Since 1943, the implantation of endocrine organs to patients of various skin diseases have been tried by many authorities in our country, while the mechanisms of the effects have not been m ide clear.
The author have carried out some experiments with implantations of pituitary gland, thyroid gland, and epinephric gland.
We observed increase of leucocytes, decline of lymphocytes, increase of eosinophile cells, scantry of segmentations of nucleus of neutrophile cells, acceleration of blood sedimentation rate, and decrease of serum protein.

View full abstract

We prepared a photoradiographic dark box, taking films by rotatory crossgraphic, and took relatively good photography. By this method we will be able to determine easily and continuously the gross of the lung and the places of disease.

View full abstract

1) On 30 cases of pulmonary tuberculosis, the number of tubercle bacilli in 80 twentyfour-hour-specimens of sputa were counted by smear and culture methods. The methods and the results were described and discussed in the present paper.
2) There were many cases who showed significant differences between the Gaffky numbers of purulent parts of sputa and of the homogenized specimens in 24-hours excretions. Therefore, in order to know the number of bacilli excreted, it may be more accurate to examine the homogenized sputa in twenty-four-hours.
3) The daily fluctuation of the number of bacilli excreted by one patient for twenty-four-hours was comparatively little.
4) The daily number of bacilli counted by the culture method was generally smaller than that obtained by the smear method. Most of the examinations showed that the ratio between the bacillary counts by culture and the count by smear covered 11% to 100%, and the average was 43.2%.

View full abstract

On tuberculosis patients including severe, moderate and slight cases, the eosinophils in the circulating blood were counted and the diurnal fluctuation were studied. The counts were taken 4 times a day and the total examination was 499.
Results were as follows;
1) Number of eosinophils in 1mm³ of blood varied from 0 to 2, 819. Number of cases, whose eosinophils were 70-450 at 6 a. m., were 71.8% of the total cases.
2) Taking the counts at 6 a. m. as the stanlard of diurnal variation of eosinophils, the cases were divided into three types; decreasing type (62 out of 102 cans), increasing type (31 out of 102 cases) and inconstant type (9 out of 102 cases).
3) There was no remarkable difference in the trends of changes of eosinophils counts by time.
4) Those who had more than-40% of changes of eosinophil counts were mostly severe cases.
5) In the severe cases who received chemotherapy and recovered favourably, the number of eosinophils increased and their diurnal change became less than before the treatment.

View full abstract

Spleens of 76 tuberculosis cases autopsied in our sanatorium were examined hiscologically with attention to the cells of reticuloendothelial system and tubercles.
Results were as follows;
1) Tubercles were found in follicle (31 cases), in pulpa (31 cases), in trabecula (10 cases) and at the periphery of the follicle (34 cases). The periphery of the follicle was most frequently involved. In the same spleen, many parts were seen simultaneously involved by tubercles. The tubercles at the periphery of the follicle extended to the central part of the follicle as well as to the pulpa.
2) By observation with silver impregnation method, elipsoids (sheathed arteries) were proved in many tubercles. It is recognized that the reticulum fibrils of the elipsoids transformed into fibrils which consisted the tubercles, and tubercles developed along the elipsoids which showed swelling and proliferation of reticulum fibrils. The relation between tubercles and elipsoids was more clearly observable in the early tubercles than in the old ones. Most tubercles in follicles developed at their periphery, and many tubercles in pulpas localized near the follicles. Elipsoids were proved in the trabecular tubercles.
3) There were proliferation of reticulum cells around the early small tubercles in the follicle. These cells were found also in the tubercle. The protoplasmatic projection of reticulum cells inside and outside of the tubercle were connected tvith each other. In some cases, focal proliferation of reticulum cells, which shall be regarded as atypical or early tubercle, were found near the follicles. Old tubercles contained many reticulum cells or histiocytes and had not clear borders. Fibrous network of the tubercles sprerded into the surrounding tissues. These findings indicate that reticulum cells have a important role in the formation of tubercle.
4) Follicles showed the tendency of atrophy, decrease of lymphocytes and increase of reticulum cells. Hypertrophied follicles were observed in cases with slight tuberculous changes in other organs.
5) In the spleen in which follicles were heavily involved, the cell proliferation and infiltration around the elipsoids were found.

View full abstract