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Volume 28, Issue 12
Displaying 1-15 of 15 articles from this issue
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Mitsuo OTA, Kosei YASUMOTO, Masaoki KOMORI, Atsushi TANAKA, Osamu KOHA ...1974 Volume 28 Issue 12 Pages 1035-1038
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSThe active immunotherapy was performed on the 9 patients who had had pulmonary resections for the carcinoma. Membrane extracts of the autochthonous tumor cell were used for a tumor antigen and AD6 fraction used for an adjuvant. This AD6 fractionated from acetylating Wax D has been proved as having only adjuvant activity and not having antigenicity.
Following the resection of the lung cancer the tumor cell vaccine was once or twice innoculated subcutaneously in the upper extremity.
The survival rate of 9 cases treated with an active immunotherapy increased rather higher up to 18 months, as compared to the other 218 cases without an immunotherapy. The 3 year survival rate, however, decreased down to the survival rate of 218 cases.
According to our studies, the active immunotherapy seemed to be effective in the prolongation of lifespan during the first 18 months. A disadvantage of this therapy was hard-healing ulcer at the injection site.View full abstractDownload PDF (468K) -
Yuhei AMAMOTO, Ryuzaburo TAKAO, Kenji KUBOTA, Masaaki YASUNAGA, Kenro ...1974 Volume 28 Issue 12 Pages 1039-1044
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSIn radiotherapy for stage I and stage II cancer of the uterine cervix, the irradiating fields should be limited to the primary lymphnodes, parametrium and pelvic wall. Injury to the intestine and bone marrow and irradiation of the femoral neck and kidneys should be kept at a minimum.
With the aid of pelvic lymphadenography and angiography, and radiography of the pelvis at surgery, the corresponding area's correlation to the pelvis was investigated.
The irradiation areas were hexagonal, derived from points 1, 1', 2, 2', 3, 3'on the anteroposterior (AP) and from a, a', b, b', c, c'on the posteroanterior (PA) projections.
1 and 1': A transverse plane at the level of the posterior portion of the iliac crests, (lateral points from the fourth lumbar vertebra by a half of the vertebral width).
2 and 2': A transverse plane midway between that at the iliac crests and one at the level of the ischial tuberosities (the midway of each iliac shadow).
3 and 3': intersections of a transverse plane at the midsymphysis level and the lateral margin of each obturator foramen.
a and a': correspond to 1 and 1'on the AP projection. b and b': correspond to 2 and 2'on the AP projection. c and c': intersections of a transverse plane at the level of the inferomedial angle and the lateral margin of each obturator foramen.
These hexagons formed opposing cobalt-60 irradiating fields for therapy of stage I and stage II cancer of uterine cervix, with central shielding.
The hexagonal fields for each patient were obtained radiographically using a measuring plate. The fields were about 100 cm2, excluding the central shielded zones.
The method of describing the fields and their reliability are discussed.View full abstractDownload PDF (9530K) -
—AN ANALYSIS OF 37 CONSECUTIVE CASES AND SOME SURGICAL PROCEDURES IN ITS TREATMENT—Hidetane ONISHI, Kazuhiko YASUMURA, Koichi KOBAYASHI, Toshihiko RO, To ...1974 Volume 28 Issue 12 Pages 1045-1050
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSDuring the five year period between Jan., 1968 and March, 1974, 37 patients with obstructive jaundice were operated upon at the Okura National Hospital.
As the cause of jaundice 20 (54%) patients was benign and 17 (46%) patients had malignant lesion.
Common duct stone was a most common cause of benign obstructive jaundice and numbered 19 (95%). In malignant lesion, cancer of the head of pancreas was a most common cause and numbered 12 (70%).
In benign lesion, 9 patients underwent choledocho-duodenostomy, 5 patients transduodenal-sphincteroplasty, 5 patients choledochostomy and 1 patient other procedure.
In malignant lesion, 4 (23.5%) patients treated by resection and remaining 13 patients had an intestinal biliary by-pass procedure in which 4 patients treated with cholecysto-enterostomy, 4 patients with choledocho-enterostomy, 2 patients with Longmire's operation and 3 patients with other procedure.
