We further studied the alteration of the two already reported cases of “periodic fever” introduced by Reimann and another case of a female patient of 51, artificially causing her to be suffering from the similar fever.
In a case of a male patient, 26 years of age, suffering from periodic panalgia and periodic fever, we observed remarkable polyuria (10.800cc in the maximum) on the day of fever and oliguria or anuria in the interval period. We tentatively gave this symptom a name of “periodic alteration of polyuria and oliguria (anuria)”. In the day of polyuria, we further observed increased excretion of electrolytes, such as Na, K, etc. In the latter half of the period of polyuria, we transiently observed dissociation between the amounts of urine and electrolytes excreted, similar to diabetes inspidus. Through Thorn's test and eleqtroencephalography, we presumed presence of disturbance in the hypothalamus-pituitary system. Furthermore, we noticed accumulation of water in the body before and lack of water after and drop of serum potassium level during the attack.
In a case of a female patient, aged 26, suffering from periodic fever, we observed polyuria and increased excretion of electrolytes, etc. on the day of fever, accumulation of water in the body before and drop of serum potassium level during the attack Administration of potassium chlorid was ineffective in both prevention and treatment of the disease.
Thirdly we studied another case of a female patient, 51 years old who had tabes dorsalis in a mild grade. We artificially cauged her to be suffering from the similar fever to periodic fever through the intravenous injection of typhoid vaccine, and after we studied the case further, comparing it with two cases above-mentioned, we found that although the alteration of urine was somewhat similar to that of the second case, it was of slight grade, i. e. lack of water in the body after attack and drop of serum potassium level during attack were slight. Thus we have come to assume that drop of serum potassium level in the cases of periodic fever had nothing but a secondary meaaing.
We presume that the alterafion of urine in our cases of periodic fever is an interesting finding which has a possibility to be adopted as a symptom of the periodic disease even from literary point of view.

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In order to learn the prognosis of TB cases who had no access to chemotherapy, and to find the status quo of TB cases among disabled ex-soldiers, a study was cooducted on 2, 160 ex-soldiers treated in our sanatorium for the period of 7-13 years.
1. Of the 2, 160 cases, 14.5% were working, 5.9% were still recuperating, 45% were dead and 34.7% could not be followed-up.
2. Cases which had their onset at the ages between 22 and 24 were mos tfrequent, frequency distribution for 22 years of age was as many as one fourth of the total.
3. 27% cases had fever as their chief complaint at the beginning of the disease, and the mortality rate for this group was 46%. 10.4% cases had coughs and sputa excretion as their chief symptoms at the beginning and their motality rate was 55.8%.
4. 44.4% cases of the total contacted the disease in Japan Proper. Mortaiity rate in the course of hospitalization was very low in the cases treated in sanatoria.
5. 80.9% cases were hospitalized in the sanatorium within a year and half after contracting the disease. Mortality rate for those who had been hospitalized within 3 years from the onset was 45%, while that of the other group was 5.%.
6. 70% cases were diagnosed as lung tuberculosis at the hogpitallzation and 50% of them were fatal. Almost all the cases who had laryageal and intestinal tuberculosis complications were dead.
7. In 50% of the total cases, term of hospitalization was less than 1 year and their motality rate was about 33%. The longer the term was, the higher the rate of employment was.
8. 33% of the total cases died within 5 years from their first attack. 50% of the cases who had been discharged from the sanatorium died within 3 years.

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This paper deals with the relation between clinical effects of anti-tuberculous drugs and mode of administration with the reflection of resistance, in the chemotherapy of tuberculosis. The following results were obtained from our 95 cases.
1. By mode of administration, percentages of alleviation varied as follows: SM and PAS combined group-33.3%; Continued SM group-28.5%; Intermittent SM group-40%; Continued PAS group-33.3%; INAH and SM or INAH and PAS combined group-42.8%; TB₁ continued group-33.3%; INAH continued group-35%; Intermittent INAH group-33.3%.
2. Alleviation was observed in 4% of the registant group; in 19% of sensitive group and in 74% of negative group, respectively.
3. By the degree of seriousness of the disease, the chemotherapy was found to be more etfective in moderately advanced cases than in far advanced cases.
4. By means of chemotherapy, 12 cases and 2 resistant cases out of the 95 cases turned into so better conditions that the indication for the surgical treatment was coasidered.
5. Homoptysis arose more frequently in INAH administration groups than in other groups. However, no relation was found between the cause of death and the degree of resistance.

