Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 26, Issue 11
Displaying 1-16 of 16 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1977 Volume 26 Issue 11 Pages Cover9-
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.Cover9
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1977 Volume 26 Issue 11 Pages Cover10-
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.Cover10
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Bibliography
    1977 Volume 26 Issue 11 Pages Misc3-
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.Misc3
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  • A Study on Bronchail Asthma Induced by Pollen of Boehmeria Nivea(Ramie)
    Sadahiro Asai
    Article type: Article
    1977 Volume 26 Issue 11 Pages 731-739,782
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.731
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    purpose:Boehmeria nivea(Ramie)is a plant of genus Boehmeria in the Urcicaceae(Urtica family)and is widely distributed in Japan, China and Southeast Asia. In Nagasaki area, the pollen of Boehmeria nivea is the most numerous among the scattered pollens in the weed season, and consequently it was studied to see if bronchial asthma was caused by the pollen of Boehmeria nivea, as well as to apprehend the clinical picture of asthma patients sensitized by the pollen of Boehmeria nivea. Subjects and methods:For 219 cases of asthma patients in the Second Department of Internal Medicine and Department of Pediatrics of the Nagasaki University Hospital, various allergological tests were performed. Results:Intracutaneous test due to pollen allergen of Boehmeria nivea was positive in as high as 21.8% of asthma patients in the Department of Internal Medicine and in 11.1% of those in the Department of Pediatrics. These positive patients underwent further tests such as threshold value of skin test, Prausnitz-Kustner test and provocation test(bronchia test)and, as the result, 5 cases of Boehmeria nivea pollen induced asthma were found. Those cases sensitized by the pollen of Boehmeria nivea showed the findings of so-called typical atopic asthma. Since a number of species of genus Boehmeria such as B. tricuspis and B. Spicata are distributed thoughout Asia and also in North America, it was considered that pollinosis and pollen asthma due to these plants might be exist all over the world mostly in Asia as well as in Japan. The author proposed to call this pollen asthma due to genus Boehmeria as"Ramie pollen asthma."
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  • Basic Studies on the Mechanism of Antibody-Dependent Cellular Cytotoxicity(ADCC) : I.Improvement of Assay Method and Analysis of ADCC Phenomenone
    Noriyuki Sato, Kentaro Toh, Yoshifumi Ishii
    Article type: Article
    1977 Volume 26 Issue 11 Pages 740-748,782
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.740
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    Basic studies on some characteristics of ADCC were made using a modified microassay method of cytotoxicity by Takasugi and Klein and culture cells of rat methylcholanthrene sarcoma as target cells. Antisera were obtained by immunizing rabbits or allogeneic rats with the target cells. ADCC activity was much higher with human peripheral blood leucocytes(PBL)than with guinea pig PBL as effector cells and 100 times higher than complement-dependent cytotoxicity(CDC). Lymphoid cells from the spleen and the peripheral blood have much efficient compared with the lymph node cells as ADCC effector cells. Specificity of ADCC with these antisera was clearly demonstrated in this assay system. ADCC activity was dependent on the concentration of the antiserum, the incubation time of cytotoxic assay and the effector dose. Our data also showed that effector cells become cytotoxic after binding of antiserum to target cells but not to effector cells. The existence of Fc receptor on the surface of effector cells was required to the appearance of ADCC.
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  • The Subpopulations of the Peripheral Blood Lymphocytes in the Perinatal Period
    Tomoko Yamashita, Fusako Komoda, Hiroshi Hayakawa
    Article type: Article
    1977 Volume 26 Issue 11 Pages 749-756,783
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.749
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    T and B lymphocytes were examined in cord blood, peripheral blood of the newborn infants and the healthy adults;using the E-rosette forming cell, EAC-rosette forming cell and active E-rosette forming cell assays. Subjects tested were 20 cord blood, 57 healthy newborn infants(1 day through 6 day old)and 32 healthy adults as controls. In cord blood the percentage of E-rosette forming cells and active E-rosette forming cells against whole lymphocytes were significantly lower than those of adults, while the percentage of EAC-rosette fcrming cells was slightly lower(but not significantly)than that of adults. However, in newborn infants, the percentage of E-rosette forming cells, active E-rosette forming cells and EAC-rosette forming cells showed no significant difference from those of adults, throughout the neonatal period. As far as the absolute numbers of each subpopulations of lymphocyte was concerned, in cord blood E-rosette forming cells, active E-rosette forming cells and EAC-rosette forming cells were all higher in number than those of adults. While in newborn infants E-rosette forming cells, EAC-rosette forming cells and active E-rosette forming Cells were all highest among the three groups. No correlationship betwee the levels of birilubin in serum and each subpopulations of lymphocyte in the newborn infants was observed.
