In 1898, blood pressure of psychosis was reported by M. Craig. Since then several studies concerning blood pressure and psychic factors were reported by several researchers. In 1930's, studies of hypertension through psychosomatic aspects were reported, however, number of cases handled in these reports were very few. It was only curing the last 10 years that studies on many hypertensive cases had been reported. (cf. E. Weiss, F. Dunbar. G. C. Gressel, F. M. Reiser). However, there has been no report concerning psychic differences between hypertension group and normal healthy group. The authors intended to find psychic factors relating to hypertension. Subjects were 1, 800 workers (above 30 years of age) employed at the Nikko Copper Works, Nikko, Tochigi Prefecture. Reasons of choosing that factory were: 1. It is situated on high altitude (71bm above sea lever) in cold climate and its workers are mostly laborers. These conditions expect higher blood pressure. 2. Its workers are mainly male. Life histories of each workers are very simliar, i. e., they are generally from poor farmers and of mostly primary school education. Their living conditions lasted for more than 10 years, in most cases.
In this report, preliminary general items shall be discussed.
1) Blood pressure of 1, 707 subjects were measured.
2) Mean systolic blood pressure by age group was 6-9mrnHg higher than Japanese standards by age.
3) Rate of hypertension in laborers was higher than in office workers (20.2% vs. 18.4%).
4) Rate of heredity of hypertension in hypertensive cases was higher than in normal tension cases (21.6% vs. 19.1%).
5) Rate of hypertension was higher in those residing in Nikko for more than 20 years than in those dwelling less than 20 years.
6) More obese cases were found among hypertension cases than among normal cases (11.3% ve. 9.1%).
7) Correlation between food (quantity, quality, etc.) and blood pressure was not observed.
8) More cases who indulge in alcoholic beverages were found among hypertension cases (34.6%) than those of normal (20.8%). No correlation was found between smoking and hypertension.
9) Albuminuria was found in 6.1% of hypertension cases.
10) No correlation was found between hypertension and pace of work. It is summarized that high rate of hypertension in the Nikko Copper Works may be primariry due to altitude, cold climate and not due to heredity, excessive drinking of alcoholic beverages, and physical constitutions.

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Tubercular cavity is one of the most serious sources of infection. Its types of healing process are: 1. Closed, 2. Open and 3. Cicatrized. For a long time, direct injection of various anti-tuberculosis drugs through chest's skin into cavity had been tried by many researchers. The authors checked clinical results, degree of resistance of TB bacilli by direct injection of Isoniazid into pulmonary tubercular cavity.
1) 5ml of 20mg/ml solution of Isoniazid was injected into larger pulmonary cavities of 25 TB cases. 16 to 51% of the cases were improved. Reduction of both coughing and sputum was reported in approximately 37 to 45% of the cases. Therefore, it may be stated that the method is very effective therapy in cases that have cavities and complain of cough or sputum excretion.
2) It was found that excretion of TB bacilli decreased in 45% of the cases and that dimension of cavities reduced in 50% of the cases, by means of the methcd. However, bacilli negative result was not obtained in bacteriological cultures of sputum.
3) Remarkable congestion, fibrination and purification were found in lining of cavities by histological examinations.
4) Degree of resistance of tuberculosis bacilli varied. Number of days of development of resistance did not vary regardless of means of administration of Isoniazid. In about 20% of the cases, any resistance of TB bacilli did not appeare for 16 weeks.
5) Blood concentration of Isoniazid was examined according to the method of Kelly et al. i. e., by means of spectrophotometer (with wavelength of 266mμ). If 20mg/ml of Isoniazid was injected into tubercular pulmonary cavity, blood concentration of Isoniazid became 1.6γ/ml by one hour. In case of oral administration of 200mg of Isoniazid, blood concentration of Isoniazid by 2 hours was 2.4γ/ml. In case of hypodermic injection of 50mg of Isoniazid, blood concentration by 30 minutes was 11.1γ/ml.
6) Direct injection of Isoniazid into pulmonary tubercular cavity is expected to improve symptoms, reduce tuberculosis bacilli and dimension of cavities. The authors' method may be recommended as a proper method which shall be conducted before collapse therapy.