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This paper deals with the secondary reactions caused by the percutaneous bronchography with the injection of 40% moljodol, 492 trials in 318 cases, during the period from October 1950 to August 1954 at Myojo National Sanatorium.
1. Anorexia was observed and sleeping was slightly hindered.
2. Coughs and sputa increased conparatively in about half of the total cases for 3 days subsequept to the test.
3. In 30% to 40% of the cases, accelefated blood sedimentation was observed.
4. In about half of the total cases, slightly transitory fever was observed.
5. In about 12% of the total cases, discharge of tubercle bacilli increased.
6. In about 17% of the total cases, headache was complained. Other secondary reactions were slight and few.
7. Remaining time of the contrast substauce was different by each case, the longegt was 2 years and 10 months. Generally, in collapsed lesions, eloggated time was observed.
8. General conditions were aggravated through the bronchography in one case out of the total bronchography trials and 2 cases had no changes.

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The authors have administered standard doses (10-15mg/kg, average dose of 0.6g daily, for 1-2 months) and over doses (40mg/kg, average dose of 2.0g daily, for 10 days) of INAH in 38 non-tuberculous schizophrenia cases, and have observed INAH's psycho-neurological reactions, for 3 months. The results showed that there were essentially no effects upon psychic symptoms, except some transitory changes.
Psycho-neurological side-reactions of INAH in our schizophrenic cases lacked multifariousness, which shall be expected in tuberculosis cases. However, in deteriorated cases, polyuria was characteristic reaction.
Continuous administration of INAH in schizophrenia caused relative and probably transitory reduction of the function of hypophysis' adreno-cortical system (by Thorn's Test), and autonomic Pervous system became vagotonic in many cases.
Two cases in the over-dosed group had spikes in their EEG, and increase of amplitude of α-wave was observed in the case who had convulsion after the intravenous injection of INAH.

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Out of 100, 000 case-records in 12 mental hospitals and university-clinics, in the latest 8 years, 850 were from Ichikawa City, a neighbouring Small city to Tokyo. Among these 850 cases, 518 psychosis in narrow sense and 278 neurotics cases were found. Results of our ecological study on these cases are as follows:
1. Histogram by age gave the highest frequency in the 15-25 age class and a little upwards curve at 75 years of age and more. The frequency distribution is different from that of American authors, who reported the always increasing frequency in proportion with age.
2. Occurrence of schizophrenia was highest in the 20-25 age class, that of general paresis was high in the 50-65 class and that of M-D-I had no sigaificant difference by age class.
3. As for education, schizophrenia cases were the lowest, in the average, and M-D-I cases were the highest. As for matrimony, schizophrenia cases had the highest frequency of celibacy, while general paresis cases had the highest frequeacy of narried life. As for occupation, highest unemployment's rate in schizophrenia and lowest rate of that in M-D psychosis were found.
4. As of 1950 census, except under 14 years of age group, in 20 areas, we could not find any concentration of the disorders in the centre of the city. However, it was found that the rate was highest in the condensed residential area and lowest in the agricultural area. Especially, the rate of schizophrenia was highest in the area with high special mobility and lowest in that of low spacial mobiliy. Rate of M-D-I was highest in the most jammed area and lowest in the least jammed area. Rate of general paresis was remarkably high in the needy factorial area and lowest in the agricultural area. Rate of neurosis was highest in the residential area and lowest in the agricultural area.
5. In 5 small sample areas; i. e., residential: condensed-residential; commercial; factory and agricultual areas; as of 1950 census, number of meatal disorders per 100, 000 populations were largest in the factory and condensed-resideptial areas, and was small in the agricultual area. The same order was found by schizophrenia. M-D-I had no significant difference by area. Rate of epilepsy was higher in the factory area. Rate of general paresis was high in the factory and condensed areas, and that of neurotics was high in the condensed residential and commercial areas.
6. Through case-study in each social stratification, in the sample areas, it was found that rate of socially-adjusted was high in the factory area and low in the agricultural area.

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By means of the formulae, t=Kg/GM; P(Atm.)=(1000×S×W/2420)×t/T₀;t=freezing-point depression; K=constant (in case of water, 1, 8c0); M=molecular weight of solute; g=weight of solute; G=weight of solvent; S=density of solution; W==latent heat (in case of water, 79.6cal.); T₀=temperature of fusion by absolute scale), freezing-point depression and osmotic pressure of 5 dye golutions=: mercurochrome, eosin, flumejodin, rhodamin and fluorescein natrium of 1% solution, respectively were theoretically calculated.
The following table is the result of the calculated.
The values of t and P of fluorescein nat. are the highest and those of flumejodin are the lowest values. In case of mercurochrome and eosin their values are very alike, taking the intermediate values of the two extreme dye solutions.

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