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2010 Volume 59 Issue 7 Pages
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2010 Volume 59 Issue 7 Pages
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Shunpei Yokota
Article type: Article
2010 Volume 59 Issue 7 Pages
785-794
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Ken Ohta
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2010 Volume 59 Issue 7 Pages
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2010 Volume 59 Issue 7 Pages
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Akiyoshi Konno
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2010 Volume 59 Issue 7 Pages
804-809
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Kazuyo Moro, Shigeo Koyasu
Article type: Article
2010 Volume 59 Issue 7 Pages
810-814
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Kenji Matsumoto
Article type: Article
2010 Volume 59 Issue 7 Pages
815-821
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Atsushi Isozaki, Yutaka Kawano, Tetsuo Shoda, Sho Mimura, Norifumi Oga ...
Article type: Article
2010 Volume 59 Issue 7 Pages
822-830
Published: July 30, 2010
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Background and object: Two major convenient questionnaires of asthma control in childhood, Japanese Pediatric Asthma Control Program (JPAC) and Childhood Asthma Control Test (C-ACT) have been available in Japan. The aim of this study is to evaluate relationship of two questionnaires in terms of the changes of respiratory function and fractional nitric oxide (FE_<NO>) in each individual. Subject and methods: The 102 samples from patients with asthma aged 6 to 11 years old and their parents' answers for the two questionnaires at regular visits were collected. At the same time, respiratory functions and FE_<NO> were measured. The correlations of each difference of scores (±JPAC or ±C-ACT), correlations of ±JPAC or ±C-ACT and increased ratio of respiratory functions and FE_<NO> (ΔFE_<NO>%) were examined. We analyzed the factors that influences on respiratory functions and FE_<NO>. Moreover, the correlations of increased ratio of respiratory functions and ΔFE_<NO>% were examined. Results: Changes of JPAC and C-ACT correlated with each other. (ρ=0.725, p<0.0001) ΔFE_<NO>% was influenced by medications, especially ICS. ±JPAC weakly correlated with ΔFEV_1% and ΔFEF_<25-75>% and ΔPEF%, so did C-ACT. ±JPAC correlated most strongly with the change of ΔFEF_<25-75>% among the parameters of respiratory functions. (ρ=0.357, p=0.0003) ±JPAC, but not ±C-ACT weakly correlated with ΔFE_<NO>%. (ρ=-0.2045, p=0.0401) Conclusion: JPAC and C-ACT reflect the change of the respiratory function of each patient rather than those at random visit. Furthermore, JPAC may reflect FE_<NO>. In conclusion, recognition of the changes of the scores of these questionnaires may increase the utilities of the same scores obtained at a single visit. It is needed further study how to use FE_<NO> added on these questionnaires.
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Kenya Ie, Atsuto Yoshizawa, Satoru Hirano, Sinyuu Izumi, Masaaki Hojo, ...
Article type: Article
2010 Volume 59 Issue 7 Pages
831-838
Published: July 30, 2010
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Background: We investigated the risk factor of perioperative asthmatic attack and effectiveness of preventing treatment for asthmatic attack before operation. Methods: We performed retrospective chart review of one hundred eleven patients with asthma underwent general anesthesia and surgical intervention from January 2006 to October 2007 in our hospital. Results: The rate of perioperative asthmatic attack were as follows; 10.2% (5 in 49 cases) in no pretreatment group, 7.5% (3 in 40 cases) in any pretreatments except for systemic steroid, and 4.5% (1 in 22 cases) in systemic steroid pretreatment group. Neither preoperative asthma severity nor duration from the last attack had significant relevancy to perioperative attack rate. The otolaryngological surgery, especially those have nasal polyp and oral surgery had high perioperative asthma attack rate, although there was no significant difference. Conclusion: We recommend the systemic steroid pretreatment for asthmatic patients, especially when they have known risk factor such as administration of the systemic steroid within 6 months, or possibly new risk factor such as nasal polyp, otolaryngological and oral surgery.
