All issues
Volume 26, Issue 8
Displaying 1-14 of 14 articles from this issue
- |<
- <
- 1
- >
- >|
-
Article type: Cover
1977 Volume 26 Issue 8 Pages Cover41-
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (35K) -
Article type: Cover
1977 Volume 26 Issue 8 Pages Cover42-
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (35K) -
Article type: Bibliography
1977 Volume 26 Issue 8 Pages Misc10-
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (264K) -
Katsuji Nakamura, Takami YoshidaArticle type: Article
1977 Volume 26 Issue 8 Pages 573-580,621
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThirty children (22 boys and 8 girls) with bronchial asthma, whose ages ranged from 2 to 13 years old, were studied as to the monthly changes of their serum IgE and antidermatophagoides farinae specific IgE (A.D.f.IgE) levels during the period of one year. Serum IgE was measured by the radioimmunosorbent test (RIST) and A.D.f.IgE by the radioallergosorbent test (RAST). Serum levels of both IgE and A.D.f.IgE increased significantly during September to November in 12 children who began to receive the hyposensitization therapy with house dust extract (Torii Co.) during March to August. However, similar increases of these levels were also observed in the untreated children. In both treated and untreated children, except a few, these levels were observed to decrease after November and return to the almost original levels after one year. In 7 out of 8 children who began to receive the hyposensitization therapy during October to December, these levels were observed to decrease during the subsequent 8 to 9 months. It was concluded from these observations that the increases of serum IgE and A.D.f.IgE levels in asthmatic children during September to November would not be due to the effect of the hyposensitization therapy, but mainly due to the increase of mite as allergen during this period. The sera from five asthmatic children, among whom four were treated with house dust extract and one was not, were also examined monthly as to PCA antibody to mite (Dermatophagoides farinae) using guinea pig. PCA reaction to any sera from these children was negative throughout the period under observation.View full abstractDownload PDF (1133K) -
Yukinobu Ichikawa, Kenji Koriyama, Shigeru ArimoriArticle type: Article
1977 Volume 26 Issue 8 Pages 581-588,621-62
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSGuinea-pigs were immunized with the Freund's complete adjuvant mixed with the microsomal or the soluble fraction which was separated from rat submaxillary gland. Neither the guinea-pigs immunized with the microsomal nor the soluble fraction developed any lesions of sialadentitis, microscopically. The delayed hypersensitivity of the immunized guinea-pigs to both fractions, however, was demonstrated specifically by the skin test. The sera of the guinea-pigs immunized with the soluble fraction were revealed to contain the precipitating and agglutinating antibodies against the soluble fraction. Precipitating antibody was determined to be non-specific in this group because of multipotential reactivity to the soluble fractions of various rat organs such as the liver, lung, kidney and spleen. The antigen reacting with precipitating antibody in the soluble fraction was separated in both albumin and pseudogloblin fractions by salt-out method, and in the first fraction (void volume) by Sephadex-G100 gel filtration, being assumed its molecular weight as more than 100000. On the other hand, the antigen reacting with agglutinating antibody in the soluble fraction was showed to have an specificity to the rat submaxillary gland, and was separated in the third fraction by the gel filtration, being assumed its molecular weight as 69000. A complement fixing antibody to the microsome was demonstrated in the sera of the guinea-pigs immunized with the microsomal fraction, but not in the sera of the guinea-pigs received the soluble fraction. The above data suggested that sialadenitis of the guinea-pigs similar to the human Sjogren's syndrome was hardly developed under the heterologous immunization of the microsomal or the soluble protein separated from rat submaxillary gland, although the soluble or the microsomal fraction had a specific antigenecity in hemagglutination or complement fixation, and the delayed type skin reaction of guinea-pigs immunized with the soluble or the microsomal fraction was detected.View full abstractDownload PDF (1311K) -
Toshihiko Jyo, Kanji Kohmoto, Satoru Oka, Takashi Katsutani, Shinji Ts ...Article type: Article
1977 Volume 26 Issue 8 Pages 589-595,622-62
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe serum IgE level was determined by the RIST (Radioimmunosorbent Test) in 18 cases of sea-squirt asthma (A), 10 cases of ordinary bronchial asthma (B), 9 healthy oyster farm workers (C) and 8 healthy individuals (D), and also determination was made with the RAST (Radioallergosorbent Test) with Ei-2 or Gi-2 coupled Sepharose 4B (named Ei-2or Gi-2 RAST value respectively) using the same serum. The results obtained were as follows: 1. Both the Ei-2 and Gi-2 RAST values were significantly high in Group (A), but failed to demonstrate significant differences among Group (B), (C) and (D). 2. The RIST values showed Group (A) to be significantly higher than (B), (C) and (D), and (B) was higher than (C), but there was no significant difference between (C) and (D). 3. A significant correlation was observed only between the Ei-2 and Gi-2 RAST values for Group (A), whereas no correlation could be demonstrated for (B), (C) nor (D). 4. A tendency for correlation could be observed between the Ei-2 or Gi-2 RAST values and their RIST values for (A), particularly, the correlation between the Gi-2 RAST and RIST values were significant. However, there was no correlation between the two values for subjects in the other groups. 5. In the cases of (A), Ei-2 value was inhibited by preincubation with Gi-2. Based on the facts that there is a great difference in molecular weight between the Ei-2 and Gi-2 antigens and their responses to mucous membrane tests differ in (A), but the respective RAST values for (A) are high and a good correlation exists between the two and also Ei-2 RAST values are inhibited by preincubation with Gi-2, then the assumption can be made that the substance which is common to both the Ei-2 and Gi-2 antigens and actively reacts to skin tests, possesses an antigenic determinant of almost identical structure.View full abstractDownload PDF (939K) -
