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Volume 41, Issue 6
Displaying 1-18 of 18 articles from this issue
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Article type: Cover
1992 Volume 41 Issue 6 Pages Cover27-
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (1345K) -
Article type: Cover
1992 Volume 41 Issue 6 Pages Cover28-
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (1345K) -
Article type: Appendix
1992 Volume 41 Issue 6 Pages App11-
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
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Masanao Watanabe, Masahiro Tamura, Takao Nagoya, Yuichi Takahashi, Sus ...Article type: Article
1992 Volume 41 Issue 6 Pages 637-644
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe produced monoclonal antibodies against the major allergen of Japanese cedar (Cryptomeria japonica) pollen, Cry j I. KW-S10 antibody reacted only with Japanese cedar pollen and KW-S91 antibody reacted to most angiospermae pollens as well as Japanese cedar pollen. Using these antibodies, we devised a new counting method of Japanese cedar pollen allergen particles by an immunoblotting technique. Airborne pollen allergens were collected on vaseline coated glass slides or Burkard's sampling tape and were transferred onto polyvinylidene difluoride (PVDF) membranes. The membranes were treated with anti-Cry j I monoclonal antibody conjugated with alkaline phosphatase. Pollen allergens were detected as spots on the membranes after staining with phosphatase substrate (BCIP/NBT). This method using KW-S10 antibody measured only the amounts of allergen from Japanese cedar pollen, while with KW-S91 antibody, the method measured the amounts of pollens which have antigenicity in common with Japanese cedar pollen.View full abstractDownload PDF (845K) -
Ayami Iwasaki, Yoshifumi Yamashita, Toshikazu Tsubaki, Syuichi Matsuda ...Article type: Article
1992 Volume 41 Issue 6 Pages 645-653
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe measured serum GOT levels in babies with atopic dermatitis and food allergy. Two hundred and fourteen babies (133 male, 81 female, under 2 years of age) who first visited the Department of Allergy in the National Children's Hospital were examined. Their serum GOT levels were higher than normal; the younger they were, the higher the serum GOT levels were. We carried out the ^<13>-methacetin breath test (MBT) on 11 babies with atopic dermatitis and high serum GOT levels as well as 5 normal babies to estimate their hepatic microsomal function. ^<13>C-methacetin was administered (0.5 mg/kg) orally, and breath was collected at 30 minutes before and immediately before administration. After administration it was collected at 15 minute intervals for the first hour and 45 minute intervals for 90 consecutive minutes afterwards. The level of ^<13>CO_2 in their breath was determined with a mass spectrometer. The peak level of ^<13>CO_2 excretion (%dose/hr) in the atopic babies with high serum GOT levels was lower and the time required for ^<13>CO_2 excretion to reach its maximum level was longer than in normal babies. Also their ^<13>CO_2 clearance rate (%/hr) was lower. These results suggested that there was some relationship between atopic dermatitis and liver dysfunction in babies.View full abstractDownload PDF (887K) -
Yuichi Adachi, Akira Yoshizumi, Takao Ikarashi, Miki Takayanagi, Masak ...Article type: Article
1992 Volume 41 Issue 6 Pages 654-661
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe aim of this study was to evaluate the efficacy and safety of continuous isoproterenol inhalation therapy for asthma attacks in children. We used l-body isoproterenol (Proternol L^(R)) in 22 children with 32 episodes of severe attacks. One of them did not respond to this therapy, and two had complications (atelectasis and pneumothorax). Twenty-nine cases were divided into three subgroups according to their clinical scores; A) scores ≤4, which meant that they were in the early stage of severe attack (n=9), B) scores 5-6, which meant impending respiratory failure (n=17), C) scores ≥7, which meant respiratory failure (n=3). The values of SpO_2 at the start of this therapy were 94.8, 91.5, 82.0%, respectively. The more severe their attacks were, the lower their SpO_2 levels were. The periods until their scores became zero were 0.78, 6.3, 17.2 hours, respectively. There were significant differences between each period respectively (p<0.001, p<0.01). Heart rates decreased when their symptoms improved, and other adverse effects were not detected. These results suggest that this therapy is effective and safe for children with severe asthma attacks, especially in the early stage.View full abstractDownload PDF (792K) -
Kazuaki Tabe, Makoto Nagata, Hideaki Yamamoto, Kaoru Kuramitsu, Hideno ...Article type: Article
1992 Volume 41 Issue 6 Pages 662-667
