1) The fact that diabetes mellitus was often accompanicd with liver cirrhosis had been observed by many clinicians. We surveyed and analyseb about occurrences of fatty liver anb liver cirrhosis in associated with diabetes mellitus.
Practically the history of hepatitis or alcoholism was significant factors to diabetogenic liver damage. In the series of needle liver biopsies of 8 diabetics, 2 patients who had obesity and disturbance of BSP excretion were disclosed as fatty liver.
2) During the period 1956 through 1953, accompanying liver cirrhosis among 162 diabetic patients, was found in 9 cases (5.6%), including liver fibrosis. Most of them was confirmed by needle biopsy and autopsy. There were evidence on histological findings in one of them as heochromatosis, 3 as septal cirrhosis and 3 as posthepatitic cirrhosis. On the other hand, 6 cases had history of hepatitis and 5 were alcoholics, and nutritional factor may be not negliable in the course of cirrhosis developing from diabetics.
3) In 83 cases who diagnosed and treated as live rcirrhosis among the above period, 7 diabetics (7.9%) were detected. Three cases of diabetes mellitus (6.1%) were identified from 49 cirrhotic patients at autopsy since 1946, and 12 autopsy cases of the diabetics informed complication of liver cirrhosis in 3 patients (25%).
4) In 2 diabetics combined with hepatitis, one of them showed remission of diabetic manifestation pararelling to improvement of jaundice, and clinical course of the others was indifferent to development of hepatic injury.

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Brain waves of 60 male and 55 female diabetic patients were recorded, Of these 115 cases, abnormal brain waves were noted in 55 cases; i. e. 30 cases (26%) with markedly slow waves, 18 with slightly slow waves and 5 cases with spike. Borderline abnormalities were observed in 10 cases and the remaining 52 cases were normal.
The correlation between the EEG abnormalities and clinical findings were studied. In the younger age group less than 29 years of age, 7 out of 8 cases were found to have abnormal waves. Abnormal waves were frequently observed inn cases with loss of KJ and also in cases with positive EKG under st ress. Brain waves were often abnormal in cases with positive CCF in liver function test.
To pursue the origin of these abnormal brain waves, 40 cc of 50% glucose I.V. was given in 11 cases demonstrating abnormal waves. The blood sugar level prior to and following glucose administration were determined and EEG was taken continuously. In 5 cases there was a decrease in slow waves by glucose administration, but no remarkable change in slow waves was noted in 6 cases, In all the cases showing a decrease in slow waves, there was loss of KJ and in the group showing no remarkable chang in slow waves only one case demonstrated loss of KJ. Moreover, the group showing a decrease in slow waves showed marked elevation of blood sugar following glucose administration, but the elevation rate was lesser in the group showing no remarkable change in slow waves. In the group showing a decrease in slow waves the EEG abnormality prior to glucose administration was more remarakble than that of the group showing no remarkable change in slow waves.
In view of the foregoing, it was assumed that the marked slow waves of diabetic patients are an indication that brain cells cannot perform their normal function unless more glucose is supplied, because the glucose uptake rate of the brain or nerve cells is reduced even though the blood sugar value is high.

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During the past 5 years 8 to 14 patients (1.01-1.85%) of 803 to 890 hospitalized pulmonary tuberculouss patients in our sanatorium had been combined with diabetes mellitus yearly. The percentage of this complication at the date of 1st July, 1964 was 2.9% (14 out of 479 patients). The yearly value of this percentage did not show a remarkable change and there was no difference with sex distinction.
In 21 of 26 pulmonary tuberculous patients with diabetes, the onset of diabetes was more than 30 years old; 7 of 26 patients (27%) had been suffering from diabetes before the onset of pulmonary tuberculosis (J group), 5 patients (19.2%) suffered from both diseases at the same year, and 14 patients of them (53.8%) suffered from pulmonary tuberculosis before development of diabetes (III group) . That the 3rd group has a majority in these patients is due to the insufficient urinalysis and to that the patients in this study were all admittedd in tuberculous sanatorium. In the 3rd group the onset of diabetes had not been related exactly with obesity nor antituberculous drugs.
The yearly percentage of the patients with occasional or renal glycosuria during the past 5 years was about zoo until 1962, but increased to about 5% in 1963. Of these actual 98 patients with occasional glycosuria, 8 cases had positive results more than twice and 16 cases revealed positive results only at the time of admission.
Among 476 pulmonary tuberculous patients without diabetes in July 1964, 41 patients (8.6%) were positive urine glucose 2 hours after breakfast by administration of antituberculous drugs; in 3 cases (0.6%) Nylander (+) and Tes-tape (+), in 27 cases (5.7%) Nylander (-) and Tes-tape (+) in 11 cases (2.396) Nylander (+) and Tes-tape (+). Of these 41 patients 21 cases did not become positive again by withdrawing of antituberculous drugs. The rest of 20 patients had positive urine glucose more than twice.
As a result of G. T. T. for these 20 patients, 3 cases were overt diabetes, 12 cases were suspected diabetes, and 6 cases were normal or with renal glycosuria. Of 12 suspected diabetes 4 cases showed oxyhyperglycemia. Of another 8 suspected diabetic, 5 cases revealed positive and 3 cases revealed negative results in consequence of P. G. T. T. Of these pulmonary tuberculoss patients with newly discovered diabetes, 2 cases were far advanced form and in another one diabetic became overt after thoracic surgery. Eight patients with P. G. T. T. showed mainly moderately advanced chest-roentgenogram.
We conclude 8 patients as subclinical diabetes (3 are latent chemical, 5 are chemical diabetes) i. e. as prediabetic state in a wide sense. Furthermore we believe that we have to consider the existence of these subclinical diabetic state during the treatment of pulmonary tuberculosis.

