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Volume 28, Issue 5
Displaying 1-13 of 13 articles from this issue
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Article type: Cover
1979 Volume 28 Issue 5 Pages Cover22-
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (38K) -
Article type: Cover
1979 Volume 28 Issue 5 Pages Cover23-
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (38K) -
Article type: Bibliography
1979 Volume 28 Issue 5 Pages Misc6-
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (238K) -
Tetsuzo Fujitani, Takashi Maki, Tetsuo Takahara, Hirokazu Morimoto, Yu ...Article type: Article
1979 Volume 28 Issue 5 Pages 403-409
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effect of immunotherapy with aqueous house dust extract on changes in direct intradermal reaction, intranasal provocation test, eosinophile leucocyte count test of nasal smear, and serum IgE and IgE antibody was analyzed in 115 patients with known house dust allergy who were treated for over 3 years with this hyposensitization The results of these pre- and post-hyposensitization examination were compared with clinical effects. 1. The highest degree of effectiveness was obtained in the group receiving a maintenance dose. 2. Blocking antibody titers and patient self-test were highest in the group receiving a maintenance dose. There was a significant increase of blocking antibodies in the therapy responcive as compared with the therapy non-responsive group. 3. There was no relationship between the effect of the therapy and levels of serum IgE and IgE antibody. However, cases with increased bloking antibody levels seemed to have a for decresed amounts of IgE antibody. We suggest that the important factors in treating atopic nasal allergy are increasing the blocking antibody and decreasing the serum IgE antibodies.View full abstractDownload PDF (731K) -
Nobuyuki Miyasaka, Hisae Kawamitsu, Takaaki Nishido, Masaharu OkudaArticle type: Article
1979 Volume 28 Issue 5 Pages 410-416
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSMitogenic factor (MF) which stimulates proliferative response of lymhocytes is one of the lymphokines released from lymphocytes triggered by mitogens or specific antigens but this factor has not been available for chinical use as an indicator of cell-mediated immunity. In the present study, the method of measurement of MF was studied for clinical application using 10 normal healthyadults. MF was induced from the T lymphocytes by the culure with Con A-Sepharose, of which optimal concentration was about 0.5%. MF was released in the supernatant after 6 hours of incubation and its activity reached maximum after 24 to 36 hours. MF stimulated both autologous and allogeneic cells and seemed to act mainly on T lymphocytes. MF activity was mostly elicited in Con A-stimulated culture. But soluble factor(s) which suppress the proliferative response of lymphocytes seemed to be released in the supernatant at higher concentration of Con A-Sepharose.View full abstractDownload PDF (663K) -
Akihide Koda, Toshimitsu Yamada, Naoto NakagiriArticle type: Article
1979 Volume 28 Issue 5 Pages 417-422
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe anti-allergic actions of procaterol, a new β_2-adrenergic drug were studied. 1) In homologous PCA in rats, 0.3 to 10 μg/kg, i.v. procaterol inhibited the reaction dosedependently and the inhibitory activity was approximately 10 times more potent than that of salbutamol. Two to 5 mg/kg of procaterol p.o. also inhibited the reaction. Such an inhibition, however, was not observed by 10 mg/kg of salbutamol p.o.. 2) Heterologous PCA in guinea-pigs was inhibited dose-dependently by the i.v. injection of 0.3 to 10 μg/kg and the activity was approximately 10 times more potent than that of salbutamol. 3) Antigen-induced histamine release from sensitized guinea-pig lung was dose-dependently inhibited by 10^<-9> to 10^<-6> M・procaterol. Inhibition by procaterol was evidently potent compared to that effected by isoproterenol and salbutamol.View full abstractDownload PDF (770K) -
Yoshifuji Matsumoto, Jun Ishihara, Keiko EguchiArticle type: Article
1979 Volume 28 Issue 5 Pages 423-429
