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Volume 30, Issue 9
Displaying 1-13 of 13 articles from this issue
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Article type: Cover
1981 Volume 30 Issue 9 Pages Cover32-
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (44K) -
Article type: Cover
1981 Volume 30 Issue 9 Pages Cover33-
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (44K) -
Article type: Bibliography
1981 Volume 30 Issue 9 Pages Misc11-
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
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Kazuo Kobayashi, Hisashi Noguchi, Hiroshi Narimatsu, Toshio Yokokawa, ...Article type: Article
1981 Volume 30 Issue 9 Pages 877-882
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSerum uric acid levels in patients with bronchial asthma were measured. In addition, analysis of correlation between elevated serum uric acid levels in patients of asthma and theophyline administration was carried out. The conclusion were as follows: 1) Serum uric acid levels in patients with asthma were significanty high as compared with those of health indiduals (p<0.005). 2) Not a difference was observed in serum uric acid levels between extrinsic type and intrinsic type of asthma. But, serum uric acid levels were signifacantly high in patients treated with theophylline (over 300mg/day) administration (p<0.001). 3) There was correlation between serum uric acid and theophyline levels in healthy individuals and ashma, significantly (r=0.403, r=0.527 respectively). 4) Both serum theophyline and uric acid levels in healthy individuals 24 hr after treatment withtheophylline intravenously almost returned to levels of pretreatment. From these results, it was suggested that elevated uric levels in patients with asthma were not caused by disease specific metabolic disturbance but by theophylline administration. In addition, elevated serum uric acid in patients with asthma caused by theophyline considered to be unnecessary for antihyperuricemic therapy.View full abstractDownload PDF (565K) -
Yukie Niwa, Koichi Ishimoto, Susumu Miyake, Tsuyoshi Sakane, Masao Shi ...Article type: Article
1981 Volume 30 Issue 9 Pages 883-892
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSeventeen patients with Behcet's desease receiving colchicine and/or glucocorticosteroids (steroids) were classified into two groups as complete and incomplete type. Both groups were further divided into active and inactive stages. Neutrophils from patients stimulated with opsonized-zymosan were subjected to measurement of oxygen intermadiates (O^-_2, H_2O_2, OH・, ^1O_2)(OI) and lysosomal enzymes (lysozyme, α-mannosidase, β-glucuronidase). The results were compared with those assessed in the control groups which included cases of goutreceiving colchicine and/or steroids, cases of asthma and dermatosis placed on steroids, and healthy individuals. In addition, ^51Cr-labeled human umbilical vein endothelial cell cultures obtained from the placenta immediately after birth were utilized for cytotoxicity test by stimulated-neutrophils from the complete type patients in active stage. In the cases of complete type in active stage, despite administration of colchicine and/or steroids, OI and especially OH・were significantly increased, compared to the healthy controls. Patients in the other groups showed significant rise in OI compared to the diseased control groups receiving the drugs. Similar changes in lysosomal enzymes were observed in them, although the differences in the quantity of enzymes between the patients and control groups were not very great. When the stimulated-neutrophils from the patients were incubated with endothelial cells, elevated ^<51>Cr release was demonstrated. Simultaneous addition of xanthine, which can quench OI, reduced ^<51>Cr leak almost to control levels. This indicates that the neutrophils from Behcet patients are highly sensitive and can be enhanced and amplified by antigenic stimulation, especially to the large particle, immune complexes, resulting in potential production of OI and leading to tissue damage in the disease.View full abstractDownload PDF (1322K) -
Jun Yasunami, Toshishige Inoue, Satoru Doi, Hisao Niwa, Michiaki Hayas ...Article type: Article
1981 Volume 30 Issue 9 Pages 893-898
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn this study, we assessed the bioavailbility of sustained-release theophylline granule (KT-200G), and simulated the serum concentration of theophyline in asthmatic children. The absorption rate constant of KT-200G in adult was 0.44h-and 0.31h-before and after breakfast, respectively. Asthmatic children were treated with KT-200G and sustained-release tablets (Theona[○!R] and/or Theona-P[○!R]); there was no significant difference in the serum concentration of theophyline between the two regimens. To assess the pharmacokinetic properties of theophylline, asthmatic childen were treated with single dose of aminophylline i.v.. The volume of distribution was 0.473±0.093 (1/kg), and the elimination rate constant was 0.117±0.016(h^-)(mean±SD). Serum concentration time curve was simulated for KT-200G in asthmatic children using the one compartment open model. It was predicted that safe and effective serum concentration could be maintained with 12 hours multiple dosing. This study shows that the relative bioavailability of KT-200G is adequate for clinical use, and that KT-200G has good sustained-release properties. Infants will assimilate KT-200G more easily, and the dosage need to be titrated more elaborately with KT-200G as compared with tablets.View full abstractDownload PDF (674K) -
Hirokuni Ohtsuka, Minoru OkudaArticle type: Article
1981 Volume 30 Issue 9 Pages 899-904
