Using a scanner of a scintillating type medical spectrometer, foundamental examinations were performed to obtain the true distribution volume of radioiodine-131 in the thyroid glands.
The scintigram of the thyroid glands always gives enlarged or reduced size as compared to its real size, These variations are caused by the following factors; a, the distribution volume of radioiodine-131, b, distance between the subject and the collimator, c, isoresponse field, d, sensitivity of the detector, and e, dot factor. So, the author performed several kinds of measurements. They are:
1. Isoresponse field with various kind of collimator,
2. The effect of dot factor and curiage on the appearance of scan,
3. The effect of distance and dot factor on the appearance of scan,
4. Variation of phantom and of depth with I-131 capsule source, Results
It was noted that the enlargement percentage is proportional to the curiage per cm² and is inversely proportionate to the dot factor and the distance. Therefore, when the estimate weight of thyroid gland is 50 to 100 grams and the uptake rate of radioiodine-131 is 60-90 percent, the administration amount with 100 to 150μc and about 4 counts per dot appears to be most effective.

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Adjusting experimentally to have similar amount between simultaneous blood replacement and depletion, and giving various solution to 15 adults dogs, effects on the blood compositions were investigated. The solution used in this experiment were crystalloids represented by saline solution, glucose represented by 596 dextrose solution, and colloidal solution such as glycoalgin etc.
In 3 cases saline solution was used. In one case Ringer's solution was used. In 3 cases 5% dextrose solution was used. In two cases Ramel solution was used. In 3 cases glycoalgin solution was used. In one case plasgen, dextran-G and blood itself was used.
Results:
Gradual diminutive changes of RBC and hemoglobin concentration were noted with crystalloid-, glucose-, and colloidal-solution till the amount of depleted blood reached 10-20ml/kg body weight. Beyond this level the decrement became sharp. When blood was used for replacement, this decrement was not observed till the level of depleted blood reached 60ml/kg, then diminution was rather minimal.
The reticulocyte count had remarkable increase with crystal-, glucose-solution, and in the glycoalgin case, while rather minimum increase was shown in plasgen and dextran-G cases.
In the animals who had replacement with glucose-, crystal-solution and glycoalgin, a marked shift to left of the reticulocyte series was noted. Except in the animal where blood was used for replacement, protein concentration decreased in all of these experiments. The diminution was 4-15% in depleted animals with 10ml/kg body weight, 20-27% in 20ml/kg, 30-36% in 30ml/kg, and 35-46% in 40ml/kg bled dogs.
Decrease of hematocrit values occured in all animals. When the depleted amount reached 10ml/kg, then the decrease was found to be 4-7%, in 20ml/kg 10-21%, 30ml/kg 22-33%, and in 40ml/kg depletion the decrease was 33-38%.
In the animal where blood was used for replacement, the hematocrit value did not change till the depleted amount reached 60ml/kg; beyond this value, whole picture was minimal.
In the animal where blood was replaced with crystalloid solution, a retardation of sedimentation rate was observed. This retardation of sedimentation rate was, however, temporary and it soon returned to its pre-experimental value. Retardation was also noted in the case given plasgen, but acceleration of sedimentation rate was observed in the animals where dextran and glycoalgin were used as the replacements.

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In regard to atypical mycobacteria in Japan the author collected specimens of the same bacteria of yellow type isolated from patiens' sputum, which were gathered in such a way that each patient was required to submit specimens more than twice, and bacteriological investigations were performed, Simultaneously the author also made study on scotochromogen, Ishii, which was isolated from deseased female child patients. As for animal experiment, using method of Yamamura the author inoculated rabbit atypical mycobacteria (yellow type) and succeeded in producing an artificial cavity in the lung of the rabbit which enabled the author to confirm the pathogenity of the germ.
And sensitivity to the various antituberculous agents of the atypical mycobacteria was also studied and as a result the author recognized that this study had significant meaning. The author made phage-typing studies on the atypical mycobacteria.
The author was able to confirm the existence of biochemical differences between this bacteria and other mycobacteria, namely in regard to several fermenting activities some were similar to bac, smegma and it was found that this fact was significant in differentiation of atypical mycobacteria from the ordinary mycobacteria. A notable fact was confirmed that using atypical mycobacteria we could exhibit an immunologically positive reaction to tuberculin and it is believed that this fact will render great services toward the progress of the immunological study.
In conclusion, the author emphasizes that both at the clinics or the laboratory the atypical mycobacteria should not be ignored as “non-pathogenic” but great concerning should be paid to it, particularly, if it's the yellow type.

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