Japanese Journal of Allergology

[title in Japanese]

Article type: Index
1964 Volume 13 Issue 9 Pages 799-803
Published: September 30, 1964
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.13.799_11

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[title in Japanese]

Article type: Bibliography
1964 Volume 13 Issue 9 Pages Misc10-
Published: September 30, 1964
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.13.Misc10

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Studies on the "Transfer Factor" of Tuberculin Hypersensitivity : II.Passive transfer of tuberculin hypersensitivity with fractions of either disrupted alveolar macrophages or serum of sensitized and challenged rabbits

Takateru Izumi

Article type: Article
1964 Volume 13 Issue 9 Pages 583-592,644
Published: September 30, 1964
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.13.583

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Since the first success of Chase in 1945, it has been thought in general that the passive transfer of tucerculin hypersensitivity is successful when viable lymphoid cells of sensitive donor animals are inoculated into recipients and that if non-viable cellular constituents of these cells are used, passive transfer of sensitivity is almost impossible. Neverthless, the writer performed passive transfer experiments using either alveolar macrophages which are new materials for passive transfer experiments or the serum of sensitized and challenged rabbits. Results are as follows. (1)It was shown that living alveolar macrophages have apparent capacity to recipients tuberculin sensitive by intraperitoneal inoculations of 10'or more cells. (2)In passive transfer experiments with cellular fractions separated by successive centrifigations of alveolar macrophage disrupted by five cycles of freezing and thawing, mitochondria fraction seemed to have a definite capacity to confer sensivity. It was of note that cellular supernatant (after centrifigation by 20,000 G 90 minutes) per se had no activity to confer sensitivity, but afetrt dialysis against distilled water, transfer activity appeared in this fraction. It may be postulated that a certain low molecular factor possessing activity to inhibit transfer of tuberculin hypersensitivity(Inhibitor) is contained in dialysed outer fluid of the cellular supernatant. Nuclei and microsomes had no transfer activity. (3)Dialysed inner fluids of sera of sensitized and challenged rabbits showed apparent activity to confer sensitivity, though serum per se had no activity. Thus, it was very likely that also serum contained both transfer factor and inhibitor. (4)Tuberculin hypersensitivity transfered passively developed between the first and the third day after administration of test materials and disappeard on or after the seventh day. It may be due to two treatments, challenge of animals and separation of inhibitor from test materials, that passive transfer of tuberculin hypersensitivity with non viable materials are constantly sucessful despite many unsuccesful previous investigation.

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Studies on Allergy of Intestinal Flora-Clostridium perfringens and hepatic lesion

Ryouhei Nakagawa

Article type: Article
1964 Volume 13 Issue 9 Pages 593-604,644-64
Published: September 30, 1964
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.13.593

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Clostridium perfringens is one of the normal anaerobic resident micro-organisms in intestinalflora. It was already well known that θ-toxin of Clost. Perfringens is very similar to Streptolysin O in the biological charactor. Our previous reports showed that the anticlostolysin(anti θ-toxin) activity was sufficiently high titer in the sera with some kinds of kidney and liver diseases. In this regard, the auther tried to produce experimentally some hepatic damage by sensitizing the dogs with the cultures(centrifuged supernatant) of Clost. Perfringens. 1.Long term sensitization of dogs with the Clost. cultures: The pathological changes in the liver were various stages of angitis with fibrinoid swelling, mobilization of Kupffer's cells and slight central fatty degeneration of lobules. In the kidney was found slight enlargement of capillary loops in glomeruli. 2.Primary toxicity of the Clost. culture to the liver: The Clost. cultures were injected into the portal vein. There were found little changes except dilation of the tubuli and tubular degenerative changes in the kidney. 3.Dogs were sensitized with the Clost. cultures mixed with Freund's adjuvant and homologeous liver homogenate, and challenged with same antigen(without Freund's adjuvant)through the route of portal vein: The microscopic findings in the liver marked fatty degeneration in the peripheral portions of lobules, remarkable angitis with fibrinoid swelling, varying degree of piece meal necrobiotic alterations and mild proliferation of connective fibres in lobules. The changes of the kidney were found similar to so-called glomerulitis and moreover small number of "hematoxylin body"like substance was shown to be inclused in the juxtraglomerular vasa, inside and outside of the capillary tuft of glomeruli. These results of mesenchymal reaction in the liver suggested that metabolites of Clost. perfringens might be participating in immunlogical mechanisms for the pathogenesis of some liver diseases.

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Studies on the Biological Activity of Bradykinin and its Role in the Allergic or Inflammatory Reaction : 1st Report Purification and biological activity of bradykinin

Yoshitaka Miyanaga

Article type: Article
1964 Volume 13 Issue 9 Pages 605-613,645
Published: September 30, 1964
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.13.605

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Actions of bradykinin, its mechanisms in vitals and the relations of other plasma kinins have been studied by meny researchers since bradykinin was first discribed by Rocha a Silva, Beraldo and Rosenfeld(1949). Recently, bradykinin has attracted the attention as on of chemical mediators and vital active peptide in allergic or anaphylactic and inflammatory reactions. The author studied on the isolation of bradykinin and its biological activity and suggested that bradykinin might participates in allergic or inflammatory reactions. The results obtained were as follows: 1)Bradykinin contracts smooth muscle of guinea-pigs ileum, trachea and rats uterus. The contractracting activity to guinea-pig's ileum and trachea was as same as histamine and acetylcholine. However its activity to rat's uterus was 3 folds higher than that of acetylcholine 2)By subcutaneous injecting test, it was observed that the increasing action to capillary permeability and inflammatory reaction of bradykinin was much stronger than histamine. 3)Guinea-pigs died with anaphylactoid shock by intravenous. injection of 1.5mg/kg of bradykinin 4)The LD-50 of bradykinin to normal mice was 11.31mg/kg and LD-50 to adrenalectomized mice was 4.28mg/kg.

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

Article type: Article
1964 Volume 13 Issue 9 Pages 614-643
Published: September 30, 1964
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.13.614

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[title in Japanese]

Article type: Bibliography
1964 Volume 13 Issue 9 Pages 644-645
Published: September 30, 1964
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.13.644

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