Research has been done by the author on the change of the Plasma Prothrombin Time of rabbit's blood obtained by means of cardiac puncture when the rabbits are shocked with various methods. Kato's micromethod was applied and the Prothrombin Index was calculated according to the following formula:
Injections with several kinds of drugs were given to the rabbits before they caused shock. Then each Prothrombin Index at the time of the shock was examined. In an attempt to find out the most effective drugs to control the shock, the following experiments were performed and obtained results were as follow:
1) When no shock is given the Prothrombin Index shows very little change in the course of 30 minutes to 5 hours. However, the Index decreases after 24 hours through 48 hours.
2) In cases of traumatic shock such as injury shock, burn shock, as well as drug shocks such as peptone, acetylcholine and histamine shock, the Prothrombin Index increase is the greatest during the 30 minutes after the shock. After 5 hours of shock the Prothrombin Index decreases steadily and gradually. In case of tourniquet shock, for 30 minutes after the shock the Prothrombin Index did not increase, then it decreases gradually. The acetylcholine-and histamine-shock show little change in the index. The change of Prothrombin Index during tourniquet shock, burn shock, acetylcholine and histamine shock are parallel in degree to the stresses given previously.
3) Before rabbits are shocked various kinds of drugs were administered. Comparison of the Prothrombin Index curve with drugs and the non-shocked curve are made available. +++ indicates markedly effective, ++ effective and + slightly effective. Obtained results are as follow:
Summarily VB₁, VC and V. P. seemed to be most effective drugs.
4) In case of traumatic shock in which the rabbit was administered solutions of VB₁, VC and C. P.; a marked controlling effect was observed. With the drug no marked control was observed.

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Five cases of brain injury in the 2nd world war (1937-1945), who have been keeping alien substances in the brain substance were followed for 10-20 years with details.
1) The first case had a blinding bullet wound in the left parietal lobe. His general condition, after 20 years, was almost unchanged in comparison with that of some years after wound.
2) The 2nd case had a piercing bullet wound in left temporal lobe. His conditions became a little worse in 19 years.
3) The 2nd, 3rd and 4th cases had a blinding bullet wound of right temporal lobe. Their conditions became worse between 15 and 18 years.
4) The 5th case had a splinter wound from a hand-grenade in left temporal lobe. His general condition after 10 yers was worse.

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La vésiculographie est pratiquée par v. Bügner (1901), par Pick (1912), par Belfield (1913), par Thomas et Pancoast, et par Young, etc, et, au Japon, par Yanagihara et Miyata (1927), etc.. Les vésiculogrammes sont étés classifiés par G. Pallin (1901), par R. Picker (1911), par Goto (1930), par Yanagihara et Miyata (1935), par Yamamoto et Kojima (1938), par Tobari (1938), et par Imaizumi et Yamasaki (1942). Bien que les recherches sur la vésiculographie soient mis en pratique par ces plusieurs savants, on ne peut pas dire qu'elles épuisées.
Nous aeons classifié les vésiculogrammes pris Bans notre clinique en 6 types, c'est-àdire: 10 type de Ia ligne directe ou de la tache du point, 20 type du vaisseau principal gros et sinueux sans diverticul, 30 type du vaisseau principal gros et sinueux avec diverticul, 40 type du vaisseau principal délicat avec diverticul, 50 type du vaisseau principal avec diverticul comme une grappe de raisin, 60 types de la tache inclassable, Ces types n'ont une relation avec les âges ni les maladies, ils sont plutôtpropre aux chaques individus. Au-dessus de les vésiculogrammes, ses grandeurs (longueur et largueur) et les angles d'inclination ne sont pás égals àu coté droit et àgauche.

