On the purpose to know the autonomic nervous functions of the essential hypertension, changes of the blood pressure, EEG and GSR by administration of chlorpromazine were studied in this report
Materials and methods: 24 cases of the essential hypertension containing II type of Keith-wagener's classification 6 cases, III type 13 cases and IV type 5 cases ranging 40 to 60 years of age and as control 7 cases with normal blood pressure were used. Each cases was administered 25mg of chlorpromazine intramusculary, and before and after injection blood pressure, EEG and GSR were examined.
Results:
1) The blood pressure: Although slight decreae of systolic and diastolic pressure were appeared in cases with normal blood pressure, significant decrease were seen in the hypertensive patients after 20 minutes of chlorpromazine injection.
2) EEG: There were slight increase of α-waves and decrease of β-waves both in normal adults and hypertensive patients by chlorpromazine injection. Therefore marked change of cortical function was not seen.
3) GSR: In spite of no significant changes by chlorpromazine administration in normal adults, disappearance of GSR were seen in a half of hypertensive patients.
Conclusion:
Because marked decrease of the blood pressure and significant depression of GSR were observed in hypertensive patients compared with normal adults, the blood pressure and the autonomic nervous function in the essential hypertension are estimated were unstable than normal.

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E. coli obtained from appendix, caecum and stool in 137 cases of appendicitis patients were chiefly examined.
The character of isolated microorganism, especially the type of E. coli was studied, and the problem of distribution of E, coli in intestine are investigated. Beside E. coli, other microorganisms isolated were also studied.
In 11 cases, contents of caecum were obtained aseptically by double-tube method and yielded to culture.
In 52 cases serum agglutination titre to E. coli was estimated.
The results of the experiments were as follows;
1) Twenty eight types (53 strains) of different E. coli and 72 strains of non-typable E. coli were isolated from the contents of 104. Appendix out of 126 cases.
Sixty two point two percent of typable E. coli distributed within the types O-1-O-25 averagely.
2) Fifty different types of E. coli (109 strains) were isolated and non-typable 206 strains were also isolated in 126 cases from stools. The distribution of 45.9% of typable E. coli proved within the types O-1-O-25.
3) In 11 cases different 7 types of E. coli were isolated 7 strains, and non-typable 6 strains were also isolated from caecum, 42.8% of typable E. coli was distributed within the types O-1-O-25.
4) The types of E. coli which were obtained from each portions mostly belonged to different ones. This fact was also observed in non-appendicitis cases.
5) The serum agglutination titer to E. coli were compared on patient in admittance and discharge from hospital, but no definite conclusion was obtained.
6) The microorganisms isolated from the contents of appendix in pure culture and their frequency were as follows, E. coli 32 cases (25.4%), Ps. aeruginosa 5 cases, Strept. faecalis 4 cases, Klebsiella 2 cases, Strept. haemolyticus 1 case, Shigella 1 case, and the total was 45 cases.
No specific types of E. coli or microorganism were obtained from the contents of appendix. The frequency of E. coli in pure culture which was considered as normal non-pathogenic microorganism was predominant, so the character of inflammatory origin of E. coli will be reported in the next experiment.

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The author previously reported Ultramicro-Ca⁺⁺-Azotmetry (AZM).
As its application, the present study is the divising of the method for Cap t determination in the urine and the serum.
In case of the serum, it is necessary to eliminate the protein by the use of trichloroacetic acid, because trichloro-acetic acid liberates calcium from protein-bound-calcium. Needless to say, this method is for the determination of total calcium in the serum.
In any case of serum or urine calcium determination, PH are adjusted to 5 as well as Ultramicro-Ca⁺⁺-AZM.
It is considered that this method has several excellent points as follows.
1) Only about 0.05ml of urine or serum is needed.
2) By this method, 10-3γ of Ca⁺⁺ can be determined with high accuracy (with possible error of never more than 3%).
3) Simple procedures and no special reagents, are necessary.
Ultramicro Urine and Serum Ca⁺⁺-AZM can be applied to the clinical examination of the substances to be tested on all living body.
Particulary, it is considered that this method is suitable for the routine work in case of microquananties and high accuracy to be requested.

