Radiological investigations were conducted on the relation between primary lesions and secondary, lesions, the period from onset of infection to metathesis stage, and on the prognosis of the metathesis, in 49 tuberculoss cases in Myojo National Sanatorium, during the period from April 1949 to March 1953. The results were as follows:
1) The primary lesions of secondary pulmonary tuberculosis were located generally in the upper fields of the lungs, As for the original lesions accompanied by cavities, such cavities were found almost always in the dorsal part of the apex of upper lobe, and there were few cases of which cavities were found in the upper part of lower lobe.
2) In case of the metathesis of cavity, new cavity was found to be located lower than the location of tide original cavity and the new cavity was frequently found in thee opposite side to the original cavity. If the cavity was in apex area, so-called ‘apicocaudally’ metathesis was frequently observed.
3) Secondary lesions were frequently located in the upper fields of lungs, and few in the apex fields. When they were in the upper or lower fields, they were situated mm re or less centrifugally and those in the middle fields region were frequently centripetal locations. Metathesis lesions in the upper fields inclined to develop into cavities.
4) The secondary lesions of cases who had haemoptysis in their anamnesis appeared lower than the primary lesions disseminatedly.
5) Since acinous lesions, tuberculoma and productive lesions without, cavities had also the possibility of developing metathesis, considerations should be paid against fresh cases.
6) The periods from the onset to the metathesis were between 3 months and 4 2 years. In most cases, they were within one year to three yeas. Lesions accompanied by cavities caused metathesis more quickly than those without cavity.
7) Prognosis of the metathesis had more close relation with the nature of the respective lesions than the dimensions of the lesions. Lesions having cheesy degenerations with thick x-ray shadows in their center inclined to develop into cavities Temporary infiltration inclined to be entirely absorbed. If lesions were of the same nature, the bigger ones were worse in their prognosis. Lesions, which had evenly thick x-ray shadows and which were larger than the dimensions of a lobules, frequently inclined to become cavities. Disseminated lesions had far better prognosis than the infiltrated lesions.

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Salt metabolism was studied by means of the measurement of Sodium and Chloride in urine and serum in 47 TB cases (in-patients) at National Kanagawa Sanatorium drying INAH administration.
The results were as follows:
1) In pulmonary tuberculosis, tuberculous pyothorax accompanied by effusion and nephrophthisis cases, of which body temperature before treatment was above 36°C and to which INAH was administered per as, improvement of general symptoms was recognized. In these cases, Sodium and Chloride excretion in the urine was identified, especially during the defeveresent period. Sodium and Chloride in the serum were almost normal.
2) In cases of afeverish stage (body temperature —below 37.9°C) of pulmonary tuberculosis and hilum tuberculous lymphadenitis cases, to which INAH was administered, salt metabolism was almost normal. However, moderate increase of Sodium and Chloride excretion in the urine was observed temcorarily.
3) Na-Cl quotient of the urine was 1.0 during INAH administration in these cases. When the general symptoms were arrested by INAH treatment, Na-Cl quotient was above 1.0 in the early ten days and below 1.0 after that period.

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Time experienced has a close connection with self-consciousness, and the variety of the latter may give a person various kinds of time experienced. Unusual time experienced of insane person will be the most interesting one. Our study was not the kind of phenomenological or psychopathological description of subjective time as it is described by normal or insane person. We investigated subjective valuation of certain physical and objective time. Our experimental subjects were 573 normal cases, 63 blind cases and 71 insane cases.
Set tasks were as follows:
normal group -30″ of listening; 1′ of rest and 3′ of listening insane group -30″ of listening; 1′ of rest; 3′ of dectation and 5′ of reading
1) Results of valuation of time in the normal group varied by age, i. e., the younger person showed a marked tendency of overestimation. Tipple valued was more cr less influenced by sex, time spent, and set tasks given.
2) Results of valuation of time in the blind group was almost equal to that of the normal group.
3) The 71 insane cases (some of them were at their initial stages of illness and the rest were not yet under any treatments) were as follows: 34 schizophrenia cases, 3 mania cases, 10 melancholia cases, 19 general peresis cases and 5 chronic alcoholism cases. Of course, it gces without saying that these diseases are of different mental discrders and unable to be discussed as one group, however, the results were that each cases of these illness showed the tendency of overestimation, with the exception of depressive psychosis cases.
4) Schizophrenia and melancholia cases were given the set tasks to value the same time exposures three times; i. e., preliminary to electroshock, immediately after five electroshock and immediately after ten electroshock. Thus variety in time valuation through electroshock was investigated. In each case, mental symptoms diminished by means of electroshock and remarkable overevaluation was given by schizophrenia cases. On the contrary, the influence of electroshock in melancholia was little. The mechanism of such a difference is unknown, however, it may by considered that the difference in biological and psychological structures of them is responsible cause. In case of certain set tasks and time valued, little influences were observed.

