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Volume 24, Issue 6
Displaying 1-16 of 16 articles from this issue
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Article type: Cover
1975 Volume 24 Issue 6 Pages Cover33-
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
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Article type: Cover
1975 Volume 24 Issue 6 Pages Cover34-
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (49K) -
Article type: Bibliography
1975 Volume 24 Issue 6 Pages Misc8-
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
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Yoji IikuraArticle type: Article
1975 Volume 24 Issue 6 Pages 465-471,523
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe present study is to demonstrate the time required for the exercise-induced bronchoconstriction to return to the normal status, and to present relatively marked changes observed in pulmonary function study, blood lactate and pyruvate and blood pH, blood sugar in a series of 48 asthmatic children and 6 non-asthmatic children. The procedure for the exercise has already been described in the author's previous paper. In the group with bronchial asthma with moderate severity, recovery of the pulmonary function was known to occur in an earlier phase, or 5 minutes following the exercise (r=0.984), whereas in the severely asthmatic group the time required for the recovery was as long as 30 minutes (r=0.615). Following the exercise, both blood lactate and pyruvate showed an ample increase, which consequently returned to the normal level rapidly. On the contrary, in both moderate and severe groups the changes in the blood chemistry were more marked with longer duration. Blood pH dropped immediately after exercise, which elevated rapidly above the normal level at 30 minutes of the exercise in the meantime, there was an inclination to metabolic acidosis in the severe group. The elevated blood sugar returned to normal promptly after exercise.View full abstractDownload PDF (941K) -
Hirotaka Shinoda, Eisuke Kojima, Kazumi Kanda, Zenjyuro Mouri, Tsutomu ...Article type: Article
1975 Volume 24 Issue 6 Pages 472-482,523
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSEffect of N-benzenesulfonyl-β-alanine hydrazide (KH-125)on nephrotoxic nephrites was evaluated from the following three points: 1) Decrease in proteinuria, 2) light microscopic findings and 3) electron microscopic findings. Prophylactic, suppressive and therapeutic effects of KH-125 on nephrotoxic nephritis were clearly observed. Proteinuria was decreased dose-dependently and light microscopic findings were improved by KH-125 administration. In electron microscopic findings, fusions index of epithelial foot processes was improved and thickening of glomerular basement membrane was suppressed by the treatment with KH-125. Decrease in proteinuria and suppression of thickening of glomerular basement membrane were prominent effects in nephrotic rats administered with KH-125. Comparative experiment of KH-125 with known agents, 6-MP, cyclophosphamide and prednisolone indicated that KH-125 was the most effective of the others as judged from decrease in protein-uria, improvement of fusions index of epithelial foot processes and suppression of thickening of glomerular basement membrane.View full abstractDownload PDF (3930K) -
Tadao Ise, Suetsugu Mue, Yasuo Ono, Tamotsu Takishima, Kisaburo Akasak ...Article type: Article
1975 Volume 24 Issue 6 Pages 483-489,524
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn the crab eating monkeys treated with propranolol no increase of pulse rate, blood glucose and lactic acid, and no decrease of the peripheral eosinophiles were observed after the injection of adrenalin. In the Japanese monkeys, judging from adrenalin response, the beta-adrenergic blockade was not so typically formed as in crab eating monkeys. In the crab eating monkeys vaccinated with pertussis vaccine, the serum agglutination titer showed 160 folds and the adrenalin response slightly decreased. In vaccinated Japanese monkeys, the agglutination titer raised up to 640 folds at 5th day after the vaccination and the beta-adrenergic blockade was partially formed. In the beta-adrenergic blockade of the monkeys, the adenyl cyclase activity of the leukocytes significantly decreased, whereas the phosphodiesterase activity of the leukocytes increased in some cases treated with pertussis vaccine.View full abstractDownload PDF (882K) -
Suetsugu Mue, Tadao Ise, Yasuo Ono, Tamotsu Takishima, Kisaburo Akasak ...Article type: Article
1975 Volume 24 Issue 6 Pages 490-496,524
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSChanges in the phosphodiesterase activity of the peripheral blood leukocytes were investigated of the patients with bronchial asthma. Estimation of the leukocyte phosphodiesterase was carried out by the modified method of Poch's, incubating ^3H-cyclic AMP (50 mμ Ci) with the leukocyte suspension and 5′-AMP. The phosphodiesterase activity was significantly elevated during asthmatic attacks, irrespective of the type of disease or the kinds of drugs treated. There was no clear correlation between the leukocyte phosphodiesterase and the percentage of lymphocytes, neutrophiles and eosinophiles. There was also no clear relationship between the activities of phosphodiesterase and the adenyl cyclase of the same leukocyte. The ratio of the adenyl cyclase activity to the phosphodiesterase activity (phosphodiesterase/adenyl cyclase) lowered under 1 during asthmatic attack, reflecting the reduction of adenyl cyclase and the increment of phosphodiesterase.View full abstractDownload PDF (917K) -
Junzaburo Kabe, Norio Kihara, Mitsuo Kezuka, Tatsushi IshizakiArticle type: Article
1975 Volume 24 Issue 6 Pages 497-509,525
