Employing the Okada-Mimura's method an investigation was carried out on the process of bony-growth, the local influence, the time element, and the mechanism of reconstruction of the growing bony tissue.
For the experiment rabbits weighing 1000 to 1400 grams were used. The animals were sacrificed two to three weeks after they had been given lead acetate intravenously every three days.
In many cases were found several sedimentary lines of lead in the endo-chondral and endc-osteal parts which afforded daily study of the speed of the growing process.
In the bones of fore-arm and femur the growth was rapid at the lower end, while in bumerus and tibia a rapid growth was noted at the upper end.

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Congo-red index and plasma catalase value were employed to determine the function of the reticuloendothelial system. The results are as follows:
1) Conga-red index showed a similar value as the percentage of azorubin-S excretion.
2) The function of reticuloendothelial system seems to be more accurately elicited by the plasma catalase value, but further investigation is necessary.
3) The splenectomy seems to have a different influence on the reticuloendothelial system than the “blocking” it by injections of India ink. It seems that the former has an stimulating influence upon certain tissues of the reticuloendothelial system.

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Kativ (160mg. of vitamin K in each ampule prepared by Takeda Co.) was injected daily for 30 days to ten tuberculous patients and clinical observations were made. Following are the findings:
1) The administration of vitamin K which is found to be lacking in tuberculous patients aids in the improvement of the general condition and vitalizes the hepatic funtions. However, such favorable results are seldom seen in serious cases.
2) In pulmonary tuberculous patients vitamin K acts to restore the specific gravity of blood and serum from its abnormal to normal value. Hence good influences are noted upon the albumen metabolism in the liver.
3) Vitamin K acts to elicite Elmonogram in tuberculous its normal curve.
4) Upon general symptoms vitamin K has no remarkable effect except that it slightly improves the exudative infiltration as observed in roentgen examination of the chest.
5) In mild cases an increase in histiocytes may be noted indicating an influence over the reticuloendothelial system.
6) During vitamin K administration the urinary sugar test gives a positive reaction.
7) While no changes are noticiable in the intestinal tract during vitamin K treatment, Triboulet's reaction may sometimes show positive.

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In order to find out what a atitude E. Coli-group would take toward streptomycin, following investigations were cart zed out: the amount of streptomycin which was excreted in feces, the manner of the growth of Coli-group, the resistance of Coli-group against strptomycin, and the relationship between clinical findings and streptomycin in feces. Nine intestinal tuberculosis patients and three nurses as control were subjected to these tests.
The results are as follows 1) During the course of treatment streptomycin was recovered in feces as: 100% of cases in which a diagnosis of intestinal tuberculosis was definitely proved, 75% of those clinically diagnosed, and 50% of those suspected for intestinal tuberculosis.
As the clinical symptoms improved, the exretion of streptomycin in feces was found decreased or absent; thus in those in which the diagnosis of intestinal tuberculosis was definitely proved the excretion of streptomycin was absent in 75%, and of the group of clinically diagnosed it was found absent in 66%.
The excretion of streptomycin was not observed in feces of healthy control.
The concentration of streptomycin excretion in feces was less than 6.25 γ/cc.
2) A slight drop in the number of Coli-group colonies found about 3 days after beginning of streptomycin treatment showed a return to the pretreatment number in 10 days.
3) The resistance of Coli-group against streptomycin was studied on 4 strains of E. Coli Type 1 which were recovered from the cases of proven intestinal tuberculosis. Coli-group were found to rapidly acquire the resistance against streptomycin. The detailed account an this score will be published shortly.
4) The fact that streptomycin is excreted only in patients of intestinal tuberculosis and is absent in healthy individuals seems to show that streptomycin may be advantageously used as a diagnostic means for intestinal tuberculosis.

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