We performed a total of 90 central venous catheterizations in 51 patients admitted between 2004 and 2007 with a primary diagnosis of respiratory diseases who received total parenteral nutrition or administration of antibiotics or in whom a peripheral venous line could not be obtained. To obtain a central venous line while avoiding the risks of pneumothorax and hemothorax, we performed 25 peripherally inserted central venous catheterizations (PICC) and 65 femoral venous catheterizations. Of these episodes of catheterization, 29 episodes required immediate removal or re-insertion of a catheter, reasons for which included suspected catheter-related bloodstream infection in 23 episodes and occlusion of a catheter in 6 episodes. Causing no serious complications, both PICC and femoral venous catheterization were useful for the management of patients with respiratory diseases.