Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 27, Issue 11
Displaying 1-16 of 16 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1978 Volume 27 Issue 11 Pages Cover7-
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.Cover7
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1978 Volume 27 Issue 11 Pages Cover8-
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.Cover8
    JOURNAL FREE ACCESS
    Download PDF (89K)
  • [title in Japanese]
    Article type: Bibliography
    1978 Volume 27 Issue 11 Pages Misc3-
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.Misc3
    JOURNAL FREE ACCESS
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  • Ventilation Images of Krypton-81m and Assessment of Regional Lung Function in Children with Exercise-Induced Asthma
    Kazuo Sugimoto
    Article type: Article
    1978 Volume 27 Issue 11 Pages 831-841,878
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.831
    JOURNAL FREE ACCESS
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    Exercised-induced asthma (EIA) was studied by ^<81m>Kr lung ventilation imaging. EIA was identified by a 15% fall or more in lung function (FVC, FEV_<1.0>) and clinical symptoms in 10 out of 13 patients studied by the free running exercise. In all cases, the ventilation defects were observed in lung scintigrams of ^<81m>Kr continuous inhalation. They were defined as suspectable lesions of segmental or subsegmental which appeared mostly in the region of both middle lung fields. Definite defects were frequently observed in the superior segments of both lower lobes. EIA was clinically resproduced in a case by repeating the exercise test after the first EIA subsided, and the ventilation defects of the second ^<81m>Kr images appeared almost in the same segments as of the first ones. The effective use of the prophylactic agents against EIA such as disodium cromoglycate (DSCG) were clinically confirmed in 7 out of 10 patients who were undergone to the repeated exercise after the spontaneous remissions from the first EIA were achieved. DSCG was preventive against EIA in all 7 cases in respect of pulmonary function tests (% fall in FEV_<1.0>), but as far as the ^<81m>Kr ventilation studies concerned there were moderate defects remained in all cases but one even after the use of DSCG. The ventilation index (VI) was calculated as the values indicative for the regional pulmonary function by using the nuclear data processing technique. It is defined as the relative values of the mean counts per disignated area. As the result, the correlation between changes in VI and those in FVC or FEV_<1.0> after the exercise was proved to be significantly high (p<0.05). The ^<81m>Kr ventilation study could become clinically a useful test for the regional dynamic pulmonary function.
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  • Measurement of Specific IgG Antibody Using Protein A-Sepharose CL-4B in Patients Treated with Hyposensitization Therapy
    Toshihiko Jyo, Kanji Kohmoto, Takashi Katsutani, Tadashi Otsuka, Shinj ...
    Article type: Article
    1978 Volume 27 Issue 11 Pages 842-849,879
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.842
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    Anti-hoya (sea-squirt) IgG antibody was measured by radioimmunoassay using Protein A-Sepharose CL-4B. In comparison with healthy adults (group A), anti-hoya IgG value of healthy oyster workers (group B), not hyposensitized hoya-asthma cases (group C) and hyposensitized hoya-asthma cases (group D) was significantly higher. Anti-hoya IgG value of group D was significantly higher than that of group B and group C, but there was no difference between group B and group C. When hyposensitization was conducted ones a week, anti-hoya IgG value of group D made a rapid increase immediately after the treatment was commenced and after 4-5 months the value reached a peak, followed thereafter by an almost constant level. The value did not decrease even during the off-season so long as maintenance therapy was provided. When the interval of hyposensitization injection was a month, anti-hoya IgG value showed still moderately high level but when the interval was extended to 2-3 months or more, the value did not showed much difference from the group C. Anti-hoya IgE and IgG value was measured using the same serum. In group A, both the anti-hoya IgE and IgG value was low. In group B, anti-hoya IgE value was low as in cases of group A and anti-hoya IgG value was higher than that of group A. In group C, anti-hoya IgE value was markedly high as in cases of group D and anti-hoya IgG value was as high as that of group B. In group D, anti-hoya IgG value was higher than that of any other groups.
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  • Studies on Platelet Surface Antigens : Reactions of Rabbit Antiserum to Daudi Cells with Human Platelets
    Hiroshi Yoshida, Reiji Kasukawa, Takeo Yoshida
    Article type: Article
    1978 Volume 27 Issue 11 Pages 850-855,879-88
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.850
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    In order to analyse surface antigens of human platelets, mixed agglutination with platelets was employed using antiserum to Daudi cells which was known to be absent in β2-microglobulin (β2-m) and HLA. The antiserum reacted with platelet samples taken from 10 individuals with similar antibody titers around 25600. These results could suggest that the antibody(ies) in the serum reacted with antigen(s) commonly distributed on the surface membrane of individual platelets. The absorption of the antiserum was performed with platelets, kidney or spleen cells of various mammalian species. Antibody activity against human platelets were completely removed by absorptions with human spleen cells and platelets, but not with erythrocytes. Chimpanzee platelets and Japanese monkey kidney cells removed also significantly the antibody activity. However, no significant decrease in antibody titers was obtained by absorptions with kidney cells of ox, porcine, rabbit and guinea pig, and also with a mixture of kidney and spleen cells of rat and mouse. The chimpanzee platelets were employed as another target cells and were reacted with rabbit antisera to various human nucleated cells and their membrane components including Daudi cells, platelets, β2-m, and HLA-KCI extract. The obtained results of positive reactions clearly indicated that the chimpanzee platelets contain surface antigens commonly distributed on human platelets and nucleated cells. It was concluded that the major antigen(s) reacting with antiserum to Daudi cells distributed on the surface membranes of both platelets and nucleated cells as the species specific antigens.
