1)Renal anaphylactic shock was induced by single injection of the anti-rabbit-kidney guinea pig serum. In one group the antiserum was injected into the left renal artery of the pregnant rebbits, and in the other the injection was carried out similarly into the marginal ear vein, and these histological changes in the kidney were investigated. 2)Concerning with the group of rabbits injected into the left renal artery, no significant changes were observed in the right kidney, and slight changes were found in the left kidney. Namely, anemia of the glomerulus and dilatation of the glomerular capillaries were found. 3)On the other hand, various findings were observed in the group of the rabbits injected into the ear vein. Pathohistological changes of the glomerulus in this group were divided into three groups. These changes in respective group were as follows: i)Degenerative changes of the glomerulus, with eosinophilic substances in the Bowman's capsule, adhesions of glomerular loops, anemia, and swelling of the glomerulus. ii)Productive changes of the glomerulus, with prolifiration of mesangial cells and anemia of capillaries. iii)Glomerulus showing only slight anemia. 4)As the result of those experiments above mentioned, anaphylaxis was emphasized in pregnancy and it was suggested that the function of endocrine organ might play a considerably important part on the mechanism to occur nephritis. But, it is necessary to study the genesis of this point in detail.

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Antigenic stimulation with either bovine serum albumin(BSA) ro bovine gamma globulin (BGG) upon rabbits under condition of prolonged sensitization with egg albumin for more than 500 days developed increased formation of antibodies, chromatograpyically interpreted as 19s, and depressed formation of precipitating antibodies against BSA or BGG.Moreover, disappearance of the new antigen from the circulating blood by formation of antigen, antibody complex, so-called immune elimination was not convincingly clarified, It was remarked here that antibody forming organs as spleen and lymph nodes demonstrated atrophy and little tendency to plasma cellular response. The experimental pathological condition here induced is interpreted to be a posthyperergic exhaustion of antibody forming tissues, especially of plasma cellular reaction. It may be said that animals under the condition of prolonged sensitization show a tendency to immunological exhaustion in its later stage.

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