The author examined EEGs of 160 cases of hypertension and found abnormal EEGs in 63.1% of the cases. They were alow activity (17.5%), abnormal fast activity (23.1%), abnormal high voltage (17.5%), abnormal low voltage (8.1%), prominent asymmetry (11.3%) and slowing of alpha activity (18.8%).
The author studied the correlation between these abnormalities and various clinical findings and it was found that EEG abnormalities, especially, slow activity, were related to the following clinical symptoms;
1) brachial systolic blood pressure.
2) brachial diastolic blood pressure.
3) diastolic blood pressure of retinal central artery.
4) arteriosderotic degree of retinal vessels.
5) various neurological symptoms such as mental deterioration, speech disorder, motor paralysis and sensory disturbance.
6) ECG abnomalities suggesting myocardial infarction of coronary insufficiency.
From these results, EEG abnormalities in patieats with hypertension may be related with many more factors than those described in other previous papers (Bagchi et al.; Roberts and Walker; Misao et al. and Kimura et al.).
The presence of various EEG abnormalities in patients with hypertension may be resulted from varied cerebral blood flow, abnormal functioning of cerebral vessels, cerebral bleeding, cerebral anemia and softening of the brain. As the EEG's slow activity in hypertension is connected with diastolic blood pressure, arteriosclerotic findings and various clinical symptoms, the author concluded that hypertensive cerebral damage and cerebral arteriosclerosis are important factors that cause frequently slow activity of EEG.

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In order to bserve the effects of hot-spring bath upon the cutaneous connective tissue, its permeability subsequent to bath was investigated in rabbits, by means of examining the dispersionof dye stuff.
1) In the preliminary test, conspicuous difference was observed between the group of Hyalmonidase and non-hyaluronidase group, the control.
2) As for simple-water bath, the rate of dispersion of dye in hyaluronidase group was low compared to the normal condition with hyaluromidase, on the other hand, the rate of dye spreading without hyaluronidase was high comparing to the normal condition without hyaluronidase.
3) As for the Yuda hot-spring bath, we could not find remarkable difference than the simple bath, but the decreasing rate of dye dispersion was between the rate of normal condition and the simple water bath. The activity of hyaluronidase was highly restficted than in case of the simple bath.
4) The similer test was performed with Yuda hot-spring water in which hyaluronidase was solved. The result of simple bath was almost the same with the rate of dispersion of dye solved in distillated water. The rate of dispersion of dye by Yuda hot-spring bath was almost the same with the dispersion rate of dye solved in hyaluronldase and distillated in Yuda hot-spring bath, furthermore, Yuda hot-spring water restricted the activity of hyaluronidase directly.

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The authors used radioactive colloidal gold (Au¹⁹⁸) in 8 cases of breast cancer for the purpose of preoperative radiation. The colloidal gold, injected into breast deposited in subcutaneous tissues and fatty tissues of breast, resulting black-purple staining, and reached at axillary lymphnodes, coloring them black-purple, thus facilitating the detection of lymphnodes at the time of radical operation.
With proper care, by the injection, colloidal gold distributed almost uniformly in breast. By injecting 50mc of colloidal gold, the radiation dose in the central part of breast reached at 7, 500-15, 200 rep of β-ray, and 1, 370-2, 250r of γ-ray, and the axillary lymphnodes received 130r of γ-ray, and about the half of them irradiated by β-ray in the dose of more than. 7, 600rep. The radioactive gold deposited also in the metastasied lymphnodes and gave 35, 000rep of β-ray, when they had not been filled up completely with cancer cells.
By histological examination, the colloidal gold in the breast was recognized as particles, mostly phagocytized by histiocytes. These particles accumulated in lymphatic vessels around blood vessels and mammary glands, intruding into connective tissue of the cancer. Inflammation was marked around the deposited gold particles, where epithelial elements showed irregularity of arrangement, atrophy and degeneration, and the blood vessels showed severe arteritis. The cancer cells were also heavily injured, showing atrophy, clunping and destruction of nucleus, and formation of vacuoles and giant cells. Particles of gold in lymphnodes were present in lymphsinuses and mostly phagocytized by sinus endothels and reticulum cells. Destruction of lymphatic tissues and lesions of blood vessels were noted. Metastatic cancer cells in nodes were also injured by radioactive gold in the same manner as in the prlmary focus. By microscopic examination, density of distribution of these partlcles in tissue was in parallel to the blackening of the film in autoradiogram, thus in case of gold (Au¹⁹⁸), distribution of radioactive substances in tissue could be demonstrated without using autoradiography.
Preoperative irradiation with Au¹⁹⁸ for breast cancer brought no significant colmplication and no marked change in blood picture, and gave considerably large radiation doses to breast and axillary glands, showing typical radiation effects, in histological pictures. We may expect the preventive effect by this method against recurrences and metastases of cancer in postoperative period.

