Changes of peripheral vascular tone and of sweat gland activity due to cold stimuli were investigated in the present experiment comparing with each other. The former was estimated by changes in amplitude of pulse wave and by base line deviation of the photoelectric digital plethysmogram, and the latter was estimated by the galvanic reflex (GSR).
Twenty healthy adults (8 males and 12 females) served as subjects. The plethysmogram and the GSR were recorded from finger tips of one hand, immersing the opposite hand into cold water of various temperatures.
1) When startling stimuli, such as sudden noise and electstimulus, were applied the GSR appeared with latency of 1-2 seconds, The plethysmogram, on the other hand, was observed to decrease in amplitude and to show downward deviation of base line with the same latency. These changes reached to the maximum about 5 seconds after stimulation, then returned gradually to the initial state after about 20 seconds.
2) By cold stimuli, the appearance of the GSR was not always observed. In this experiment, amplitude of the pulse wave became smallest and base line deviation reached to the maximum after about 5 seconds. Soon after these primary changes, secondary changes of the same type followed. The primary changes were similar to those caused by startling stimuli in respect to the time course as well as to the degree of changes, and did not differ with the differences of water temperature, of the size of the immersed skin area and of the initial skin temperature.

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Histological examinations on 445 pregnant uterine cervices were conducted at the clinic of the Obsteric and the Gynecology, the Kanazawa National Hospital during three years periods from January 1955 to December 1957. The following results were obtained:
1) Changes in the glandular epithelial layer.
a) The glandular hyperplasia-increase in the number of glands in cervix.
b) Hyperplasia of glandular epithelium-stratification of glandular epithelial cells.
c) The adenomatous hyperplasia-Invasion of numerous small glands into larger glands.
These epithelial changes should strictly be differentiated from adenocarcinoma.
2) Changes in the squamous ells layer.
Edema and growth of blood vessels are noticed within the epithelial layer together with the thickening of this layer.
a) Squamous cell invade into the glands mixed with columunar epithelium.-There is squamous metaplasia accompanying the cellular atypicality, which must be carefully differentiated from the carcinoma in situ or invasive carcinoma.
b) Basal cell hyperplasia (B. C. G.)-The basal cell proliferated to form multiple layers, some of which show advanced degree by growing nearly up to the surface. Caution should be paid on some of the cases with this change, for it might sometimes develop to a carcinoma in situ.
3) Edema and decidual reaction. These changes are sometimes noticed in the connective tissue.
The author's studies indicated that 14 cases (16.6%) which hyperplasia of glandular epithelium and adenomatous hyperplasia were seen. Squamous metaplasia were noticed in 158 cases (35.5%) and among which 68 cases (15.2%) were accompanied with cellular atypy. The basal cell hyperplasia (B. C. H.) were seen in 25 cases (5.67%) and those which had advanced change were seemed to be difficult to differentiate them from carcinoma in situ. This change, however, was reversible in most of the cases except two cases which showed progressing tendency.
These changes were recognized on the pregnant cervical tissue, particularly it was deemed that the squamous cell metaplasia and basal cell hyperplasia were important in the differential diagnosis with cervical cancer.
Neverthless since these changes might often regress by the interruption on pregnancy or delivery, in purpose of establishing an accurate diagnosis these equivocal changes should be followed and re-examined at the time when the examine is not pregnant.

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1) On 201 surgical patients including 145 cases of diseases of stomach, hyponatremia (less than 135mEq/1) and hypopotassemia (less than 3.9mEg/1) were examined.
2) A clear-cut trend was found, that hyponatremia occurs very often in cancer and severe chronic diseases.
3) Hypopotassemia occured rarely, except in acute ileus.
4) On 33 postoperative patients including 28 gastrectomies, urinary sodium concentration and potassium-nitrogen ratio were followed up by a ruled fluid transfusion; sodium concentration was highest in 1, 2 postoperative days, and lowest in 3, 4 postoperative days, but K/N ratio showed descending curve in postoperative days.
From point of view of sodium concentration in urine-cancer patients conserved sodium as well as non-cancer patients, not withstanding the difference of sodium serum level.
5) On hyponatremia and postoperative fluid therapy, reviews were made from medical and surgical points.

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Some examinations were made on hepatic functions about the patients with alveolar pyorrhoea. The symptoms of alveolar pyorrhoea were divided into three types; the inflamed type, the atrophic type and the combined type, and the relations between the three types and the disturbances of hepatic functions were observed. And some experimental examinations were made on the significance of the increase of γ-globulin (blood plasma) which was observed in the patients with alveolar pyorrhoea. Cases: Normal healthy group 20, inflamed type 65, combined type 31, atrophic type 25.
1) As to the positivities of urinary urobilinogen, bromsulphalein test, and cephalincholesterol-flocculation test, and the decrease of serum choline-estelase and blood-plasma albumin, and the increase of α-globulin and γ-globulin, more than 15% of the patients were in abnormal values.
2) Hippuric acid synthesis test indicated that its results were in abnormal values in both the inflamed type and the combined type, especially in what inflamatory symptoms were clearly observed.
3) In β-globulin and Takata's reaction, there were indications that abnormal values were found only in the inflamed type.
4) Significant differences were not observed, in all types, between the mean value of cholesterine (total serum) and the healthy normal group. There were, however, in all types, some cases (10-20% of all patients) that serum cholesterine increases or decreased abnormally, and the measure of the dispersion was great.
5) Total protein (serum), and alkaline-phosphatase (serum) were almost in normal ranges, and there were few abnormal cases.
6) It was observed, in all types, 8% of the patients were cases of hepatic swelling of more than 1.5 finger-size.
7) The cases which showed the value of morbid positivity in the examin ations of hepatic functions were generally found more in the patients who usually showed extensive symptoms of alveolar pyorrhoea.
8) Agglutination test was applied between the bacterium that was extracted from the gingival pockets of a patient with alveolar pyorrhoea, and the serum of a patient, and the change of γ-globulin value by the paper electrophoreisis method was assured. As a result of this test, it was observed that there were cases in which γ-globulin clearly agglutinated detected staphylococcus. From this fact it follows that there were certain immuno-chemical relations between the increase of γ-globulin which was observed in patients with alveolar pyorrhoea and the bacterium in gingival pockets, especially staphylococcus.
9) From what has been mentioned above, it is clear that there are certain relations between the alveolar pyorrhoea and the disturbances of hepatic functions, but it is observed that the disturbances of hepatic functions in the atrophic type that has not inflamed aspects have the relationship mechanism different form those of the inflamed type.