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As a part of the investigations to reveal the differences in the effects between radiological treatment and chemical therapy in case of milignmt tumors upon the peripheral blood picture and the hematopoetic organs, radioactive phosphorus (P³²) was administered to experimental rats. The dose of Pwas l/c per gram, and was administered subcutaneously. As for the results, leucocytes decreased to 3, 000-4000 by 2-4 days and their recovery proceeded slowly requiring 4 weeks. Decrease and recovery of lymphocytes counts were more rapidly than in case of granulocytes. During the one month of observation, in the first week, one rat a day was autopsied and thing the following weeks of investigation, one rat per every week was autopsied. Their histological changes in haernatopoetic organs were traced and observed. Main findings by P³² administration were similar ones as in case of x-ray, radium or various chemical treatments, however, they differed from the latter ones in slowness in recovery of peripheral blood pictures and in delay of recovery of findings in bone marrow and other haematopoetic organs. These differences may be considered to be caused by the specific deposits of P³². Bleeding in organs as it may be observed in case of Nitrogen-mustard were not seen, however, remarkable congestion of organs was observed.

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This is to report the data of patho-histological studies on sclerosis of pleura and lung tissues obtained from 12 resected lobes operated at the Kiyose National Sanatorium. In the 1st and 2nd reports, we classified sclerosis of pleura into 4 types and fibresis of lung tissue into 4 stages. The same classifications were applied to the observation of the above mentioned materials. Results were as follows;
1) In 10 lobectomied cases, the same conclusion was obtained as in the 1st and 2nd reports. However, more intensive and frequent hemorrhage, hyperemia and exsudation subsequent to the operative manipulation were observed.
2) One empyema case and one hemothorax case were observed and lobectomied. They had developed into ‘unexpandable lungs’, subsequent to the artificial pneumothorax. Their clinical findings were compared and discussed together with their histapathological findings in the sclerosis of pleura and the lung tissues obtained by means of resection. In these two cases, almost same conclusions were obtained as in case of the 1st and 2nd reports.

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1) Out of the combinations of INAH with one of the following drugs, DSM, PAS, TB₁, Vitamin-K, Ceharanthim Protomin, Z-Furan and Neo-Ninophagen-A. T. INAH+DSM, INAH+PAS, INAH+TB₁, INAH+Vitamin-K and INAH+Z-Furan showed synergistic effects. The effects were strongest in INAH+DSM and INAH+Vitamin-K. Combinations of 3 or 4 kinds of these drugs were also effective, and the combination of INAH+DSM+PAS was the most effective one. Combinations of 4 kinds of drugs were not more effective than the cornbinaticns of 3 kinds of drugs.
2) If DSM was added to one of the following dregs, PAS, TB₁, Vitamin-K, Cepharanthin, Protomin, Z-Furan and Neo Minophager-A. T., PAS, TB₁, Vitamin-K, Cepharanthin and Z-Furan groins showed synergistic effects. 4n the contrary, if ore of these drugs were added to DSM, only PAS, TB₁, Vitamin-K, Protomin and Z-Furan groups showed synergistic effects. In any case, DSM-PAS, or PAS-DSM was the most effective one.
Combinations of more than 3 kinds of drugs cut of DSM, INAH, PAS and TBr were effective, however, their antimicrobial activities were not higher than that of DSM+PAS.
3) Among the combinations of PAS with one of the following drugs, TBi, Vitamin-K, Cepharanthin, Protomin, Z-Furan and Neo-Minophagen-A. T., Vitamin-K+PAS and Z-Furan+PAS showed synergistic effects and Neo-Minophagen-A. T.+PAS gave antagonism. The combinations of 3 kinds or 4 kinds of these drugs were effective, and the antimicrobial effects of PAS became highest at PAS+INAH+DSM, however lower effects were obtained at the combinations of 4 drugs.
4) If TB₁ was added to one of the following drugs, Cepharanthin, Protomin, Z-Furan and Neo-Minophagen-A. T. only Z-Furan+TB₁ group showed synergistic effect, while Cepharanthin +TB₁, Protomin+TB₁ and Neo-Minophagen-A. T.+TB₁ showed antagonism, and Vitamin-K+TB₁ showed antagonism even at low density. When TB₁ was added to one of the other drugs, synerid in was observed in Z-Furan₁TB₁ group, meanwhile antagonism was seen in Vitamin-K+TB₁ and Protomin+TB₁ groups and a little synergistic effect was obtained in Cepharanthin+TB₁ at high density and antagonistic effect at thin density. In the combinations of 3 or 4 of TB₁, INAH, DSM and PAS, the antimicrobial action was highest in the combination of 4 kinds of drugs.

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