Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 40, Issue 1
Displaying 1-17 of 17 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1991 Volume 40 Issue 1 Pages Cover1-
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.Cover1
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1991 Volume 40 Issue 1 Pages Cover2-
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.Cover2
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1991 Volume 40 Issue 1 Pages App1-
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.App1
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1991 Volume 40 Issue 1 Pages 1-7
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.1
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  • RELATIONSHIP SPECIFIC IgE AND IgG_4 ANTIBODY TO FOOD ALLERGEN AND OTHER ALLERGIC FACTORS IN 0-YEAR OLD ALLERGIC CHILDREN
    Emiko Nakazato
    Article type: Article
    1991 Volume 40 Issue 1 Pages 8-20
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.8
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    We investigated the relation IgE and IgG4 antibody to food allergen and other allergic factors in 94 0-year old allergic children. And then, we compared this result data with the data of allergic children over 2-years old reported before. In 0-year old children, IgE antibody to food allergen and IgE RAST score to egg white were related more tightly to IgE RIST. And the tightness of these factors was 4 times as strong as those in allergic children over 2-year old. This fact was suggested the polyclonal production and induction of IgE antibody in infant children. And IgG4 antibody to food allergen was related tightly to eosinophile counts in 0-year old allergic children. The tightness of 2 factors was about 2 times as strong as those in allergic children over 2-years old. The fact was suggested the necessity of investigation of relationship between 2 factors.
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  • IMMUNOGLOBULIN LEVELS, NUMBER OF EOSINOPHILS IN THE PERIPHERAL BLOOD AND BRONCHIAL HYPERSENSITIVITY IN CHILDREN WITH MYCORLASMA PNEUMONIAE PNEUMONIA
    Toshio Shimizu, Hiroyuki Mochizuki, Masahiko Kato, Makoto Shigeta, Aki ...
    Article type: Article
    1991 Volume 40 Issue 1 Pages 21-27
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.21
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    We studied the immunoglobulin levels and the number of eosinophils in the peripheral blood during the course of Mycoplasma pneumoniae pneumonia in children. Nineteen children with Mycoplasma pneumoniae pneumonia, including eight asthmatic children, were the study subjects. In eight of them, bronchial hypersensitivity was also measured by the Astograph method in both the convalescent phase and the healing (non-symptomatic) phase. The results were as follows. 1) Total serum IgA and IgM increased in the convalescent phase. 2) The levels of total serum IgE were higher in the acute phase and then decreased gradually. 3) The number of eosinophils in the peripheral blood increased over the acute-to-convalescent phase. 4) Bronchial hypersensitivity increased after Mycoplasma pneumoniae pneumonia, and two asthmatic children who exhibited bronchial hypersensitivity had asthmatic attacks. 5) Bronchial hypersensitivity persisted for over one month in two non-asthmatic children.
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  • THE EFFECT OF A SPECIFIC THROMBOXANE A_2 ANTAGONIST, AA-2414 ON AIRWAY HYPERRESPONSrVENESS INDUCED BY OZONE EXPOSURE IN DOGS
    Toshimichi Imai, Mitsuru Adachi, Keizou Idaira, Takao Suganuma, Terumi ...
    Article type: Article
    1991 Volume 40 Issue 1 Pages 28-36
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.28
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    To determine whether thromboxane A_2 (TxA_2) is involved in airway hyperresponsiveness induced by ozone exposure, we studied the effect of a specific TxA_2 antagonist, AA-2414 on ozone-induced airway hyperresponsiveness in seven dogs. Airway responsiveness to inhaled methacholine was determined by modified Astograph (7 Hz oscillation method), and numbers of neutrophils in the peripheral blood, neutrophil counts in bronchoalveolar lavage fluid (BALF), the levels of TxB_2 and 6-keto-Prostaglandin F_<1α> (6-keto-PGF_<1α>) in BALF were measured before and after ozone exposure, and after ozone exposure with pretreated AA-2414. Ozone exposure was carried out for 2hr at an ozone level of 3.06±0.06 ppm (mean ± SE). Airway responsiveness to inhaled methacholine increased significantly after ozone exposure (p < 0.01), and the hyperresponsiveness induced by ozone exposure was inhibited significantly by pretreated AA-2414 (p < 0.01). Numbers of neutrophils in the peripheral blood and neutrophil counts in BALF increased after ozone exposure, and these increase were not inhibited by pretreated AA-2414. There was no apparent change in the levels of TxB_2 in BALF after ozone exposure and after ozone exposure with pretreated AA-2414, however the levels of 6-keto-PGF_<1α> in BALF decreased after ozone exposure and after ozone exposure with pretreatd AA-2414 (p < 0.1) These results suggest that TxA_2 plays an important role in the development of airway responsiveness after ozone exposure in dogs, and ozone-induced airway hyperresponsiveness may not be associated with the hyperproduction of TxA_2 but with the relative increase of TxA_2 due to the decrease of PGI_2.