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From the ventilatory aspect the pulmonary functions were studied on patients with chronic pulmonary diseases: 117 cases of pulmonary tuberculosis, 12 bronchial asthma, 8 chronic pulmonary emphysema, 7 silicosis and 8 bronchiectasis. Also the relationship between the pulmonary function and the pulmonary circulation was investigated. According to the clinical process of the patients, their ventilatory functions were changed.
Obtained results are as follow
1) A pronounced decrease of vital capacity was observed in far advanced pulmonary tuberculosis and this was considered mostly due to a restrictive impairment caused by scarring etc. Marked elevation of residual air was noticed among patients with obstructive impairment e. g. bronchial asthma, chronic pulmonary emphysema etc.
2) Appreciable falls of values of M. B. C., Vital Capacity Time and M. M. F. etc. were seen, simultaneously markedly prolonged expiration time was noticed.
3) In regard to intrapulmonary gas distribution, the index of intrapulmonary gas mixing and the index of intrapulmonary gas distribution and the clearance equivalent were measured.
The case with obstructive impairment showed disturbed gas distribution. And the cases with restrictive impairment had relatively mild disturbance of intrapulmonary gas mixing and distribution, while the clearance equivalent was of considerably high value indicating an insufficient gas distribution.
4) The ventilatory function varies in the clinical course. Particularly, despite improvement of chest x-ray findings, the impairment of the ventilatory function was noticed among certain pulmonary tuberculos patients.
5) The changes of pulmonary circulatory hemodynamics in the patients with ventilatory insufficiency were so complicated that no definite tendency was observed except for that, in more than half of the examined cases, elevation of pulmonary arterial pressure, increase of vascular resistance and abnormalities of blood gas which were corroborated.

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Investigations of pulmonary tuberculosis patients with goiter were made and relation between the goiter and PAS (para aminosalicylacid) was studied.
1) Frequency of occurence of goiter -10.5% on average on both sex; 5.4% in males and 20.3% in females. Goiter occured among patients whose ages were mostly between 20-29 years old. Maximum was the 3rd degree in size.
2) Relation between goiter and PAS-A significant difference was noticed in male patients with goiter in which more than 4, 000g PAS was administered. In female patients no significant difference was noticed. However, dose of PAS 5, 000g seemed to have meaning in both sex patients, since more patients with goiter were seen when more than PAS 5, 000g was administered.
3) Function of thyroid gland-Among pulmonary tuberculosis patients with goiter hyperthyoidism was seen more than hypothyroidism.

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The author studied on 57 pulmonary tuberculous patients of whom extrapleural plombage had been performed in the period between 1948 to 1950 at the Banzai National Sanatorium. The substances applied for the plombage were either lucite or ping-gong balls.
In almost all cases complications were observed, and they were perforation (10.5%) and exsudation in the plombaged cavities (45.8%). In 32 cases out of 57 the plombaged balls were removed by the following operations, in 20 cases the substances were not removed and in 7 cases their results remained unknown.
Twenty three patients out of 57 are living and are doing well, 7 patients are still hospitalizing, 18 patients are dead and 9 patients are unknown.
In general, removal of the plombaged balls seemed to have better results than leaving them in place.
Due to the fact that this operation has frequent complications, it is recommended that the indication of this procedure should be strictly limited, and also a very careful postoperative administration is necessitated.

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For the purpose of knowing the positional variation of vomica after the performance of thoracoplasty and operation of gloves (balls) filling, the authors adopted an original fixation method with silver rings. We believe we could obtain satisfactory results.
From April 1951 to March 1952 thirty-two patients with comparatively large cavities were undergone operations either with gloves-filling or with thoracoplastic.
It is concluded that after the above mentioned operations the sinks of the vomica was noticed especially closing to mediastinum. In the process of sinking down vomica does not hold it's proper form and taking oblique direction, the upper part of vomica faces to outside and the lower part of the vomica faces to inside.
So if we look down the vomica we will find tow changing parts, a) lower half part of the cavity is fixed, b) upper half is twisted and is compressed with it's back inside and it's front outside,
The silver rings seemed to giveno influence to the human bodies.

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1) Clinical conditions of the patients, isoniazzd resistance, and virulence to guinea pigs of the bacilli were observed on 5 patients with chronic pulmonary tuberculosis, far advanced in extent, who had been given 200 to 350mg of INH daily for a year. The clinical conditions of all cases were not changed, the isoniazid resistance increased on 4 cases except one. The attenuated virulence with increase of isoniazid resistance was noted on 2 cases. Any definite relation was not observed on the other 3 cases.
2) The clinical conditions were observed on 106 cases with isoniazid resistant bacilli for up to 6 years.
The isoniazid resistance did not always make the prognosis of the pulmonary tuberculous patients worse; clinical symptoms were unchanged or became better at least.
It was believed that the extent of pulmonary lesion and the grade of the SM-resistance were large factors to give influence on their clinical course.

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