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  • MIF Production by Peripheral Lymphocyte with Mitogenic Stimulation : Studies on Various Diseases in Childhood
    Jun-ichi Hirao, Nobuo Izumi, Isao Sekine, Tohju Ichimura, Masano Shiba ...
    Article type: Article
    1978 Volume 27 Issue 11 Pages 856-863,880
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.856
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    Human peripheral lymphocytes were stimulated by non-specific mitogens (i.e., PHA-P, ConA, PWM), which were coupled with sepharose 4B to make the mitogens insoluble. Good MIF productions were observed by the lymphocytes stimulated with the non-specific insolubilized mitogens as well as with the PPD stimulation. MIF production was studied using the insolubilized mitogens on the peripheral lymphocytes obtained from cord blood, severe brochial asthmatic children and MCLS children. Relatively good MIF productions were observed by the lymphocytes obtained from cord blood and MCLS patients and decreased MIF production was seen by the lymphocytes from children with severe bronchial asthma.
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  • Effects of β-blocker Acebutolol on Bronchial Asthma
    Takashi Horie, Satoshi Enomoto, Tsuneto Akashiba, Masateru Goto, Koshu ...
    Article type: Article
    1978 Volume 27 Issue 11 Pages 864-869,880-88
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.864
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    In order to investigate the cardioselective effects of new β-blocker acebutolol, cardio-pulmonary functions were studied with normal and bronchial asthmatics. In normal subjects, heart rates reduced after intravenous injections of propranolol and acebutolol, however, no significant changes were observed in Rr, Raw, VC, FEV_1, CV, and FV curves. Acebutolol, was injected intravenously after inhalation of metaproterenol to 15 asthmatics on remission and to 10 asthmatics with mild attack. In both groups, tachycardia induced after inhalation of metaproterenol was blocked by acebutolol. After inhalation of metaproterenol, VC, FEV_1, and flow on FV curves increased and Rr decreased significantly. After acebutolol injection, slight reduction of PF and elevation of Rr were observed, however, these values remained better than those of control. V_<50> and V_<25> improved after metaproterenol and were not affected by acebutolol. These results suggest that acebutolol may cause constriction to the central airways but only in slight degree. The results show that acebutolol would be a cardioselective β blocker.
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  • Studies on the Change of Histamine Levels in the Blood of Infants and Children : Part 4.Effect of H_1 Blocker, Chlorpheniramine, and Prostaglandin E_1 on Histamine Sensitive Adenyl Cyclase, Blood Histamine Levels and Respiratory Functions of Asthmatic Children
    Yasuo Horiuch, Tsuneo Tsuruhara, Takeyuki Sugahara
    Article type: Article
    1978 Volume 27 Issue 11 Pages 870-877,881
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.870
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    The Purpose of this study was to approve the hypothesis that chlorpheniramine (c.p.), an H_1 blocker, can cause bronchodilation if administered orally in less doses than those currently prescribed in accordance with the effect of cyclase activation by PGE_1. In 9 subjects with asthma, FVC, FEV_1, FEF_<25-75%> and RR were recored on different days before and up to 2 hr after administration of 6 to 10 mg per os chlorpheniramine with or without 10 and 20 μg PGE_1 inhalation. PGE_1 was inhaled from a pressure cycled ventilator (Bennet) in the time of 90 min after c.p. administration. c.p. with PGE_1 produced reproducible increases in FEF_<25-75%> and also resulted in an increase of plasma cAMP with a decrease of blood histamine levels and RR. The increase averaged 33.5% for FEF_<25-75%> and the average decrease in RR was 40%. Mean blood histamine levels before and 2 hr later after c.p. administration with or without PGE_1 were 0.04±0.01, 0.066±0.015 and 0.048±0.011, 0.087±0.009 (μg/ml), respectively. Mean plasma cAMP levels were 7.4±2.1, 5.9±2.8 and 6.4±5.1, 8.8±1.0 (p mol/ml) with 10 and 20μg PGE_1 inhalation in addition of c.p. administration. These results suggest that there are at least two types of receptors by this in vivo-studies, i.e. one is responsive to histamine and the other to the prostaglandin.
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  • [title in Japanese]
    Article type: Bibliography
    1978 Volume 27 Issue 11 Pages 878-881
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.878
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1978 Volume 27 Issue 11 Pages 882-891
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.882
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  • [title in Japanese]
    Article type: Appendix
    1978 Volume 27 Issue 11 Pages 892-895
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.892
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  • [title in Japanese]
    Article type: Appendix
    1978 Volume 27 Issue 11 Pages 896-
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.896
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  • [title in Japanese]
    Article type: Appendix
    1978 Volume 27 Issue 11 Pages 897-898
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.897
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1978 Volume 27 Issue 11 Pages 899-903
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.899
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1978 Volume 27 Issue 11 Pages Cover9-
    Published: November 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.Cover9
    JOURNAL FREE ACCESS
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