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Article type: Cover
2004 Volume 53 Issue 12 Pages
Cover8-
Published: December 30, 2004
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Article type: Index
2004 Volume 53 Issue 12 Pages
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Atsushi Nagai
Article type: Article
2004 Volume 53 Issue 12 Pages
1181-1183
Published: December 30, 2004
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Takahide Nagase
Article type: Article
2004 Volume 53 Issue 12 Pages
1184-1186
Published: December 30, 2004
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Hideaki Taira, Eri Yoshii, Hidetoyo Teranishi
Article type: Article
2004 Volume 53 Issue 12 Pages
1187-1194
Published: December 30, 2004
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Minoru Okuda, Kimihiro Ohkubo, Minoru Goto
Article type: Article
2004 Volume 53 Issue 12 Pages
1195-1202
Published: December 30, 2004
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Recent suggestions emphasizes the importance of assessing medical care outcomes from the point of view of both professional opinion and patient's subiect like patient satisfaction as well as quality of life. Selfadministered questionnaires are often used as an instrument for this purpose. When compared with quality of life, there is less useful questionnaire for patient satisfaction. Accordingly, we here aimed to develope the questionnaire, which is disease-specific, comprehensive, simple, clinically available and satisfied psychometric validation study. The items were collected from patients and satisfaction-related literature's review, and the total 20 were selected fmally from them after excluding inadequate or overlapped items. Then, we conducted validation study in 214 subjects sampled randomly from 603 patients with Japanese cedar pollinosis who had visited clinics in 2003 by mailing self-administered questionnaire in spring, 2004. The response rate was 65.3%. In factor analysis, items were divided into four domains such as doctorpatient relationship, treatment outcome, geniality in hospital and convenience of medical service. The former two domains were the most correlated well with patient satisfaction. The quality of this questionnaire such as responsiveness, reliability, construct validity, convergent/discriminate validity, and clinical validity satisfied international standard. Thus, it was verified that our newly developed questionnaire is a useful and scientific tool for examination of patient satisfaction with medical care in allergic rhinitis.
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hidehiko Hirata, Komei Ito, Shinpei Torii, Tatsuo Sakamoto
Article type: Article
2004 Volume 53 Issue 12 Pages
1203-1209
Published: December 30, 2004
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Eosinophilic inflammation of the airways is a key characteristic of asthma. Glucocorticoids can suppress the inflammatory response in part by promotion of eosinophilic apoptosis. We investigated the effects of glucocorticoids on leukocyte infiltration and apoptotic resolution of eosinophils and neutrophils in Sephadex-treated rat lung. Sephadex beads were injected intravenously, followed 24 h later by i.p. administration of dexamethasone (DEX, 0.1 mg/kg) or its vehicle. At 24 h post-DEX treatment, the bronchoalveolar lavage fluid (BALF) was collected. Differential leukocyte counts and the numbers of apoptotic eosinophils and neutrophils, and macrophages with engulfed eosinophils or neutrophils in BALF were determined microscopically from Diff-Quik stained cytospin preparations. Sephadex beads markedly increased cell counts of eosinophils and neutrophils in BALF. Compared with a vehicle-treated group, the DEX treatment significantly decreased the number of eosinophils, but not neutrophils, in BALF. Dexamethasone in BALF also significantly increased eosinophilic apoptosis and engulfment of apoptotic eosinophils by macrophages, but had no effect on neutrophilic apoptosis and engulfment of apoptotic neutrophils by macrophages. These results suggest that the increased clearance of eosinophils from airways by glucocorticoids may be partly due to the prornotion of eosinophilic apoptosis.
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Yoshiki Kobayashi, Hirotka Yasuba, Hideo Kita, Kazuyuki Hamada, Junich ...
Article type: Article
2004 Volume 53 Issue 12 Pages
1210-1215
Published: December 30, 2004
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These days some reports say that bronchial asthma, especially severe asthma, is systemic inflammatory and its severity correlates with eosinophil counts. Some patients with asthma have positive tests for rheumatoid factor (RF) which is detected in systemic hyper immunoreactive desease such as rheumatoid arthritis. So we investigated each of these factors in asthmatic patients. We ramdomly selected 100 asthmatics from regular outpatients of our hospital. In a positive RF Ievel group (over 21lU/ml), Eosinophil counts were significantly higher than those in a negative RF level group. RF Ievels were significantly and positively correlated with the logarithm of eosinophil count. And in severe groups (patients with severe asthma, treated with high dose inhaled steroids, and with history of systemic steroids use for the last one month), RF levels were significantly higher than those in other groups. Our result suggested that RF levels reflect eosinophilia and asthma severity.
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2004 Volume 53 Issue 12 Pages
1216-1219
Published: December 30, 2004
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Article type: Appendix
2004 Volume 53 Issue 12 Pages
1220-1304
Published: December 30, 2004
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Article type: Appendix
2004 Volume 53 Issue 12 Pages
1305-1315
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Article type: Appendix
2004 Volume 53 Issue 12 Pages
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Article type: Appendix
2004 Volume 53 Issue 12 Pages
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Article type: Appendix
2004 Volume 53 Issue 12 Pages
1317-1318
Published: December 30, 2004
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Article type: Index
2004 Volume 53 Issue 12 Pages
1319-1327
Published: December 30, 2004
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Article type: Index
2004 Volume 53 Issue 12 Pages
1328-1330
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Article type: Index
2004 Volume 53 Issue 12 Pages
1331-1334
Published: December 30, 2004
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Article type: Appendix
2004 Volume 53 Issue 12 Pages
1335-1336
Published: December 30, 2004
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Article type: Appendix
2004 Volume 53 Issue 12 Pages
1337-1338
Published: December 30, 2004
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Article type: Appendix
2004 Volume 53 Issue 12 Pages
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Article type: Appendix
2004 Volume 53 Issue 12 Pages
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Article type: Appendix
2004 Volume 53 Issue 12 Pages
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Published: December 30, 2004
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Article type: Appendix
2004 Volume 53 Issue 12 Pages
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Published: December 30, 2004
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Article type: Cover
2004 Volume 53 Issue 12 Pages
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Published: December 30, 2004
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