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The preseat paper deals with the ventilatory function in pulmonary tuberculosis. Effects of various collapse procedures, such as pulmonary excision and irreversible lung after pneumothorax were observed. The subjects were 81 men and women, admitted to the Umemori Kofuen National Sanatorium Benedict-Roth's spirometry was used for spirometry and maximum breathing capacity.
The patients, who had minimal pulmonary lesions showed generally norlmal condition of pulmonary function. It seems that minimal lesions do not give any effects for the function.
Great varieties were seen among cases of moderately advanced tuberculosis. Total lung capacity and vital capacity were redused, but residual volume increased in all cases. The residual volume in % of total lung capacity became higher. Reduction rate of maximal breathing capacity and vital capacity were in parallel. Intrapulmonary mixture of gases was a little high grade.
These results may be due to the larger extent of lesion and distrubance of pleura and diaphragm. The effects upon ventilatory function were slight, even when extrapleural pneumothorax had been performed. As collapse is of reversible nature, extrapleural pneumothorax should be carried out successfully, even if the patient has lesions in the contralateral. This adventageous fact was also shown in pneumoperitoneum even after deeping diaphragm at high position. However, pneumoperitoneum with phrenic crush showed reduction of vital capacity.

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PZA-INH or PZA-IHMS combined therapies were given to 18 pulmonary tuberculosis cases. In 12 cases out of the total 18 cases, liver and kidney function tests were conducted repeatedly.
PZA-INH combined therapy (7 cases) and PZA-IHMS combined therapy (5 cases) were continued for 4 months by the following proportions:
The liver function test was conducted every two weeks. The test included the following items: urine-urobilinogen; icteric index; BSR clearance; thymolttlrbidity test; cephalin-cholestero1-floculation test; cobaltreaction; and plasma protein level. Furthermore, the following tests were also made to facilitate the study: Hijmans Van den Berger reaction; serum alkali phosphatase; Plasma cholesterol level; and plasma protein fraction (Tiselius).
The kidney function test was made every month comparing the results with the test before the administration. The test induded the following items: glomerural filtration rate; renal plasma flow; renal blood flow; filtration fraction; PSP clearance; and Fischberg test.
The results are as follows:
1) In one case, symptoms of jaundice were noticed after 10 weeks of the administration. Examination of sample by the function test and aspiration liver biopsy indicated the possibility of the growth of hepatitis by PZA. Histologically, subacute nonspecific hepatitis was seen in tissue system.
2) By the liver function test in 11 cases (excluding 1 jaundice case), the following temporary tendencies were noticed at 6 to 10 weeks after the administration: BSP dye retention; and icteric index elevation.

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The present paper deals with the streptomycin-resistant tuberculin (SM-RT) made from streptomycin-resistant tubercle bacilli through the same method as that of old-tuberculin, and its comparison with the Hokken-tuberculin as to the antigen specificity, hemagglutination and precipitation.
1. Skin test: No difference was found between SM-RT and Hokken-tuberculin in their reactions in tuberculous patients, in rabbits and in guinea pigs, infected with TB. (The reaction seems not to be related with SM-resistant degree)
2. Hemagglutination test: In 116 patients with positive tubercle bacilli in sputum, the reaction of Hokken-tuberculin was not found to have any relation with SM-resistant rate of tubercle bacilli, on the other hand, the reaction of SM-RT had close relation with the rate. In SM-sensitive cases, it was negative and in resistant cases, generally it was positive.
In rabbits, infected intravenously with strain of H37Rv or SM-resistant tubercle bacilli (10γ, 1, 000γ), the reactions of the both tuberculin were observed for 4 months. The reactions were in parallel to the amount of viablebacilli and reaction curve reached at the highest by 3 weeks and descended gradually after 4 weeks. There action of SM-RT was negative in rabbits, infected with H37Rv, and it was positive in rabbits, infected with SM-resistant tubercle bacilli. Generally, SM effected decline of the reaction. However, in rabbits, infected with SM-resistant tubercle bacilli, SM prevented the decline, and INH had effects to prevent that.
3. Precipitation test: No difference was found between there actions of SM-RT and Hokkentuberculin in the serum of tuberculous patients and of rabbits, infected with the said tubercle bacilli. Positive serum to one tuberculin was also positive to the other.
The SM-RT antigen may be assumed to be specific to SM-resistant tubercle bacilli. In the serum of SM-resistant cases, speclfic antibody responsive to SM-RT seems to be present.

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[in Japanese]

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[in Japanese]

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