Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 47, Issue 11
Displaying 1-24 of 24 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1998 Volume 47 Issue 11 Pages Cover4-
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.Cover4
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1998 Volume 47 Issue 11 Pages Cover5-
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.Cover5
    JOURNAL FREE ACCESS
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  • HUMAN ECOLOGICAL VIEWPOINT OF ALLERGIC DISEASE
    Shinpei Torii
    Article type: Article
    1998 Volume 47 Issue 11 Pages 1151-1155
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1151
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  • MOLECULAR MECHANISM OF AUTOIMMUNE DISEASES
    Kazuhiko Yamamoto
    Article type: Article
    1998 Volume 47 Issue 11 Pages 1156-1159
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1156
    JOURNAL FREE ACCESS
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  • HIV/AIDS RESEARCH.THE CURRENT STATUS AND FUTURE PROSPECTS
    Yoshiyuki Nagai
    Article type: Article
    1998 Volume 47 Issue 11 Pages 1160-1162
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1160
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  • FOOD AND FOOD ADDITIVES HYPERSENSITIVITY IN ADULT ASTHMATICS : III.Adverse Reaction to Sulfites in Adult Asthmatics
    Yasuo Arai, Hajime Muto, Yasuyuki Sano, Koji Ito
    Article type: Article
    1998 Volume 47 Issue 11 Pages 1163-1167
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1163
    JOURNAL FREE ACCESS
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    Many studies show that sulfites cause multiple atopic manifestations by oral challenge in USA and Europe, however, there are few reports of sulfites sensitivity in Japan.The aim of this study establishes the presence of sulfites hypersensitivities in asthmatic subjedts in Japan Subjects and Method Twenty adult asthmatic patients, who were non-steroid-dependent and without a suggestive history of sulfite sensitivity, underwent challege with oral solution of metabisulfite.Result Of 12 patients reacted to metabisulfite.They demonstrated airway obstruction 5(41.7%), urticaria 4(36.7%), skin manifestation 2(16.7%)and nasal congestion 1(8.3%).All patients who demonstrated airway obstruction, were sensitive to aspirin.Conclusion Oral sulfite challenge should be made in patients with urticaria, that are not able to find out causative antigen, even though no suggestive history of sulfite sensitivity.
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  • EXPRESSION OF L-SELECTIN ON PERIPHERAL MEMOTY CD4^+ T CELLS IN ATOPIC DISEASES
    Hitoshi Yamashita, Yasuo Tanno
    Article type: Article
    1998 Volume 47 Issue 11 Pages 1168-1175
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1168
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    L-selectin is one of the adhesion molecules, which is known as a leukocyte homing receptor.L-selectin contributes labile rolling adhesion of leukocytes on the blood vessel wall.To elucidate characteristics of L-selectin expression on peripheral CD4^+ lymphocytes in atopic diseases, flow cytometoric analysis was performed.Subjects were 7 patients with atopic asthma(BA), 10 with atopic dermatitis(AD), 9 with allergic rhinitis(AR) and 10 normal adults(control).Peripheral lymphocytes in all subjects were three-color-analyzed using monoclonal antibodies.As a result, compared with the control group, BA and AD showed significantly higher proportions of L-selectin-positive memory CD4^+T cells(BA 64.0%;AD 62.0%;AR 50.9%;Control 38.0%), and significantly lower proportions of L-selectin-negative memory CD4^+T cells(BA 18.3%;AD 11.6%;AR 21.1%;Control 29.2%), respectively(reported percentages represent average values for each subject group).As previously reported, L-selectin-positive memory CD4^+T cells produce mainly Th2-type cytokines(Kanegane et al., 1996);Given these results, the present study suggests that increased Th2-like cells express L-selectin for extravasation in the process of local infiltration in atopic diseases.
