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Volume 35, Issue 4
Displaying 1-14 of 14 articles from this issue
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Article type: Cover
1986 Volume 35 Issue 4 Pages Cover18-
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (169K) -
Article type: Cover
1986 Volume 35 Issue 4 Pages Cover19-
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (169K) -
Article type: Appendix
1986 Volume 35 Issue 4 Pages App4-
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (371K) -
Masahiro Sakaguchi, Sakae Inouye, Shuji SuzukiArticle type: Article
1986 Volume 35 Issue 4 Pages 233-237
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe have developed a fluorometric enzyme-linked immunosorbent assay for measuring IgE antibody to Cryptomeria japonica (Japanese cedar) pollen. Polystyrene microplates were coated with proteins extracted from the pollen. IgE antibody which attached to the solid-phase antigen was detected by β-galactosidase-conjugated anti-IgE antibody. 4-methylumbelliferyl-β-D-galactoside was used as the enzyme substrate and the fluorescence intensity of the reaction product was measured. The antibody levels determined by this method well correlated with those determined by the"Phadezym RAST". This method is simpler and less expensive to carry out when dealing with a large number of serum specimens in the study of seroepidemiology of the pollinosis.View full abstractDownload PDF (556K) -
Sumio Kawakatsu, Hajime Kishimoto, Hiroyuki Imai, Atushiko SatoArticle type: Article
1986 Volume 35 Issue 4 Pages 238-244
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThree hundred and fifty six healthy individuals were investigated in Hamamatsu to establish reference values for the total serum IgE in the adult non-atopic population in Japan. Questionnaires and personal interviews revealed that 169 individuals (N-group) had no history of atopic disorders. We measured the total serum IgE levels by RIST, RIA-PRIST, and EIA-PRIST. The geometric mean of the total serum IgE by RIST was significantly lower in the N-group in Hamamatsu (87kU/l), than in a previously reported group in Kyoto (114kU/l). This suggests the inadequacy of selecting a normal group on the basis of only questionnaires and personal interviews. Examination of the N-group in Hamamatsu by RAST for 8 common, local allergens revealed that 38 individuals were not non-atopic, because their RAST scores being more than 1 or their absorption rate of radioactivity, compared with disc D, being more than x + 2SD. Therefore, they were eliminated from the N-group, and the N(-) group was established. The geometric mean and the 1.282 SD ranges of the total serum IgE levels in the N(-) group were 56kU/l(27-115) by RIST, 20kU/l(4-92) by RIA-PRIST, and 20kU/l (4-93) by EIA-PRIST. These values were much lower than those previously reported in Japan. The geometric mean of the total serum IgE in the N(-) group of subjects by RIA-PRIST was similar to that reported in a study using a similar method. Thirty-eight subjects out of the 356 healthy individuals were considered to be atopics, because of previous atopic symptoms and at least one of their RAST scores being more than 2. Thirty-two (84%) of the atopic individuals had higher total serum IgE levels than the upper limits we had set. The new values obtained from the N(-) group may be worthwhile clinically.View full abstractDownload PDF (890K) -
Tsuneo Ashida, Takashi Matsunaga, Takeshi Ide, Shiro TabataArticle type: Article
1986 Volume 35 Issue 4 Pages 245-249
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThis paper deals with the first report of Kohyamaki pollinosis (Sciadopitys verticillata Sieb. et Zucc., Umbrellapine, Kohyamaki) in Japan. A 39-year-old house-wife visited our clinic complaining of sneezing attacks, watery discharge and nasal obstruction in spring since 1971. Since 1978 these symptoms were aggravated when she handled blooming Kohyamaki branches. The nasal smear test for eosinophils was positive. The intradermal test and the radioallergosorbent test using allergen extracts from Kohyamaki pollen, Sugi pollen and Hinoki pollen were also positive. The nasal provocation test using a nasal disc with allergen extract on it from Kohyamaki pollen also proved to be positive. The intradermal test with the above allergen extracts showed positive in 83% of the tested group, which consisted of eighteen volunteers who suffered from Sugi pollinosis, but were not thought to have been exposed to Kohyamaki pollen in the past. It was suggested that Kohyamaki pollen had specific allergenicity by way of RAST inhibition and Ouchterlony double diffusion analysis using anti-Sugi rabbit serum and anti-Hinoki rabbit serum.View full abstractDownload PDF (684K) -
