This paper summarizes clinical, cytologic and biochemical investigations of five cases of Hurler syndrome and three cases of genetic mucolipidoses.
The urine from children of Morquio syndrome showed excessive amount of all acid mucopolysaccharides which have been found in urine of normal children. In Scheie syndrome all of the acid mucopolysaccharides with the exception of chondroitin sulfate C and A are excreted in excess.
On the other hand, urinary mucopolysaccharides of Gml-gangliosidosis, Type I were studied.
Although no increase of cpc-precipitable fraction was detected, in contrast, a large amount of non cpc-precipitable fraction was demonstrated.
A case of new mucolipidosis with β-galactosidase deficiency and excessive excretion of noncpc-precipitable fraction was reported. Furthermore, a case of I-Cell disease with corneal opacity was also reported.

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The clinical, rentgenologic, laboratory findings and treatment of 39 patients with pulmonary aspergillosis admitted to Muramatsuseiranso National Sanatorium have been reviewed.
1) general description
The number of cases per year was generally 2 to 8 during the period from 1957 through 1968.
This figure suggests that pulmonary aspergillosis is rare disease, and does not indicate an annual increase of this disease.
Most of them were found in the course of the treatment of pulmonary tuberculosis for 3 to 10 years. All except one showed an aspergilloma on chest X-ray film. Five cases accompanied with non-tuberculous changes also showed an aspergilloma.
No significant difference between both sexes was observed. The more cases were found rather in higher age.
The basic changes of them were pulmonary tuberculosis or pulmonary cysts or bronchiectasis.
All of the aspergilloma were suprophytic.
2) chest X-ray findings
The key point of the rentgenologic diagnosis is to inspect an open healed tuberculous cavity of the lung and bronchiectasis. The tuberculous changes in the background field were cicatrization or fibrosis lacking in perifocal opacity. In some cases the cavity showed diffuse opacity at the beginning of the disease.
The rentgenograms of some types of aspergilloma were presented.
3) clinical symptoms and the results of laboratory examination
Although hemoptysis was common at the time of the confirmation of an aspergilloma on the chest X-ray film, it was unlikely that the hemoptysis attribute to the development of an aspergilloma. Usually sputum culture for tubercle bacilli were negative at this time. It was noticeable that a typical conidiophore and vesicle with sterigmata was not found in resected fungus balls except one which was obtained from a big well airated cyst. All except one aspergillus cultured from sputum or resected fungus balls could be classified in Aspergillus fumigates group.
4) treatment
Pulmonary resection or cavernostomy were performed for 27 patients out of 29 cases. Eight out of 12 conservatively treated cases died of cardiopulmonary insufficiency caused by their previous pulmonary tuberculosis or other diseases which were not related to the aspergilloma.

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It is difficult to diagnose porphylia with absence of special color of urine. We experienced cases of two sisters, in whom little sister was involved first and started with abdominal aching and received operation twice, then she had diagnosis of polyneuritis, anorexia nervosa and finally was diagnosed as myogenic disease. Before her death, elder sister started to have sign of port wine colored urine, thus she was diagnosed as porphylia. This elder sister also had abdominal aching and sensory disturbance of both legs with dysesthesia, so that she was diagnosed as SMON. She was admitted to the another hospitals several times and transfered to us.
Case one, A 34-years-old lady had stomachache in April, 11467 and received surgery with diagnosis of appendicitis, after which once or twice a month she had had abdominal aching and pollakiuria with fever. She had diagnosis of acute nephritis and was admitted to some hospital. But she had second operation with diagnosis of post-operative adhesion of the intestin. After then she lost appetite and developed sensory disturbance of hand which spread over abdominal wall and she was transfered to the medical department of our hospital. At this time she had slight pain at extremities and muscle atrophy. A couple of weeks later she developed nausea and vomiting whenever she saw the meal. She got diagnoses of pyelonephritis, myopathy, polyneuritis and anorexia nervosa. She had several investigations and treatments, and was discharged in improved state in Jan., 1968. At that time she had no sensory or motor disturbance, and she could stand and walk well. In Feb., 1969 she had abdominal aching, lumbago, pain of legs and muscle atrophy. She was admitted to some other hospital without diagnosis and transfered to the neurological department of our hospital. She had no abnormal findings in spinal fluid except increased pressure. She had no change in liver function test and urinalysis. She was diagnosed as polyneuritis, and improved in one month, when her eider sister started to have symptom and visited us.
Case two, A 36-years-old lady developed fever, abdominal aching and constipation in March, 1999. She was admitted in some hospital for two months. She had sensory disturbance, slight pain in both legs and feet. In July, 1969 she developed stomachache, sensory disturbance of legs and difficulty of walking. She had diagnosis of SMON (subacute myelo-optico-neuropathy), then admitted to our hospital in Oct., 1969. She had weakness of grip, sensory disturbance of the upper and lower extremities, difficulty of walking and standing. Tendon reflex of the upper and lower extremities were lost, but no pathological reflex was elicited, In urinalysis urobilin and urobilinogen were positive. Several days after her urine showed port wine like red color, Then by examination of PBG, they were diagnosed as porphylia.
In the hereditary investigation, we found four PBG positive cases in their family including those two patients. But this two other cases showed no sign or symptom.

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One hundred new patients with amblyopia and squint were recorded in the Amblyopic and Squint Eye Clinic of the Zentsuji National Hospital, during the last ten months. They were examined and then treated. The data obtained were analysed from various stand points.
The results could be summarized as follows:
1) The rate of the patients with amblyopia or squint was 6.1% to the total of the new patients who visited the eye clinic.
2) The age of the patients with amblyopia was 5 to 7 years old in about half of them.
3) Refractive state of binocular amblyopia were severe state of hypermetropia or astigmatismus mixtus.
4) Amblyopia was severe in the patients with monocular amblyopia.

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1) Since last February, 1970, survey of both Au-antigen and Au-antibody have been checked as routine examination in our hospital. Examined sera were 22, 571 in total number, which were taken from 9, 440 patients. Similar detection were proceeded about 685 sera from bottle blood for transfusion. Among these sera, Au-antigen was found to be present in sera of 517 materials, and 171 cases. As for blood for transfusion, Au-antigen was recognized to be positive in 11 cases.
2) Sensitivity of micro-Ouchterlony method shows not much difference, as it is generally mentioned, from other precipitation test in Gel, but the method shows in suitable condition almost similar sensitivity as immunoelectrosyneresis and single radial immunodiffusion methods.

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