Japanese Journal of Allergology

[title in Japanese]

Article type: Cover
1997 Volume 46 Issue 4 Pages Cover15-
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.Cover15

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[title in Japanese]

Article type: Cover
1997 Volume 46 Issue 4 Pages Cover16-
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.Cover16

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[title in Japanese]

Article type: Appendix
1997 Volume 46 Issue 4 Pages App4-
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.App4

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[title in Japanese]

Article type: Appendix
1997 Volume 46 Issue 4 Pages App5-
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.App5

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CLINICAL AND EXPERIMENTAL ASPECT OF LATEX ALLERGY

Akira Akazawa

Article type: Article
1997 Volume 46 Issue 4 Pages 349-353
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.349

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EPIDEMIOLOGICAL RESEARCH ON INCIDENCE OF ATOPIC DISEASE IN INFANTS AND CHILDREN IN RELATION TO THEIR NUTRITION IN INFANCY

Masahiko Arita, Haruki Mikawa, Masuo Shirataka, Kouich Takahashi, Hiro ...

Article type: Article
1997 Volume 46 Issue 4 Pages 354-369
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.354

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Incidence and relative risk of atopic disease (atopic dermatitis; AD, bronchial asthma; BA, allergic rhinitis; AR) in Japanese infants and children in relation to their nutrition in infancy was analyzed from the data of the epidemiological survey which was conducted for 10,000 mothers of infants and children in 1993. A total of 4,610 replies were recieved: 2,714 from mothers of infants (12 months old) and 1,896 from mothers of children (2 years old). The subjects were allocated to following 3 groups based on their nutrition during first 3 months after birth; the breast-fed group (BF), the formula-fed group (EF), the mixed-fed group (MF). Incidence of atopic disease in BF, FF and MF was 23.5%, 22.2% and 21.8%, respectivery and no statistical difference could be found among these 3 groups. AD was developed 17.0%, 14.4% and 13.9%; BA was 4.4%, 8.5% and 5.2%; AR was 4.9%, 6.5% and 5.8% in BF, FF and MF, respectively. Incidence of AD was significantly different between BF and MF (p < 0.01). Incidence of BA was also significantly different between BF and FF (p < 0.01). Risk of onset of BA and AR in FF was higher (adjusted odds ratio 2.2, 95% confidence interval 1.5-3.2 and adjusted odds ratio 1.5, 95% confidence interval 1.0-2.2, respectively) than that of BF controlled by age and family history with Cochran-Mantel-Haenzel test. With multiple logistic regression analysis, relative risk of the onset of BA in FF at the age of one year was 2.1, 95% confidence interval 1.2-3.5 and at the age of two years old was 2.5, 95% confidence interval 1.4-4.4. These results suggest that the breast-fed have certain suppression effects on incidence of bronchial asthma in infants and children.

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COMPARATIVE STUDY OF SUSTAINED-RELEASE IN THEOPHYLLINE (SLOBID, THEOLONG, THEODUR) BY PHARMACOKINETICS

Takeshi Kotake, Masakazu Mihara, Masahiko Shibakawa, Hitoshi Asamoto

Article type: Article
1997 Volume 46 Issue 4 Pages 370-375
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.370

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We made a comparative study of three kinds of sustained-release of theophylline compounds by means of analysis of plasma concentrations. The drugs were Slobid (SB) (Up-john) 11 patients (10 men, 1 woman), Theolong (TL) (Eisai) 22 (10 men, 12 women), Theodur (TD) (Nikken chemicals) 34 (18 men, 16 women), who were hospitalized from January 1989 to November 1994. These patiens were given oral theophylline, bid at 9:00 and 21:00, plasma concentration of theophylline was determined at 9:00, 12:00, 15:00, 18:00 and 21:00, after plasma concentration reached a plateau. There were no significant differences as to the zero absorption rate, the moment absorption rate, clearance, but there were significant differences to the half life time (T1/2) of SB (18.9 hr) > TL (13.5) > TD (10.1) (p = 0.0061), mean residence time (MRT) of SB (21.3 hr) > TL (16.7) > TD (15.2) (p = 0.0034), by measurements analysis of variance. These results suggest that these sustained-relase drugs have different pharmacokinetics judging from the important indices including Cmax-Cmin, T1/2, V, MRT and Tm1/2, and that the best one is the SB, the second is the TL, and the third is the TD for RTC therapy.

