses. However, the usefulness of liposomes containing protein antigen with or without MMC is suggested in the control of seasonal aggravation of atopic diseases. The suppressive effect of the liposomes on the primary IgE antibody formation was observed to similarly affect the secondary reacrion.View full abstractDownload PDF (850K) -
Tsuyoshi Sakane, Yoshio Taniguchi, Masaaki Honda, Hiroyuki KotaniArticle type: Article
1981 Volume 30 Issue 12 Pages 1106-1112
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo investigate the basis for abnormalities in T cell function, we first studies T lymphocytes from patients with Behcet's disease during the latent period of active disease and apparently active and inactive phases of the disease to examine their ability to develop normal responses to the mitogens such as phytohemagglutinin and concanavalin A (Con A) and to autologous and allogeneic B cells. In each case, the ability of T lymphocytes to proliferate in response to each of these stimuli was perfectly normal regardless of the clinical state of the patient. We also evaluated Con A-induced suppressor T cell activity and percentage of Con A-induced autorosette forming cells which had been demonstrated to correlate well with suppressor cell function, in patients with Behcet's disease with various degrees of disease activity. Results showed that when patients were during the latent period of active disease, they had significantly lower suppressor T cell activity compared to the rest of the patients with Behcet's disease or normals. Patients with active or inactive Behcet's disease and normals had comparable suppressor T cell activity. Similarly, decrease in the Con A-induced autorosette levels could be demonstrated only in patients during the latent period of active disease, but ont in patients with active or inactive disease. Thus, the suppressor T cell dysfunction could be responsible for the initiation, but not the maintenance, of the autoimmune and/or inflammatory abnormality in Behcet's disease. The machanisms responsible for the transient appearance of suppressor T cell dysfunction at the latent stage of the active disease unknown.View full abstractDownload PDF (964K) -
Sankei Nishima, Hiromi Kaizuka, Hayao Araki, Shunjiro koizumiArticle type: Article
1981 Volume 30 Issue 12 Pages 1113-1122
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to clarify the relation between the severity of asthmatic symptoms and that of exercise-induced bonchospasm(EIB), 84 asthmatic and 23 healthy children were examined on pre-loading asthmatic symptoms and on ventilatory function at the load of exercise, 0.035kp/kg, 60rpm, 6min, using a bicycle ergometer. 1. A significant correlation was confirmed between the severity of asthmatic symptoms of definite term before the exercise-load, and that of EIB. 2. However, no singnificat correlation was obtained between the grade of response of ventilatory function in EIB and the initial values in ventilatory function, pre-exercise total IgE, or body weight. 3. On the other hand, the study suggested that the standard critical values for determining as positive response of EIB should be over 10% fall in FVC, FEV_1, over 15% fall in MMF, PEFR, over 20% fall in V_<50>, V_<25>, respectively. 4. Finally, among these parameters, there was revealed that MMF was the most sensitive and FVC was the most insensitive to detect positive response of EIB. Thus using MMF and PEFR in combination to detect positive response, 91.5% of cases were interpreted as positive among those who responded to exercise-load. 5. The heart rates of the severely asthmatic children did not return to any considerable extent to the pre-exercise values, and a few severe asthmatics could not keep the speed and load indicated on the bicycle ergometer.View full abstractDownload PDF (1065K) -
Masaharu TsudaArticle type: Article
1981 Volume 30 Issue 12 Pages 1123-1131
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA technique for dectecting circulating complexed IgE using 4% polyethylene glycol (PEG) precipitation and gel filtration has been reported earlier. Measurement of the fraction including complexed IgE was carried out in patients with anaphylactoid purpura (AP) and mucocutaneous lymph node syndrome (MCLS). In 20 patients with AP, ranging from 4 to 16 years of age, and 16 patients with MCLS, ranging from 8 months to 5 years of age, serum IgE levels and 4% PEG precipitated IgE levels were measured by paper radio-immunosorbent test. PEG precipitated index (PP index) was calculated as follows: PP index(%)=(PEG presipitated IgE levels)/(Serum IgE levels)×100 The following results were obtained: 1) In AP and MCLS, serum IgE levels were elevated at the acute stage and diminished gradually with clinical improvement. However, in some cases with MCLS, serum IgE levels were elevated transiently about 2 weeks from onset. While, IgE PP indices were elevated at the acute stage and diminished rapidly with clinical improvement. It was suggested that IgE PP indices reflected the clinical progress more than serum IgE levels. 2) In serious cases of AP with bloodly stool, papular ecchymosis, recurrent purpura and complicated nephritis, IgE PP indices were constantly high. 3) In an autopsy case of MCLS, IgE PP indices remained at high levels until the terminal period. These results suggested that complexed or aggregated IgE may exist in the serum of patients with AP and MCLS and play an etiological role in pathogenesis of both diseases.View full abstractDownload PDF (851K) -
