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Volume 41, Issue 4
Displaying 1-21 of 21 articles from this issue
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Article type: Cover
1992 Volume 41 Issue 4 Pages Cover21-
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Cover
1992 Volume 41 Issue 4 Pages Cover22-
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1992 Volume 41 Issue 4 Pages App9-
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
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[in Japanese]Article type: Article
1992 Volume 41 Issue 4 Pages 467-474
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
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Shigeru Ito, Taiko Kawaoi, Yasuo Kondo, Fujiaki Hiruma, Tomoko Togo, H ...Article type: Article
1992 Volume 41 Issue 4 Pages 475-484
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe correlation between patient visits and meteorological parameters were analyzed regarding asthmatic children who visited the outpatient emergency clinics at Teikyo University Hospital in Tokyo and Ogaki Municipal Hospital in Gifu, during the two years of 1986 and 1987. The yearly climatological changes are quite similar in both areas. Moreover, variations in the number of patient visits were also remarkably similar in both areas. High temperatures and high vapor pressure significantly correlated with increased numbers of visits in both areas. High humidity and high barometric pressure had some correlation with increased numbers of visits in both areas. As for wind direction, northerly synoptic winds had a significant correlation with increased numbers of visits in Tokyo, while contrarily, southerly winds produced the same effect in Ogaki. Precipitation and cloud density showed no correlation with the number of patient visits in either area.View full abstractDownload PDF (883K) -
Yoko NagayamaArticle type: Article
1992 Volume 41 Issue 4 Pages 485-488
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSCytological analysis of nasal smears was carried out for 295 asthmatic children aged 2 to 15 years old at the time of asthma attack and non-attack, in combination with blood tests and chest roentgenograms. Damaged ciliated cells (ciliocytophthoria, CCP) were loked for as a marker of viral infections. The appearance rate of >2+ of CCP was higher among children during attack (38/70, 54.3%) than that among children not suffering an attack (6/29, 20.7%); this was pronounced among young children under five. However, the results of blood examinations and chest roentgenograms did not correlate with the rate of positive signs of infections in CCP positive- or negative-attack. These results suggest that the cytological examination of nasal smears in useful in evaluating the presence of viral infections during asthma aggravation among young children, whereas evaluation of these infections may be difficult by blood tests or chest roentgenograms.View full abstractDownload PDF (479K) -
Yoshiro Tanizaki, Hikaru Kitani, Morihiro Okazaki, Takashi Mifune, Fum ...Article type: Article
1992 Volume 41 Issue 4 Pages 489-496
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAsthma classification by clinical symptoms and signs (clinical diagnosis) was compared with the classification by score calculated from clinical findings and examinations (score diagnosis) in 25 patients with bronchial asthma. 1. Ten subjects classified as Ia (simple bronchoconstriction type) by clinical diagnosis were divided into 6 cases with expectoration of less than 49 ml a day and 4 cases with expectoration of between 50 and 99 ml. The level of serum IgE and number of eosinophils in BALF were significantly higher in the latter cases than in the former cases. The cases whose expectoration was from 50 to 99 ml a day were classified as Ib (bronchoconstriction with hypersecretion type) by score diagnosis. 2. The six subjects who were classified as type Ib by clinical diagnosis were also evaluated as type Ib by score diagnosis. 3. Nine of the 10 subjects classified as type II by clinical diagnosis were evaluated as type II by score diagnosis. One case, whose score was under 12 points, was evaluated as questionable type II by score diagnosis.View full abstractDownload PDF (800K) -
Masahiro Irie, Hiromi Kihara, Chiharu Kubo, Haruko Kawamura, Hiroshi S ...Article type: Article
1992 Volume 41 Issue 4 Pages 497-503