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Sixty eight cases of pulmonary tuberculosis in the children of school age were studied. According to Oka the pulmonary tuberculosis is classified as follows; a) primary pulmonary tuberculosis, type I, b) disseminated pulmonary tuberculosis, type II, c) apical pulmonary tuberculosis, type III and d) infiltrative pulmonary tuberculosis, type IV.
Results
1) Patients of type I were characteristically predominant, while the number of the patients of type II, type III and type IV were found increasingly with age in that order.
2) Looking different from cases of adult tuberculosis, cavities were more frequently located in the hilar regions. This fact was also understood by us with a fact that tuberculosis in the children of school age was mostly belonged to type I, the primary tuberculosis.
3) Chemotherapy was remarkably effective for these patients with cavities and this treatment disappeared all of the cavities within 3 to 6 months.
4) Medical screening performed in school seemed to have an excellent and favorable influence for prognosis of the pulmonary tuberculosis in the children of schoolage.

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It has been previously reported that OMK reaction which is based on the specific tuberculosis hemagglutination reaction established by Middlebrook-Dubos is available for the determination of tuberculinlike substance in urine.
In this experiment, the determination of low-concentration tuberculin by hemagglutination was studied for a basis of OMK reaction.
The agglutination of human O-type erythrocytes sensitized with low-concentration old tuberculin (OT) was examined by goat sera which reached to the high titer of 1:20, 480 in Middlbrook-Dubos' reaction.
By the use of hole-glass m ethod which was previously reported, there ob served not so constant reappearance. This irregularity of the reappearance was likely due to the individuality of erythrocytes in the response to sensitization with OT, or due to the difficulty in the reading of endpoint, which derived from a “stick” phenomenon, namely a sticking of erythrocytes to the bottom of hole.
By the addition of casein in a concentration of 0.01 per cent to the dilution medium (isotonic phosphate buffer) of antisera, the “stick” phenomenon was completely prevented, and became possible to read the endpoint very distinctly. Consequently, the constant reappearance of reaction became to be observed. Therefore, the individual difference in erythrocytes might not be considered.
The sensitivity of erythrocytes to tuberculin also was increased by diminishing their mixing rate to OT solution.

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Several investigators have shown that combination of Isoniazid plus glucosamine hydrochloride gave the high blood concentration of Isoniasid. Thirteen patients with far advanced pulmonary tuberculosis were selected in order to observe the effects of Isoniayid-glucosaniine therapy during six months.
1) Roentogenorams reveald evidence of effects in 3 cases, no changes in 10.
2) Two cases with positive sputa at the beginning of treatment became negative.
3) No remarkable side reactions to the drug were observed.
In some severe cases, it seems to us that effects of this treatment are hopeful ones.

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The patient, 50 years old female, suddenly suffered from pain in the chest and back followed by rapid development of long tract signs. The post-mortem examination revealed rupture of malformed blood vessel in the posterior tract of the 9th thoracic cord resulting hemorrhage which spread in few segments up and down. Multiple malformations were also noted throughout central nervous system and adrenals,

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A long-term results for 5 to 12 years on 129 cases of schizophrenic lobotomized patients at the Shimofusa National Sanatorium during 1948-1955 were followed.
Results
1) By remission discharged from hospital, 34.8%; with remarkable effect engaging in house work or occupation, 100%; working under the care of family, 3.8%. Totally 13.8% of the all cases were found to have certain favorable effects of lobotomy.
2) 55.8% of the patients are still hospitalizing, however, some of them responded to shock therapy to which before lobotomy they did not respond.
3) Cases within five years after onset the lobotomy were effective.
4) Among similar types of heredity the resssion form had relatively respond,
5) Operative death, 3.3%; temporary convalsion, 4.8%; convalsion still seen, 3.1%; urinary incontinence, 10.8%; (most cases were temporary and still seen, 10.9%). No other complications were seen.

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