Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 24, Issue 12
Displaying 1-14 of 14 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1975 Volume 24 Issue 12 Pages Cover13-
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.Cover13
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1975 Volume 24 Issue 12 Pages Cover14-
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.Cover14
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Bibliography
    1975 Volume 24 Issue 12 Pages Misc4-
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.Misc4
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  • A Cytological Study of Washed Sputum (Bronchial Secretion) in Lower Respiratory Tract Disorders of Children, Especially in Bronchial Asthma of Infancy and Childhood
    Sekka Ryu
    Article type: Article
    1975 Volume 24 Issue 12 Pages 797-807,833
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.797
    JOURNAL FREE ACCESS
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    A microscopic study of washed sputum was performed in infants and children with disorders of the lower respiratory tract to investigate the clinical significance of its cytological features (alveolar macrophages or dust cells, ciliated epithelium, lymphocytes, neutrophils, eosinophils, and squamous epithelial metaplasia) in etiologic diagnosis and in asthma of infancy and childhood, with the results leading to the conclusions as follows: 1) In allergic bronchitis, asthma and chronic bronchitis, increased eosinophils (〓to〓) were significantly more frequent (p<0.01) than in acute lower respiratory tract infections. None of the latter patients showed a plus 3 or greater degree of eosinophilia in washed sputum. 2) Squamous epithelial metaplasia was demonstrable with higher incidence in recurrent or chronic lower respiratory tract disorders, particularly in chronic bronchitis (55.2%), compared with acute lower respiratory tract disorders, the difference being statistically significant (p<0.01). In children with asthma, this cytological feature was noted to be significantly more frequent with the perennial type (39.4%) in comparison with the seasonal type (p<0.05). 3) Data analysis of incidence and degree of increased eosinophils related to prognosis in these conditions showed a higher but not statistically significant rate of outgrow for patients with eosinophilia of bronchial secreta. 4) As for interrelation of respiratory tract infection (viral or bacterial) and cytologic findings pathognomonic of such infection during the attack of asthma, increased neutrophils (plus 3 or more) were significantly higher in incidence with cases positive for bacterial pathogens as compared to negative cases (p<0.01), irrespective of presence or absence of symptoms and signs of infection. No conclusive data could be obtained, however, from a few cases of viral infection which did not permit trend analysis.
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  • Exercise on Asthmatic Children and Pathophysiological Changes : III. The Study on Serum Histamine as Chemical Mediator
    Yoji Iikura
    Article type: Article
    1975 Volume 24 Issue 12 Pages 808-814,833-83
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.808
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    The literatures so far published suggest that the increase in chemical mediator after exercise in asthmatic children is one of the major causes of exercise-induced bronchoconstriction. In this present study the possible role of histamine as one of the chemical mediators was investigated. 1. The serum histamine levels showed an increase (0.01μg/ml-0.09μg/ml) after the exercise in 19 children out of 23 children. In contrast, a decrease was observed in 3 children (0.01μg/ml-O.10μg/ml), and no change in 1 child. No significant correlation was demonstrated between severity of asthmatic children and the changes in serum histamine level after the exercise. 2. Histamine sensitivity test were performed on the taenia coli of guinea pig. Just as expected from the serum histamine level, the contraction pattern of taenia coli with diluted post exercise serum (1:15) showed no increase in taenia coli contraction. This can be attributed to the fact that after the exercise (for 5 min) some substances was increased in the serum, which inhibit smooth muscle contraction. 3. The histamine release from leucocytes to the same antigen was studied before and after the exercise. There was an increased histamine release after the exercise in 9 children out of 13 children, and histamine release was reduced 4 out of 13 children.