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For the purpose of investigating the prognosis of tuberculous pregnant women undergoing chemotherapy, comparative studies were made periodically on vital capacity, erythrocyte sedimentation rate (referred as ESR, hereafter), bodyweight and excretion in tuberculous pregnant women and in 10 control healthy pregnant women from the 6th month of pregnancy to 12th month post partum. As a result the following conclusions were obtained: 1) Vital capacity and ESR.: In the healthy group (A) and in the tuberculous group (B) both the indices changed almost in parallel during the whole course of the experiment.
2) Body weight: Until the 6th month of pregnancy body weight changed almost in parallel in (A) and (B) groups. However, 12 months after delivery a slight increase was noted in (A) group, while the minimum value during the whole course was encountered in (B) group. On the other hand, a tendency of body weight to fall was manifested in both the groups during the period of childbirth and of succeeding lactation and puericulture.
3) Roentgenography of the chest: (B) group consisted of one moderately advanced case and 9 minimal cases according to the classification of the N. T. A., the former having a solitary cavity of the size of a pigeon egg. One year after delivery the moderately advanced case revealed an exacerbation, while out of the 9 cases of minimal disturbances 4 showed an improvement and 5 were unchanged.
4) Examination for mycobacterium tuberculosis: In all of the 10 cases of (B) group negative results were obtained with smear preparation, but many colonies were detected from the moderately advanced case and 1/2 colony was found from one of the minimal cases by means of culture method. As for the process thereafter the moderately advanced case demonstrated no change until 12 months after delivery, while one of the minimal cases turned negative from the 8th month of pregnancy. The other 8 cases were negative throughout this experiment.
5) From the result obtained in the present experiment it was found that the prognosis of the 9 tuberculous pregnant women undergoing chemotherapy, excluding the one case of the open tuberculosis with a cavity, was good at least 12 months after pregnancy similarly to that of healthy pregnant women.
6) The type of pulmonary tuberculosis is, of course, an important factor determing the prognosis of the tuberculous pregnant female.
However, attention should be paid to the fact, hereafter, that such unch unfavorable living conditions as overwork or deficiency in nourishment and sleep during the period of parturition and puericulture is another factor influencing the prognosis for a long period after delivery.

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Examinations were made on pulmonary tuberculous patients who had either hyper- or hypo-thyroidism. The main symptoms of hyperthyroidism among the above mentioned patients were tumor, nervousness, palpitation, hyperthidrosis, dyspnoea, body weight loss, weakness, goiter, etc. Whereas, the main symptoms of hypothyroidism were pallor of skin, loss of hair, pallor of lips and menorrhagia etc.
The appearance of the above thyroid disturbance was seen more frequently among patients whose tuberculous conditions were serious, the patients whose process and prognosis wore werse than the others, and the patients who were treated with larger doses of PAS. This tendency was noted among hyper-and hypo-thyroid patients.

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It has been said that the prominence of Löwenstein-Jensen's medium (L-J) in the culture of tubercle bacilli is essentially based on the potato flour in it. It was reported by Saito et al. that they made a new 3% KH₂PO₄ egg medium with potato flour (AEP), by adding 5% potato flour to Ogawa's medium, and this AEP proved much better than any of Oka-Katakura's, Ogawa's or L-J's medium. We made quantitative cultures of the sputum from 114 tuberculous patients using AEP, Ogawa's and L-J's medium at the same time.
Comparing the results from these pure cultures the following observations were made:
1) AEP was superior than Ogawa's and L-J's medium in the rate of positivity, the growth and the rapidity of the growth of bacilli, and the number of the colonies.
2) In the rate of contamination AEP was a little less desirable than Ogawa's or L-J's medium.

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The mission of our medical institution is basically to treat pulmonary tuberculous patients. However, due to the submountain location of the sanatorium, which is far from the town, the sanatorium has had many opportunities to see patients with various kinds of diseases. In other words, the sanatorium has played a role as an emergency hospital.
The author reports statistical analysis on 170 patients mostly of bone and joint injuries from January 1, 1953 to December 31, 1958. Simultaneously, the author desires that a review and discussion be made by the readers on what the sanatoriums in the similar enviroments should do when they meet with the same difficulties.

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