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  • THE ROLE OF THROMBOXANE A_2 IN THE DEVELOPMENT OF AIRWAY RESPONSIVENESS AFTER PLATELET ACTIVATING FACTOR INHALATION IN DOGS
    Toshimichi Imai, Mitsuru Adachi, Keizou Idaira, Takako Hiyama, Takao S ...
    Article type: Article
    1991 Volume 40 Issue 1 Pages 37-45
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.37
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    To determine whether thromboxane A_2 (TxA_2) is involved in airway hyperresponsiveness after platelet activating factor (PAF) inhalation, we studied the effect of a specific TxA_2 receptor antagonist, AA-2414 on the development of airway responsiveness induced by PAF inhalation in six dogs. Airway resistance and airway responsiveness to inhaled methacholine were determined by modified Astograph (7 Hz oscillation method). PAF inhalation (1000μg/ml, ten miniutes) caused a significant increase of airway resistance (p < 0.01), and the increase of airway resistance was not inhibited by pretreated AA-2414. Airway responsiveness to inhaled methacholine increased significantly 3 hr after PAF inhalation (p < 0.01). Pretreated AA-2414 inhibited the increase of airway responsiveness significantly (p < 0.01), but the inhibition was partial. After PAF inhalation, total cell counts, neutrophil counts, eosinophil counts and the levels of TxB_2 in bronchoalvolar lavage fluid increased significantly (p < 0.05), and these increase were not affected by pretreated AA-2414. These results suggest that TxA_2 is not involved in the bronchoconstriction induced by PAF inhalation, but TxA_2 plays a partial role in the development of airway responsiveness after PAF inhalation in dogs.
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  • RABBIT IMMUNIZATION TO INDUCE EXPERIMENTAL ASTHMA : Relationship Between Antigens and Airway Reactivity
    Kazuaki Inoue, Yasushi Sakai, Ikuo Homma
    Article type: Article
    1991 Volume 40 Issue 1 Pages 46-50
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.46
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    Japanese white rabbits were immunized with either alternaria or ragweed starting at birth to induce experimental asthmatic model. We studied the characteristics of contractile responses of tracheal smooth muscle isolated from these sensitized animals and compared them with non-sensitized control animals. Both sensitivity and reactivity of contraction induced by acetylcholine (ACh) were intreased in the alternaria sensitized group, but only sensitivity was increased in the ragweed group. Contractile responses to electrical field stimulation were enhanced in both sensitized groups, and responses in the alternaria group were significantly greater than those in the ragweed group. In the alternaria group, atropine supressed the contractile response to KCl, indicating that the contraction was mediated partially through a muscarinic mechanism. In the ragweed group, atropine supressed responses to 20 mM KCl. Stimulation of the intramural nerve plexus facilitated the release of neurotransmitters, especially ACh. This was more obvious in the alternaria group than in the ragweed group. These results suggest that alternaria sensitization of rabbits produces a better model for studying changes in interaction between nerves and smoth muscle in the airway.
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  • IMMUNOCHEMICAL QUANTIFICATION OF THE AIRBORNE CHIRONOMID ALLERGENS
    Masatomo Matsuno, Gyokei Murakami, Yuichi Adachi, Yoko Adachi, Masako ...
    Article type: Article
    1991 Volume 40 Issue 1 Pages 51-59
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.51
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    We collected airborne particles in the air using a high-volume air sampler, and measured chironomid allergen in the air-filter extract by use of RAST inhibition assay. The results obtained were as follows: 1) The assay revealed the presence of chironomid allergen in the air varying from 6.8 to less than 0.3 ng/m^3. 2) In Toyama, seasonal fluctuations of airborne chironomid allergen demonstrated some large peaks in summer (Jun to August), and showed a tendency to decrease in winter. 3) There were significant correlations between airborne chironomid allergen and dry weight of chironomid midges, collected by using light traps, in all period of a week just before, 1 to 2 weeks before, 2 to 3 weeks before, or 3 to 4 weeks before air sampling. There were not significant correlations between airborne chironomid allergen and weathers (temperature, wind speed and precipitation) during or just before air sampling. 4) In Toyama, the frequency of asthma attacks in the asthmatic children with positive C.p. RAST was much increased in summer compared with that of the negative, in which the amount of airborne chironomid allergen was increased. These results show that there is large amount of chironomid allergen in the air from spring to autumn, especially large in summer, and it is related for some asthmatics to the increase of the frequency of asthma attack.