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Mika Ogata, Akinori Shukuya, Chizuko Sugizaki, Kaori Ikematsu, Takanor ...
Article type: Article
2010 Volume 59 Issue 7 Pages
839-846
Published: July 30, 2010
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Objective: We investigated the usefulness of skin prick test (SPT) using bifurcated needle (BN) for the diagnosis of cow's milk allergy (CMA) in early infancy. Subjects and methods: Among atopic dermatitis infants with suspicion of food allergy who visited Sagamihara National hospital from January 2001 to April in 2005, 168 cases had received both SPT and IgE ImmunoCAP of CM (CM-IgE) at first visit. We analyzed results of SPT and CM-IgE, focused on infants with negative CM-IgE to examine the usefulness of SPT, and checked positive conversion of CM-IgE with aging. Results: Among 124 infants (73.8%) with negative CM-IgE, 34 infants (27.4%) showed positive SPT results. Forty two infants (33.6%) among the 124 cases were diagnosed as CMA by combination of elimination and provocation test, and 21 infants (50.0%) had positive SPT. In the follow up study of 39 negative CM-IgE cases with CMA, 21 CM-IgE (53.8%) turned positive later infantile period (mean CM-IgE: 4.2+/-4.8Ua/ml at 9.3+/-5.3 months old). Conclusions: SPT using BN seemed to be more useful than CM-IgE for the diagnosis of CMA in early infancy with AD. But, the sensitivity is lower than in the egg case.
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Koa Hosoki, Takao Fujisawa, Sawako Masuda, Satoko Usui, Hiroaki Ito, M ...
Article type: Article
2010 Volume 59 Issue 7 Pages
847-854
Published: July 30, 2010
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We report a case of 18-old girl with primary ciliary dyskinesia (PCD) who had been diagnosed as asthma. Since birth, she had presented with unexplained productive cough, sputum, rhinorrhea, and stridor with situs solitus. Her familial history was negative for PCD. At 2 years of age, ciliary beat frequency and beat pattern were normal. She was diagnosed as rhinosinusitis, chronic secretory otitis media. At 3 years of age, she was diagnosed as asthma because of wheezing not associated with respiratory infection. Various asthma medications were then administered, including DSCG, inhaled corticosteroids, and salmeterol, but varying responses to the treatment were noted. Spirometry revealed persistent severe small airway obstruction. Beta2 agonist reversibility was recognized by impulse oscillation system, not with FEV1. At age of 18, chest CT disclosed bronchiectasis, and nasal nitric oxide concentration was very low, 98ppb and a diagnostic approach for PCD was performed. Electron microscopic analysis of nasal cilia demonstrated defects of the outer and inner dynein arms, and the diagnosis of PCD was made. Mutations in DNAH1 and DNAI1 genes were found. The diagnosis of PCD is often difficult in the absence of situs inversus totalis. Recurrent wheeze with chronic rhinosinusitis, chronic otitis media, and brochiectasis may warrant detailed investigations for PCD, especially with nasal NO measurement.
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[in Japanese]
Article type: Article
2010 Volume 59 Issue 7 Pages
855-858
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Article type: Appendix
2010 Volume 59 Issue 7 Pages
859-881
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Article type: Appendix
2010 Volume 59 Issue 7 Pages
882-913
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Article type: Appendix
2010 Volume 59 Issue 7 Pages
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Article type: Appendix
2010 Volume 59 Issue 7 Pages
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Article type: Appendix
2010 Volume 59 Issue 7 Pages
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Article type: Appendix
2010 Volume 59 Issue 7 Pages
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2010 Volume 59 Issue 7 Pages
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2010 Volume 59 Issue 7 Pages
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2010 Volume 59 Issue 7 Pages
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2010 Volume 59 Issue 7 Pages
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2010 Volume 59 Issue 7 Pages
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2010 Volume 59 Issue 7 Pages
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Article type: Cover
2010 Volume 59 Issue 7 Pages
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