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Article type: Cover
1997 Volume 46 Issue 6 Pages
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Published: June 30, 1997
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Article type: Cover
1997 Volume 46 Issue 6 Pages
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Published: June 30, 1997
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Yuichiro Kamikawa
Article type: Article
1997 Volume 46 Issue 6 Pages
475-482
Published: June 30, 1997
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Atsushi MIyajima
Article type: Article
1997 Volume 46 Issue 6 Pages
483-488
Published: June 30, 1997
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Hideaki Taira, Hidetoyo Teranishi, Yukiko Kenda
Article type: Article
1997 Volume 46 Issue 6 Pages
489-495
Published: June 30, 1997
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The previous years mean temperature of July, total solar radiation of July and August and the male flowering index were used to predict atmospheric pollen counts. We examined the adaptability of these predictions and we get following results: 1. Following good harvest years of male flower, atmospheric pollen counts predicted by previous year's mean temperature of July and the total solar radiation of July and August are higher than the actual atmospheric pollen count. 2. Prediction of atmospheric pollen counts by factors within the previous five years are more exact because matured Cryptomeria forests are increasing yearly. 3. There are few errors in prediction by the flowering index because the flower index reflects the actual harvest of male flower.
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Yuko Takeda, Jun Tamaoki, Isao Yamawaki, Mitsuko Kondo, Atsushi Nagai
Article type: Article
1997 Volume 46 Issue 6 Pages
496-501
Published: June 30, 1997
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To determine the role of neutrophil elastase in allergen-induced airway microvascular leakage, we assessed vascular permeability of guinea pig trachea by measuring the extravasation of Evans blue dye in the circulating blood. Inhalation of ovalbumin (OA) to guinea pigs sensitized with OA caused Evans blue extravasation, indicating an increased microvascular permeability. Pretreatment with ONO-5046, a specific inhibitor of neutrophil elastase, inhibited OA-induced vascular leakage in a dose-dependent manner. Tracheal instillation of human neutrophil elastase likewise increased microvascular permeability, and this effect was almost completely abolished by ONO-5046. Challenge with OA increased the number of neutrophils and neutrophil elastase activity in the bronchoalveolar lavage fluid, and these effects were inhibited by ONO-5046. These results suggest that neutrophil accumulation into the airway and the subsequent release of neutrophil elastase may play a role in the airway microvascular leakage produced by antigen challenge.
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Kuniteru Kou, Masaharu Hayashi, Tadashi Nakajima, Izumi Yoshizawa, Yut ...
Article type: Article
1997 Volume 46 Issue 6 Pages
502-510
Published: June 30, 1997
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Effect of TYB-2285 and its metabolites on immune responses by peripheral blood mononuclear cells (PBMC) from children with bronchial asthma was investigated. TYB-2285 and its metabolites have immunosuppressive activity for the proliferation by Df-stimulated patients' lymphocytes. Concanavalin A (Con A)-activated peipheral blood mononuclear cells (PBMC) from the patients were not affected by the same treatment. The results indicate that TYB-2285 and its metabolites are capable of suppressing antigen-induced 3H-thymidine (^3H-TdR) uptake but not the response induced by Con A. Interferon-γ (IFN-γ) production by Df-stimulated PBMC from patients with active asthma, which was lower than that of normal lymphocytes, were reversed beyond the levels of that in normal subjects. Thus reduced production of IFN-γ by Df-stimulated patients' lymphocytes was increased by TYB-2285 and its metabolites in a dose-dependent manner. This phenomenon was not observed in lymphocytes from normal subjects. Furthermore, TYB-2285 inhibited IL-4 production induced by Df antigen in asthmatic patients' lymphocytes. Taken, together, TYB-2285 could work as a weak immunosuppressant to modify lymphocytes' responses to allergen in patients with bronchial asthma. These data underscore the potential benefit for the patients with bronchial asthma.
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Satoshi Yokota, Takashi Mifune, Fumihiro Mitsunobu, Yasuhiro Hosaki, K ...