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  • APPEARANCE OF OVOMUCOID IN COAGULA EGG YOLK PASSING THROUGH FROM SOLUBLE FRACTION OF COAGULATED EGG WITH IN BOILED EGG
    Kentaro Sakai, Aoi Matsuoka, Yu Ushiyama, Taeko Shimoda, Nobuo Ueda
    Article type: Article
    1998 Volume 47 Issue 11 Pages 1176-1181
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1176
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    Ovomucoid is a egg white protein which has a strog allergenicity with a unique characteristic in heart-noncoagulable one contrast to heat-coagulable other major egg white proteins.By ELISA and immunoblots analysis, ovomucoid was detected in heat-coagulated egg yolk after immediate boiling of hen's egg for 15 min(boiled egg)at the concentration of 4.8±0.8μg/g egg yolk, but not detected in raw egg yolk collected by insertion of a meedle into the egg yolk cavity.Ovomucoid in heart-coagulated egg yolk was increased by standing the boiled eggs at room temperature for 10, 30, 60 and 120 min at the concentration of 7.5±3.4, 17.2±15.1, 28.1±5.9 and 78.8±31.3μg/g egg yolk, respectively. The soluble fraction prepared from heat-coagulated egg white of boiled egg contained 37.7±3.2mg/ml of proteins including 14.2±11.9mg/ml of ovomucoid as a major and miners of detectable ovalbumin and ovotransfferin. Theses results suggested that the appearance of ovomucoid in coagulated egg yolk of boiled egg was due to passing the soluble fraction rich in ovomucoid in heat-coagulated egg white through into the coagulated egg yolk, which may have notable consequences for the present of ovomucoid as a major egg white allergen in yolk egg of boiled egg.
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  • JAPANESE CEDAR POLLINOSIS IN CHILDREN IN OUR ALLERGY CLINIC
    Sawako Masuda, Kazuhiko Takeuchi, Atsushi Yuta, Chikahisa Okawa, Kotar ...
    Article type: Article
    1998 Volume 47 Issue 11 Pages 1182-1189
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1182
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    Recently, it is pointed out that the incidence of Japanese cedar pollinosis has increased in children. We studies on the rate of sensitization and the onset of the disease in children under sixteen who visited allergy clinic in the Department of Otorhinolaryngology in Mie University Hospital.The percentage of positive rate of skin test and IgE antibodies of house dust mite was about 80 to 90% in 1981, 1991, and 1996.However, the percentage of positive rate of skin test and IgE antibodies of Japanese cedar pollen was 43% and 26%, respectively in 1981, but both increased to 58% in 1996.Most of Japanese cedar pollinosis patients also had house dust mite allergy.Among 115 pediatric patients who visited our allergy clinics in the past seven years, 32.2% were allergic to house dust mite alone, 8.6% were allergic to Japanese cedar pollen alone, 40.9% were allergic to both, and 6.1% were allergic to house dust mite, Japanese cedar pollen, and orchard grass pollen.68% of the total 115 patients were boys, but significantly more girls had the pollinosis.17.4% of those who are sensitized to the pollen were asymptomatic during the pollen season.Thus, it was confirmed that the rate of children sensitized to the pollen has apparently increased for the past twenty years.We should take care of those children who are sensitized to the pollen but asymptomatic during the pollen season.
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  • ANALYSIS OF AIR POLLUTION AND PREVALENCE RATE OF ALLERGIC DISEASES AMONG ELEMENTARY SCHOOL CHILDREN IN KAWAGUCHI AND HATOGAYA CITY
    Shoichi Oyama, Noriko Nasuko, Setsuko Tsuchiya, Masaki Tajima, Hitoshi ...
    Article type: Article
    1998 Volume 47 Issue 11 Pages 1190-1197
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1190
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    Kawaguchi and Hatogaya City are located on the northern edge of Tokyo.We analysed between air pollution and prevalence rate of allergic diseases among elementary school children in this area.A prevalence rate of allergic diseases in 1996 May and June was as follows;bronchial asthma 13.5%, atopic dermatitis 24.5%, allergic rhinitis and/or conjuctivities 22.8%, urticaria 12.4%, food allergy 7.8% and drug allergy 2.2%, respectively.Air pollution of this area was analysed to check the levels of nitrogen dioxide(NO_2), sulfur dioxide(SO_2)and suspended particulate matters(SPM).NO_2 pollution was relatively high in urban area, and SPM pollution was especially high around the highways.SO_2 pollution was lower than the environmental standard.No relationship was found between the prevalence rate of bronchial asthma, atopic dermatitis, allergic rhinitis and/or conjuctivities and air pollution, but it was found that these diseases are slightly related to population density(p<0.1, p<0.01, p<0.1, respectively).