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe studied whether histamine concentration released from the nasal surface is enough to produce nasal manifestation in order to demonstrate that the trigger of nasal manifestation is in the nasal mucosal surface. And we also studied which factor is most responsible to the degree of nasal provocation by antigen among three factors such as basophilic cell number in the nasal surface, the releasability of histamine from these basophilic cells and the reactivity of the nasal mucosa to histamine. The net histamine content released from the specimens of the nasal surface ranged from 25.5 to 310.7μg/cm^3, which was enough to produce nasal manifestation. The correlation coefficients were calculated in 4 pairs of the degree of provocation by antigen to histamine content release from the nasal surface, to basophilic cell number, to histamine releasability and to histamine releasability and to histamine reactivity. The values were 0.645, 0.440, 0.481, 0.155 respectively, and when they were analysed statistically, significant close correlations were obtained between the degree of provocation most to the histamine content released from the nasal surface, next to basophilic cell number or histamine releasability but less to histamine reactivity (p<0.01). Therefore, conclusively the very important factors for nasal manifestation are the number as well as histamine releasability of the basophilic cells in the nasal mucosal surface, being followed by histamine reactivity.View full abstractDownload PDF (838K) -
Susumu Furukawa, Chiyuki Abe, [in Japanese]Article type: Article
1981 Volume 30 Issue 9 Pages 905-910
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSPGE_2 (prostaglandin E_2) generation by human PMN (polymorphonuclear leukocytes) was examined. Human peripheral PMN were separated and suspended in a medium containing reduced glutathione and autologous serum. PMN were incubated with serum treated zymosan. Some PMN were incubated with cytochalasin B dimethylsulfoxide to determine wheather phagocytosis was a prerequisite for PCE_2 generation. Chromatographic separation of PGE on silicic acid columns and subsequent radioimmunoassay were performed. Antibody to PGE_2 was provided by Institute Pasteur Production. As a result, human PMN stimulated with zymosan generated comparable amounts of PGE_2 and generation of PCE_2 occured independently of phagocytosis. In addition, PMN incubated with reduced glutathione generated small amounts of PCE_2.View full abstractDownload PDF (612K) -
Kazuko Nishikawa, Yoji IikuraArticle type: Article
1981 Volume 30 Issue 9 Pages 911-918
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to assess the presence and severity of EIA in adult asthmatics and to evaluate the effect of physical training, pulmonary function was measured after exericise tolerance test according to master-one-step method. Forty seven adult asthmatics and 7 normal subjects were first exercised and after six months of training 7 of the asthmatics were exercised a second time. The incidence of EIA was 63.8% in the asthmatics and none of the normal subjects. Percent changes in FEV_<1.0> at 5 min after exercise among mild, moderate and severe asthmatics demonstrated significant reductions of -12.28±12.68%, -18.84±19.48% and -31.13±17.74% respectively (p<0.01). Even 14 mild asthmatics showed a more than 15% decrease. The training was carried out over a six month period unsupervised in the home. When strictly reviewed, only 4 asthmatics were well trained of the 7 asthmatics who performed the exercise tolerance test a second time. Results in these 4 patients were that audible wheezing was induced in 3 asthmatics before training and in 2 after training, and the numbers of the numbers of the patients who showed a more than 15% decrease in FEV_<1.0> after exercise were 4 before training and 1 after training. We concluderd that when we see out-patients, it is necessary to assess the pulmonary function ofter exercise tolerance test and to recommend to them daily exercises for their training.View full abstractDownload PDF (989K) -
Kazuharu TsukiokaArticle type: Article
1981 Volume 30 Issue 9 Pages 919-929
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to elucidate the mechanism developing Candida albicans (Candida)-induced asthma, a clinical study of this type of asthma was done compared with house dust-induced asthma. Diagnosis of Candida-induced asthma was made when the bronchial provacation test (BPT) was only positive for Candida, and diagnosis of house dust-induced asthma was made with same manner as when BPT was only positive for house dust. In this present study, 29 patients over 13 age per each of Candida-induced and house dust-induced asthma were studied, and the following results were obtained: 1) The age of onset of Candida induced asthma (mean±1 standard deviation; 35.3±14.2y.o.) was significantly higher than that of house dust-induced asthma (14.8±12.2y.o.)(p<0.001). 2) Occurrance of allergic diseases in the family history was significantly higher in the group of house dustinduced asthma (51.7%) than in that of Candida-induced asthma (20.7%)(p<0.05). 3) Total serum IgE level of house dust-induced asthma (1455±1243U/ml) was significantly higher than that of Candida-induced asthma (291±281U/ml), in which it stayed almost within normal limits (p<0.001). 4) P-K reaction was positive in a high rate among patients with house dust-induced asthma (90.9%), but in a low rate among those with Candida-induced asthma (27.8%)(p<0.01). 5) By radioallergosorbent test (RAST), IgE antibody against mites was found in all patients with house dust-induced asthma (100%), but that against Candida was seen only in a small number of patients with Candida-induced asthma (13.3%)(p<0.001). 6) As to the type of reaction on BPT, an immediate response was predominant among house dustinduced asthma and a late response was seen in a high rate among Candida-induced asthma. These results suggest that IgE antibody may be of minor importance in the development of Candida-induced asthma in contrast with house dust-induced asthma.View full abstractDownload PDF (1346K) -
Article type: Appendix
1981 Volume 30 Issue 9 Pages 931-
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1981 Volume 30 Issue 9 Pages 933-936
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
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Article type: Cover
1981 Volume 30 Issue 9 Pages Cover34-
Published: September 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (749K)
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