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This was a 36-years-old male patient, who had diabetic heredity and had been suffering from diabetes mellitus for nearly seven years, during which he had been maintaining his standard weight properly.
He fell into diabetic coma after the aggrevation of a carbuncle at the back.
Furthermore during the course of the brittel diabetes, hypoglycemic attacks were frequently noted, in spite of a tendency toward the favorable progress.
It was considerd that they are caused by lessening of the excitability of the sympathetic and parasympathetic center in hypothalamus, accompanied with his abnormal character.
Above mentioned functional abnormality in hypothalamus was seen based on the results of Norepinephrine-Mecholyl test, cold pressure test and E. E. G..
The analysis of abnormal character on the basis of the score of Rorschach test, Mosle test and profit of Yatabe--Gvilford test were performed.

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The author studied 143 cases of diabetics who had been admitted during the period of 1951 to 1963 in the Konodai National Hospital.
This study was aimed upon vascular disorder in diabetics clinically and pathologically.
1) Arteriosclerotic changes of diabetic cases, for example cerebral apoplexy, retinopathy, myocardial changes, leg necrosis and hypertension are observed.
2) There were 15 per cent of apoplexy, 6.7 per cent of myocardial infarction, 15 per cent of diabetic retinopathy and 7 per cent of leg necrosis among them.
3) Infectious disease of the patients were 8 per cent of tuberculosis, 11 per cent of liver and biliary duct infection and 9 per cent of urinary tract infection.
4) The main cause of death (45 per cent) were the brain, heart and renal failure with marked arteriosclerosis.
5) Nine of 11 cases showed intercapillary glomerulosclerosis, 6 cases showed hypertension with high grade sclerosis, and 9 cases had over 300 gram of enlarged heart.
6) Severe myocardial changes had some relationship with longterm history, hypertension, retinopathy and nephrotic syndrome.

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New method of calculating diabetic diet “diabetic food exchange list” has been adopted.
Japanese foods are so complexed, that forming of Japanese food exchange scheme is very difficult.
Investigation of diabetic food at home was as follows
1. Comprehension of diabetic food exchange list : 70% of both male and female,
2. Drinker: 50% of male
3. Testing cake: 50% of female
4. Keeping the diabetic diet: 33%
5. Protein deficiency: 39%
6. Fat deficiency: 61%
These diabetics have been controlled by docter 2 or 4 times a month at our our diabetic clinic.

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We got the following fruits after we compared the minimal intercepting concentrations of mycobacterium tuberculosis of cycloserine on 196 Ogawa medium, Kirchner agar medium and Kirchner semi-solid agar medium.
1) When we judged the minimal intercepting concentration of mycobacterium tuberculosis on 1% Ogawa medium after four weeks and on Kirchner semi-solid agar medium after three weeks, both of them were 20-3omcg/ml. So they were nearly coincided. But the minimal intercepting concentration of mycobacterium tuberculosis of Cycloserine on Kirchner agar medium was 50-75mcg/ml after four weeks. It was always higher than the former two media.
2) We determined that 1% Ogawa medium or Kirchner semisolid agar medium, whose minimal intercepting concentration of mycobacterium tuberculosis is low, is suitable to routine drug resistance determination of Cycloserine.

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Since 1958 till 1965. in 364 patients who were admitted to the 2nd Tokyo National Hospital, C-Reactive Protein tests were examined and followed up before and after the operation. Those patients were selected at random in surgical ward.
The result obtained are as follows:
1) C. R. P. test showed high value among the patients of inflammatory disease.
2) C. R. P. value mostly becomes positive eight hours after the operation; 1+, then in case the patient's prognosis is better becomes highest after one or two days, then vanishes after one or three weeks following the operation, but in case of inguinal hernia or prolapse ani, the value becomes positive in 18 to 24 hours, then becomes negative within one week.
3) C. R. P. highest value and numbers of days in which its value becomes negative, depend on the type and scale of operation, duration and patient's preoperative general condition.
4) C. R. P. value appears and vanishes earlier than blood sedimentation test and reacts later than white blood cell count; therefore it corresponds the patient condition much more accurately than white blood cell count, B. S. T. anb temperature. C. R. P. test is very valuable to find out the early complication.
5) C. R. P. test is not specific nor suitable for detecting early cancer.
6) For the observation for following operation, capillary method is more preferable than rapid slide test.
7) Serum GOT and Serum GPT show high value at the time when the operation is completed and till 2 hours after the operation in spinal anesthetic case.
In general anesthesia or epidural anesthesia they show high value during the operation and become high again two or five hours after the operation, then become preoperative status -- at that time C. R. P. becomes positive (1+).
8) C. R. P. test has no close relation with B. S. P. test, C. C. F. test, alkaline phosphatase test and ictenic index.

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