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557 TB patients in the Niigata National Hospital were observed in absolute resting for 2 hours in the morning and 2 hours in the afternoon everyday, and Donaggio Reaction Test was conducted prior to and after each resting in each case. For the control, the same examination was performed on 118 healthy cases.
Results showed that Donaggio value decreased after resting in 460 cases, did not vary in 28 cases, and increased in 69 cases. In the decrease group, most frequent value of difference between the Donaggio value prior to resting and after the resting was from 3.7 to 6.2, while in the increase group, it was from 3.4 to 6.7. Those cases of which increase or decrease of the Donaggio value was greater than the most frequent values may be thought to be incapable of recovering from fatigue satisfactorily by the given time of resting and to be inadequate to be relieved of resting. The author took the said most frequent value of difference of Donaggio value as the reference value, and counterchecked clinically ordered degree of resting for its excess or insufficiency in each case. Thus the author set proper grade of resting by TB patients.

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Twenty-one male mice were injected with a strain of human type H37RV tubercle bacilli which were resistant to Isoniazid. They were divided into 3 groups of 7 mice; Group-1—control. Group-2—those treated with 200mg per kg daily of para-aminosalicylic acid, subcutaneously, Group-3—those treated with 200mg per kg daily of streptomycin, hypodermically.
Treatment begun 48 hours after injection of the test strain and continued for three weeks. At the end of the experiments, all survivers were killed and autopsied.
Widely spread destructive tuberculous lesions were seen in the control group, while regression of active lesions was seen more remarkably in the streptomycin treatment group than in para-aminosalicylic acid treatment group, as determined by macro-, microscopic, and bacteriological exminations.
It is concluded that, by means of the method of application used in the experiments, streptomycin is more effective than para-aminosalicylic acid in progressive tuberculosis in mice caused by human type H37RV tubercle bacilli, which are resistant to Isoniazid. The authors will report further results of experiments on tubercle bacilli, which are more highly resistant to Isoniazid in the next chance.

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The authors observed four cases of psychosis which were subsequent to administration of INAH. These cases showed clinical patterns of endogenous psychosis (schizophrenic patterns).
Two cases were of reversible schizophrenic reactions which disappeared by discontinuance of INAH administration. Case-1: age-44, male, of schizothymic character, hospitalized on account of serious pulmonary and intestinal tuberculosis. By administration of 10g of INAH, headache and irritableness were recorded. Later, depersonalisation, acustic hallucination, ideas of reference developed. In two months, complete recovery was reported. Case-2: age-30, male, pulmonary tuberculosis. Administration of 20g of INAH caused anorexia, headache, overactivity, wandering-about, delusion of persecusion, acustic hallucination In four months, complete recovery was reported without any special treatment.
Two other cases were not reversible and presented clinical patterns of schizophrenia. They are still hospitalized in the mental wards. Case-3: age-29, female, serious pulmonary tuberculosis, heavy heredity of schizophrenia, i. e., father and three brothers were schizophrenia and dead. By administration of 4g of INAH, hebephrenic reaction was observed. Recovery was not permanent by discontinuance of INAH administration. In six months, hallucination and delusion attacked, which led her to suicide. Case-4: age-18, female, pulmonary tuberculosis, schizothymic character. By administration of 10g of INAH, depression developed. Distrubance of thinking gradually developed. In two months, she fell in katatonic agitation suddenly.
According to the authors' observation of side-reactions of INAH, toxic process of INAH may be suspected to affect mainly diencephal-hypophyseal system.
Patho-biochemical effects of INAH has been considered to be of glycoregulatory disturbance and of vitamin deficiency due to inactivitation of amine oxidase.
Psychosis which develops by administration of INAH presents various patterns, such as intoxication psychosis by overdosis, symptomatic psychosis due to metabolic disturbance or internal secretory disturbance, and probably schizophrenia (reversible or irreversible).

