1) The Rate of Occurance of Homologous Serum Hepatitis.
Observations of homologous serum hepatitis with jaundice were made in 27 national hospitals and 46 national sanatoria in Japan.
The number of the patients with the disease described above treated at the sanatoria were one in 1951, 6 in '52, 23 in '53, 63 in '54, 248 in '55 and 205 in '56, totaling 550. While the number of the patient with infectious hepatitis observed at the national hospitals was 254 during the year of 1955.
The mortality is 2.46 with the serum hepatitis and 4.796 with the infectious hepatitis.
2) Morbidity of Serum Hepatitis
Out of 7, 638 patients 370 blood recipients were found to have serum hepatitis, indicating 4.8% of the morbidity. And out of 6, 031 patients with pulmonary tuberculosis 307 blood recipients (5.1%) were found to have hepatitis, while out of 1, 372 non-tubercular patients we found 59 (4.3%) who were suffering from hepatitis in addition to their original diseases, This indicated that the former had a higher morbidity than that of the latter.
3) Some Findings of Serum F epatitis
The number of the patients was 419 male and 131 female and the largest number of patients were in their twenties, In most cases 1, 000-1, 500cc of blood was obtained. These were stored blood from the blood bank, fresh blood Plasma, serum and their combinations, The number of patients who received stored blood from the blood bank was 358 and this was the largest number, It is evident that lately we have much more opportunity to use stored blood, however, we are not able to tell that the occurrence of jaundice is more frequent with stored blood rather than with fresh blood.
In regard to the period of the jaundice outbreak after the transfusion, it is indicated that 80% of the patients lay in from one to three months, 36 patients lay within 30 days and 13 patients lay in over 180 days.
4) Search for Carrier
There were 14 carrier donors. A donor who caused more than two patients with serum hepatitis was diagnosed as a carrier
Explanation of Figures
(A), (B) or (C), is the sign of the donor and (1), (2) or (3) etc, is the recipient, (A) (B) shows that the recipients received blood of the donor (A) (9, 15) shows the date that blood was collected.
1 or 2 etc, is the sign of a recipient suffering from jaundice.
(A) or (B) etc. is the sign of the carrier donor.
(-) indicated no history of jaundice.
Figure 1
There were four donors (A), (B), (C) and (D) who previously had supplied blood to a recipient (1) who later had jaundice. The donor (A) also supplied his blood to the other four recipients (2), (3), (4) and (5) The recipient (2) also suffered from jaundice, The donor (B), (C) or (D) supplied their blood to several other recipients respectively, but none of them suffered from jaundice, Accordingly we regarded the donor (A) as a carrier.
Since recipient (1) and (2) were given blood from donor (A) on 20 August and 15 September, these days were decided as the date of receiving blood, so 27 days were recognized as the date that infectious agents were kept by the two recipients, And donors (A), (B), (C) and (D) have no history of jaundice.
Fig. 2, Fig. 3 and Fig. 4 indicate that donor is the carrier, while Fig. 5 indicates that donor (A) and donor (B) are the carriers, Fig. 6 shows the carriers are whether donor (A) or (B) or both of them. Fig. 7 shows the carrier is unable to determine.
An investigation was made to know the period of time that the fourteen carriers held the infectious agents with them individually and it was found as from 23 days to 252 days.
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