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe pituitary-adrenal function was studied in seven asthmatic subjects who had been received daily inhalations of 800 to 1,000 μg of beclomethasone dipropionate (BDP) over a year. None of the subjects had taken oral corticosteroids for at least six months prior to the study. As indices of pituitary-adrenal function, 1) circadian rhythm of plasma ACTH and cortisol, 2) urine 17-OHCS and 17-KS, and 3) the response of cortisol in rapid ACTH test were examined. All subjects showed normal circadian rhythms of plasma ACTH and cortisol levels. Urinary 17-OHCS and 17-KS excretions over a 24-hour period were also within the normal range. Plasma cortisol levels in the rapid ACTH test were significantly increased and judged as normal responses in all subjects. These results indicate that long-term treatment with BDP ranging from 800 to 1,000 μg/day induces no suppressive effect on the pituitary-adrenal function.View full abstractDownload PDF (612K) -
Tatsushi Ishizaki, Ryuzo Fueki, Akira Saito, Kazuhiro Egawa, Ichiro Do ...Article type: Article
1992 Volume 41 Issue 6 Pages 668-675
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSkin tests of the scratch type were performed on 132 asthmatic patients with 28 allergens. The threshold titers of skin test, RAST and ELISA of house dust, HD mites, Japanese cedar pollen, ragweed pollen and orchard grass pollen were included. The main skin-positive allergens among the patients were as follows: house dust, HD mites, Japanese cedar pollen, orchard grass pollen, timothy grass pollen and ragweed pollen. There are age differences on skin-positive rates among 4 age groups of the patients; 90% of the patients under 40 years old groups reacted positively to any of 28 allergens, while half number of the patients groups over 40 years old reacted positively to the allergens. According to the quantitative analysis between threshold titers of skin test and RAST titers using house dust and HD mites allergens, specific IgE production shall be decreased in the patients over 40 years old. Using 5 main allergens above mentioned, the agreements of positive responses between three methods were compared. RAST positive responses correlated well with the skin test results, while ELISA positive responses correlated rather poorly with the skin test results. However, correlation between RAST and ELISA results was relatively good. The correlation of positive responses to house dust and HD mites by the three methods was very good, but there were some cases where positive responses were obtained by only one of the methods.View full abstractDownload PDF (640K) -
Takeshi Nabe, Hideki Yamamura, Shigekatsu Kohno, Katsuya OhataArticle type: Article
1992 Volume 41 Issue 6 Pages 676-685
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe anti-allergic action of N-[4-(4-methoxyphenyl)-2-thiazolyl]-1H-tetrazol-5-carboxamide (SA-103) was investigated and compared with that of disodium cromoglycate (DSCG). 1) Oral administration of SA-103 (0.1-10 mg/kg, p.o.) showed dose-dependent inhibition of 48 hr homologous passive cutaneous anaphylaxis (PCA) in rats. The inhibition rate (50%) of the compound at 1 mg/kg was comparable to that of DSCG at 1 mg/kg (i.v.). 2) Both of the drugs concentration-dependently inhibited the release of in vitro anaphylactic histamine from rat peritoneal exudate cells, but SA-103 was 1,000 times as potent as DSCG. 3) High doses (50 and 100 mg/kg, p.o.) of SA-103 tended to suppress 7-day homologous PCA in guinea pigs by only 20-30%. DSCG (100 mg/kg, i.v.) did not influence the reaction. 4) Neither anaphylactic histamine nor leukotriene release from guinea pig lung fragments was markedly influenced by SA-103 (10^<-8>-10^<-5> g/ml) or DSCG (10^<-5>-10^<-3> g/ml). 5) The histamine and serotonin induced contractions of the isolated guinea pig ileum were minimally enhanced or suppressed by very high concentrations (10^<-4> g/ml) of SA-103 and DSCG. In addition to the above results, prolonged treatment with either compound before antigen challenge decreased the inhibitory response to anaphylactic histamine release from rat peritoneal cells. It is suggested, therefore, that the main mechanism (s) of the anti-allergic action of SA-103 is similar to that of DSCG, and SA-103 may be expected to be effective against allergic diseases.View full abstractDownload PDF (963K) -
Kiyoshi Takahashi, Ryo Soda, Takumi Kishimoto, Takashi Matsuoka, Masan ...Article type: Article
1992 Volume 41 Issue 6 Pages 686-692