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  • Study on Effects of Prostaglandins on Ciliary Activity of Respiratory Epithelium in Experimental Bronchial Asthma : Part 2. In Vivo Experiment
    Kuniko Yamada
    Article type: Article
    1975 Volume 24 Issue 12 Pages 815-819,834
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.815
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    For the purpose of in vivo study on the effects of prostaglandin (PG) E^1, F^<2α>, histamine, acetylcholine and the antigen on the induced asthma attacks in experimental animals. The drugs and the antigen inhaled by the nebulizer to nonsensitized and sensitized guinea pigs with Maiko antigen. After the administration of those drugs and the antigen, bronchus of the animals were resected and the frequency of ciliary activities were estimated by cinematographic recording under the phase difference microscope to investigate the effects of them on ciliary activities. The following results were obtained. 1) There are no influences on ciliary activities in nonsensitized guinea pigs inhaled with PGE^1 and PGF^<2α>. 2) In sensitized guinea pigs, the inhalation of PGE^1 was likely to protect or to prevent the depression of the ciliary activity due to the causative antigen. 3. The ciliary activities were not influenced by the inhalation of PGE^1 and PGF^<2α>, in induced asthma of guinea pigs with histamine or acetylcholine. 4. The inhalation of PGE^1 increased cleary the tracheal secretion with eosinophilia.
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  • Inhibitory Effect of Mycophenolic Acid on Expression of Tuberculin Hypersensitivity in Guinea Pigs
    Yoshiyuki Ohsugi, Kaoru Miura, Tatsuichiro Hashimoto
    Article type: Article
    1975 Volume 24 Issue 12 Pages 820-825,834-83
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.820
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    The experiments were performed to study the inhibitory activity of mycophenolic acid (MPA) on expression of tuberculin hypersensitivity in guinea-pigs. The expression of tuberculin reaction elicited by PPD injection in animals sensitized with living BCG was inhibited by successive administration of MPA during sensitization. MPA also inhibited tuberculin skin reaction in actively and passively sensitized animals. Furthermore, MPA suppressed skin reaction induced by SRF which is known as the mediator of tuberculin reaction. But, cytotoxicity of MPA to the sensitized cells was not found in the ability of passive sensitization. All the effects mentioned above were shown under the dosage of MPA which did not cause leucopenia. On the basis of these results, it was considered that MPA inhibited the tuberculin reaction by suppressing the terminal process caused by chemical mediator of the reaction.
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  • Subpopulations of Human Peripheral Blood Lymphocytes Distinguished by Formation of Rosettes with Sheep and/or Dog Erythrocytes
    Koji Nishiya, Seizo Yamana, Tadashi Ofuji
    Article type: Article
    1975 Volume 24 Issue 12 Pages 826-832,835
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.826
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    Rosette formation of human lymphocytes with erythrocytes from various species was investigated in this study. Human peripheral lymphocytes formed rosettes 66.1±6.6% for sheep erythrocytes, 37.1±10.0% for dog (DRBC), 46.1±10.7% for pig and 2.9±1.0% for mouse. Most of the rosette forming lymphocytes bound both SRBC and DRBC at the same time when they were incubated with the mixture of SRBC and DRBC. However, small number of the lymphocytes adhered either SRBC or DRBC erythrocytes. In addition, when the receptor of human lymphocytes were saturated with either erythrocyte and then challenged with the other, the increase in the number of rosette forming lymphocytes. was observed. The present data suggests that although the majority of human peripheral lymphocytes has the receptors for both SRBC and DRBC, a minor group of the rosetting lymphocytes has the receptor for either erythrocytes alone. In other words, the lymphocytes rosetting erythrocyte are heterogenous. The surface structure of SRBC or DRBC rosetting lymphocytes was observed by a scanning electron microscopy. Both lymphocytes demonstrated the similar structure characterized by the thymus derived lymphocytes.
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  • [title in Japanese]
    Article type: Bibliography
    1975 Volume 24 Issue 12 Pages 833-835
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.833
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1975 Volume 24 Issue 12 Pages 836-837
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.836
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  • [title in Japanese]
    Article type: Index
    1975 Volume 24 Issue 12 Pages 838-843
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.838
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  • [title in Japanese]
    Article type: Appendix
    1975 Volume 24 Issue 12 Pages 844-
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.844
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  • [title in Japanese]
    Article type: Cover
    1975 Volume 24 Issue 12 Pages Cover15-
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.Cover15
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1975 Volume 24 Issue 12 Pages Cover16-
    Published: December 30, 1975
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.24.Cover16
    JOURNAL FREE ACCESS
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