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THE CORRELATION BETWEEN INTERLEUKIN-10 AND INTERFERON-γ PRODUCED BY PERIPHERAL BLOOD MONONUCLEAR CELLS STIMULATED BY HOUSE DUST MITE ANTIGEN IN ATOPIC DERMATITIS

Yoshikazu Motoki, Yasuyuki Kikkawa, Yukio Kojima, Takashi Matsui, Fumi ...

Article type: Article
1997 Volume 46 Issue 4 Pages 376-383
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.376

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The pruduction of interleukin (IL)-10 and interferon (IFN)-γ by peripheral blood mononuclear cells (PBMC) stimulated by house dust mite (HDM)antigen and concanavaln A (Con A) was measured in patients with atopic dermatitis (AD). The HDM-stimulated PBMC from AD patients revealed to produce significantly higher levels of IL-10 (12 h: 918.4 ± 206.5, 24 h: 1252.5 ± 145.8, 72 h: 1332.7 ± 123.9 pg/ml) than those from normal control subjects (12 h: 231.1 ± 139.0, 24 h: 585.7 ± 196.2, 72 h: 813.5 ± 181.8 pg/ml). Con A-stimulated AD-PBMC also showed significantly higher levels of IL-10 production than those from normal controls, although they were lower than the productions induced by HDM antigen. By contrast, the levels of IFN-γ from AD PBMC stimulated with HDM or Con A, were significantly lower than those from normal controls. IFN-γ production might be down-regulated by IL-10 in AD-PBMC. The overproduction of IL-10 seems to show that helper T type 2 (Th2) cells are rather dominantly activated than Th1 cells and Th2 cells might contribute to produce the cytokines in response to HDM antigen in AD patients.

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ENHANCED LYMPHOCYTE PROLIFERATIVE RESPONSE TO HOUSE DUST MITE IN THE OLDER BUT NOT IN THE YOUNGER ASTHMATIC CHILDREN

Mitsuaki Kimura, Satoru Tsuruta, Takami Yoshida

Article type: Article
1997 Volume 46 Issue 4 Pages 384-390
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.384

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Allergen-specific lymphocyte proliferation was measured by flow cytometry in 16 children with atopic dermatitis (AD), 26 with bronchial asthma (BA) and 13 non-atopic controls. Although the level of mite-S.I.F. (stimulation index measured by flow cytometry) in the younger AD children (2-7 y) was significantly higher than that in the non-atopic subjects (189.6 ± 70.7 vs 115.9 ± 11.0, p < 0.02), there was no elevation in the younger BA children (122.6 ± 23.4). It is therefore likely that the elevated mite-S.I.F. level is related to the development of the allergic cellular inflammation representing the pathology of AD, rather than the IgE-mediated allergic reaction as a mechanism of childhood BA. Because the level of mite-specific IgE antibody in the younger BA children is elevated (93.6 ± 41.2 PRU/ml), the result also indicates that mite-specific peripheral T lymphocytes do not play a critical role in stimulating the mite-specific IgE synthesis. On the contrary, the older BA children (8-15 y) showed an elevated mite-S.I.F. level (176.0 ± 54.6) significantly higher than that in the non-atopic subjects (114.6 ± 13.9, p < 0.05) as well as that in the younger BA children p < 0.05). Because other investigators have reported that the level of mite-specific lymphocyte proliferation is increased in the adult BA patients, the transition from childhood BA to adult-type BA may start at the age of about 8 y.

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A CASE OF BRONCHIAL ASTHMA FOR WHOSE STATUS ASTHMATICUS AN ANTICHOLINERGIC DRUG WAS EFFECTIVE IN WEANING FROM INHALED ANESTHESIA

Takumi Takizawa, Hirokazu Arakawa, Hiroyuki Mochizuki, Kenichi Tokuyam ...

Article type: Article
1997 Volume 46 Issue 4 Pages 391-394
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.391

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[title in Japanese]

Article type: Appendix
1997 Volume 46 Issue 4 Pages 395-
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.395

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[title in Japanese]

Article type: Appendix
1997 Volume 46 Issue 4 Pages 397-398
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.397

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[title in Japanese]

Article type: Appendix
1997 Volume 46 Issue 4 Pages 399-
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.399

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[title in Japanese]

Article type: Appendix
1997 Volume 46 Issue 4 Pages 400-402
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.400

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[title in Japanese]

Article type: Appendix
1997 Volume 46 Issue 4 Pages 403-406
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.403

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[title in Japanese]

Article type: Cover
1997 Volume 46 Issue 4 Pages Cover17-
Published: April 30, 1997
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.46.Cover17

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