In the article “UBER EINE EIGENTUMLICHE GRANULAMASSE IM CARCINOMGEWEBE DES MENSCHEN UND DER TIERE” Proceeding of the Imperial Academy, VI (1930), No. 81, the author had previously reported a finding that a particular type of invisible virus particle, which becomes visible by way of the special treatment with silverchloride solution, exists in the cell of malignant tumor.
It is assumed that particular virus particles always exist in the cell of the tissue of any malignant tumor, Accordingly the said virus particles exist and are being defused in the body fluid of a patient such as lymph or blood. The author considers it would be convenient to make a correct diagnosis of a cancer if the existence of a cancer cell in lymph or blood is proved and accordingly if such a cancer cell could be multipled by tissuecultivation with a proper medium.
Basing upon the above assumption, the author had made a new culture medium with which particular particles were successfully separated from the body liquid, especially blood, of 76 patients of cancer and 11 patients of sarcoma and cultivated respectively. Particularly, a strain, that is seemed to be a virus, was separated from the blood of the melanosarcoma patient. Furthermore, the author observed that a filterable virus, being obtained after filtration with Chamberland L₃, produce a sort of cell and tissue like a tumor (fig. I. II) to produce melanin when being cultivated. Also, the said filterable virus causes a cancerous change to produce melanin in the cell and tissue of liver and lung of mouse.
Also, the author observed that the particle obtained from the cancer of human stomack causes the lung cancer of mouse and produces kelatom in a certain medium with a piece of animal hair.
Furthermore, it was proved that the particles obtained from Melano-Carcinoma 2F, Glioma 2F, or Usteo-Sarcoma were cultivated to produce particular cell and tissue respectively.

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In a recent study of YAMANAKA, the lung tumors were developed with using carcinogenic substance (20-methylchoianthrene pellets) in the lung of rats, and tumors induction rate was sixty-four per cent.
Present study attempts to induce the experimentally lung tumors in the tuberculous lung of 150 Wistar male rats in this manner.
Living Miwa strain of mycobacteria bovis were suspended 5.0mg per 0.1ml of saline solution, and right lower lobe was injected the suspension with thoracotomy under the ether narcosis of rat.
The pellet consisted of the cholesterol and carbowax 4000, containing 3.4-benzpyrene 2.5mg, was implanted in this place of tuberculous rat.
Adjacent broncheolus of the pellet were proliferation in one or two weeks. It demonstrated squamous metaplasia and keratosis in three or four weeks, also the pellet was surrounded with the squamous metaplasia which contact squamous metaplasia of broncheolus, and it made keratosis.
Squamous metaplasia developed the lung tumor in 17 of 19 (89.5%) from 31 to 78 weeks.
Metastasis and transplantation of the lung tumors were not observed in other organ of rats.
The pellet was found into the lung tumor, and was observed 3.4-benzpyrene by fluorometer.
This lung tumor growth was not inhibited by tuberculous foci.
Similar tumor induction was observed in pellet only implantation group, but other control groups were not observed tumor induction.

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In general, the patient of early lung cancer produce scanty amount of sputum, Therefore, it is impossible to make a cytological examination for definite diagnosis of the disease.
A new method, which is a transbronchial biopsy utilizing a newly designed small curette through the fluoroscopic control, was devised.
Since 1962, this method was carried out on 67 cases of lung cancer, and correct diagnosis of 88.9% was obtained in small foci of 2.0cm in diameter, It is believed that this method is extremely useful in diagnosing an early lung cancer.

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Ninety two cases of metastatic lung cancer who were treated at National Cancer Center Hospital during the period of June 1962 to June 1963 were studied from the clinical standpoint of view. Primary cancer of these metastatic lung cancer were as follows; 21 cases with mammary cancer, 10 cases with gastric cancer, 7 cases with lung cancer, 7 cases with uterine cancer, 6 cases with rectum cancer, 6 cases with renal cancer, 5 cases with testicle cancer, 4 cases with maxillary cancer, 3 cases with esophageal cancer and 23 cases with others. And the followings findings were obtained.
The duration of the first appearance of the metastatic lesion in the lung after the resection of the primary lesion were variable. In general, the metastatic lesion was appeared within one and half years in 50% of cases and they were appeared after 2 years following the operation in about 40% of cases.
The duration of the appearance of the metastatic lesion is also different depend on the variety of the primary organ. That is to say, the metastatic lesion were appeared after two years following operation in about 50% of cases with mammary and rectum cancer, and after 9 to 19 years in a few cases of rectum cancer, The radiological findings in the chest X-ray film were classified into the following seven types; large nodural type, small nodural type, lymphangitic type, pneumonitic type, pleuritic type, lymphadenopathic type and pleural type, and the relation between the radiological appearance and the primary cancer. All of five cases with the lymphangitic type were metastasis from the mammary and gastric cancer and those were quite rich of subjective symptoms such as dyspnea, cough and sputum which were quite characteristic compared with others. The metastasis from the rectum cancer, testicle cancer and osteosarcom showed mostly the large nodular type. Pleural metastasis were all from renal cancer. Solitary lesion in the lung were found in 14 cases, however, no relation was found with the primary cancer.