Takeshi Noma, Junichi Yata, Yoshimasa Shishiba, Yasunori Ozawa, Bunmei ...Article type: Article
1981 Volume 30 Issue 12 Pages 1132-1138
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAnti-thyroglobulin (Tg) antibody forming cells from cultured lymphocytes were detected by plaque forming cell (PFC) assay, using Tg-coated sheep erythrocytes (SRBC). In order to reduce the background PFC, T-and non T-cells were separated by polystylene bead column which allowed avoidance of sensitization of the T-cells with SRBC antigen. The SRBC-specific B-cells were eliminated from the B-cell population by SRBC rosette sedimentation. More than 20 PFC appeared from 2×10^5 non T-cells helped by the number of T-cells in the lymphocytes of some of the patients with chronic thyroiditis, especially of those who showed high anti-Tg serum antibody titres. The help of T-cells seemed to be essential for the appearance of Tg-specific PFC. The generation of PFC was suppressed by the addition of T-cells of healthy individuals or of the patients whose lymphocytes did not produce PFC, but not by the addition of T-cells of patients from whose lymphocytes a significant number of PFC had appeared. This suggested that Tg antigen-specific suppressor T-cell function which was observed in healthy individuals was impaired in some patients.View full abstractDownload PDF (811K) -
Takashi SaitoArticle type: Article
1981 Volume 30 Issue 12 Pages 1139-1148
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe molecular organization and chemical structure of the antigen-specific suppressor factor (TsF) derived from the T cell hybridoma was investigated. The TsF was obtained in ascites of the hybridoma-bearing mice as a secreted from of the TsF. The analysis using various immunoadsorbent columns of antigens and antibodies showed that the TsF possessed both antigen-binding moiety and determinants encoded by genes in the I-J subregion of the H-2 complex. Moreover, the TsF was found to have a structure similar to that of the variable region of the immunoglobulin heavy chain. The two distinct determinants of the TsF were shown to be present on the separate molecule and to be associated with disulfide bonds, since the TsF activity was abrogated by the reduction and alkylation, and was reconstituted by the reassociation of the two chains. Thus, the antigen-binding and I-J encoded chains are essential for the expression of the TsF activity. Immunochemical analysis demonstrated that the TsF was a glycoprotein composed of two polypeptide chains, each of which carried the molecular weights of 45000 dalton with antigen-binding activity and 25000 dalton with I-J determinants.View full abstractDownload PDF (1074K) -
Kazuo KobayashiArticle type: Article
1981 Volume 30 Issue 12 Pages 1149-1156
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe in vitro effects of betamethasone on lymphocyte proliferative (LP) response, autologous mixed lymphocyte reaction (AMLR) to mitogens and concanavalin A (Con A)-induced suppressor cell activity were studied, using peripheral blood mononuclear cells (PBMC) from eight healthy individuals. The results were as follows: 1) In vitro lymphocyte proliferative response was significantly suppressed by any dose of betamethasone ranging from 1×10^<-4>μg/ml to 1×10^2μg/ml. 2) Betamethasone inhibited AMLR to mitogens at dosages responsively ranging from 1×10^<-4>μg/ml to 1×10^<-1>μg/ml. When betamethasone was added to the second culture, these effects were observed to be marked. 3) When betamethasone was added at low concentration (1×10^<-4>μg/ml to 1×10^<-3>μg/ml) to the first (suppressor cell generation) culture, Con A-induced suppressor cell activity was significantly diminished. In contrast, when any dosage of betamethasone was added to the second culture, it significantly enhanced Con A-induced suppressor activity by dose responsive manner. These results indicate that Con A-induced suppressor cells were most sensitive to betamethasone, especially at the phase of Con A-induced generation of suppressor cells.View full abstractDownload PDF (870K) -
Sankei Nishima, Hiromi KaizukaArticle type: Article
1981 Volume 30 Issue 12 Pages 1157-1162
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effects of swimming and bicycle ergometer test on ventilatory functions were studied in 35 asthmatic children. The mean maximum heart rate was 81.3% of the values predicted for their ages in bicycle ergometer group and 88.3% in swimming group. Exercise-induced bronchospasms(EIB) were observed in 85.7% of the bicycle ergometer group and 37.1% of the swimming group. Maximum % decreases in ventilatory functions in the swimming test were less than those in the bicycle ergometer test statistically, except for forced vital capacity. EIB were sbserved in all of severe asthmatic subjects, but the magnitudes of the EIB caused by swimming were slight in severe asthmatics. We conclude that swimming seems to be a suitable sport for asthmatic children, although medical support is necessary for moderate and severe asthmatics.View full abstractDownload PDF (664K) -
Article type: Index
1981 Volume 30 Issue 12 Pages 1163-1168
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1981 Volume 30 Issue 12 Pages 1169-1174
Published: December 30, 1981
Released on J-STAGE: February 10, 2017
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