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  • REAPPRAISAL OF INHALANT ALLERGENS AVAILABLE FOR ALLERGY PRACTICE IN JAPAN A Need to Increase Allergen Extracts Available for Immunotherapy
    Hiroshi Nagaya
    Article type: Article
    1991 Volume 40 Issue 1 Pages 60-64
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.60
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    In an attempt to assess whether or not the availability of inhalant allergens for diagnosis and treatment of allergic diseases in Japan is adequate, we tested 21 Japanese patients with allergic rhinitis or bronchial asthma against 75 inhalant allergens commonly used in the United States of America. These 21 patients had never lived outside of Japan and came to the United States for the purpose of diagnosis and treatment of their allergic diseases. We determined the importance of each allergen by calculating an allergenicity index. Allergenicity index for a given allergen was defined as a sum of a multiple of each of 4 grades of prick test reactions to the allergen and a number of patients reacting to the allergen with each corresponding grade. Mite had the highest allergenicity index, followed by house dust. All 14 pollen allergens occupying the 3rd through 12th ranks including many grass and weed pollens are not available for immunotherapy in Japan. Japanese cedar pollen which is considered the most important pollen allergen in Japan ranked the 13th. Of a total 25 allergens occupying from the 1st through 13th ranks 22 allergens are not available for immunotherapy including the most important allergen, mite. These results suggest that we should expand the list of allergens available for diagnosis and treatment of allergic diseases in Japan.
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  • AN ELECTRON MICROSCOPIC STUDY OF MIGRATING CELLS IN THE NASAL EPITHELIAL COMPARTMENT OF HUMAN ALLERGIC RHINITIS
    Chen-Hsien Yen
    Article type: Article
    1991 Volume 40 Issue 1 Pages 65-71
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.65
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    Since intraepithelial migrating cells are the first to come into contact with various foreign particles inhaled and deposited on the nasal surface, it is important to study the distribution and function of these cells in the epithelial layer of nasal mucosa. We examined nasal scrapings by means of electron microscopy and electron microscope immunocytochemistry and found that lymphocytes were the major population in the epithelial layer, followed by eosinophils, basophilic cells, globule leukocytes and neutrophils in the order of predominance in patients with allergic rhinitis. However, no significant difference was noted in lymphocyte population between the allergy group and the chronic infectious rhinitis group, While significant increase was found in the normal group than in other two groups. Meanwhile, significant difference of osinophils and basophilic cells were found between allergic group and non-allergic group. Globule leucocytes, characterized by their huge and irregular size and granules, were observed in the allergy group and the implication of their existence was discussed. In immunoelectron microscopic study, CD8 positive cells were more numerous than CD4 positive cells. However there was no relation between the surface marker and ultrafine structure.
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  • DECREASED RELEASE OF LEUKOTRIENE B_4 FROM MONOCYTES AND POLYMORPHONUCLEAR LEUKOCYTES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
    Goutam Pada Shome, Kazuhide Yamane
    Article type: Article
    1991 Volume 40 Issue 1 Pages 72-81
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.72
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    The leukotriene B_4 (LTB_4) releasing capacities of monocytes and polymorphonuclear leukocytes (PMN) were studied using a specific radioimmunoassay in 28 patients with systemic lupus erythematosus (SLE) and 9 normal controls. LTB_4 release from both monocytes (7.3±3.3 ng) and PMN (6.6±3.4 ng) in SLE patients was decreased compared with that (15.2±4.3 ng for monocytes, 20.7±4.5 ng for PMN) in normal controls. There were no differences in the releasing capacities of monocytes and PMN between patients with active and inactive disease. LTB_4 suppressed lymphocyte blastogenesis by PHA-P and induced suppressor cells. The significance of the decreased release of LTB_4 from monocytes and PMN in SLE patients was discussed.
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  • LATE ASTHMATIC RESPONSE BY RECRUITMENT OF HOMOCYTOTROPIC ANTIBODY FROM CIRCULATING BLOOD TO THE AIRWAY WALL IN GUINEA PIG
    Motoyasu Saito, Masaki Fujimura, Yasushi Miyake, Sayuri Sakamoto, Masa ...
    Article type: Article
    1991 Volume 40 Issue 1 Pages 82-86
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.82
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    Many reports have been published about the late asthmatic response (LAR) of animal model. But most of the animals used were sensitized actively and it is considered generally that it is impossible to generate LAR in passively sensitized animals, especially in guinea pig. About the mechanism of LAR, most discussion are focused on airway hyperreactivity, inflammation and chemical mediators. But little is known about the direct initiator of the late phase bronchoconstriction. Instead of the circulating antibody which is generated by antibody producing cells in actively sensitized animals, anti-serum was administered to guinea pigs intravenously as passive sensitization fifteen minutes prior to antigen inhalation. Four to eight hours after antigen inhalation, we investigated bronchoconstriction. Eight hours after antigen challenge, bronchoalveolar lavage (BAL) were performed. In the BAL fluid, macrophages decreased and neutrophils increased significantly. These results suggest that LAR can occur without airway inflammation and the inflammation might be the result of antigen-antibody reaction at the airway wall, and that the direct initiator of late phase bronchoconstriction might be the recruitment of homocytotropic antibody from circulating blood to the airway wall.
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  • [title in Japanese]
    Article type: Appendix
    1991 Volume 40 Issue 1 Pages 87-88
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.87
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  • [title in Japanese]
    Article type: Appendix
    1991 Volume 40 Issue 1 Pages 89-92
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.89
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  • [title in Japanese]
    Article type: Cover
    1991 Volume 40 Issue 1 Pages Cover3-
    Published: January 30, 1991
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.40.Cover3
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