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Volume 39, Issue 11
Displaying 1-16 of 16 articles from this issue
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Article type: Cover
1990 Volume 39 Issue 11 Pages Cover8-
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (382K) -
Article type: Cover
1990 Volume 39 Issue 11 Pages Cover9-
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (382K) -
Article type: Appendix
1990 Volume 39 Issue 11 Pages App2-
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (246K) -
[in Japanese]Article type: Article
1990 Volume 39 Issue 11 Pages 1461-1469
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (736K) -
Shigenobu Umeki, Hiroshi Kawane, Rinzo SoejimaArticle type: Article
1990 Volume 39 Issue 11 Pages 1470-1476
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSChanges in leukocytes and eosinophils in 60 patients with non-infectious attack (NIA patients) were compared with those in 50 patients with infection-related attack (IRA patients). In 30 (50%)of the 60 NIA patients, eosinophilia without leukocytosis was observed on admission, and in 23 (76%) of these 30 patients eosinophilia disappeared within 2 weeks of admission. In 36 (72%) of the 50 IRA patients, leukocytosis without eosinophilia was observed on admission, and the periods from the onset of infection to admission were inversely correlated with leukocyte counts. In 22 eosinophilia patients among the 50 IRA patients, the periods from the onset of infection to admission were correlated with eosinophil counts for up to 40 days, and in 13 (76%) of 17 eosinophilia patients not receiving a long-term steroid therapy during admission, eosinophilia continued for more than 2 weeks even after anti-asthmatic and anti-infectious therapies. There was no significant difference in serum IgE levels between the two groups on admission. These results suggest that evaluations of leukocytes/eosinophils on admission and clinical courses are very useful in the management of asthmatic patients with or without bacterial infections.View full abstractDownload PDF (950K) -
Tetsuro Yamaguchi, Hirotsugu Kohrogi, Izumi Honda, Mineharu Sugimoto, ...Article type: Article
1990 Volume 39 Issue 11 Pages 1477-1483
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo study whether a novel leukotrienes antagonist ONO-1078(4-oxo-8-[p-(4-phenylbutyloxy)benzoylamino]-2-(tetrazol-5-yl)-4H-1-benzopyran hemihydrate) prevents leukotrienes C_4- and D_4-(LTC_4, LTD_4) induced human bronchial smooth muscle contraction, we examined the bronchial contractile response to LTC_4 and LTD_4 in the presence or in the absence of ONO-1078 in human bronchial strips. We prepared 4 strips from each of 5 patients undergoing lobectomy of the lung because of lung cencer. We mounted the strips in organ baths and measured the contractile response to LTC_4 and LTD_4 from 10^<-11>M to 10^<-7>M after incubation with ONO-1078 (10^<-8>M, 10^<-7>M and 10^<-6>M) and without ONO-1078. ONO-1078 shifted the dose response curve to LTC_4 to higher concentration in dose dependent fashion, and it significantly inhibited the contractile response to LTC_4 and LTD_4. In the presence of L-serine borate complex (45mM), an inhibitor of γ-glutamyl transpeptidase, ONO-1078 significantly inhibited the LTC_4-induced contraction. On the other hand, ONO-1078 had no effect on the contractile response to acetylcholine. These results suggest that ONO-1078 is a specific antagonist of LTC_4 and LTD_4 receptors in human bronchial smooth muscle. Because the effect of LTC_4 and LTD_4 is thought to be an important part of the pathogenesis of bronchial asthma, our results also suggest that ONO-1078 may be a usefull prophylactic drug for bronchial asthma.View full abstractDownload PDF (759K) -
Akira KawakitaArticle type: Article
1990 Volume 39 Issue 11 Pages 1484-1491
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTotal IgE, specific IgE・IgA・IgG・IgM antibodies to whole cow's milk and β-lactoglobulin were neasured in 32 team and 23 premature infants. 1) The term infants who developed eczema till one month had significantly high spacific IgG titers to whole cow's milk and β-lactoglobulin in cord blood serum. It is concluded that specific IgG antibody to whole cow's milk and β-lactoglobulin in cord blood serum have predictive value for the development of eczema till one month. 2) Some of mixed feeding premature infants produced specific IgE・IgA・IgG・IgM antibodies to whole cow's milk and β-lactoglobulin till one month. These infants produced various kind of specific antibodies to whole cow's milk and β-lactoglobulin. 3) The premature infants who developed eczema at one month had significantly high specific IgA・IgG titers to cow's milk and high specific IgA titers to β-lactoglobulin in serum at one month. These infants had a tendency to show high total IgE value and high specific IgM titers to cow's milk and high specific IgG・IgM titers to β-lactoglobulin. It is concluded that specific antibodies to whole cow's milk and β-lactoglobulin are responsible for the development of eczema in one month infants.View full abstractDownload PDF (1060K) -