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Peripheral blood pictures and functions of pituitary-adrenal system (by means of Thorn's method) were examined before and after administration of vermifuges in 38 inpatients, who had no other complications than hoakwoim infection.
By means of liver function test, effects of vermiguges and their secondary reactions on liver functions were also investigated.
Results were as follows:
1) Subjective symptoms decreased by two or three days after administration of vermifuges, 7 days at the latest and in most cases symptoms were completely released by one month.
2) Since all the cases had slight anaemia. no clear relations were found between decrease of blood cells or haemoglobin, and number of worm eggs or worms in excrements. Relation between increase of eosinophile cells and number of hookworm eggs or hookworms in excrements was hardly seen, however, eosinophile cells seemed to resume their normal conditions generally six weeks after discharge of hookworms in excrements.
3) A low correlation was seen between reaction of occulte blood and number of hookworm.
4) No relation was seen between pituitary-adrenal functions and number of discharged worms or worm eggs, or perecentage of increased eosinophile cells.
5) Liver functions were generally slightly damaged and resumed normal conditions by one week after discharge of worms.
6) No differences in effects between tetrachloraethylen and tetren (derivative of tetrachlcraethylen) were observed, however, tetrachloraethylen gave less secondary reactions against liver than tetren.
Therefore, tetrachloraethylen may be preferable as a vermifuge. The results were concerning to Dubini hookworm cases, and further studies on Necator Americanus cases are under research by the authors.

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For the purpose of study of haematopoesis of pregnancy anaemia, relation of erythrocytes' volume and diameter with reticulocytes' maturation was investitated in about 50 cases (17 of them were of Hb. value of 60% or less).
Results were as follows:
1) Group of cases of which Hb, value was more than 60%: Most of them were not so different from normal non-pregnant case in dimension of erythrocytes and maturation of reticulocytes at their initial stages of pregnancy. However, after mid stages of pregnancy, microcytosis and delay of reticulocyte's maturation were found slightly, but maturation was observed partly.
2) Group of cases of which Hb. value was less than 60%: Most of them showed more abnormality in M. C. V., Price-Jone's curve, and in delay of reticulocytes' maturation. Macrocytic anaemia cases showed most remarkable delay of maturation.
3) Grade of anisocytosis was generally parallel to the delay of reticulocytes' maturation.

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Distribution of radioactive phosphorus in mice was researched and the following results were obtained:
1) When radioactive sodium phosphate (Na₂HP³²O₄) was given subcutaneously intramuscularly or oraly, it distributed very rapidly in organs and tissues of mice, independent of methods of administration. Ratio of radioactivity per gram by each organs or tissues were examined and it was in the following order: bone, liver, spleen, kidney, small intestine, heart muscle, lung, muscle and skin. Brain tissues showed the lowest value.
2) Distribution velocity of radiophosphorus given by injection was more great than in case of oral administration, and also ratio of distribution of radiophosphorus in organs or tissues was lower in the latter cases.
Peak of distribution in liver and kidney was seen by one hour and that of the other organs and tissues were from three to twelve hours after administration of radiophosphorus, however, in case of bone tissues, about twenty-four hours were recorded.
3) Peak of distribution of radiophosphorus in digestive tracts were at twelve hours after administration, except for large intestine, and higher value was recorded in duodenum and small intestine than other parts. In case of large intestine, it was about twenty-four hours after administration According to the results, circumstances of absorption or excretion of radiophosphorus in digestive tract could be suspected.
4) Distribution of radiophosphorus in transplantable malignant tumor (sugar sarcoma) was little value during a short period after injection, however, by twenty-four hours it became almost similar value to that of liver, spleen, or kidney.
The results could suggest clinical usefulness of radiophosphorus for diagnosis or treatment of malignant tumors.

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