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  • Experimental Membranous Glomerulonephritis Induced in Rats by the Injection of Pronase-Digested Homologous Renal Tubular Epithelial Antigen : III.Relationship between Serum Content of Anti-Tubular Antibody and Development of Renal Lesions in the Chronic Stage of Experimentel Glomerulonephritis
    Sosuke Oike, Takuji Naruse
    Article type: Article
    1977 Volume 26 Issue 11 Pages 757-761,783
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.757
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    Experimental membranous glomerulonephritis was induced in rats by the injection of pronase-digested homologous renal tubular epithelial antigen. Radioimmunoassay for rat tubular antigen and the corresponding antibody was developed utilizing <125>^I-labeled purified tubular antigen. Nephritic rats were studied on serum contents of anti-tubular antibody, total protein, total cholesterol and BUN, as well as immunopathological changes throughout the observation period of six months, and following results were obtained. After the development of proteinuria, anti-tubular antibody disappeared from serum of some rats and never reappeared, while in others, the antibody persisted in the serum throughout the observation period. Sera from antibody-positive rats revealed a typical feature of nephrotic syndrome, whereas those from antibody-negative rats showed mild abnormalities. The results of histopathological studies of kidneys were as follows;antibody-positive rats showed marked thickening of GBM with numerous electron-dense deposits in it, whereas in antibody-negative rats, deposits in the GBM became lucent. These results suggest that anti-tubular antibody in the serum plays a significant roll for the acceleration and the maintenance of pathlogical process in kidneys of chronic stage.
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  • Inhalative Provocation Tests with Autologous Streptococcal Freezing and Thawing Antigen and Streptococal Polysaccharide Antigen on Patients with Asthmatic Bronchitis
    Toshisada Kimura, Tatsuo Matsumura
    Article type: Article
    1977 Volume 26 Issue 11 Pages 762-771,784
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.762
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    Using autologous atreptococcal antigen inhalative provocation tests were carried out on 25 patients with asthmatic bronchitis or bronchial asthma, with the following results. Intracutaneous tests with freezing and thawing antigen on 9 patients with asthmatic bronchitis or bronchial asthma revealed immediate reaction in 2 patients. None of them suffered from delayed reaction. P-K tests with polysaccharide antigen were positive in 2 out of 5 patients. Inhalative provocation tests using freezing and thawing antigen demonstrated early and late type reaction in 13 out of 15 patients with asthmatic bronchitis. In the case of polysaccharide antigen, inhalative provocation tests induced only early type reaction in 7 out of 8 patients with asthmatic bronchitis or bronchial asthma. Respiratory symptoms provoked by inhalation of streptococcal antigen were mild and existed for only a short time in patients with asthmatic bronchitis, while they were sever and persisted longer in patents with bronchial asthma. The role of bacterial allergy in the etiology of asthmatic bronchitis was discussed.
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  • Histological and Immunological Studies on the Small Intestine in Food Allergy in Childhood
    Yoshihiro Kawamura
    Article type: Article
    1977 Volume 26 Issue 11 Pages 772-781,784
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.772
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    Intestinal biopsies were performed in 26 chilren with food allergy, 16 with asthma and 37 non-allergic patients. The following results were obtained. 1) The number of eosinophils in the lamina propria increased significantly in the food allergy group as compared with other groups(P<0.001). Furthermore, the eosinophils in the lamina propria of the folld allergy group were significantly more numerous in the specimens obtained after challenge of allergens than those obtained during elimination of allergens(p<0.001). 2) The hyperemia and hemorrhage in the lamina propria were specific findings in the food allergy group. However, villous atrophy observed in the food allergy group seemed to be nonspecific, since mucosal damage was also prominent in nonallergic patients. 3) Distribution of immunoglobulin-containing cells in the lamina propria did not show significant difference among the groups studied. IgE containing cells were rematkably numerous in one of 26 food allergy cases. These results indicate that the intestinal biopsy is of diagnostic value for food allergyin childhood.
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  • [title in Japanese]
    Article type: Bibliography
    1977 Volume 26 Issue 11 Pages 782-784
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.782
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  • [title in Japanese]
    Article type: Appendix
    1977 Volume 26 Issue 11 Pages 785-788
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.785
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  • [title in Japanese]
    Article type: Appendix
    1977 Volume 26 Issue 11 Pages 789-
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.789
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1977 Volume 26 Issue 11 Pages 790-
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.790
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  • [title in Japanese]
    Article type: Appendix
    1977 Volume 26 Issue 11 Pages 791-
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.791
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  • [title in Japanese]
    Article type: Cover
    1977 Volume 26 Issue 11 Pages Cover11-
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.Cover11
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  • [title in Japanese]
    Article type: Cover
    1977 Volume 26 Issue 11 Pages Cover12-
    Published: November 30, 1977
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.26.Cover12
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