Tatsuo Sakamoto, Komei Ito, Masanori Yamada, Hideko Iguchi, Masano Ued ...Article type: Article
1990 Volume 39 Issue 11 Pages 1492-1498
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSRecently large amounts of Aspergillus restrictus, a species of osmophilic fungi, have been detected in house dust using culture media with low water activity. But little attention has been paid to this fungus as an allergen. In the present study, the authors examined the allergenic activity of A.restrictus by skin prick tests and redioallergosorbent tests (RAST) on 94 asthmatic patients (mean age 12.0, range 3-18). Aspergillus fumigatus, Alternaria alternata and house dust were used for comparison. In the skin prick tests, A.restrictus, A.fumigatus, A.alternata and house dust elicited positive reactions in 8(8.5%), 8(8.5%), 15(16.0%) and 69(73.4%) patients, respectively. RAST showed positive reactions in 27(28.7%) subjects for A.restrictus, 22(23.4%) for A.fumigatus, 35(37.2%) for A.alternata, and 75(79.8%) for house dust. These results indicated that some asthmatic individuals showed immediate-type hypersensitivity to A.restrictus, and the prevalence of hypersensitivity of A.restrictus determined by skin prick rests and RAST was comparable with that of A.fumigatus but lower than that of A.alternata or house dust. This indicates that this fungal species may be of importance as a causative agent in atopic diseases.View full abstractDownload PDF (811K) -
Shin-ichi Konno, Hideki Kobayashi, Takashi Kawazoe, Takako Hiyama, Hir ...Article type: Article
1990 Volume 39 Issue 11 Pages 1499-1508
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe examined lung tissues in a guinea pig model actively sensitized by inhalation of aerosolized ovalbumin (OA) and found reproducible late bronchial responses (LBR) 7 h and 24 h after OA challenge. Light microscopic examination revealed bronchoconstriction, damage to the epithelium, eosinophil infiltration in both the epithelium and subepithelium, retention of mucous in the pulmonary bronchial lumens and a decrease in the mucous content of periodic Acid-Schiff (PAS) stain positive cells in the bronchial epithelium in LBR. An increase in the number of PAS-stain positive cells of in the bronchial epithelium was also observed in LBR. Electron microscopic examination revealed eosinophil migration around mast cell at 7 hs after OA challenge. Two different mechanisms of degranulation of eosinophil specific granules were observed in LBR. In one mechanism, the granule core changes after its matrix has changed. In the other mechanism, the granules were exocytosed as a whole, accompanied by vagueation of the cell membraine and densely clumped chromatin, suggesting burst of eosinophil.View full abstractDownload PDF (1918K) -
Isao Todoroki, Izumi Yoshizawa, Yutaka Kawano, Takeshi NomaArticle type: Article
1990 Volume 39 Issue 11 Pages 1509-1514
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSEffect of azelastine on the induction of Dermatophagoides farinae (Df)-antigen specific IL-2 responsiveness of the lymphocytes was examined. Azelastine suppressed the induction of IL-2 responsiveness induced by Df antigen in peripheral blood mononuclear cells from patients with bronchial asthma in a dose dependent manner. Azelastine suppressed antigen presenting adherent cells but not non-adherent responder cells (T cell rich fraction). The antigen specific IL-2 responsiveness induced by purified protein derivative (PPD)in healthy adults was also suppressed by this drug, but not by concanavalin A (Con A). These data suggest that Azelastine suppresses the antigen specific Lymphocyte reactions, and that these effects are based on the weak suppressive effect on antigen presenting and/or processing pathway.View full abstractDownload PDF (736K) -
Fumiko Juji, Hiroya Takashima, Matsunobu Suko, Makoto Doi, Toshiaki Ta ...Article type: Article
1990 Volume 39 Issue 11 Pages 1515-1522
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA 17 years old girl experienced an anaphylactic reaction of urticaria, dyspnea, syncope and hypotension while riding a bicycle 55 minutes after eating shellfish Lapas shellfish which was a-like Sulculus Supertexta (SS). She recovered within several hours after the emergency treatment. Another attack occurred 3 months later while she was running with a dog 30 minutes after eating shellfish (Turbo Cornutus; TC). RAST scores were 4 for Lapas and 2 for TC. RAST inhibition test by ERISA showed a high crose-reaction between keyhole limpet hemocyanin (KLH) and Lapas, and between KLH and TC, while the cross reaction between Lapas and TC was low. Gel chromatography with sephacryl G-200 revealed that both Lapas and TC had several allergens with different molecules which were detected by ELISA. Exercise challenge produced an immediate fall of FEV_1 and a significant increase in plasma histamine levels for 45 minutes.View full abstractDownload PDF (875K) -