Article type: Article
1997 Volume 46 Issue 6 Pages
511-519
Published: June 30, 1997
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To evaluate the effects of complex spa therapy (swimming training in a hot spring pool + fango therapy + inhalation of iodine salt solution) on psychological factors, three psychological examinations; CMI (Cornell Medical Index), SDS (Self-Rating Depression Scale) and CAI (Comprehensive Asthma Inventory); were given 25 patients with bronchial asthma (10 male, 15 female, mean age 60 years), and the results of these examinations were compared before and after spa therapy. (1) Physical symptoms, respiratory system and CIJ symptoms by CMI were significantly improved after spa therapy, however the improvement of psychical symptoms was not significant. (2) In SDS, 11 of 25 patients showed more than 40 points, indicating depressive state. The number of such patients decreased from 11 to 2 and the mean SDS score significantly improved from 38.7 to 34.2 after spa therapy. (3) Conditioning, suggestion, fear of expectation, frustration, flight into illness, negative attitudes towards prognosis, and decreased motivation towards therapy by CAI were significantly reduced after spa therapy, with the reduction in negative attitudes towards prognosis and decreased motivation towards therapy being relatively large. Furthermore, CAI score, which is the average of the categories in CAI, was also significantly decreased from 37.9 to 28.4 after spa therapy. These results suggested that complex spa therapy improves psychological factors in patients with bronchial asthma.
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Mitsuaki Kimura, Satoru Tsuruta, Takami Yoshida
Article type: Article
1997 Volume 46 Issue 6 Pages
520-527
Published: June 30, 1997
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Eosinophils (Eo) are known to play a critical role in the chronic allergic inflammation, featuring pathologically in atopic dermatitis (AD), and the Eo percentage in the peripheral blood is elevated in AD infants (0y) as well as in older AD children (3-15 y). In search of the most important factor in the increase of Eo percentage, we analyse the correlation between the level of Eo percentage in the peripheral blood and the levels of various allergy-related parameters. In AD infants, the level of Eo percentage was found to be correlated most strongly with the level of mite-specific lymphocyte proliferation expressed by S.I.F. (stimulation index measured by flow cytometry) (r=0.88, p<0.001). It also correlated significantIy with the levels of serum IgE (r=0.56, p<0.05), egg white-specific IgE-RAST (r=0.64, p<0.01) and egg white-specific S.I.F. (r=0.59, p<0.02), but not with the levels of mite-specific IgE-RAST or candida-specific S.I.F. On the contrary, the level of Eo percentage correlated most intimately with the levels of serum IgE (r=0.73, p<0.001) and mite-specific IgE-RAST (r=0.71, p<0.001) in older AD children. These results suggest that mite-specific peripheral blood helper T lymphocytes, the proliferation of which is thought to be represented by S.I.F., play a more essential role in AD infants than in older AD children in the increase of Eo percentage in the peripheral blood.
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Article type: Appendix
1997 Volume 46 Issue 6 Pages
528-
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Article type: Appendix
1997 Volume 46 Issue 6 Pages
528-
Published: June 30, 1997
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Article type: Appendix
1997 Volume 46 Issue 6 Pages
529-
Published: June 30, 1997
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Article type: Appendix
1997 Volume 46 Issue 6 Pages
530-533
Published: June 30, 1997
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Article type: Appendix
1997 Volume 46 Issue 6 Pages
534-537
Published: June 30, 1997
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Article type: Appendix
1997 Volume 46 Issue 6 Pages
538-549
Published: June 30, 1997
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Article type: Appendix
1997 Volume 46 Issue 6 Pages
550-551
Published: June 30, 1997
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Article type: Appendix
1997 Volume 46 Issue 6 Pages
552-
Published: June 30, 1997
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Article type: Appendix
1997 Volume 46 Issue 6 Pages
552-
Published: June 30, 1997
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Article type: Appendix
1997 Volume 46 Issue 6 Pages
553-560
Published: June 30, 1997
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Article type: Appendix
1997 Volume 46 Issue 6 Pages
561-564
Published: June 30, 1997
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Article type: Cover
1997 Volume 46 Issue 6 Pages
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Published: June 30, 1997
Released on J-STAGE: February 10, 2017
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