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSOne hundred and eighty five patients with asthma were treated for more than one year in the 7-year period, 1967 through 1974. The subjects were divided into two groups according to the treatment. The first group (159 patients) received systematic treatment intended to correct or block the pathophysiologic process leading to the manifestation of the disease, i.e. specific hyposensitization treatment, non-specific"Umstimmung"treatment with aurothioglucose, aurothiomalate, neurotropin, histaglobin, etc. The second group (26 patients) received symptomatic treatment only. The average follow-up time were 2 years and 5 months in the former group and 2 years and 8 months in the latter group. There were 74 patients who had asthma of moderate to severe degree originally and had no symptom or only occasional wheezing for long time, enough to compare the changes in the evaluation of individual subjects, as a result of the treatment in the first group, but only one showing such a definite improvement in the second group. Subjects showing complete remission for more than one year were 25 of 83 (25 per cent) treated with specific hyposensitization, 5 of 23 (22 per cent) treated with non-specific"Umstimmung"treatment, and 13 of 53 (25 per cent) treated with a combination of specific and non-specific treatment, reaching 43 of 159 (27 per cent) subjects as a whole treated systematically. It appeared that about a quarter of the systematically treated patients improved permanently irrespective of the treatment.View full abstractDownload PDF (2285K) -
Takeshi ShinoharaArticle type: Article
1975 Volume 24 Issue 6 Pages 510-516,525
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA study was made of the effect of inhaled prostaglandin F_<2a> (PGF_<2a>) and acetylcholine (Ach) on FEV_1 in 10 piatients with atopic asthma and in 10 non-atopic healthy young volunteers. The concentration of the inhaled solution eliciting at least 15% decrease of FEV_1 was designated as respiratory threshold (RT) and the following results were obtained. 1) In asthmatic patients, serially diluted PGF_<2a> solutions ranging from 2 ng/ml to 1000 ng/ml were inhaled. RT-PGF_<2a> ranged from 63 ng/ml to 1000 ng/ml and the mean, calculated by alteration to logarithm, was 330 ng/ml. On the other hand, serially diluted Ach solutions ranging from 12 μg/ml to 25000 μg/ml were inhaled. RT-Ach ranged from 12 μg/ml to 1563 μg/ml and the mean was 257.3 μg/ml. Thus the ratio of the mean RT-PGF_<2a> to the mean RT-Ach was 1:1500 in molar dose. 2) In healthy volunteers, serially diluted PGF_<2a> solutions ranging from 2μg/ml to 1000 μg/ml were inhaled. RT-PGF_<2a> was 1000 μg/ml in only one subject. On the other hand, same series of Ach solutions as in asthmatic patients were inhaled. RT-Ach ranged from 3125 μg/ml to 25000 μg/ml in 4 subjects. 3) In asthmatic patients, the time course of PGF_<2a>-induced alteration of FEV_1 differed significantly from that of Ach-induced one. The effect of PGF_<2a> lasted much longer and the recovery was gradual. In conclusion, the bronchial tree of the asthmatic patient demonstrated the extreme hyperreactivity to the inhaled PGF_<2a>.View full abstractDownload PDF (964K) -
Kenji Hojo, Chiharu HiramineArticle type: Article
1975 Volume 24 Issue 6 Pages 517-522,526
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe role of the thymus in the pathogenesis of experimental allergic thyroiditis in the guinea pig was studied by means of leaving for a sufficiently long time following thymectomy in adult life prior to thyroid sensitization. Seven to 13 months after thymectomy or sham-operation at 10 to 12 weeks of age, female Hartley guinea pigs were sensitized by a single injection of homologous thyroid extract in complete Freund's adjuvant. The following results were obtained. 1. Eight of 9 sham-operated and later thyroid-sensitized guinea pigs (control) developed moderate to severe thyroiditis. In contrast, adult-thymectomized and later thyroid-sensitized animals showed a markedly depressed ability to develop thyroiditis, 18 of these 21 animals having thyroid lesions which could be graded as slight or less than. 2. The thymectomized sensitized animals showed a reduced delayed skin reaction to thyroid antigen as compared with the sham-operated controls, although no subject with negative skin reaction was found in both the groups. 3. The lymph node cells obtained from 15 of 16 animals which were thymectomized and thereafter left for 11 to 13 months prior sensitization, showed a greatly reduced MIF activity as compared with the sham-operated controls. 4. Although circulating anti-thyroid hemagglutinating antibody was not detected in about a quarter of the thymectomized sensitized animals, the titers of the remainders were found to be at the level similar to the sham-operated controls. From the data presented in this study, it is reasonable to conclude that experimental allergic thyroiditis in the guinea pig is a thymus-dependent disease. These suppressive effects on the development of the disease and related cellular immunity is probably due to a gradual decrease in peripheral T_2 cell population combined with a failure of the recruitment of further T cells during a long term after thymectomy in the adult.View full abstractDownload PDF (1554K) -
Article type: Bibliography
1975 Volume 24 Issue 6 Pages 523-526
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1975 Volume 24 Issue 6 Pages 527-
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1975 Volume 24 Issue 6 Pages 527-
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (64K) -
Article type: Appendix
1975 Volume 24 Issue 6 Pages 528-
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
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Article type: Cover
1975 Volume 24 Issue 6 Pages Cover35-
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (44K) -
Article type: Cover
1975 Volume 24 Issue 6 Pages Cover36-
Published: June 30, 1975
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (44K)
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