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Eighty-eight cases of primary lung cancer (_??_77, _??_ 17) among 1732 autopsy cases during past 13 years in our hospital have been observed.
The percentage is 5.1% in total, 6.9% in male (71 cases among 1015 autopsy cases) and 2.3% is in female (17 cases among 717 autopsy cases)
The incidence increases year by year.
The age incidence is 25 cases in fifties, 26 cases in the sixties for the male and it hold a majority of cases; for the female 6 cases in the forties, 2 cases in the fifties and 6 cases in the sixties.
Initial symptoms are for the most part cough, sputum and chest pains. The suspicious disease on the first consideration: are at first pulmonary tuberculosis and secondary mediastinal tumour.
Acceleration of sedimentation rate is moderate or remarkable indifferently to the sex. Anaemia and leucocytosis have been also observed.
The primary foci of tumour are mostly in the right side of lung and in upper lobe.
The detection of malignant cells from sputum reveals 45%, and it reveals low average compared with the reports of others. On x-ray finding lung cancer of “tumour-type” and “lung field-type” are most frequent. In histological classification, adenocarcinoma is slightly much and then epidermoid carcinoma is the same incidence with undifferentiated carcinoma. Metastasis has been found most in lymphnodes and in liver, next bone, pleura, adrenal glands and kidney have been listed in order. In the treatment of the lung cancer the radical operation combined with radiological therapy are best method.

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Eighty one consecutive cases of pulmonary cancer, admitted in Muramatsu Seiranso between Jan., 1956 through May, 1964 were studied. Conclusions were as follows:
1) 63 patients were primary pulmonary cancer and the other 18 patients were metastatictumor, and three of former were accompanied with active pulmonary tuberculosis.
2) The most common symptoms were continuous cough and haemoptysis. About 90 per cent of all patients had symptoms less than 6 months duration.
3) Most valuable diagnosis were obtained by cytologic examination of sputum specimen, and analysis of other diagnostic procedure, such as bronchoscopies, scalene node byopsies, mediastinoscopies were also believed to be of value.
4) Twenty-five patients (30%) were underwent resectional therapy and exploratory thoracotomy were perfomed in other twelve patients.
5) The original tumor of those metastatic tumor were breast, thyroid, and GI tract, etc., but 3 cases of pancreatic cancer were noted by necropsy without clinical evidence.

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A man, 74-years-old, was diagnosed as pulmonary tuberculosis based upon the chest x-ray films showing the presence of the cavities in both upper lung fields and AFB in his sputum.
With chemotherapy, the cavities disappeared and sputum culture for AFB became negative after six months, But a chest x-ray film showed the reappearance of a shadow in the upper field of the right lung where the cavity was found previously.
Bronchial carcinoma was found in the tuberculous scar of the right lung by the post mortem examination.
The histological examination showed that it was squamouscell carcinoma.

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The most important two problems of cancer of the Lung complicated with pulmonary tuberculosis are as follows:
1) How many cases in which cancer and tuberculosis are found in the same pulmonary region?
2) Does actually the tuberculous focus in the lung become the original focus of cancer ?
The author described about one case in which cancer and tuberculosis had been found in the same pulmonary lobe by pathohistological tests. The result of tests pointed out the cancer formation from either tuberculous scar or cavity of the lung. But speaking from the general observation of many reported cases of pulmonary cancer with tuberculosis, although pulmonary cancer cases are far rarer than pulmonary tuberculosis in Japan, and the most of pulmonary cancer cases have their own original foci in the lung, the remarkable pathogenetical relations between cancer and tuberculosis are not recognized.
To clear up the problems above mentioned, the authors insist on the necessity to follow up the tuberculous patients of so-called cancer age.

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During the period from January, 1959 through October, 1964, 100 cases of the primary lung cancer were treated and observed postoperatively in Kochi National Hospital.
Fourteen cases among these 100 cases came under I or 11 stadium of Anacker's classification, but the rest of cases progressed ; over III stadium. 56 cases died within 6 months after the diagnosis of lung cancer were established.
Fifteen cases were carried out pneumonectomy, and 13 cases died within 2 years and 2 cases are living more than 3 years after the operation.
Seventy cases were treated with 6Co radiation, 27 cases among them received total amount of 6, 000-10, 000, but no survivors were found more than 2 years after the completion of the treatment. 14 cases were treated with total amount of 3, 000-5, 000 and 3 cases died within 6 months and 6 cases are still alive more than 1 year after the completion of the treatment.

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1. Fifty consecutve cases of pulmonary suppuration have been studied during the 8 year period prior to June, 1964.
2. Thirteen of 50 patients received medical therapy alone, 8 achieved a good results, 4 patients were improved but two of them have chronic abscess, and one patient were died by cerebral abscess.
3. Thirty-seven patients received surgical treatment after prolonged medical therapy. In 34 of these 37 patients, pulmonary resection were performed, in two cases pneumolysis and in one case cavernostomy were performed.
4. In these surgically treated 37 patients, 33 (89.2%) were cured, 3 died of corn plication and one case is yet hospitalized.
5. Through all of our cases early right diagnosis and early right initial treatment by proper antibiotics were most important factor in treatment.
6. Despite of effectiveness of antimicrobial therapy, pulmonary suppuration were still surgical disease. Certain clinical factors suggest need of operation, such factors as follows:
a) Duration of symptoms, b) Duration of antimicrobial therapy longer than 3 months. c) Location of disease in lower and d) When secondary suppuration were suspected, particulary of pulmonary cancer.

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A case of nocardiosis of 64-year-old man was reported.
Initial symptome was a localized mediastinal tumor, which was treated with sanamycin, sulfisomidin and penicillin, and the tumor was disappeared roentogenologically.
There was remission until 3 years after the onset, when he developed hematogenous dissemination, which resisted against the treatments and died.
Cultures of the abscesses which were found by autopsy showed Nocardia asteroides.

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