Terumasa Miyamoto, Tamotsu Takishima, Tatsuo Satake, Junzaburo Kabe, M ...Article type: Article
1986 Volume 35 Issue 4 Pages 250-261
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to establish guidelines for determining the optimum doses of E-0686, a new sustained-release preparation of theophylline, a clinical study was conducted on 685 patients of various ages with bronchial asthma. The optimum doses were determined for the different age groups of patients and the levels of theophylline in their respective blood were measured after administration of E-0686. In establishing guidelines for the optimum dose determination, the optimum dose of E-0686 and C/D ratio were considered (C represents the levels of theophylline in the blood at the optimum dose of E-0686 and D means optimum dose of E-0686 determined in each patient). The initial dose could be increased to the average dose in cases when clinical responses were insufficient and no side effects were observed. In case no monitoring of theophylline levels in the blood is made, the maximum dose was determined so that levels of theophylline in the blood would not exceed 20 μg/ml calculated from C/D ratio in 80% of patients. The subjects were divided into 3 groups according to body weight: infants weighing 20kg or less, children weighing 21 to 40 kg, children weighing more than 41 kg and adults. The progressive doses for these groups were 15→18→21 mg/kg/day, 12→15→18 mg/kg/day and 400→600→700mg/day, respectively. Improvements in clinical effectiveness and safety are expected by the introduction of these gudelines into the clinical field.View full abstractDownload PDF (1495K) -
Yoshio Umegae, Tsugio NakazawaArticle type: Article
1986 Volume 35 Issue 4 Pages 262-274
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSFive cases of hypersensitivity pneumonitis related to sericulture (silk production)were examined. One of the patients was a man and four were women, ranging in age from 48 to 70 years. All had engaged in sericulture or its related works for more than 10 years and had developed respiratory or systemic symptoms, or both. In three cases the clinical features suggested a relation between to occurrence of symptoms and their work. This disease may occur as an acute or insidious form differring in onset, type and intensity of respiratory and systemic symptoms. Laboratory examination of three patients when they were symptomatic revealed elevated ESR, positive CRP and leukocytosis. Chest X-rays showed diffuse fine nodular infiltrates in one and reticular shadow in four cases. Pulmonary function disclosed decrease of vital capacity and carbon monoxide diffusing capacity. Arterial hypoxemia at rest was seen in three of the four tested. Mantoux reaction was negative in one of the three studied. Histological examination revealed granulomatous interstitial pneumonia in one acute case and prominent fibrosis in one insidious care. Serum precipitating antibodies against antigens extracted from the body constituents of silkworms were detected in all patients. Macrophage migration inhibition tests using extracts from silkworms as antigens were positive in two of the three cases tested. Inhalation of the silkworm antigens reproduced clinical features of the disorder in all five cases. These results indicate that hypersensitivity pneumonitis related to sericulture (sericulturist's lung disease) is due to the inhalation of body constituents of silkworms and that type III and IV allergy might be involved in its immunopathogenesis.View full abstractDownload PDF (2066K) -
Kunihiko Yoshimura, Naohiko Chonabayashi, Tatsuo Nakatani, Yoshitaka N ...Article type: Article
1986 Volume 35 Issue 4 Pages 275-281
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe studied natural killer (NK) cell activity in the peripheral blood of 34 patients with diffuse panbronchiolitis (DPB) and of 10 healthy controls by ^<51>Cr releasing assay. NK cell-mediated cytotoxity was 50.2±20.6% in DPB patients and 58.5±12.0% in the healthy controls at effector/target ratio of 50:1, so there was no significant difference in NK cell activity between the patients with DPB and the healthy controls. Furthermore, NK activity did not vary among 3 groups of DPB sufferers divided according to a causative organism of lower respiratory tract infection and treatment with corticosteroids. In both DPB patients and the health controls, there was no significant correlation between NK cell activity and the following: age, number of peripheral blood lymphocytes (PBL), each proportion of OKT4 positive cells and OKT8 positive ones, and OKT4/OKT8 ratio in PBL. There was also no significant difference in NK cell activity between the groups in DPB with positive and with negative skin reaction to tuberculin. Although exact role of NK cells in DPB is not clear, these results seem to suggest that DPB is not a disease with immunodeficient conditions.View full abstractDownload PDF (754K) -