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe investigated the binding of autologous and allogeneic human erythrocytes to peripheral lymphocytes (H-rosette) from normal individuals and patients with systemic lupus erythematosus (SLE). 1. A small percentage (3-4%) of normal peripheral lymphocytes formed H-rosette with allogeneic and autologous erythrocytes. The rosettes were formed equally in either serum-free or buffer containing solution. 2. The level of H-rosette was higher in SLE than in normal individuals. Moreover, high level of H-rosettes was more prominent in serum-free buffer solution. 3. Active SLE patients had higher levels of H-rosettes than inactive cases. High level of H-roset teswas more prominent in serum free buffer solution. 4. There was no difference in the level of H-rosette between Coombs' direct test positive and negative patients. 5. In active SLE, the level of H-rosettes correlated positively with anti-DNA antibody titer and negatively with the level of peripheral T-lymphocyte-bearing receptors for Fc portions of IgG.View full abstractDownload PDF (863K) -
Koji Saito, Nobuhiko Tamaki, Tohru Nishihara, Jiro Inui, Yoshiki Kawab ...Article type: Article
1979 Volume 28 Issue 5 Pages 430-439
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe reported earlier that the ultrafiltrated extracts (M.W.<5000) of peripheral leukocytes from tuberculin-sensitive donors contain the materials (transfer factor, TF) which enable nonsensitive recipients to gain the ability to react to this antigen. The crude ultrafiltrate was then subjected to gel filtration on a Sephadex G-10 column to fractionate the active components. The present study was undertaken to determine whether the fractionated materials may specifically transfer the donor's sensitivity to a nonsensitive recipient and whether chemotactic activity exists in these materials. The elute from Sephadex G-10 was assayed for polypeptide content by the fluorescamine reagent (Fluram) and 4 Fluram reactive peaks (i.e. G-1, G-2 (subfractions F-G-2 and B-G-2), G-3 and G-4) were noted. The administration of B-G-2 or G-3 fraction to a tuberculin nonreactive recipient could elicit a reaction to this antigen. Moreover, by using the modified Boyden-chamber method and in vivo skin tests, these fractions were shown to have no chemotactic activity to neutrophils.View full abstractDownload PDF (963K) -
Toru Hikita, Shigeru Nakatani, Shigeru Miyagi, Yukio Matsumoto, Tetsuh ...Article type: Article
1979 Volume 28 Issue 5 Pages 440-446
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDopamine-β-hydroxylase (DBH) is thought to be discharged together with catecholamine from the adrenal medulla and sympathetic nerve endings by a process of exocytosis. Since insulin-induced hypoglycemia is a stimulus associated with markedly enhanced catecholamine secretion, we investigated whether there was any difference in the response of plasma DBH activity to acute hypoglycemia between normal subjects and asthmatic patients. Regular insulin (0.1 unit/kg) was intravenously injected to 8 asthmatic and 10 normal subjects. Blood samples were obtained before and 30, 60, 90 and 120 min after insulin injection and checked for blood glucose and plasma DBH activity. Urine was collected for the period of 2 hours before and after insulin injection and assayed for catecholamines. There was no significant difference in the decrease of blood glucose between two groups. No significant increase of urinary norepinephrine was observed, but urinary epinephrine was markedly increased in both groups. These findings suggest that release of catecholamines following insulin induced hypoglycemia was similar in the groups. Percent change of post-injection plasma DBH activity was not significant in normal subjects. In asthmatic patients, however, this enzyme activity decreased significantly at 60 and 90 min after injection as compared with the initial values. These results suggest that as no significant increase of plasma DBH activity was observed in response to acute hypoglycemia, plasma DBH measurement is not necessarily suitable for assessing sympatho-adrenomedullary function in the groups studied, and that DBH metabolism, including release from the nerve endings and disappearance from circulation, might be different in asthmatic patients from that in normal subjects.View full abstractDownload PDF (870K) -
Article type: Appendix
1979 Volume 28 Issue 5 Pages 447-
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (65K) -
Article type: Appendix
1979 Volume 28 Issue 5 Pages 447-
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (65K) -
Article type: Appendix
1979 Volume 28 Issue 5 Pages 448-
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (323K) -
Article type: Cover
1979 Volume 28 Issue 5 Pages Cover24-
Published: May 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (206K)
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