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe investigated the quality of life (QOL) in 72 patients with bronchial asthma who are under our gradational psychosomatic treatment (GPT) by means of an 11-item questionnaire. The results were summarized as follows: 1) Ninety-two percent of the subjects showed a good understanding of mind-body relations and modified their stressful adaptive patterns. 2) Asthmatic symptoms improved in 86 percent of the subjects. Other symptoms also improved in 72 percent of the subjects. 3) In 81 percent of the subjects, their daily life improved. Furthermore 96 percent of the subjects obtained some advantages through GPT. 4) There were various improvements in psychological states, personal relations and life style in most of the subjects. 5) The attitudes of their families toward the patients improved in 46 percent of the subjects, however 71 percent of the families developed a better understanding of the cause of asthma from the psychosomatic point of view. 6) Most of the subjects with moderate or severe symptoms were considered to have reduced the grade of severity of their symptoms from the doctor's standpoint.View full abstractDownload PDF (855K) -
Tamotsu Ishizuka, Motohiro Kurosawa, Koichi Hanawa, Sakae Aoki, Hiroyu ...Article type: Article
1992 Volume 41 Issue 4 Pages 504-511
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSVasoactive intestinal peptide (VIP) is suspected to be a neurotransmitter of nonadrenergic and noncholinergic inhibitory nerves in human respiratory tracts. Although VIP affects T lymphocytes through its specific receptor, the effects of VIP on inflammatory cells except T lymphocytes are obscure. We investigated the effects of VIP on superoxide anion (O_2^-) generation from five kinds of human cells; neutrophils, eosinophils and mononuclear cells isolated from peripheral blood, alveolar macrophages obtained from the bronchoalvolar lavage, and human monocyte cell line, U937, the capacity of which for O_2^- generation was induced by interferon-γ. O_2^- generation from human cells stimulated by 10^<-5> M fMLP was measured by the cypridina luciferin analog, MCLA, -dependent chemiluminescence method. VIP inhibited O_2^- generation from fMLP-stimulated neutrophils, mononuclear cells and U937 in a dose-dependent manner. 3×10^<-6> M VIP inhibited O_2^- generation from fMLP-stimulated eosinophils and alveolar macrophages significantly. These results indicate that VIP might inhibit the activation of inflammatory cells and act as an antiinflammatory agent.View full abstractDownload PDF (858K) -
Kazuyuki Kurihara, Takashi Yamada, Hirohisa Saito, Youji IikuraArticle type: Article
1992 Volume 41 Issue 4 Pages 512-518
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSEosinophil cationic protein (ECP), which is one of the eosinophil granule proteins, can now be measured with a radioimmunoassay kit. However, the level of ECP in blood samples is afftected by the method of treatmnet of the samples. We investigated the effect on ECP level of a variety of treatment methods to establish the fundamental condition for the measurement of ECP level in blood samples. ECP levels in serum or heparin plasma increased time-dependently until 2 hr. This increase was considered to be due to active in vitro release of ECP from eosinophils. Serum ECP level at 1 hr was temperature-dependent, being higher at 37℃ than at 25℃. On the other hand, ECP level in EDTA plasma did not change significantly during a 3 hr period, and this level of ECP was considered to be that which had been released into the blood in vivo. ECP levels were always in the order of serum>heparin plasma>EDTA plasma. Though there was a positive correlation between serum ECP level and peripheral blood eosinophil count, the degree of correlation was not strong (r=0.466, 0.05>p>0.01). This suggests that the serum level of ECP, or the "releasibility" of ECP from eosinophils, may reflect the activation of eosinophils.View full abstractDownload PDF (691K) -
Naoya Sakaguchi, Hirohisa Saito, Yoji IikuraArticle type: Article
1992 Volume 41 Issue 4 Pages 519-525
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSMurine bone marrow-derived mast cells at 3 wk in culture were further cultured in the absence (N-BMMC) or presence (F-BMMC) of 3T3 fibroblasts in the medium containing LI-3, and were examined for their functional responses to either histamine releasing stimuli such as compound 48/80 or an inhibitor of histamine release, disodium cromoglycate. After 3 weeks in coculture with 3T3 fibroblasts, the mast cells increased their histamine content>10 fold, and>10% of the cells changed histochemically to become safranin positive. F-BMMC released〜10% histamine when challenged with compound 48/80 or substance P, whereas N-BMMC failed to do so. Furthermore, when the sensitized cells were challenged with DNP-HSA antigen, histamine release from F-BMMC but not from N-BMMC was inhibited by preincubation with disodium cromoglycate. We also examined changes in intracellular Ca^<2+> ([Ca^<2+>]i) in the cells when challenged with compound 48/80. A transient increase in [Ca^<2+>]i was observed on stimulation with the compound in F-BMMC but not in N-BMMC. Taken together, our results indicate that the interleukin 3-dependent cultured murine mast cells change functionally, as well as histochemically, into in vitro counterparts of connective tissue mast cells when cocultured with 3T3 fibroblasts and may be useful tools for analyzing the mechanisms involved in degranulation from connective tissue-type mast cells.View full abstractDownload PDF (854K) -