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo clarify the relation between human lung mast cells and parasympathetic nerve function as well as IgE mediated allergic reactions, highly purified dispersed human lung mast cells were obtained by using the techniques of scissors dispersion, enzymatic treatment, percoll centrifugation and exclusion of adherent cells. The reactivity to acetylcholine was examined by observing the histamine release of purified mast cells. Moreover, peripheral blood basophils, which have many functional similarities with mast cells, were also examined in the same manner. The following results were obtained; 1) Histamine was significantly released from dispersed human lung mast cells at a final concentration of 10^<-5> M acetylcholine (p<0.05); the peak of histamine release was 10^<-4> M of acetylcholine. Acetylcholine had the additional effect of releasing histamine in response to anti-IgE. Histamine release was partially inhibited by 10^<-5> M atropin. 2) Basophils had no response to acetylcholine. These results suggest that human lung mast cells play an important role in the defensive mechanism as an effector cell of acetylcholine-mediated autonomic nerve system as well as IgE-mediated allergic reaction.View full abstractDownload PDF (700K) -
Toshiro KatagiriArticle type: Article
1992 Volume 41 Issue 6 Pages 693-698
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe accessory cell (AC) functions of peripheral blood dendritic cells (PDC) in concanavalin A (Con A)-induced T cell proliferation were investigated in patients with systemic lupus erythematosus (SLE). In Con A-induced T cell proliferation using added autologous PDC, AC activity was present in SLE patients (p<0.01). The Con A-induced T cell proliferation, however, was significantly lower in SLE patients than in normal subjects (p<0.01), and the level of decrease became greater with increased activity of the disease (p<0.01). In investigating the Con A-induced T cell proliferation using added allogeneic PDC, we compared T cells from SLE patients + PDC from normal subjects or T cells from normal subjects + PDC from SLE patients with T cells + allogeneic PDC both from normal subjects. The former two combinations showed significantly reduced T cell proliferation in active SLE (p<0.01 for each), while no significant differences were found for inactive SLE. The above results suggest that the reduced function of PDC as AC may be involved in reduced Con A-induced T cell proliferation in patients with active SLE.View full abstractDownload PDF (629K) -
Sanae Tomoe, Itsuo Iwamoto, Sho Yoshida, Hisao TomiokaArticle type: Article
1992 Volume 41 Issue 6 Pages 699-703
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to determine the role of CD4^+ T cells and CD8^+ T cells in causing antigen-induced eosinophil infiltration into the site of late-phase reaction (LPR), we examined the effect of the in vivo depletion of CD4^+ T cells and CD8^+ T cells on antigen-induced eosinophil infiltration into mouse skin. Eosinophil infiltration into the skin of ovalbumin (OA)-sensitized BALB/c mice was biphasic after subcutaneous OA challenge, reaching the first peak at 6 h and the second peak at 24 to 48 h. The in vivo depletion of CD4^+ T cells by pretreatment with anti-L3T4 monoclonal antibody (mAb) significantly decreased the second peak (at 24 h and 48 h), but not the first peak (at 6 h), of OA-induced eosinophil infiltration into the skin of OA-sensitized mice. However, the depletion of CD8^+ T cells by pretreatment with anti-Lyt-2 mAb had no significant effect on either the first or second peak of OA-induced cutaneous eosinophilia in the mouse. These results indicate that CD4^+ T cells, but not CD8^+ T cells, play an important role in causing antigen-induced eosinophil recruitment of cutaneous LPR.View full abstractDownload PDF (541K) -
Tohru Ando, Reiko Homma, Yoshitaka Ino, Goro Ito, Atsushi Miyahara, Hi ...Article type: Article
1992 Volume 41 Issue 6 Pages 704-707
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA trypsin-like protease was purified from mite (Dermatophagoides farinae) fecal extract. In SDS-PAGE, the mite trypsin-like protease showed a single band at 34 kD. The purified trypsin-like protease possessed potent allergenic activity. Both the twenty N-terminal amino acid sequence and the amino acid composition of the purified protease were very similar to those of Der f III. These data strongly suggest that the trypsin-like protease in the mite is a Der f III allegen.View full abstractDownload PDF (378K) -
Article type: Appendix
1992 Volume 41 Issue 6 Pages 708-
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (47K) -
Article type: Appendix
1992 Volume 41 Issue 6 Pages 708-
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (47K) -
Article type: Appendix
1992 Volume 41 Issue 6 Pages 709-
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (46K) -
Article type: Appendix
1992 Volume 41 Issue 6 Pages 710-712
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
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Article type: Cover
1992 Volume 41 Issue 6 Pages Cover29-
Published: June 30, 1992
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (198K)
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