The overall operative mortality was 24.3%, and in benign lesion 1 (5%) patient died and in malignant lesion 8 (47%) patients died postoperatively.
The striking finding is the high mortality (75%) after cholecysto-enterostomy.
A comparative study of choledocho-duodenostomy and transduodenal spbincteroplaty was carried out.
Choledocho-intestinal anastomosis is the preferred operation for palliative biliary-intestinal decom-pression because the high mortality rate was resulted if cholecysto-intestinal anastomosis was performed.View full abstractDownload PDF (879K) -
Yoshiharu KAYASHIMA, Ken IWATA, Kunihiko HASHINAGA1974 Volume 28 Issue 12 Pages 1051-1056
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSFifty gram glucose was given at fasting to 32 control subjects consisted of 6 normal persons and 26 patients without remarkable abnormal signs, 38 patients with pancreas disease, 77 patients with liver disease, 17 patients with diabetes mellitus, 10 patients with peptic ulcer and 18 patients with various abdominal complaints, whom organic disease was excluded by physical examinations.
Observation of serum amylolytic activity was performed just before and 1 and 2 hours after glucose ingestion. as compared with the serum amylase after glucose ingestion and at fasting the values decreased following oral glucose administration in the bulk of control cases. Conversely, increased amylase response was found in those patients such as with pancreas or liver disease, especially in those patients during the course of development.
From these result, we assumed that the investigation of serum amylase response to glucose ingestion was not only useful for a supplemental examination of pancreas or liver disease but also for an information of various conditions of the course of their inflammation.
This response may be based on conditions of cell membrane per se allosteric control or degener-ation of cell membrane followed by hormones or enzymes release or activation by inflammative mechanism.
Above hypothesis may be permitted by the fact that chemical mediators and phospholipase which acts on cell membrane, are released or activated during the course of pancreatitis or immunologic reaction of hepatitis, and may be suported by other worker's opinion such that serum amylase response to glucagon (decrease), adrenalin (increase) and ACTH or corticoid (increase following initial decrease), and amylolytic enzyme contacts cell membrane of microvilli in digestive tract, furthermore, serum immunoreactive glucagon level is rised during the glucose ingestion by means of the enteroglucagon release.
1) Janowitz, H. D. et al. Amer. J. Med., 27: 294, 1959.
2) Ugolev, A. M. et al. Biochem. Biophys. Acta, 86: 205, 1964.
3) Unger, R. H. et al., J. Clin. Invest., 47: 48, 1968.View full abstractDownload PDF (770K) -
USE OF SETS OF QUESTIONNAIREKen OKAMOTO, Akio YOSHIDA1974 Volume 28 Issue 12 Pages 1057-1062
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSDetailed informations obtained directly from the patient are of paramount importance in the diagnostic work-up of vertigo.
Two sets of questionnaire to be filled out by the patients, the original Güttich version and the other more detailed version of our own modification, have been put to clinical trial on 70 patients at the Munich University Clinic and 98 patients at the 2nd Tokyo National Hospital in order to evaluate their usefulness in sorting out those cases with Meniere's disease and other diseases associated with vertigo in various combination of symptoms.
It was found that patients could not be counted on to grasp the idea and follow the intended design of the examiner. Multiplication of detailed questions would not be of much value in defining a clearer clinical picture in each case.View full abstractDownload PDF (844K) -
Susumu TOMITA, Kazuo KAMIKUBO, Mitsuo MASHIKO1974 Volume 28 Issue 12 Pages 1063-1070
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSDuring recent three years, we experienced six cases of young children suffered from hypoplastic anaemia which had been treated with combined oral medication of adrenocortical steroids and anabolic hormone. 4 cases were idiopathic type and other 2 cases were pancytopenic type.
