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Volume 46, Issue 12
Displaying 1-22 of 22 articles from this issue
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Article type: Cover
1997 Volume 46 Issue 12 Pages Cover10-
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
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Article type: Cover
1997 Volume 46 Issue 12 Pages Cover11-
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1997 Volume 46 Issue 12 Pages 1-19
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
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Yukiyoshi YanagiharaArticle type: Article
1997 Volume 46 Issue 12 Pages 1209-1215
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
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Masaru Taniguchi, Hiroshi Sato, Junging Cui, Tetsu KawanoArticle type: Article
1997 Volume 46 Issue 12 Pages 1216-1223
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe found a novel lymphoid cell lineage, Vα14 NKT cell, which is characterized by 1) the expression of both NK1.1 (NK receptor) and an invariant TCR encoded by Vα14 and Jα281 gene segments; 2) the expression of unusual phenotypes, such as NK1.1^+, B220^+, Mac-1^+, HSA^+, CD44^+, CD45R^<low> and MEL-14^<low>; and 3) the extrathymic development: Vα14 NKT cells appear at d9.5 of gestation before thymus development. Moreover, the deletion of the invariant Vα14 TCR gene expression caused the lack of NKT cells in vivo, while transgene of the invariant Vα14Vβ8 TCR in the RAG-deficient background resulted in the generation of only Vα14 NKT cells without other lymphoid cells. These results indicate the essential requirement of invariant Vα14 TCR for the development of NKT cells. Recent studies clearly show that Vα14 NKT cells, but not NK cells or T cells are the primary target of IL-12 in the IL-12-mediated tumor rejection.View full abstractDownload PDF (943K) -
Junzaburo KabeArticle type: Article
1997 Volume 46 Issue 12 Pages 1224-1226
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
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Tatsuro Koshibu, Masaru Kishida, Itsuo Suzuki, Tomoko Nagayama, Hirohi ...Article type: Article
1997 Volume 46 Issue 12 Pages 1227-1234
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo investigate the new criteria for skin prick test (SPT) of seventy-four atopic infants (2-5 months of age at the first visit, Mean 3.8 months, M:F=54:20) to diagnose for hypersensitivity to egg white. It was classified into three groups by reaction type of SPT in the first visit. Group A were the infants who seemed only late (6 hours) or delayed (48 hours) reaction (n=26), Group B were seemed immediate (15 minutes) and late or delayed reactions (n=26), Group C were seemed only immediate reaction (n=23). Atopic infants and controlled infants without no symptom but have any atopic disease a relative in the third degree, agreed to undergo SPT in the first visit, the prior were undergo 9-12 months of age, too. Serum total IgE (RIST), serum specific IgE antibody of egg white (EWRAST) and peripheral eosinophil counts in the blood (Eo. counts) were determined at the same time of SPT in atopic infants. The best criterion for SPT was the longest diameter of a erythema were greater than 3 mm at late and/or delayed reaction (Sensitivity: 100%, Specificity: 60%) in group A. Two third of infants in group A were seemed immediate reaction and EWRAST levels were increased to lager than gread two at 9-12 months (p<0.001). RIST levels and Eo. counts at the first visit were increased compared with the normal levels in the all groups, the prior and EWRAST levels in group B were higher than group A or C (p<0.05, p<0.05). RIST and EWRAST levels in group A at 9-12 months were higher than the first visit (p<0.05, p<0.01). In conclusion, SPT in atopic early infants were seemed several reactions at the first visit, but all reactions were useful for diagnose for hypersensitivity to egg white.View full abstractDownload PDF (943K) -
Osamu Nohara, Toru Imai, Tomohiko Endo, Kensaku Saneyoshi, Takechika O ...Article type: Article
1997 Volume 46 Issue 12 Pages 1235-1242
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSRelease of major allergens (Cry j 1, Cry j 2) from Japanese cedar (C. japonica) pollen grains treated with high pressure was investigated. C. japonica pollen grains crushed by high pressure treatment using FRENCH^<【○!R】> Pressure Cell Press released greater amounts of major allergens, particularly Cry j 2, compared to those without crush. This suggests that the cytoplasm of C. japonica pollen grains contains more Cry j 2 than previously reported. The effect of nasal fluid on the release of major allergens from C. japonica pollen grains was analyzed in vitro. Nasal fluid from patients with nasal allergy remarkably increased the release of major allergens from pollen grains, compared to controls, and the amount of Cry j 1 was greater than Cry j 2. Further studies revealed that nasal fluid affects the outer wall of pollen grains, where Cry j 1 is located, to a greater extent than its effect on the cytoplasm, where Cry j 2 is located.View full abstractDownload PDF (1255K) -
Masahiko Aoyagi, Naoki Shimojo, Yoshinori Sato, Hiroko Watanabe, Kunio ...Article type: Article
1997 Volume 46 Issue 12 Pages 1243-1250
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSBy use of flow cytometry, we have investigated intracellular activated eosinophil cationic protein (ECP) in eosinophils and mitogen-induced cytokine production of T cells in peripheral blood from children with acute severe asthma. In addition, we mesured ECP releasability (serum ECP/lysate ECP) as a maker of activated eosinophils. The monoclonal antibody EG2 (anti-activated ECP/EPX antibody) was used for measuring the amount of intracellular activated ECP. ECP releasabilities and mean fluorescence intensity (MFI) values of EG2-positive eosinophils increased at the time of asthmatic attack and reduced after treatment with improvement in peak expiratory flow. Furthermore, the frequency of T cells which produced IL-4, IL-5 and IFN-γ stimulated with phorbol myristate acetate and ionomycin increased and reduced in parallel with MFI of EG2-positive cells. These observations suggest that flow cytometric analysis for intracellular ECP and mitogen-induced cytokine production reflects the activation of T cells in bronchial mucosa, and is useful for monitoring airway inflammation in bronchial asthma.View full abstractDownload PDF (743K) -