Takashi Watanabe, Yuji Sakamoto, Hidemi Tomonaga, Masahito Inuyama, Ha ...Article type: Article
1990 Volume 39 Issue 11 Pages 1523-1528
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA 15-year-old man with food-dependent exercise-induced anaphylaxis is reported. The patient had begun to run 4 hours after he had lunched on fried shrimps. When running about 2000 m, he suffered from general cutaneous erythema with itching, urticaria, angioedema of face and dyspnea. He had experienced the similar episodes associated with postprandial exercise before. Skin test and IgE-RAST were positive for shrimp. Exercise challenge test after having 20 g boiled shrimp was conducted, and the elevation of plasma histamine level was recognised. 25 cases with food-dependent exercised-induced anaphylaxis have reported in Japan. 13 of 25 cases were related with wheat, and 10 cases were related with shrimp. 14 of 25 cases had experiensed the similar episodes. Exercise as part of planned health program has virtually mushroomed world-wide. Therefore, the fact that anaphylaxis can be a complication of such exercise must be recognised if appropriate prevention and treatment are to be administered.View full abstractDownload PDF (819K) -
Toshiro Komuro, Ayako Mabuchi, Kozo Yokomuro, Goro AsanoArticle type: Article
1990 Volume 39 Issue 11 Pages 1529-1540
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSMorphological and cytochemical changes were investigated in spleen cells after 70% hepatectomy in mice. During liver regeneration after the hepatectomy, the spleen weight gradually rose to a peak at 6 day. In the spleen, the number of POD-positive myelocytic cells and NCAE-positive granulocytic cells also reached peak 4 days after the operation and then decreased. On the other hand, ANBE-positive monocytic cells gradually increased up to 9 day and didn't decrease for this period. On day 9 of the culture, the boundary between the red and the white pulps of the spleen became unclear. In this spleen, the clusters of blast cells were sporadically observed. Splenic T cells cocultured with nonparenchymal adherent normal liver cell or nonparenchymal adherent normal liver cell supernatant developed into granulocyte colonies in earlier periods and monocyte colonies in later periods. These findings suggest that the factors released from liver cells may regulate strictly spleen cell activation. Blast cell formation in the culture with nonparenchymal adherent normal liver cell supernatant was amplified by anti interferon (α+β) antibody. These facts indicate that the functional network of cytokines is formed by the interaction of various cytokines (IL-1, IL-6, CSF, IFN, etc. ) in nonparenchymal adherent normal liver cell supernatant.View full abstractDownload PDF (2761K) -
Yuji Ohashi, Shinji Motojima, Takeshi Fukuda, Sohei MakinoArticle type: Article
1990 Volume 39 Issue 11 Pages 1541-1545
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe hypothesis that epithelial damage is related to the development of bronchial hyperreactivity has been supported by many studies. Therefore, we further examined whether or not subjects with bronchial epithelium damage showed increased bronchial responsiveness. We took biopsy specimens of the airway mucosa from 20 asthmatic patients with various degrees of disease severity and bronchial hyperreactivity by using a bronchofiber scope. The morphology of the biopsy specimens was studied by electron microscopy. Bronchoscopy was carried out after local anesthesia. Specimens of bronchial mucosa were obtained from 20 asthmatic patients (14 males, 6 females) in remission. The electronmicroscopic studies showed widening of the intercellular space between the epithelial cells and openings of the tight junctions, as well as infiltrations of eosinophils and their granules beneath and between epithelial cells. The tight junction refers to the space between epithelial cells exposed to the airway surface, leading down to the intercellular space. The intercellular space refers to the space between epithelial cells, below the tight junction. Interestingly, eosinophils and their granules were found mainly in the widened intercellular space. The incidence of a widening of the intercellular space was higher in specimens showing eosinophil infiltration than in those not showing eosinophil infiltration. A significant correlation was found between the respiratory threshold to acetylcholine and the percentage of opened tight junctions (r=-0.47, p<0.05) and/or the widening of the space between epithelial cells (r=-0.65, p<0.01). These results suggest that widening of the intercellular space may be caused by infiltrations of eosinophils and that this widening increases bronchial reactivity.View full abstractDownload PDF (1061K) -
Article type: Appendix
1990 Volume 39 Issue 11 Pages 1546-1548
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (275K) -
Article type: Cover
1990 Volume 39 Issue 11 Pages Cover10-
Published: November 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (51K)
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