We treated them with the middle dose level, which initially 2-1mg/kg/day of predonisolone for 1-2 months, and after that reduced finally to intermittens administration, also combined with anabolic hormone (Oxymetholone or Methandrostenolone) 1mg/kg/day for several years. In addition to these medication, we treated with the blood transfusion at initial period.
As results of this treatment, 3 cases had a remarkable effect and are survive, 1 case had a moderate effect, and 2 cases with pancytopenia (2-years-old and 4-years-old girls) had no effect. Thus the effective rate was 66% and the survival rate was 50%.
This treatment may improve the regeneration of the haematopoiesis in the bone marrow slowly, although corticosteroids will recover rapidly the poor general condition, (fever, anorexia or haemo-rhagic tendency, ) and in addition stimulate the haematopoietic activity of the bone marrow at early time. At the same time the anabolic hormone will increase the production of “erythropoietin”in the bone marrow, but will not be effective for the thrombopoiesis.
As the side effect of this treatment, androgenic manifestation was common, but we took pre-caution against the susceptibility for bacterial or viral infections and liver damage (elevation of GOT, GPT-titer), as well as vulnerability of the treatment of leucaemia.View full abstractDownload PDF (2645K) -
Gyoichi KOYA, Masatsugu MAESAWA, Michio HONGO, Akira YAMAZAKI1974 Volume 28 Issue 12 Pages 1071-1076
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSSix patients other than SLE including progressive systemic sclerosis with sjögrens syndrcme and rheumatoid arthritis, idiopathic thrombocytopenic purpura with nephrotic syndrome, genuine epilepsy with nephrotic syndrome, psychosomatic state in poly-surgery and pulmonary fibrosis which fulfilled four items of preliminary criteria proposed by American Rheumatism Association were described.
Criteria of SLE published in the papers of British Medical Council (1962), Stevens (1963), WHO (1967) and ARA (1971) were compaired by the retrospective analysis of 161 patients with SLE seen at 24 National Hospitals during past four years. Considerable numbers of cases in the series were excluded in the percentage of 28.5, 28.0, 27.0 and 12.0 by the criteria of ARA, MRC, Stevens, and WHO respectively.
The limited usefulness of these criteria was discussed.View full abstractDownload PDF (707K) -
—THE RESULTS ON THE COMBINED USE OF BOTH OGAWA AND YAMANE MEDIA—Takeshi NISHIMURA1974 Volume 28 Issue 12 Pages 1077-1081
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSThe co-operative study group of laboratory technicians of National Sanatoriums in Tohoku District made a comparative study with the use of both Ogawa and Yamane media for the clinical detection of tubercle bacilli from sputum specimens of total 3, 832 which contain those of individual 1, 265 admited cases and 37 out-patients. Following results were obtained:
1. The bacilli grew more rapidly in Yamane medium than in Ogawa medium.
2. The detection rate of the bacilli in both media were significantly similar.
3. The contamination rate in Yamane medium was less than that in Ogawa medium. 4. Yamane medium positive and Ogawa medium negative cases and the reverse cases were observed in almost same number.
5. From the above results the combination use of both media was proved to be better.View full abstractDownload PDF (794K) -
Yoshihiro TAKITA, Toshihide DANTSUKA, Toshiro OGAWA, Mitsugi IKEDA, Ju ...1974 Volume 28 Issue 12 Pages 1083-1086
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSA 54-years-old male had been treated for past twenty years for edema in the face and extremi-ties, palpitation and vertigo, while his anemia, hypoproteinemia, hypocholesterolemia, positivity on stool examination for occult blood and abdominal pain had been aggravated in degree. Repeated G. I. series disclosed multiple ulcers in the small bowel. As symptoms of chronic intestinal obstruction were manifested, laparotomy was made in the 5th hospital year. It proved no ascitic fluids nor adhesion was present in the ileum. The small bowel, whose wall was generally edema-tous and thin, was distended from the ligament of Treitz to a point ca. 170 cm distal from it, in which the first constricting lesion existed;while the last was placed at a point ca. 170 cm proximal from the terminal ileum. Between them, there were 10 different large or small annular constrictions and dilatations. A segment of about 88 cm containing the lesions was resected with end-to-end anastomosis. On mucous membranes of the excised specimen, superficial ulcers compatible with the annular constrictions were seen while serous membranes were edematous and reddish. The specimen did not have any characteristics of formation of granulation tissues on the bases of ulcers except many inflammatory cellular infiltrations, suggestive of primary nonspecific ulcer of the small bowel. His postoperative course was uneventful and various examinations in the 3rd month showed normally recovered results. The patient has done well for these 20 months after sugery. A case of nonspecific ulceration of the small intestine have been reported with literary speculations.View full abstractDownload PDF (3788K) -
Yukio UESHIBA, Sango HAMANO, Michinari ITO1974 Volume 28 Issue 12 Pages 1087-1091
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESS(A) Two cases of diaphragmatic hernia through the foramen of Bochdalek were encountered. The patients were 9-years-old boy and 7-years-old girl. They were discovered by the mass chest X-ray surveys. The radical operations were performed successfully. The patients have been in good condition.