Atsuo MoriArticle type: Article
1992 Volume 41 Issue 4 Pages 526-531
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSInduced interleukin 2 (IL2) responsiveness in allergen-stimulated lmphocytes from children with post respiratory syncytial virus (RSV) infection was studied. Induction of IL2 responsiveness in the patients lymphocytes was observed upon stimulation with allergens such as Dermatophgoides farinae (Df) antigen, ovalbumin (OVA) and α-casein. Such responses were not induced in age-matched normal lymphocytes. Maximum response was shown in lymphocytes from children who had been suffering from the infection for approximately one month, and the response gradually decreased over the course of eight months. The frequency of induced IL2 responsiveness was unrelated to family history of atopic diseases, although there was a high incidence (67%) of family history among the patients. These results indicate that RSV-sensitized lymphocytes from the patients have acquired hypersensitivity to allergens such as food and mite antigens, factors which are commonly involved in the onset of atopic diseases.View full abstractDownload PDF (606K) -
Masato KantakeArticle type: Article
1992 Volume 41 Issue 4 Pages 532-542
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA T cell antigen receptor (TcR) gene is considered to be a model system for studies of developmentally-regulated, lineage-specific gene expression. For the TcR α gene expression, it has been shown that the enhancer region located at 3.0 kb in mouse or 4.5 kb in human downstream of TcR Cα gene is essential. The enchancer is demonstrated to contain at least four nuclear protein binding sites called Tα1-Tα4. In this report, we analysed the molecular requirement for murine TcR α gene enhancer function by using in vitro mutagenesis system and CAT assay, and obtained the following results: 1. The Tα2 element, especially ACATCC sequence, is important for enhancer activity, because the mutation in the sequence completely abolished the activity. 2. The sequence TCTGG near by the ACATCC sequence seems also important for the enhancer function, since the mutation lost the half of the activity. 3. The ets1, which is known to bind the ACATCC site, upregulates the enhancer activity of the reporter gene containing the concatemers of Tα2 region. The results indicate that ets1 has a trans-activating activity to the Tα2 region of TcR α chain enhancer.View full abstractDownload PDF (1020K) -
Ikuo Akutsu, Takeshi Fukuda, Keiko Majima, Sohei MakinoArticle type: Article
1992 Volume 41 Issue 4 Pages 543-547
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe examined the effects of inhaled FK-506, a potent immunosuppressive agent, on increased bronchial responsiveness to acetylcholine and on eosinophil infiltration in a guinea pig models of asthma. The guinea pigs were sensitized by repeated inhalation of ovalbumine (OA). Twenty four hours after antigen challenge, bronchial responsiveness to acetylcholine significantly increased and a marked accumulation of eosinophils in the airways was observed. However, when the guinea pigs were treated with aerosolized FK (10 mg/ml) for 5 min per day for 6 successive days before antigen challenge, the increase in bronchial responsiveness was significantly suppressed and the eosinophil accumulation was strikingly reduced. Since inhaled FK significantly suppressed these responses, there is a possibility that inhaled FK may be a useful therapy for patients with chronic bronchial asthma in the future.View full abstractDownload PDF (524K) -
Article type: Appendix
1992 Volume 41 Issue 4 Pages 548-
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1992 Volume 41 Issue 4 Pages 549-
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1992 Volume 41 Issue 4 Pages 550-
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1992 Volume 41 Issue 4 Pages 551-
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1992 Volume 41 Issue 4 Pages 552-
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1992 Volume 41 Issue 4 Pages 553-555
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Cover
1992 Volume 41 Issue 4 Pages Cover23-
Published: April 30, 1992
Released on J-STAGE: February 10, 2017
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