Basing upon the informations obtained from analysing the radiographical lesions on chest film, the investigation was carried out to find useful parameters in the diagnosis and the treatment for the patients with lung cancer by elucidating the relationship between its prognosis, the radiographical appearance in the progression of the lesion and the various histological types.
Clinical materials consisted of 68 patients with adenocarcinoma and 78 patients with squamous cell carcinoma, all of them were underwent to surgical intervention and were postoperatively followed up regularly.
The study was done by comperatively analysing the tomographic findings obtained just prior to operation, the resected lungs checked in anatomically segmental fashion. The radiographical findings were classified according to the relationship between the location and size of tumor and pulmonary structure (pleura, bronchi, pulmonary arteries and veins, and lymph nodes). Further investigation was done for correlating the change seen on the chest X-ray film to the term period postoperatively in which the recurrence or metastases appeared clinically.
Ninety per cent of the pulmonary lesions with adenocarcinoma were located just beneath the visceral pleura and possessed intense pleural indentation, and this pleural indentation can be identified radiographically over 90% of cases.
Histologically, they were classified into four types; Po (not reached), P
1 (reached but not invaded), P
2 (invaded) and P
3 (invaded up to parietal pleura), and its extent of lesion is closely related with its prognosis. It has been noted that its prognosis became worse when the longest diameter exceeds over 3cm.
When considering these two findings in combination, namely in the cases with adenocarcinoma radiographically proven to have pleural indentation and tumor diameter of 3 cm, it appeared that 80% of cases would result to have metastases within one to three years postoperatively. Even in the cases with its lesion less than 3cm, the incidence of metastasis was noted to be 50% within the postoperative period of one to three years.
The pulmonary lesions due to squamous cell carcinoma can be divided patho-anatomically into the cancerous lesion extending into mucous membrane and the lesion deeply penetrating (the lesion partially invading pulmonary parenchyma extending over the outer layer of the bronchial membrane). The former results in the stenotic or obstructive lesion in the bronchial lumen and as the result of these lesions, the secondary lesions such as obstructive pneumonitis and atelectasis will develop. The latter will result in tumor formation which will produce the stenotic or obstructive lesions to the pulmonary arteries or veins adjacent to bronchus. Therefore, the extent of cancerous lesion within the bronchial lumen can be radiographically suspected by careful investigation of the degree of its secondary change, and also the location, size and degree of tumorous lesion by checking in decrease or absence of vascular shadow.
Basing upon the radiographical informations obtained from above-mentioned, analytical methods, the prognosis seems to be good in 80% in the cases with squamous cell carcinoma which originated within the area peripherally to subsegmental-bronchus but not extending proximally to segmental-bronchus.
In contrary, the cases with squamous cell carcinoma originating peripheral area invading up to segmental-bronchus or even to the large proximal bronchus or the squamous cell carcinoma originating at the bronchus proximally to segmental bronchus, one third of cases are considered to be inoperable or underwent to only conservative operation, and even one third of cases, underwent to surgical intervention, developed to have the recurrence or metastases within the follow-up period of three years. Especially, one fourth of case swith the primary lesion located in the segmental bronchus B
6 were r
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