(B) One case of Interpositio hepatodiaphragmatica coli (Chilaiditi Syndrome) was experienced. The patient was 1 year and 9-months-old boy. He had an X-ray examination of the chest in the course of hilar glandular tuberculosis and this syndrome was discovered by accident. The patient has been asymptomatic in the abdomen. This syndrome is rare. So, only 6 cases in children have been reported in Japan.4View full abstractDownload PDF (7682K) -
Tsunekazu YAMANO, Shigemoto HABA, Yasuo KASUBUCHI, Morimi SHIMADA1974 Volume 28 Issue 12 Pages 1092-1096
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSPneumoencephalography were performed on sixty-four cases of physically and mentally retarded children who were institutionalized in Fukui National Sanatorium.
Eight cases of them disclosed cerebral malformations. Of these eight cases, five showed porencephaly, two showed septum pellucidum cyst and one case was agenesis of corpus callosum. All cases who showed porencephaly had various episodes at their late pregnancy or at perinatal period, while other three cases who showed septum pellucidum cyst or agenesis of corpus callosum had no positive history in the prenatal stage. Nevertheless, the time of onset of cerebral malformations in these 3 cases were considered to be the prenatal stage by pneumoencephalographic study.View full abstractDownload PDF (8611K) -
Masao ODASHIMA, Mitsuo KAMIHARA1974 Volume 28 Issue 12 Pages 1097-1099
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSThere are many discussion about infection due to corticosteroids and due to malnutrition. It was reported by Kumagai that the severe side effects of corticosteroids were infection, complication of digestive organs and psycho-neurosis.
In our sanatorium, there are 80 patients of cerebral palsy and 10 of them died by Oct., 73, Autopsy was done in 6 cases of them. In this paper, we report about one of these autopsy case who had a hydrocephalus due to pheumococcal meningoencephalitis during treatment of nephrotic syndrome by corticosteroids. Moreover he was aggravated by starvation cure as a popular remedy of nephrotic syndrome in it's initial stage.View full abstractDownload PDF (2560K) -
Koji ONODA1974 Volume 28 Issue 12 Pages 1101-1105
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSTwenty four cases of the far advanced cancer are treated with corticosteroid (dexamethason 25mg) and anticancer drugs (CPA 2, 000-3, 000mg, MMC 40mg) in 20 days.
1) Cancerous pain are disappeared ( 9 cases).
2) High fever due to induced infection (12 cases).
3) Anticancer effect: 8 cases effective, 7 cases are aggravated.
4) Hematological change: anemia, leucopenia, thrombopenia (22 cases).View full abstractDownload PDF (681K) -
V. Humoral Immunity Goodpasture's SyndromeEisuke SARUTA1974 Volume 28 Issue 12 Pages 1106-1107
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSDownload PDF (2158K) -
1974 Volume 28 Issue 12 Pages 1108
Published: December 20, 1974
Released on J-STAGE: October 19, 2011
JOURNAL FREE ACCESSDownload PDF (118K)
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