Shogo Ito, Taro Akagi, Tetsuzo Sugisaki, Jun UchidaArticle type: Article
1986 Volume 35 Issue 4 Pages 282-289
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAcute lung injury was studied in rats by instillation of cationic BSA, native BSA and saline. Rats instilled with cationic BSA developed a severe acute alveolar hemorrhage, accompanied by fibrinoid deposits, massive accumulation of platelets in the alveolar capillaries and severe damage of the epithelial cells. Preimmunization with BSA promoted an enhancement of tissue injury. Similar changes of a lesser degree were also observed in rats preimmunized with BSA and instilled with native BSA, but not in rats which had not been preimmunized. Furthermore, linear deposits of BSA and rat IgG along the alveolar wall basement membrane were observed in rats presensitized with BSA and instilled with cationic BSA. These results suggest that the binding of cationic antigens to the anionic sites and the"in situ"formation of IC in the alveolar structures may be important in modulating lung injury.View full abstractDownload PDF (950K) -
Yasushiro Mizoguchi, Yoshihide Sakagami, Sukeo Yamamoto, Seiji Morisaw ...Article type: Article
1986 Volume 35 Issue 4 Pages 290-294
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe cholestatic factor showing potent intrahepatic activity was produced from activated lymphocytes of tuberculin-sensitized guinea pigs by stimulating them with PPD. Intrahepatic activity was observed in two fractions obtained by gel filtration on Sephadex G-75 followed by DEAE-cellulose column chromatography. When these two fractions were analyzed by isoelectric focusing electrophoresis, they were found to contain different electric charges: one with the isoelectric point at 3.0-3.5, the other at pH 7.8-8.0.View full abstractDownload PDF (556K) -
Tohju Ichimura, Shigemi Yoshiwara, Hidemi Asai, Haruo HyodoArticle type: Article
1986 Volume 35 Issue 4 Pages 295-300
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe authors found that mechanical stimulation applied perorally to the nasopharynx (Rp・S) could resolve or alleviate asthmatic attacks in child-asthmatics in about 15 seconds. On the other hand, the authors also found that the Rp・S very rarely did not result in increase of peak expiratory flow rate in off attack child-asthmatics. Since no reliable evidence for the direct innervation of the sympathetic nerve system in human airways has yet been reported, these unpublished data may suggest that the Rp・S can activate an inhibitory nerve system, that is, the so-called nonadrenergic noncholinergic inhibitory nerve (NANCIN) system, which is a component of the vagus nerve. The purpose of the study is to ascertain whether the Rp・S would actually activate the NANCIN pathway and consequently relax the lower esophageal sphincter innervated by NANCIN. Ten asthmatic children (including four patients on attack) were chosen randomly for the study after receiving parental consent. After pretreatment with 4 puffs of Sch-1000 and subcutaneous injection of 0.4-0.5ml atropine, these children were asked to swallow barium sulfate in a standing position and again in a supine position, before and after the Rp・S. X-ray pictures of the esophagus were taken and video-recorded. Three time intervals, that is, starting time of passage, finishing time of passage and retention time, were estimated. These time intervals were statistically analysed using the Student's paired t-test and the analysis revealed that they were significantly shortened after the Rp・S in the both positions. Mechanical Rp・S resulted in both bronchodilation and relaxation of the LES. It is therefore very likely that the Rp・S specifically activates the NANCIN system.View full abstractDownload PDF (670K) -
Article type: Appendix
1986 Volume 35 Issue 4 Pages 301-303
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (291K) -
Article type: Cover
1986 Volume 35 Issue 4 Pages Cover20-
Published: April 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (179K)
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