Joji Ishii, Tamotsu Ogawa, Kensei Naito, Sho Miyata, Masatake Ishihara ...Article type: Article
1997 Volume 46 Issue 12 Pages 1251-1257
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSEight Brown Norway rats were immunized twice at days 0 and 13 by intraperitneal injections of 10μg Cry j I, one of major allergen to Japanese cedar pollinosis, mixed with 4.5 mg aluminium hydroxide gel. Serum level of Anti-Cry j I IgE antibody was detected by the method of ELISA. Mean value of serum levels of specific IgE to Cry j I in the sensitized rats was significantly higher than that in the non-sensitized five rats (p<0.01). The grades of eosinophil and lymphocyte accumulation in the nasal mucosa of the sensitized rats were higher than those in the non-sensitized rats respectively (p<0.05, p<0.01). In the laryngeal mucosa, the grade of eosinophilia in the sensitized rats was higher than that in the control (p<0.01), but no significant differences of lymphocyte accumulation in the larynx between the two groups were found. Only a small number of eosinophil and lymphocyte accumulations in the trachea of the both groups were observed and no significant differences of the grade of inflammatory cells accumulation between the two groups were found. According to the results of this fundamental study, allergic laryngitis in Japanese cedar pollinosis might be originated from Japanese cedar pollen.View full abstractDownload PDF (1258K) -
Hiroshi Kawaguchi, Yurika Nishimura, Norihisa Ishii, Hiroshi Nakajima, ...Article type: Article
1997 Volume 46 Issue 12 Pages 1258-1264
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to know the role of type 2 helper T (Th2) cells on patients with atopic dermatitis (AD), peripheral blood mononuclear cells were taken from the patients, stimulated with immobilized anti CD3 monoclonal antibody in the presence of monensin, and stained with fluorescein isothiocyanate-labeled anti IL-2 or IL-4 monoclonal antibody, followed by phycoerythrin labeled-anti CD4 monoclonal antibody. The fluorescent intensity was detected by FACScan. The results showed that the frequency of IL-4 producing CD^4^+ cells from AD patients was significantly higher than that from the healthy controls, whereas that of IL-2 producing CD4^+ cells from patients were the same as healthy controls. The frequency of IL-4 producing cells was well correlated to the clinical severity of the disease, but that of IL-2 producing cells did not show any significance. Neither IL-2 nor IL-4 producing CD4^+ cells had any relation to the serum IgE levels and the number of eosinophils in the patients. Our results indicate dominance of IL-4 producing CD4^+ cells, which means Th2 cells in the peripheral mononuclear cells in the patients with AD, especially severe cases.View full abstractDownload PDF (589K) -
Sohei Kano, Sankei NishimaArticle type: Article
1997 Volume 46 Issue 12 Pages 1265-1272
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe evaluated the relationship between PEF and SpO_2 on 126 acute asthma attacks of 52 asthmatic children (25 males, 27 females, age 6-17 yrs-old) whose PEF and SpO_2 being measured either before or after inhalation of β-agonist at out-patient clinic. In the whole age group over 6 yrs-old, values of %PEF were proportional to individual SpO_2 (n=76, R=0.472, p<0.001). However, the relationship between %PEF and SpO_2 in the present study was different from that of the guideline proposed by WHO (Global Initiative for asthma, GINA), showing that the value of SpO_2 corresponding to %PEF was higher in the present study than in GINA. Regarding the difference in age group, significant relationship between %PEF and SpO_2 was observed in both lower (6-9 yrs-old) and middle age group (10-12 yrs-old) but not in older age group (over 12 yrs-old). Also, there was a significant relationship between %PEF and SpO_2 in cases whose pulmonary function during stable condition showed no-obstructive change (FEV_<1.0>%>80%), but not in cases with obstructive change. On the other hand, averaged values of %PEF, SpO_2, heart rate (HR), respiratory rate (RR) before inhalation of β-agonist at out-patient clinic in cases with or without admission were 32.3% vs 50.0%, 93.0% vs 95.0%, 115 bpm vs 100 bpm, and 27/min vs 25/min respectively, those differences being statistically significant. Although measurement of SpO_2 is thought to be a useful index for assessing severity of childhood asthma exacerbation, clinican should recognize that value of SpO_2 could be greater than 91% even though % predicted PEF is less than 60%. Especially in older age group, obstructive change during stable condition may distrub the relation of SpO_2 to % PEF. In such cases, not only SpO_2 but also PEF, which is objective index of airway obstruction, should be taken into account for assessing severity of exacerbation.View full abstractDownload PDF (743K) -
Yuji Akiyama, Teruhiko Suzuki, Masahiko Tanaka, Fumihiko Imai, Toshiyu ...Article type: Article
1997 Volume 46 Issue 12 Pages 1273-1276
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1997 Volume 46 Issue 12 Pages 1277-1282
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1997 Volume 46 Issue 12 Pages 1283-
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1997 Volume 46 Issue 12 Pages 1283-
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1997 Volume 46 Issue 12 Pages 1284-1291
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
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Article type: Index
1997 Volume 46 Issue 12 Pages 1292-1300
Published: December 30, 1997
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Article type: Index
1997 Volume 46 Issue 12 Pages 1301-1303
Published: December 30, 1997
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Article type: Index
1997 Volume 46 Issue 12 Pages 1304-1309
Published: December 30, 1997
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Article type: Appendix
1997 Volume 46 Issue 12 Pages 1310-1313
Published: December 30, 1997
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Article type: Cover
1997 Volume 46 Issue 12 Pages Cover12-
Published: December 30, 1997
Released on J-STAGE: February 10, 2017
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