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  • CORRELATIONS OF LEUCOCYTE MIGATION ACTIVATING FACTOR WITH INTERLEUKIN-1α, INTERLEUKIN-1β AND TUMOR NECROSIS FACTOR-α IN DRUG ALLERGY
    Naomi Sano, Katsuji Uno
    Article type: Article
    1998 Volume 47 Issue 11 Pages 1198-1204
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1198
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    The pathogenic mechanism of drug allergy was investigated by determining leucocyte migration activating factor(LMAF), interleukin-1α(IL-1α)and 1β(IL-1β), and tumor necrosis factor-α (TNF-α)levels in 13 patients with suspected hypersensitivity to drugs, following stimulation with the relevant agents.LMAF was detected in 10 out of 11 patients in the absence of serum and in 8 out of 9 patients in the presence of serum by means of the leucocyte migration inhibition test(LMIT).The drug-stimulated group had a significantly higher level of IL-1α production than a non-stimulated group, both without serum(p<0.05)and with serum(p<0.05), among patients positive for LMAF.Moreover, the LMAF-positive group had a significantly higher level of IL-1α production than the LMIT-negative group, both without serum(p<0.05)and with serum(p<0.05).In contrast, the level of IL-1β production showed no significant difference, either without or with serum, between drug-stimulated and non-drug-stimulated patients who were positive for LMAF.The production of TNF-α in the LMAF-positive group was significantly greater in drug-stimulated patients than in non-drug-stimulated patients, but only in the presence of serum(p<0.05).However, the level of TNF-α production showed no significant difference, either without or with serum, between the LMAF-positive group and the control group.Our findings suggest that IL-1α may be prominently involved in the production of LMAF in allergic reactions to drugs and that the production of TNF-α may be enhanced in the presence of serum.
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  • TRIAL OF USING HOMEPAGE CUSTOMIZED FOR ASTHMA DIARY
    Naruo Saito, Atsushi Yamamoto, Kazuo Nonomura, Hirofumi Aotani, Morimi ...
    Article type: Article
    1998 Volume 47 Issue 11 Pages 1205-1209
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1205
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1998 Volume 47 Issue 11 Pages 1210-1211
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1210
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  • [title in Japanese]
    Article type: Appendix
    1998 Volume 47 Issue 11 Pages 1212-1213
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1212
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  • [title in Japanese]
    Article type: Appendix
    1998 Volume 47 Issue 11 Pages 1214-
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1214
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  • [title in Japanese]
    Article type: Appendix
    1998 Volume 47 Issue 11 Pages 1215-
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1215
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  • [title in Japanese]
    Article type: Appendix
    1998 Volume 47 Issue 11 Pages 1216-
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1216_1
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  • [title in Japanese]
    Article type: Appendix
    1998 Volume 47 Issue 11 Pages 1216-
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1216_2
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  • [title in Japanese]
    Article type: Appendix
    1998 Volume 47 Issue 11 Pages 1217-
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1217_1
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  • [title in Japanese]
    Article type: Appendix
    1998 Volume 47 Issue 11 Pages 1217-
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1217_2
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  • [title in Japanese]
    Article type: Appendix
    1998 Volume 47 Issue 11 Pages 1218-1221
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1218
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  • [title in Japanese]
    Article type: Appendix
    1998 Volume 47 Issue 11 Pages 1222-1223
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.1222
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  • [title in Japanese]
    Article type: Appendix
    1998 Volume 47 Issue 11 Pages App1-
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.App1
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  • [title in Japanese]
    Article type: Cover
    1998 Volume 47 Issue 11 Pages Cover6-
    Published: November 30, 1998
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.47.Cover6
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