Koji Ito, Matsunobu Suko, Tadaatsu Ogita, Hirokazu Okudaira, Koichiro ...Article type: Article
1977 Volume 26 Issue 8 Pages 596-605,623
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSome strains of mouse can produce persistent IgE antibodies when small amount of antignes are injected intraperitoneally with aluminium hydroxide gel. Therefore, these mice are useful for the studies of human allergic diseases such as atopic asthma and pollinosis. There have been no reports, however, about the estimation of IgE level in mice. In order to estimate IgE levels in mice, an attempt was made to obtain a heterologous antiserum against mouse IgE. Sixty Balb/c mice were infected with Nippostrongyllus brasiliensis (N.B), and ten of them were further immunized with dinitrophenyl ovalbumin intraperitoneally with aluminium hydroxide gel. Sera from all mice were pooled and fractionated by a combination of ammonium sulfate precipitation, DEAE cellulose column chromatography and Sephadex G-200 gel filtration. DNP specific IgE antibodies in the fractions were examined by passive cutaneous anaphylaxis in the rat's skin. The purified IgE fraction was injected to guinea pigs subcutaneously with complete Freund's adjuvant, and the sera were obtained after two injections of the material. The antibodies to mouse proteins other than IgE were absorbed by adding a pooled normal mouse serum to the pooled guinea pig antiserum. The anti-mouse IgE thus prepared was able to absorb mouse reaginic antibodies. It was dmonstrated by radioimmunodiffusion using this antiserum that the precipitates formed with mouse antiserum to ovalbumin could bind radioactive ovalbumin. Antigenic structure of mouse IgE was destroyed by heating at 56℃ for 2 hrs as examined by the double gel diffusion test. The concentration of mouse was estimated by radioactive single radial immunodiffusion. The IgE levels in mice infected with N.B were generally higher than those in normal mice. The IgE levels in mormal mice ranged from less than 6% to approximately 30% of that in N.B infected mice.View full abstractDownload PDF (2864K) -
Tsuyoshi Toba, Seikan Shimizu, Toshiyuki Nishimuta, Shinji Kiuchi, Sei ...Article type: Article
1977 Volume 26 Issue 8 Pages 606-611,623-62
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIt seems well established that acute or chronic diarrhea in infancy is not so infrequently accompanied with secondary or symptomatic lactose intolerance. According to the fact, pediatricians in Japan give frequently lactase preparation (β-D-Galactosidase, Galantase[○!R]) to the infants with diarrhea suggestive of the symptomatic enzyme deficiency. The drug, however, is protein with molecular weight of 100000 and has some possibilities to sensitize the patients and to provoke drug hypersensitivity. The authors experienced a 2-month-old girl with immediate, anaphylactic type of Galantase[○!R] allergy and studied the case from the allergological point of view. The skin test showed positive erythema-wheal reaction 15 minutes after intracutaneous injection of the 10^<-4> diluted antigen. But radioallergosorbent test (paper disc method) for detecting Galantase[○!R] specific IgE antibody was negative (score 0). On the other hand, the presence of precipitin in the patient's serum was revealed with double diffusion in Ouchterlony plate and the Galantase[○!R] binding activity on IgG band was proved with radioimmunodiffusion using ^<125>I-Galantase[○!R]. In these studies, the other 4 classes of immunoglobulins (IgA, IgM, IgD and IgE) did not show any antibody activity. In conclusion, it was strongly suspected that the Galantase[○!R] allergy of the case was induced probably by the IgG antibody.View full abstractDownload PDF (1083K) -
Ikuro Kimura, Yoshiaki Moritani, Yoshiro Tanizaki, Shuichi Sato, Kiyos ...Article type: Article
1977 Volume 26 Issue 8 Pages 612-620,624
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA total of eleven patients with buckwheat allergy were examined for the clinical study and the reactivity of basophils. The results obtained are summarized as follows: 1. On a clinical feature, buckwheat pillows were used by mine patients for a long term, and discontinuance of their use was followed by complete cure in six of them. 2. The skin reaction and Prausnitz-Kustner reaction against buckwheat extract were positive in all of the cases. 3. Most patients showed high serum IgE levels, basophilia and eosinophilia. But, these tended to normalize with an improvement of asthema attack. 4. Under phase contrast and differential-interference microscopes, it was revealed that, when buckwheat extract was added, the migration velocity of basophils was accelerated and their forms were changed to pear-shaped or vacuolated and swollen form with decrease or disappearance of the intracellular granules. 5. On basophil degranulation test, the appearance rate of B-form basophils was higher than A-form basophils. 6. Electron microscopic observation demonstrated various changes of cytoplasmic granules such as halo formation on the edge of granules, swelling, vacuolation and fusion of granules.View full abstractDownload PDF (2155K) -
Article type: Bibliography
1977 Volume 26 Issue 8 Pages 621-624
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (323K) -
Article type: Appendix
1977 Volume 26 Issue 8 Pages 625-
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (60K) -
Article type: Appendix
1977 Volume 26 Issue 8 Pages 627-629
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (198K) -
Article type: Cover
1977 Volume 26 Issue 8 Pages Cover43-
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (37K) -
Article type: Cover
1977 Volume 26 Issue 8 Pages Cover44-
Published: August 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (37K)
- |<
- <
- 1
- >
- >|